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Results for "

APE

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AP-1 (1) Apelin Receptor (APJ) (1) Apical Sodium-Dependent Bile Acid Transporter (5) Apoptosis (1) Autophagy (2) DNA/RNA Synthesis (5) HIF/HIF Prolyl-Hydroxylase (1) Interleukin Related (2) MDM-2/p53 (1) MMP (1) NF-κB (3) Parasite (3) Phospholipase (1) PKC (1) Potassium Channel (1) Prostaglandin Receptor (1) Reactive Oxygen Species (1) ROCK (1) Sodium Channel (1) TNF Receptor (1) Topoisomerase (1) VEGFR (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (2) Infection (2) Inflammation/Immunology (7) Metabolic Disease (7) Neurological Disease (3)

By Targets:

AP-1 (1)

Apelin Receptor (APJ) (1)

Apical Sodium-Dependent Bile Acid Transporter (5)

Apoptosis (1)

Autophagy (2)

DNA/RNA Synthesis (5)

HIF/HIF Prolyl-Hydroxylase (1)

Interleukin Related (2)

MDM-2/p53 (1)

MMP (1)

NF-κB (3)

Parasite (3)

Phospholipase (1)

PKC (1)

Potassium Channel (1)

Prostaglandin Receptor (1)

Reactive Oxygen Species (1)

ROCK (1)

Sodium Channel (1)

TNF Receptor (1)

Topoisomerase (1)

VEGFR (1)

By Research Areas:

Cancer (8)

Cardiovascular Disease (2)

Infection (2)

Inflammation/Immunology (7)

Metabolic Disease (7)

Neurological Disease (3)

Inhibitors & Agonists

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-136731

APE1-IN-1	DNA/RNA Synthesis	Cancer
APE1-IN-1 is a potent and blood-brain barrier (BBB) penetrant apurinic/apyrimidinic (AP) endonuclease 1 (APE1) inhibitor with an IC₅₀ value of 2 μM. APE1-IN-1 can potentiate the cytotoxicity of the alkylating agents Methylmethane sulfonate and Temozolomide (HY-17364) to cancer cells .

HY-126425

NCGC00262650	Others	Infection
NCGC00262650 is a potent apical membrane antigen 1-rhoptry neck protein 2 (AMA1-RON2) interaction inhibitor. NCGC00262650 can block entry of merozoites into red blood cells .

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals .

HY-N3625

Coronalolic acid Coronalonic acid	NF-κB	Inflammation/Immunology
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production .

HY-122521

Sootepin D	NF-κB	Inflammation/Immunology
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity .

HY-B2098

Lucanthone

Autophagy Parasite Cancer

Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
HY-B2098A

Lucanthone hydrochloride

Autophagy Parasite Cancer

Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

Lucanthone	Autophagy Parasite	Cancer
Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

Lucanthone hydrochloride	Autophagy Parasite	Cancer
Lucanthone hydrochloride is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).

HY-15131

PNRI-299	Interleukin Related	Inflammation/Immunology
PNRI-299 is a selective AP-1 transcription inhibitor with an IC₅₀ of 20 uM. PNRI-299 is a selective *APE/Ref-1* inhibitor. PNRI-299 has no effect on NF-κB transcription or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model .

HY-W014622

CRT0044876	DNA/RNA Synthesis	Cancer
CRT0044876 is a potent and selective apurinic/apyrimidinic endonuclease 1 (APE1) inhibitor (IC₅₀=~3 μM). CRT0044876 inhibits the AP endonuclease, 3′-phosphodiesterase and 3′-phosphatase activities of APE1, and is a specific inhibitor of the exonuclease III family of enzymes to which APE1 belongs. CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds .

HY-P5824

Anthopleurin-C

Sodium Channel Neurological Disease

Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

Anthopleurin-C	Sodium Channel	Neurological Disease
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

HY-19357

E3330 2 Publications Verification APX-3330	DNA/RNA Synthesis NF-κB AP-1 HIF/HIF Prolyl-Hydroxylase VEGFR Reactive Oxygen Species	Cardiovascular Disease Neurological Disease Cancer
E3330 (APX-3330) is a direct, orally active and selective inhibitor of Ape-1 (apurinic/apyrimidinic endonuclease 1)/Ref-1 (redox factor-1) redox. E3330 is able to impair tumor growth and blocks the activity of NF-κB, AP-1, and HIF-1α in pancreatic cancer. E3330 shows anticancer activities .

HY-101190

Volixibat SHP626; LUM002	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
Volixibat (SHP626) is a highly selective, minimally absorbed, and competitive apical sodium-dependent bile acid transporter (ASBT) inhibitor. Volixibat has potential for treatment for non-alcoholic steatohepatitis (NASH) .

HY-18713A

CRT0066854 hydrochloride	PKC ROCK	Neurological Disease
CRT0066854 hydrochloride is a potent and selective atypical PKCs inhibitor. CRT0066854 is against full-length (FL) PKCι, PKCζ, and ROCK-II kinases with IC₅₀ values of 132 nM, 639 nM, and 620 nM, respectively .

HY-129982

SC-435	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
SC-435 is an apical sodium-dependent Bile acid (BA) transporter inhibitor. SC-435 can alter hepatic cholesterol metabolism and lower plasma low-density lipoprotein-cholesterol concentrations .

HY-109120

Odevixibat 2 Publications Verification A4250	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease
Odevixibat (A4250) is a selective and orally active ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor. Odevixibat decreases cholestatic liver and bile duct injury in mice model. Odevixibat has the potential for the treatment of primary biliary cirrhosis .

HY-102052

DCEBIO	Potassium Channel	Inflammation/Immunology
DCEBIO, a derivative of 1-EBIO, is an extremely potent activator of Cl ^- secretion in T84 colonic cells . DCEBIO stimulates Cl ^- secretion via the activation of hIK1 K ⁺ channels and the activation of an apical membrane Cl ^- conductance .

HY-119993

AR03 BMH-23	DNA/RNA Synthesis	Cancer
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC₅₀ of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells .

HY-100210A

FN-439 TFA	MMP	Inflammation/Immunology Cancer
FN-439 TFA is a selective collagenase-1 inhibitor. FN-439 TFA inhibits collagenase-1 with an IC₅₀ value of 1 μM. FN-439 TFA can be used for the research of cancer and inflammation .

HY-16643

Linerixibat Maximum Cited Publications 10 Publications Verification GSK2330672	Apical Sodium-Dependent Bile Acid Transporter	Metabolic Disease Inflammation/Immunology
Linerixibat (GSK2330672) is a highly potent, nonabsorbable and orally active apical sodium-dependent bile acid transporter (ASBT) inhibitor with an IC₅₀ of 42 nM human ASBT. Linerixibat can be used as lipid-lowering agent. Linerixibat has the potential for type 2 diabetes and Primary Biliary Cholangitis treatment .

HY-155774

VU533	Phospholipase	Metabolic Disease
APE-PLD (VU533) activator is a potent NAPE-PLD activator with an EC₅₀ value of 0.30 µM. NAPE-PLD activator (VU533) can enhance NAPE-PLD activity and increase efferocytosis by macrophages. NAPE-PLD activator (VU533) can be used for cardiometabolic diseases research .

HY-B1099

Hycanthone 2 Publications Verification	DNA/RNA Synthesis Topoisomerase Parasite	Infection
Hycanthone is a thioxanthenone DNA intercalator and inhibits RNA synthesis as well as the DNA topoisomerases I and II. Hycanthone inhibits nucleic acid biosynthesis and inhibits apurinic endonuclease-1 (APE1) by direct protein binding with a K_D of 10 nM. Hycanthone is a bioactive metabolite of Lucanthone (HY-B2098) and has anti-schistosomal agent .

HY-135259

CAY10580

Prostaglandin Receptor Metabolic Disease

CAY10580 is a potent and selective prostaglandin EP₄ receptor agonist (K_i=35 nM) .

CAY10580	Prostaglandin Receptor	Metabolic Disease
CAY10580 is a potent and selective prostaglandin EP₄ receptor agonist (K_i=35 nM) .

HY-15790

Elobixibat A 3309; AZD 7806	Apical Sodium-Dependent Bile Acid Transporter Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
Elobixibat (A 3309; AZD 7806) is an orally effective Apical Sodium-Dependent Bile (IBAT) inhibitor, with an IC₅₀ value of 0.53 nM (human IBAT ), 0.13 nM (mouse IBAT), 5.8 nM (canine IBAT). Elobixibat lowers LDL cholesterol, increases serum GLP-1, promotes colon motility, and has the potential to treat metabolic syndrome. Elobixibat can be used to study constipation, dyslipidemia, non-alcoholic hepatitis, and liver tumors .

HY-P3347

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)	Apelin Receptor (APJ)	Cardiovascular Disease
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (K_i=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life .

Cat. No.	Product Name	Target	Research Area

HY-P5824

Anthopleurin-C

Sodium Channel Neurological Disease

Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

Anthopleurin-C	Sodium Channel	Neurological Disease
Anthopleurin-C (APE 2-1) is a cardiotonic polypeptide that shows a powerful positive inotropic effect .

HY-P3347

NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)	Apelin Receptor (APJ)	Cardiovascular Disease
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (K_i=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life .

Cat. No.	Product Name

HY-KE7001

ApaL I

ApaL I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Alw44 I, Vne I.

ApaL I
ApaL I is a restriction enzyme for rapid DNA digestion, including plasmid, genomic DNA as well as PCR products. Isoschizomers: Alw44 I, Vne I.

Coronalolic acid Coronalonic acid	Other Terpenoids Classification of Application Fields Terpenoids Source classification Rubiaceae Plants Gardenia jasminoides Ellis Disease Research Fields Inflammation/Immunology	NF-κB
Coronalolic acid, extract from the apical bud of Gardenia sootepenesis Hutch, inhibits TNF-α-induced NF-κB activity and NO production .

Sootepin D	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rubiaceae Gardenia sootepensis hutchins. Plants Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	NF-κB
Sootepin D (compound 6), a triterpene from the apical bud of Gardenia sootepensis, inhibits TNF-α-induced NF-κB activity with an IC₅₀ of 8.3μM. Sootepin D has anti-inflammatory activity .

Species:	Human (2)
Tag:	His (1) Tag Free (1) MBP (1) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7523

	APE Protein, Human rHuAPE; APE1; APEX; APE	Human	E. coli
	APE Protein, Human is an approximately 40.0 kDa protein expressed by E. coli expression system. Human APE plays an important role in BER by acting downstream of DNA glycosylases.

HY-P702038

	SLC20A2 Protein, Human (Sf9, His, MBP, FLAG) SLC20A2; Sodium-dependent phosphate transporter 2; Gibbon APE leukemia virus receptor 2; GLVR-2; Phosphate transporter 2; PiT-2; Pit2; hPit2; Solute carrier family 20 member 2	Human	Sf9 insect cells
	The SLC20A2 protein is a sodium-phosphate symporter that transports monovalent phosphate with a stoichiometry of two sodium ions per phosphate ion. Its role in bone mineralization is critical to bone quality and strength. SLC20A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC20A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC20A2 Protein, Human (Sf9, His, MBP, FLAG) is 651 a.a., .


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Cat. No.	Product Name	Application	Reactivity

HY-P82375

APE1 Antibody (YA2120) APEX1; APE; APE1; APEX; APX; HAP1; REF1; DNA-(apurinic or apyrimidinic site) lyase; APEX nuclease; APEN; Apurinic-apyrimidinic endonuclease 1; AP endonuclease 1; APE-1; REF-1; Redox factor-1	WB	Human, Mouse, Rat

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