Search Result

Results for "

ARP

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Arp2/3 Complex (6) Apoptosis (1) Atg8/LC3 (1) FAK (1) Fluorescent Dye (1) HIV (1) MMP (3) PI3K (1) Src (1)
By Research Areas:	Cancer (7) Infection (1) Inflammation/Immunology (2)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Recombinant Proteins

Antibodies

Targets Recommended: Arp2/3 Complex

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-103444

ARP-100	MMP	Cancer
ARP-100 is a potent and selective matrix metalloproteinase MMP-2 inhibitor (IC₅₀=12 nM). ARP-100 interacts with S1＇ pocket of MMP-2 and shows anti-invasive properties in an in vitro model of invasion on matrigel. ARP-100 shows the less inhibitory activity towards MMP-1 (>50 μM), MMP-3 (4.5 μM), MMP-7 (>50 μM), and MMP-9 (0.2 μM) .

HY-101535

ARP101	Atg8/LC3 MMP	Cancer
ARP101 is a potent and selective inhibitor matrix metalloproteinase-2 (MMP-2). ARP101 induces autophagy-associated cell death in cancer cells. ARP101 is effective in inducing the formation of autophagosome and conversion of LC3I into LC3II .

HY-16926

CK-666 5 Publications Verification	Arp2/3 Complex HIV	Infection Cancer
CK-666 is a cell-permeable actin-related protein Arp2/3 complex inhibitor (IC₅₀=12 μM). CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation .

HY-16927

CK-869

1 Publications Verification

Arp2/3 Complex Cancer

CK-869 is an Actin-Related Protein 2/3 (ARP2/3) complex inhibitor, with an IC₅₀ of 7 μM.

CK-869 1 Publications Verification	Arp2/3 Complex	Cancer
CK-869 is an Actin-Related Protein 2/3 *(ARP2/3)* complex inhibitor, with an IC₅₀ of 7 μM.

HY-157916

*ARP* Aldehyde reactive probe	Fluorescent Dye	Others
ARP (Aldehyde reactive probe) is an aldehyde reactive probe for detecting abasic site (common DNA lesions and intermediates in mutagenesis and carcinogenesis) in DNA, which specificially tags AP site with biotin residues. ARP is highly sensitive with a femtomolar-level basic site detection capabilities (less than one site per 10 ⁴ nucleotides) .

HY-15892

CK-636 1 Publications Verification CK-0944636	Arp2/3 Complex	Inflammation/Immunology Cancer
CK-636 is a cell permeable inhibitor of Arp2/3 complex, that could inhibit actin polymerization, with IC₅₀ values of 4 μM, 24 μM and 32 μM for human, fission yeast and bovine, respectively. CK636 blocks cell migration.

HY-114657A

Benproperine phosphate	Arp2/3 Complex	Inflammation/Immunology Cancer
Benproperine phosphate is an orally active, potent actin-related protein 2/3 complex subunit 2 (ARPC2) inhibitor. Benproperine phosphate attenuates the actin polymerization rate of action polymerization nucleation by impairing Arp2/3 function. Benproperine phosphate has the potential for a cough suppressant and suppresses cancer cell migration and tumor metastasis .

HY-P1045

187-1, N-WASP inhibitor 1 Publications Verification	Arp2/3 Complex	Others
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor prevents the activation of *Arp2/3* complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-P1045A

187-1, N-WASP inhibitor TFA	Arp2/3 Complex	Others
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of *Arp2/3* complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-120213

YH-306	FAK Src PI3K MMP Apoptosis	Cancer
YH-306 is an antitumor agent. YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. YH-306 significantly inhibits the migration and invasion of colorectal cancer cells. YH-306 potently suppresses uninhibited proliferation and induces cell apoptosis. YH-306 suppresses the activation of FAK, c-Src, paxillin, and PI3K, Rac1 and the expression of MMP2 and MMP9. YH-306 also inhibita actin-related protein (Arp2/3) complex-mediated actin polymerization .

Cat. No.	Product Name

HY-L060

Cytoskeleton Compound Library	1,276 compounds
The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases. MCE designs a unique collection of 1,276 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cytoskeleton Compound Library

1,276 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1,276 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-157916

*ARP* Aldehyde reactive probe	Biochemical Assay Reagents
ARP (Aldehyde reactive probe) is an aldehyde reactive probe for detecting abasic site (common DNA lesions and intermediates in mutagenesis and carcinogenesis) in DNA, which specificially tags AP site with biotin residues. ARP is highly sensitive with a femtomolar-level basic site detection capabilities (less than one site per 10 ⁴ nucleotides) .

Cat. No.	Product Name	Target	Research Area

HY-P1045

187-1, N-WASP inhibitor 1 Publications Verification	Arp2/3 Complex	Others
187-1, N-WASP inhibitor, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor prevents the activation of *Arp2/3* complex by N-WASP by stabilizing the autoinhibited state of the protein .

HY-P1045A

187-1, N-WASP inhibitor TFA	Arp2/3 Complex	Others
187-1, N-WASP inhibitor TFA, a 14-aa cyclic peptide, is an allosteric neural Wiskott-Aldrich syndrome protein (N-WASP) inhibitor. 187-1, N-WASP inhibitor TFA potently inhibits actin assembly induced by phosphatidylinositol 4,5-bisphosphate (PIP2) with an IC₅₀ of 2 μM. 187-1, N-WASP inhibitor TFA prevents the activation of *Arp2/3* complex by N-WASP by stabilizing the autoinhibited state of the protein .

Species:	Human (10) Mouse (3) Cynomolgus (1)
Tag:	His (11) SUMO (1) Tag Free (1) Avi (2) GST (1) Fc (2)
Source:	HEK293 (9) Sf9 insect cells (1) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P71940A

	ARMET/MANF Protein, Human (His) Arginine rich mutated in early stage tumors; Arginine rich protein; Arginine-rich protein; ARMET; ARMET protein; ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET	Human	E. coli
	ARMET/MANF proteins critically support the survival of dopaminergic neurons in the ventral midbrain and contribute to neuronal homeostasis. It modulates GABAergic transmission and enhances inhibitory postsynaptic currents in substantia nigra dopaminergic neurons. ARMET/MANF Protein, Human (His) is the recombinant human-derived ARMET/MANF protein, expressed by E. coli , with N-6*His labeled tag. The total length of ARMET/MANF Protein, Human (His) is 158 a.a., with molecular weight of ~20 kDa.

HY-P77296

	ARMET/MANF Protein, Mouse (HEK293, His) Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; ARP	Mouse	HEK293
	ARMET/MANF proteins regulate the survival of dopaminergic neurons in the ventral midbrain and modulate GABAergic transmission to dopaminergic neurons in the substantia nigra. It enhances GABA inhibitory currents and inhibits cell proliferation while preventing ER stress-induced cell death. ARMET/MANF Protein, Mouse (HEK293, His) is the recombinant mouse-derived ARMET/MANF protein, expressed by HEK293 , with C-His labeled tag. The total length of ARMET/MANF Protein, Mouse (HEK293, His) is 179 a.a., with molecular weight of ~21 kDa.

HY-P701973

	Aldose-reductase Protein, Human (His) AKR1B10; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human (His) is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with N-6*His labeled tag. The total length of Aldose-reductase Protein, Human (His) is 316 a.a., .

HY-P701972

	Aldose-reductase Protein, Human AKR1B10; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with tag free. The total length of Aldose-reductase Protein, Human is 316 a.a., .

HY-P76731

	ARMET/MANF Protein, Human (HEK293, Fc) Mesencephalic astrocyte-derived neurotrophic factor; Arginine-rich protein; ARP	Human	HEK293
	ARMET/MANF Protein is an evolutionary conserved endoplasmic reticulum stress- (ERS-) related protein. ARMET/MANF has a protective effect on central nervous system diseases and plays an important role in several metabolic diseases. It is mainly localized to the luminal endoplasmic reticulum (ER) as an ER chaperone protein, mainly interacting with BiP and Reticulon 1-C. Meanwhile, MANF can prevent ER stress-mediated cell death in neurons and other tissues. ARMET/MANF Protein, Human (HEK293, Fc) is the recombinant human-derived ARMET/MANF protein, expressed by HEK293 , with C-hFc labeled tag. The total length of ARMET/MANF Protein, Human (HEK293, Fc) is 182 a.a., with molecular weight of ~44.9 KDa.

HY-P76733

	ARP3/ACTR3 Protein, Human (sf9, His-GST) Actin-related protein 3; Actin-like protein 3	Human	Sf9 insect cells
	ARP3/ACTR3 Proteinas, an ATPase preferentially stimulated by single-stranded DNA, crucially participates in homologous recombination repair (HRR). Independent of its ATPase function, it exhibits DNA-binding activity. SWSAP1 forms a functional complex with ZSWIM7, contributing to HRR and mutual protein stabilization. It also interacts with key players in HRR, including RAD51, RAD51B, RAD51C, RAD51D, and XRCC3, emphasizing its role in facilitating DNA repair through homologous recombination mechanisms. ARP3/ACTR3 Protein, Human (sf9, His-GST) is the recombinant human-derived ARP3/ACTR3 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of ARP3/ACTR3 Protein, Human (sf9, His-GST) is 417 a.a., with molecular weight of ~75.1 KDa.

HY-P75577

	ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His) Angiopoietin-related protein 2; ANGPTL2; ANGRP2; ARP2HARP; MGC8889	Human	HEK293
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms. This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels. ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His) is 249 a.a., with molecular weight of ~34 kDa.

HY-P75578

	ANGPTL2/Angiopoietin-like 2 Protein, Mouse (HEK293, Fc) Angiopoietin-related protein 2; ANGPTL2; ANGRP2; ARP2HARP; MGC8889	Mouse	HEK293
	ANGPTL2/Angiopoietin-like 2 protein plays a crucial role in inducing sprouting in endothelial cells through autocrine and paracrine mechanisms. It orchestrates angiogenic processes and regulates vascular development. ANGPTL2's versatile impact on endothelial cell behavior positions it as a key modulator in the molecular signals governing angiogenesis. ANGPTL2/Angiopoietin-like 2 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Mouse (HEK293, Fc) is 249 a.a., with molecular weight of ~58 kDa.

HY-P78380

	ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) ARP2; HARP; angiopoietin-like 2; ANGPTL2; ANGRP2; MGC8889	Human	HEK293
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms. This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels. ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Human (HEK293, His-Avi) is 234 a.a., with molecular weight of 31-35 kDa.

HY-P78060

	ANGPTL2/Angiopoietin-like 2 Protein, Human (Biotinylated, HEK293, His-Avi) ARP2; HARP; angiopoietin-like 2; ANGPTL2; ANGRP2; MGC8889	Human	HEK293
	ANGPTL2/angiopoietin-like 2 protein takes center stage as it induces endothelial cell sprouting through dual autocrine and paracrine mechanisms. This ability underscores its critical role in angiogenesis, where balanced signaling events control the formation of new blood vessels. ANGPTL2/Angiopoietin-like 2 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived ANGPTL2/Angiopoietin-like 2 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of ANGPTL2/Angiopoietin-like 2 Protein, Human (Biotinylated, HEK293, His-Avi) is 234 a.a., with molecular weight of 31-35 kDa.

HY-P700655

	ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4	Cynomolgus	HEK293
	ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Cynomolgus (HEK293, His) is 243 a.a., with molecular weight of 35-40 kDa.

HY-P78237

	ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) ANGPTL4; ARP4; FIAF; HFARP; Angiopoietin like 4; NGPTL2; NL2; PGAR; pp1158; ANG-3; ANG4; AGP4; ANG3; ANG-3; ANG-4; Angiopoietin-3; ANGPT4; MGC138181; MGC138183	Mouse	HEK293
	ANGPTL4/angiopoietin-related 4 protein plays a key role in regulating lipid metabolism by inactivating lipoprotein lipase (LPL) and controlling the clearance of triglycerides in the blood. Its effects extend to the regulation of glucose homeostasis and insulin sensitivity. ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived ANGPTL4/Angiopoietin-related 4 protein, expressed by HEK293 , with N-His labeled tag. The total length of ANGPTL4/Angiopoietin-related 4 Protein, Mouse (HEK293, His) is 243 a.a., with molecular weight of 35-50 kDa.

HY-P72080

	APOBEC3A Protein, Human (His-SUMO) A3A; ABC3A_HUMAN; APOBEC3A; Apolipoprotein B mRNA editing enzyme; Apolipoprotein B mRNA editing enzyme; catalytic polypeptide like 3A; ARP3; bK150C2.1; Catalytic polypeptide like 3A; Phorbolin 1; Phorbolin-1; PHRBN; Probable DNA dC >dU editing enzyme APOBEC-3A; Probable DNA dC->dU-editing enzyme APOBEC-3A	Human	E. coli
	APOBEC3A protein is a DNA deaminase that limits the mobility of viruses, foreign DNA, and retrotransposons. APOBEC3A Protein, Human (His-SUMO) is the recombinant human-derived APOBEC3A protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.

HY-P7605

	ARMET/MANF Protein, Human (158a.a, HEK293, His) rHuARMET/MANF, His; Mesencephalic astrocyte-derived neurotrophic factor; ARMET	Human	HEK293
	ARMET/MANF Protein, Human (158a.a, HEK293, His) expresses in HEK293 cells with a His tag. Armet/MANF, localized in the ER and Golgi, is a secreted protein and acts as a gene up-regulated by various forms of ER stress.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P81894

ARFRP1 Antibody (YA1639)

ARP; ARP1; ARL18
WB, IP Rat
HY-P82980

Actin Related Protein 2 Antibody (YA2725)

ACTR2; ARP2; ARP2/3 COMPLEX
WB, ICC/IF Human, Mouse, Rat
HY-P82941

ACTR1B Antibody (YA2686)

PC3; ARP1B; CTRN2
WB, IHC-F, IHC-P, ICC/IF, IP Human
HY-P82109

p16 ARC Antibody (YA1854)

p16 Arc; ARPC5; ARC16; ARP2/3 protein complex subunit p16
WB, IHC-P, IP Human, Mouse, Rat
HY-P82345

Angiopoietin Like 4 Antibody (YA2090)

NL2; ARP4; FIAF; HARP; PGAR; HFARP; TGQTL; UNQ171; pp1158
WB Human

HY-P81478

	NR2F2 Antibody (YA1223) NR2F2; ARP1; TFCOUP2; COUP transcription factor 2; COUP-TF2; Apolipoprotein A-I regulatory protein 1; ARP-1; COUP transcription factor II; COUP-TF II; Nuclear receptor subfamily 2 group F member 2	IHC-P	Human

HY-P82010

Actin Related Protein 3 Antibody (YA1755)

ACTR3; ARP3; Actin-related protein 3; Actin-like protein 3
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

HY-P81368

	AKR1B10 Antibody (YA1113) AKR1B10; AKR1B11; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein (ARP; hARP); Small intestine reductase (SI reductase)	IHC-P	Human


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: