Search Result

Isoforms Recommended:	ALK4

Results for "

ALK4

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (6) Apoptosis (3) EGFR (1) Organoid (4) ROS Kinase (1) TGF-β Receptor (10) Trk Receptor (1)
By Research Areas:	Cancer (17) Cardiovascular Disease (1) Inflammation/Immunology (1)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111482

SM 16

TGF-β Receptor Cardiovascular Disease Inflammation/Immunology Cancer

SM 16 is a ALK5/ALK4 kinase inhibitor with K_is of 10 and 1.5 nM, respectively.

SM 16	TGF-β Receptor	Cardiovascular Disease Inflammation/Immunology Cancer
SM 16 is a *ALK5/ALK4* kinase inhibitor with K_is of 10 and 1.5 nM, respectively.

HY-10432A

A 83-01 sodium 35+ Cited Publications	Organoid TGF-β Receptor	Cancer
A 83-01 sodium is a potent inhibitor of *TGF-β type I receptor ALK5 kinase, ALK4* and *ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4* and *ALK7*, respectively .

HY-13521

SB-505124 10+ Cited Publications	TGF-β Receptor	Cancer
SB-505124 is a selective inhibitor of TGF-β Receptor type I receptors (ALK4, *ALK5, ALK7), with IC₅₀s of 129 nM and 47 nM for* ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.

HY-13521A

SB-505124 hydrochloride 10+ Cited Publications	TGF-β Receptor	Cancer
SB-505124 hydrochloride is a selective inhibitor of TGF-β Receptor type I receptor (ALK4, *ALK5, ALK7), with IC₅₀s of 129 nM and 47 nM for* ALK4, ALK5, respectively, but it does not inhibit ALK1, 2, 3, or 6.

HY-10432

A 83-01 35+ Cited Publications	Organoid TGF-β Receptor	Cancer
A 83-01 is a potent inhibitor of TGF-β type I receptor ALK5 kinase, type I nodal receptor *ALK4* and type I nodal receptor *ALK7, with IC₅₀s of 12 nM, 45 nM and 7.5 nM against the transcription induced by ALK5, ALK4* and *ALK7*, respectively .

HY-10431

SB-431542 Maximum Cited Publications 162 Publications Verification	Organoid TGF-β Receptor Apoptosis	Cancer
SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC₅₀ values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways .

HY-10432G

A 83-01	Anaplastic lymphoma kinase (ALK)	Cancer
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent *ALK4/5/7* inhibitor .

HY-12071A

LDN193189 Tetrahydrochloride 45+ Cited Publications DM-3189 Tetrahydrochloride	Organoid TGF-β Receptor	Cancer
LDN193189 Tetrahydrochloride is a selective BMP type I receptor inhibitor, which efficiently inhibits *ALK2* and *ALK3* (IC₅₀=5 nM and 30 nM, respectively), with weaker effects on ALK4, ALK5 and ALK7 (IC₅₀≥500 nM) .

HY-122856

AZ12601011 1 Publications Verification	TGF-β Receptor	Cancer
AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC₅₀ of 18 nM and a K_d of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting *ALK4, TGFBR1, and ALK7*. AZ12601011 inhibits mammary tumor growth .

HY-19928

Vactosertib 3 Publications Verification EW-7197; TEW-7197	TGF-β Receptor	Cancer
Vactosertib (EW-7197) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC₅₀ of 12.9 nM. Vactosertib also inhibits ALK2 and ALK4 (IC₅₀ of 17.3 nM) at nanomolar concentrations. Vactosertib has potently antimetastatic activity and anticancer effect .

HY-19928A

Vactosertib Hydrochloride 3 Publications Verification EW-7197 Hydrochloride; TEW-7197 Hydrochloride	TGF-β Receptor	Cancer
Vactosertib Hydrochloride (EW-7197 Hydrochloride) is a potent, orally active and ATP-competitive activin receptor-like kinase 5 (ALK5) inhibitor with an IC₅₀ of 12.9 nM. Vactosertib Hydrochloride also inhibits ALK2 and ALK4 (IC₅₀ of 17.3 nM) at nanomolar concentrations. Vactosertib Hydrochloride has potently antimetastatic activity and anticancer effect .

HY-111752

*EML4-ALK* kinase inhibitor 1**	Anaplastic lymphoma kinase (ALK)	Cancer
EML4-ALK kinase inhibitor 1 is a potent orally active inhibitor of echinoderm microtubule-associated protein-like 4-anaplastic lymphoma kinase *(EML4-ALK), with an IC₅₀* of 1 nM .

HY-112140

JH-VIII-157-02	Anaplastic lymphoma kinase (ALK)	Cancer
JH-VIII-157-02 is a structural analogue of alectinib, acts as an *ALK* inhibitor, and shows an IC₅₀ of 2 nM for echinoderm microtubule-associated protein-like 4-ALK (EML4-ALK) G1202R in cells.

HY-153386

CPD-1224	Anaplastic lymphoma kinase (ALK)	Cancer
CPD-1224 is an orally active derivative of *ALK* inhibitors to cereblon ligands. CPD-1224 targets to EML4-ALK oncogenic fusions, and degrades ALK and mutant L1196M/G1202R .

HY-155227

ALK/EGFR-IN-1	Anaplastic lymphoma kinase (ALK) EGFR Apoptosis	Cancer
ALK/EGFR-IN-1 (Compound 8l) is an *ALK/EGFR* dual inhibitor that blocks the phosphorylation of EGFR and ALK. ALK/EGFR-IN-1 inhibits ALK/EGFR mutants respectively, with IC₅₀ of 4.3 nM for EGFR L858R T790M in H1975 cells and EML4-ALK in BaF3 cells, respectively. and 3.6 nM. ALK/EGFR-IN-1 may be used in NSCLC research .

HY-143557

Trk-IN-7	Trk Receptor	Cancer
Trk-IN-7 (compound I-6) is a potent TRK inhibitor with IC₅₀s of ranging from 0.25-10 nM for TRKA, TRKB and TRKC, respectively. Trk-IN-7 shows inhibition against EML4-ALK (IC₅₀<15 nM) ALK G1202R, ALK C1156Y, ALK R1275Q, ALK F1174L, ALK L1197M, and ALK G1269A (IC₅₀=5-50 nM) .

HY-12215

Lorlatinib 20+ Cited Publications PF-06463922	Anaplastic lymphoma kinase (ALK) ROS Kinase Apoptosis	Cancer
Lorlatinib (PF-06463922) is a selective, orally active, brain-penetrant and ATP-competitive *ROS1/ALK* inhibitor with anticancer activity. Lorlatinib has K_is of <0.025 nM, <0.07 nM, and 0.7 nM for ROS1, wild type ALK, and ALK ^L1196M, respectively. Lorlatinib targets to EML4-ALK, and inhibits ALK phosphorylation with IC₅₀s of 15-43 nM (ALK ^L1196), 14-80 nM (ALK ^G1269A), 38-50 nM (ALK ^1151Tins), 77-113 nM (ALK ^G1202R), respectively .

Cat. No.	Product Name	Type

HY-10432G

A 83-01 (GMP)	Fluorescent Dye
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent *ALK4/5/7* inhibitor .

Cat. No.	Product Name	Type

HY-10432G

A 83-01 (GMP)	Biochemical Assay Reagents
A 83-01 (GMP) is A 83-01 (HY-10432) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. A 83-01 is a potent *ALK4/5/7* inhibitor .

Species:	Human (3) Rhesus Macaque (1) Mouse (1) Rat (1)
Tag:	His (2) Fc (5)
Source:	HEK293 (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P75572

	*Activin RIB/ALK-4* Protein, Human (HEK293, His-Fc)** Activin Receptor IB, His; ALK-4; Activin RIB; ACVR1B	Human	HEK293
	Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Human (HEK293, His-Fc) is produced in HEK293 cells with a C-Terminal His-tag and a C-Terminal Fc-tag. It consists of 126 amino acids (S24-E126).

HY-P7486

	*Activin RIB/ALK-4* Protein, Mouse (HEK293, Fc)** rMuActivin Receptor IB, C-Fc; ALK-4; Activin RIB; ACVR1B	Mouse	HEK293
	Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Mouse (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 95 amino acids (L32-E126).

HY-P77294

	*Activin RIB/ALK-4* Protein, Rhesus Macaque (HEK293, Fc)** Activin Receptor IB; ALK-4; Activin RIB; ACVR1B	Rhesus Macaque	HEK293
	Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Rhesus Macaque (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).

HY-P75571

	*Activin RIB/ALK-4* Protein, Human (HEK293, Fc)** Activin Receptor IB, His; ALK-4; Activin RIB; ACVR1B	Human	HEK293
	Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Human (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).

HY-P7485

	*Activin RIB/ALK-4* Protein, Human (HEK293, His)** rHuActivin Receptor IB, His; ALK-4; Activin RIB; ACVR1B	Human	HEK293
	Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Human (HEK293, His) is produced in HEK293 cells with six C-Terminal His-tags. It consists of 103 amino acids (S24-E126).

HY-P76718

	*Activin RIB/ALK-4* Protein, Rat (HEK293, Fc)** Activin Receptor IB; ALK-4; Activin RIB; ACVR1B	Rat	HEK293
	Activin RIB, also known as activin receptor type-1B (ACVR1B) or ALK-4, is a type I transmembrane serine/threonine kinase receptor that is part of the TGF-β receptor superfamily. Activin binds to a type II activin receptor (ACVR2or ACVR2B) and then recruits ACVR1B. Activin RIB/ALK-4 Protein, Rat (HEK293, Fc) is produced in HEK293 cells with a C-Terminal Fc-tag. It consists of 126 amino acids (M1-E126).


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Application	Reactivity

HY-P82244

Activin A Receptor Type IB Antibody (YA1989) ACVR1B; ACVRLK4; ALK4; Activin receptor type-1B; Activin receptor type IB; ACTR-IB; Activin receptor-like kinase 4; ALK-4; Serine/threonine-protein kinase receptor R2; SKR2	WB	Human, Mouse, Rat

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.