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Isoforms Recommended: ACAT1
Results for "

ACAT1

" in MedChemExpress (MCE) Product Catalog:

13

Inhibitors & Agonists

3

Natural
Products

2

Recombinant Proteins

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-13215
    Avasimibe
    Maximum Cited Publications
    9 Publications Verification

    CI-1011; PD-148515

    Acyltransferase Cancer
    Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC50s of 24 and 9.2 µM for ACAT1 and ACAT2, respectively [1]. Avasimibe can be used for the research of prostate cancer .
    Avasimibe
  • HY-100400A
    K-604 dihydrochloride
    2 Publications Verification

    Acyltransferase Cardiovascular Disease
    K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC50 of 0.45±0.06 μM.
    K-604 dihydrochloride
  • HY-RS00136

    Small Interfering RNA (siRNA) Others

    ACAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for ACAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    ACAT1 Human Pre-designed siRNA Set A
    ACAT1 Human Pre-designed siRNA Set A
  • HY-RS00137

    Small Interfering RNA (siRNA) Others

    Acat1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Acat1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Acat1 Mouse Pre-designed siRNA Set A
    Acat1 Mouse Pre-designed siRNA Set A
  • HY-RS00138

    Small Interfering RNA (siRNA) Others

    Acat1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Acat1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Acat1 Rat Pre-designed siRNA Set A
    Acat1 Rat Pre-designed siRNA Set A
  • HY-111880

    Acyltransferase Cardiovascular Disease
    γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC50s of 12.0 and 82.6 μM [1].
    γ-Sanshool
  • HY-100399

    PD-132301; ATR-101

    Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer [1].
    Nevanimibe
  • HY-100399A
    Nevanimibe hydrochloride
    2 Publications Verification

    PD-132301 hydrochloride; ATR101 hydrochloride

    Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC50 of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC50 of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer [1].
    Nevanimibe hydrochloride
  • HY-100401A

    CS-505

    Acyltransferase Cardiovascular Disease
    Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively [1]. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .
    Pactimibe sulfate
  • HY-100401

    CS-505 free base

    Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively [1]. Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .
    Pactimibe
  • HY-N10224

    Acyltransferase Metabolic Disease
    Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .
    Terpendole C
  • HY-126455

    Vermixocin A

    Acyltransferase Metabolic Disease
    Penicillide (Vermixocin A), isolated from Talaromyces derxii cultivated on rice, shows inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) .
    Penicillide
  • HY-118486

    Acyltransferase Metabolic Disease
    LDL-IN-1 (Compound 1) is an antioxidant, and is active against copper mediated LDL oxidation (IC50 = 52 μM). LDL-IN-1 is also an Acyl-CoA:cholesterol acyltransferase-1 and -2 (ACAT-1/2) inhibitor, with IC50s of 60 μM. LDL-IN-1 can be used for anti-atherosclerotic research [1].
    LDL-IN-<em>1</em>

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