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D2

" in MedChemExpress (MCE) Product Catalog:

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759

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

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Peptides

Natural
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Recombinant Proteins

378

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-Y0127

D(-)-2-Aminobutyric acid

Endogenous Metabolite Others

D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
HY-138982

D-2-Thiolhistidine

Others Others

D-2-Thiolhistidine can be used for modification of proteins and peptides.

D(-)-2-Aminobutyric acid	Endogenous Metabolite	Others
D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

D-2-Thiolhistidine	Others	Others
D-2-Thiolhistidine can be used for modification of proteins and peptides.

HY-Y0127S

D(-)-2-Aminobutyric acid-d6	Isotope-Labeled Compounds Endogenous Metabolite
D(-)-2-Aminobutyric acid-d₆ is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-41912AS

D-2-Aminohexanoic acid-d9

Isotope-Labeled Compounds Others

D-2-Aminohexanoic acid-d₉ is the deuterium labeled D-2-Aminohexanoic acid.

D-2-Aminohexanoic acid-d9	Isotope-Labeled Compounds	Others
D-2-Aminohexanoic acid-d₉ is the deuterium labeled D-2-Aminohexanoic acid.

HY-RS03507

D2HGDH Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
D2HGDH Human Pre-designed siRNA Set A contains three designed siRNAs for D2HGDH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

D2HGDH Human Pre-designed siRNA Set A D2HGDH Human Pre-designed siRNA Set A

HY-100781

D-AP4 D-APB; D-2-Amino-4-phosphonobutyric acid
D-AP4 (D-APB; D-2-Amino-4-phosphonobutyric acid), a phosphono analogue of glutamate, is an NMDA broad spectrum excitatory amino acid receptor antagonist. D-AP4 also is an agonist for a quisqualate-sensitized AP6 site in hippocampus. D-AP4 inhibits AMPA receptor-stimulated 57Co ²⁺ influx in cultured cerebellar granule cells (IC₅₀ ≥ 100 μM) ^[2] .

HY-100714A

D-AP5 Maximum Cited Publications 16 Publications Verification D-APV; D-2-Amino-5-phosphonovaleric acid	iGluR	Neurological Disease
D-AP5 (D-APV) is a selective and competitive NMDA receptor antagonist with a K_d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors ^[2].

HY-114623

Prostaglandin D2 methyl ester	Prostaglandin Receptor	Endocrinology
Prostaglandin D2 methyl ester is a prodrug form of Prostaglandin D2. Prostaglandin D2 methyl ester binds to the human and mouse PGD2 receptors (DP and *CRTH2) with K_i* values of 160 nM, 175 nM, 460 nM, and 270 nM for mCRTH2, mDP, hCRTH2, and hDP, respectively .

HY-151515

Dopamine D2 receptor agonist-2	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor agonist-2 (compound 36) is a potent dopamine D₂ receptor biased agonism ligand with an K_i value of 11.2 nM. Dopamine D2 receptor agonist-2 can be used to research antipsychosis .

HY-N3500

Ganoderic acid D2	Endogenous Metabolite	Inflammation/Immunology Cancer
Ganoderic acid D2 (compound 27) is a triterpenoid isolated from Ganoderma lucidum. Ganoderic acid D2 has anticancer, anti-inflammatory and antioxidative activity .

HY-N7450

Icariside D2	Angiotensin-converting Enzyme (ACE) Apoptosis HIV	Infection Inflammation/Immunology Cancer
Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis ^[2].

HY-138073

Cryptomoscatone D2

Others Cancer

Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .
HY-N10074

Polygalacin D2

Others Others

Polygalacin D2 is a saponin isolated from Platycodon grandiflorum .
HY-N4087

Platycodin D2

2 Publications Verification

Others Cancer

Platycodin D2 is a saponin isolated from Platycodon grandiflorum, with anti-cancer activity .
HY-N12294

Ciwujianoside D2

Others Metabolic Disease

Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .
HY-N12220

Cinnamtannin D2

Others Others

Cinnamtannin D2 (compound 13) is a cinnamon tannin isolated from Vaccinium vitis-idaea L .

Cryptomoscatone D2	Others	Cancer
Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

Polygalacin D2	Others	Others
Polygalacin D2 is a saponin isolated from Platycodon grandiflorum .

Platycodin D2 2 Publications Verification	Others	Cancer
Platycodin D2 is a saponin isolated from Platycodon grandiflorum, with anti-cancer activity .

Ciwujianoside D2	Others	Metabolic Disease
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

Cinnamtannin D2	Others	Others
Cinnamtannin D2 (compound 13) is a cinnamon tannin isolated from Vaccinium vitis-idaea L .

HY-121636

Resolvin D2 4 Publications Verification RvD2	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC₅₀ = 0.1 nM) and TRPA1 (IC₅₀ = 2 nM) in primary sensory neurons ^[2] .

HY-139952S

Prostaglandin D2 Dopamine-d4

Isotope-Labeled Compounds Others

Prostaglandin D2 Dopamine-d₄ is the deuterium labeled Prostaglandin D2 Dopamine[1].

Prostaglandin D2 Dopamine-d4	Isotope-Labeled Compounds	Others
Prostaglandin D2 Dopamine-d₄ is the deuterium labeled Prostaglandin D2 Dopamine[1].

HY-129946

Dopamine D2 receptor antagonist-1	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity .

HY-101988

Prostaglandin D2 PGD2	Prostaglandin Receptor Endogenous Metabolite	Inflammation/Immunology
Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances ^[2]. PGD2 plays a protective role by suppressing inflammation .

HY-107260

Lucidenic acid D Lucidenic acid D2	Others	Cardiovascular Disease Inflammation/Immunology Cancer
Lucidenic acid D (Lucidenic acid D2) is a highly oxidized lanostane-type triterpenoid .

HY-103418

Dopamine D2 receptor agonist-3	Dopamine Receptor	Neurological Disease
Dopamine D2 receptor agonist-3 (compound 3) is a selective D2 receptor partial agonist and Dopamine D3 receptor antagonist (with pEC₅₀ of 8.3 and <5.5 respectively) .

HY-32350

Ercalcitriol 2 Publications Verification 1α,25-Dihydroxy Vitamin D2	VD/VDR Drug Metabolite Endogenous Metabolite	Metabolic Disease
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

HY-116083

13,14-Dihydro-15-keto-tetranor prostaglandin D2	Endogenous Metabolite	Others
13,14-Dihydro-15-keto-tetranor prostaglandin D2 (Compound VI) is a prostaglandin D2 metabolite. 13,14-Dihydro-15-keto-tetranor prostaglandin D2 as a biomarker can be used to study prostaglandin D2-related diseases .

HY-32349

Ercalcidiol 1 Publications Verification 25-Hydroxy Vitamin D2	VD/VDR Endogenous Metabolite	Metabolic Disease
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-137483

Prostaglandin D2 serinol amide

Prostaglandin Receptor Endocrinology

Prostaglandin D2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol .

Prostaglandin D2 serinol amide	Prostaglandin Receptor	Endocrinology
Prostaglandin D2 serinol amide is a weak inhibitor of the hydrolysis of [3H]2-oleoylglycerol .

HY-32348

Doxercalciferol 4 Publications Verification 1.alpha.-Hydroxyvitamin D2	VD/VDR	Metabolic Disease Cancer
Doxercalciferol is a Vitamin D2 analog, acts as an activator of Vitamin D receptor, and prevent renal disease.

HY-76542B

(R)-Vitamin D2 (R)-Ergocalciferol; (R)-Calciferol; (R)-Ercalciol	Others	Metabolic Disease Cancer
(R)-Vitamin D2 is the isomer of Vitamin D2 (HY-76542), and can be used as an experimental control. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D ^[2].

HY-76542

Vitamin D2 1 Publications Verification Ergocalciferol; Calciferol; Ercalciol	VD/VDR Endogenous Metabolite	Metabolic Disease
Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D ^[2].

HY-137308

15(R)-Prostaglandin D2 15R-PGD2	Prostaglandin Receptor	Inflammation/Immunology
15(R)-Prostaglandin D2 is a potential prostatic hormone DP(2) receptor (Prostaglandin Receptor) agonist with anti-inflammatory activity. 15(R)-Prostaglandin D2 increases actin polymerization in human eosinophils and increases cAMP levels in platelets .

HY-76801

24, 25-Dihydroxy VD2 1 Publications Verification 24,25-Dihydroxy vitamin D2	VD/VDR Drug Metabolite	Metabolic Disease
24, 25-Dihydroxy VD2 is a hydroxylated metabolite of Vitamin D2; a synthetic analog of Vitamin D.

HY-76542A

5,6-trans-Vitamin D2

5,6-trans-Ergocalciferol; 5,6-trans-Calciferol; 5,6-trans-Ercalciol
Others Others

5,6-trans-Vitamin D2 is the isomer of Vitamin D2 .

5,6-trans-Vitamin D2 5,6-trans-Ergocalciferol; 5,6-trans-Calciferol; 5,6-trans-Ercalciol	Others	Others
5,6-trans-Vitamin D2 is the isomer of Vitamin D2 .

HY-118830

13,14-Dihydro-15-keto prostaglandin D2 DK-PGD2; 15-Oxo-13,14-dihydro-PGD2; 13,14-Dihydro-15-keto-PGD2	Prostaglandin Receptor	Endocrinology
13, 14-Dihydro-15-keto prostaglandin D2 (DK-PGD2) is a PGD2 metabolite formed by the 15-hydroxyl PGDH pathway. 13, 14-Dihydro-15-keto prostaglandin D2 is a selective agonist for the *DP2* receptor. 13, 14-Dihydro-15-keto prostaglandin D2 can inhibit ion flux in canine colonic mucosa preparation .

HY-B1812S1

Veratrole-d2

Isotope-Labeled Compounds Others

Veratrole-d₂ is the deuterium labeled Veratrole. Veratrole-d₂ is an naturally occurring insect attractant ^[2].

Veratrole-d2	Isotope-Labeled Compounds	Others
Veratrole-d₂ is the deuterium labeled Veratrole. Veratrole-d₂ is an naturally occurring insect attractant ^[2].

HY-N0181

Ergosterol 2 Publications Verification Ergosterin; Provitamin D; Provitamin D2	Endogenous Metabolite	Inflammation/Immunology
Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.

HY-103414

Raclopride 1 Publications Verification	Dopamine Receptor	Neurological Disease
Raclopride is a dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively ^[2].

HY-108976

Raclopride tartrate	Dopamine Receptor	Neurological Disease
Raclopride tartrate is a selective dopamine D₂/D₃ receptor antagonist with potential antipsychotic effects. Raclopride tartrate binds to D₂ and D₃ receptors with K_is of 1.8 nM and 3.5 nM, respectively ^[2].

HY-121636S

Resolvin D2-d5 RvD2-d₅	TRP Channel	Infection Neurological Disease Inflammation/Immunology
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-101747A

ADR 851

Dopamine Receptor Neurological Disease

ADR 851 is a dopamine D2 receptor antagonist,and can be used in research on antiemetics .
HY-136820S1

Taurultam-d2 hydrochloride

Isotope-Labeled Compounds Others

Taurultam-d₂ (hydrochloride) is deuterium labeled Taurultam.
HY-N0453S1

Hypericin-d2

Apoptosis Influenza Virus Cancer

Hypericin-d₂ is deuterium labeled Hypericin.
HY-108236

Naxagolide hydrochloride

MK-458; L-647339
Others Neurological Disease

Naxagolide hydrochloride is an agonist of D2. Naxagolide hydrochloride can be used in study Parkinsonism .
HY-132383S

24,25-Dihydroxy Vitamin D2-d3

Isotope-Labeled Compounds Others

24,25-Dihydroxy Vitamin D2-d₃ is the deuterium labeled 24,25-Dihydroxy Vitamin D2[1].
HY-13631ES3

Deruxtecan-d2

Drug-Linker Conjugates for ADC Isotope-Labeled Compounds Others

Deruxtecan-d2 is the deuterium labeled Potassium oleate .

ADR 851	Dopamine Receptor	Neurological Disease
ADR 851 is a dopamine D2 receptor antagonist,and can be used in research on antiemetics .

Taurultam-d2 hydrochloride	Isotope-Labeled Compounds	Others
Taurultam-d₂ (hydrochloride) is deuterium labeled Taurultam.

Hypericin-d2	Apoptosis Influenza Virus	Cancer
Hypericin-d₂ is deuterium labeled Hypericin.

Naxagolide hydrochloride MK-458; L-647339	Others	Neurological Disease
Naxagolide hydrochloride is an agonist of D2. Naxagolide hydrochloride can be used in study Parkinsonism .

24,25-Dihydroxy Vitamin D2-d3	Isotope-Labeled Compounds	Others
24,25-Dihydroxy Vitamin D2-d₃ is the deuterium labeled 24,25-Dihydroxy Vitamin D2[1].

Deruxtecan-d2	Drug-Linker Conjugates for ADC Isotope-Labeled Compounds	Others
Deruxtecan-d2 is the deuterium labeled Potassium oleate .

HY-101988S1

Prostaglandin D2-d9 PGD2-d₉	Prostaglandin Receptor Endogenous Metabolite	Inflammation/Immunology
Prostaglandin D2-d₉ is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

HY-101988S

Prostaglandin D2-d4 PGD2-d₄	Prostaglandin Receptor Endogenous Metabolite	Inflammation/Immunology
Prostaglandin D2-d₄ is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

HY-113150S1

Hexanoylglycine-d2

Isotope-Labeled Compounds Others

Hexanoylglycine-d₂ is the deuterium labeled Hexanoylglycine[1].
HY-W115763S

Dodecanoate-d2 potassium

Isotope-Labeled Compounds Others

Dodecanoate-d₂ (potassium) is the deuterium labeled Dodecanoate[1].
HY-W115788S

Tetradecanoate-d2 potassium

Isotope-Labeled Compounds Others

Tetradecanoate-d₂ (potassium) is the deuterium labeled Tetradecanoate[1].
HY-W133986S

Stearate-d2 potassium

Isotope-Labeled Compounds Others

Stearate-d₂ (potassium) is the deuterium labeled Stearate[1].

Cat. No.	Product Name	Target	Research Area

HY-P0079

Neuromedin N 2 Publications Verification Neuromedin N (rat, mouse, porcine, canine)	Dopamine Receptor	Neurological Disease
Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.

HY-W009403

Boc-D-2-Pal-OH

Amino Acid Derivatives Others

Boc-D-2-Pal-OH is an alanine derivative .
HY-W010894

Fmoc-D-2-Nal-OH

Amino Acid Derivatives Others

Fmoc-D-2-Nal-OH is an alanine derivative .
HY-W008269

H-D-2-Nal-OH

Amino Acid Derivatives Others

H-D-2-Nal-OH is an alanine derivative .
HY-W011154

Z-D-2-Nal-OH

Amino Acid Derivatives Others

Z-D-2-Nal-OH is an alanine derivative .
HY-P1460

His-[D-2-ME-Trp]-Ala

Peptides Others

His-[D-2-ME-Trp]-Ala is a fragment of the growth hormone hexarelin.

HY-P3347

*NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal)*	Apelin Receptor (APJ)	Cardiovascular Disease
NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) (compound 40), a macrocyclic analogue of Ape13, is a potent APJ agonist (K_i=5.7 nM). NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) exhibits a favorable Gα12-biased signaling and an increased in vivo half-life .

HY-107663A

MIF-1 TFA Pro-Leu-Gly-NH2 TFA; Melanostatin TFA	Dopamine Receptor	Neurological Disease
MIF-1 TFA (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 TFA inhibits melanin formation. MIF-1 TFA blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 TFA accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) ^[2] .

HY-107663

MIF-1 Pro-Leu-Gly-NH2; Melanostatin	Dopamine Receptor	Neurological Disease
MIF-1 (Melanostatin), an endogenous brain peptide, is a potent dopamine receptor allosteric modulator. MIF-1 inhibits melanin formation. MIF-1 blocks the effects of opioid receptor activation to modulate the analgesic effects. MIF-1 accesses from the blood to the CNS by directly crossing the blood-brain barrier (BBB) ^[2] .

HY-P3277

KRpep-2d

Ras Cancer

KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research .
HY-P3277A

KRpep-2d TFA

Ras Cancer

KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research .
HY-P4869

Biotin-KRpep-2d acetate

Peptides Others

Biotin-KRpep-2d acetate is a biotin-labeled KRpep-2d (HY-P3277) .
HY-P1899

Smcy HY Peptide (738-746)

Peptides Inflammation/Immunology

Smcy HY Peptide (738-746) is a H2-D ^b-restricted peptide corresponding to amino acids 738-746 of Smcy protein .

HY-P3294

Onzigolide BIM-23A760; TBR-760	Dopamine Receptor Somatostatin Receptor	Neurological Disease Cancer
Onzigolide (BIM-23A760), a chimeric dopamine-somatostatin compound, shows potent agonist activity at both DA type 2 (D2R) and SST type 2 (SSTR2) receptors ^[2].

HY-P1585

Gp100 (25-33), human Hgp100 (25-33)	Peptides	Inflammation/Immunology
Gp100 (25-33), human (Hgp100 (25-33)) is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2D ^b and recognized by the T cells .

HY-P1585A

Gp100 (25-33), human TFA Hgp100 (25-33) (TFA)	Peptides	Cancer
Gp100 (25-33), human TFA (Hgp100 (25-33) TFA) is the amino acids 25-33 fragment of the human melanoma antigen. It is a 9-amino acid (AA) epitope restricted by H-2D ^b and recognized by the T cells .

HY-P0323

GP(33-41)	Arenavirus	Infection
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

HY-P0323A

GP(33-41) TFA	Arenavirus	Infection
GP(33-41) TFA, a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus. GP(33-41) TFA can upregulate H-2D ^b molecules at the RMA-S (Db Kb) cell surface with a SC₅₀ of 344 nM .

HY-P4582

Suc-Phe-Ala-Ala-Phe-pNA Suc-FAAF-pNA	Peptides	Others
Suc-Phe-Ala-Ala-Phe-pNA (Suc-FAAF-pNA) is a synthetic polypeptide that can serve as a substrate for the protease from Aeribacillus pallidus VP3 (SPVP), the serine alkaline protease from Caldicoprobacter guelmensis (SAPCG) strain D2C22 ^T, the alcalase ultra 2.5 L and the thermolsyin type X .

HY-P0117A

Tat-NR2B9c TFA Maximum Cited Publications 7 Publications Verification Tat-NR2Bct TFA; NA-1 TFA	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c TFA (Tat-NR2Bct TFA) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c TFA disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c TFA also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy .

HY-P0117

Tat-NR2B9c Maximum Cited Publications 7 Publications Verification Tat-NR2Bct; NA-1	iGluR NO Synthase	Neurological Disease
Tat-NR2B9c (Tat-NR2Bct; NA-1) is a postsynaptic density-95 (PSD-95) inhibitor, with EC₅₀ values of 6.7 nM and 670 nM for PSD-95d2 (PSD-95 PDZ domain 2) and PSD-95d1, respectively. Tat-NR2B9c disrupts the PSD-95/NMDAR interaction, inhibiting NR2A and NR2B binding to PSD-95 with IC₅₀ values of 0.5 μM and 8 μM, respectively. Tat-NR2B9c also inhibits neuronal nitric oxide synthase (nNOS)/PSD-95 interaction, and possesses neuroprotective efficacy ^[2] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-Y0127

D(-)-2-Aminobutyric acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.

HY-N3500

Ganoderic acid D2	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Inflammation/Immunology Disease Research Fields	Endogenous Metabolite
Ganoderic acid D2 (compound 27) is a triterpenoid isolated from Ganoderma lucidum. Ganoderic acid D2 has anticancer, anti-inflammatory and antioxidative activity .

HY-N7450

Icariside D2	Infection Natural Products Classification of Application Fields Source classification Plants Annonaceae Inflammation/Immunology Disease Research Fields Annona glabra Linn.	Angiotensin-converting Enzyme (ACE) Apoptosis HIV
Icariside D2, isolated from Annona glabra fruit, inhibits angiotensin-converting enzyme. Icariside D2 shows significant cytotoxic activity on the HL-60 cell line with the IC₅₀ value of 9.0 ± 1.0 μM. Icariside D2 induces apoptosis ^[2].

HY-138073

Cryptomoscatone D2	Structural Classification Cryptocarya mandioccana Meisn. Simple Phenylpropanols Source classification Phenylpropanoids Plants Lauraceae	Others
Cryptomoscatone D2 is a potent G2 checkpoint inhibitor .

HY-N10074

Polygalacin D2	Triterpenes Structural Classification Terpenoids Source classification Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants	Others
Polygalacin D2 is a saponin isolated from Platycodon grandiflorum .

HY-N4087

Platycodin D2 2 Publications Verification	Triterpenes Classification of Application Fields Terpenoids Source classification Platycodon grandiflorus (Jacq.) A. DC. Campanulaceae Plants Disease Research Fields Cancer	Others
Platycodin D2 is a saponin isolated from Platycodon grandiflorum, with anti-cancer activity .

HY-N12294

Ciwujianoside D2	Triterpenes Structural Classification Polysaccharides Terpenoids Source classification Acanthopanax senticosus (Rupr. et Maxim.) Harms Plants Saccharides Araliaceae	Others
Ciwujianoside D2, a saponin compound, can enhance pancreatic lipase activity in vitro .

HY-N12220

Cinnamtannin D2	Structural Classification Vaccinium vitis-idaea L. Source classification Phenols Polyphenols Plants Ericaceae	Others
Cinnamtannin D2 (compound 13) is a cinnamon tannin isolated from Vaccinium vitis-idaea L .

HY-101988

Prostaglandin D2 PGD2	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Inflammation/Immunology	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals . Prostaglandin D2 is one of the most potent endogenous sleep promoting substances ^[2]. PGD2 plays a protective role by suppressing inflammation .

HY-107260

Lucidenic acid D Lucidenic acid D2	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Source classification Polyporaceae Plants Disease Research Fields Inflammation/Immunology	Others
Lucidenic acid D (Lucidenic acid D2) is a highly oxidized lanostane-type triterpenoid .

HY-32350

Ercalcitriol 2 Publications Verification 1α,25-Dihydroxy Vitamin D2	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

HY-32349

Ercalcidiol 1 Publications Verification 25-Hydroxy Vitamin D2	Structural Classification Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Steroids	VD/VDR Endogenous Metabolite
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-76542

Vitamin D2 1 Publications Verification Ergocalciferol; Calciferol; Ercalciol	Human Gut Microbiota Metabolites other families Microorganisms Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Disease Research Fields Steroids	VD/VDR Endogenous Metabolite
Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D ^[2].

HY-N0181

Ergosterol 2 Publications Verification Ergosterin; Provitamin D; Provitamin D2	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.

HY-N0181R

Ergosterol (Standard) Ergosterin(Standard); Provitamin D(Standard); Provitamin D2 (Standard)	Structural Classification Microorganisms Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids	Endogenous Metabolite
Ergosterol (Standard) is the analytical standard of Ergosterol. This product is intended for research and analytical applications. Ergosterol is the primary sterol found in fungi, with antioxidative, anti-proliferative, and anti-inflammatory effects.

HY-N0216BS

Benzoic-3,5 Acid-d2

Classification of Application Fields

Isotope-Labeled Compounds

Benzoic-3,5 Acid-d₂ is the deuterium labeled Benzoic-3,5 Acid[1].

HY-N6960

L-Stepholidine Stepholidine; (-)-Stepholidine; L-SPD	Alkaloids Stephania intermedia Source classification Plants Isoquinoline Alkaloids Menispermaceae	Dopamine Receptor
L-Stepholidine (Stepholidine) exhibits mixed dopamine D1 receptor agonist and D2 antagonist properties. L-Stepholidine has neuroprotective effect and inhibits Heroin-induced reinstatement. L-Stepholidine is a potential medication for the research of opiate addiction ^[2] .

HY-113505

Delta-12-Prostaglandin J2 Δ12-PGJ2	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation ^[2].

HY-N0925

Tetrahydroberberine Canadine	Alkaloids Structural Classification Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	Dopamine Receptor
Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach ^[2] .

HY-N0096

Rotundine (-)-Tetrahydropalmatine; L-Tetrahydropalmatine	Alkaloids Corydalis yanhusuo W. T. Wang Source classification Plants Isoquinoline Alkaloids Papaveraceae	5-HT Receptor Dopamine Receptor
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC₅₀s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT_1A with an IC₅₀ of 370 nM.

HY-113366

Prostaglandin J2 PGJ2	Structural Classification Neurological Disease Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Disease Research Fields	Prostaglandin Receptor Endogenous Metabolite
Prostaglandin J2 (PGJ2), an endogenous metabolite of Prostaglandin D2 (PGD2; HY-101988), is a potent PGD2 receptor (DP) agonist with K_is of 0.9 nM and 6.6 nM for hDP and hCRTH2, respectively. Prostaglandin J2 stimulates intracellular cyclic AMP production with an EC₅₀ value of 1.2 nM. Prostaglandin J2 induces oxidative stress and neuronal apoptosis. Prostaglandin J2 induces the accumulation/aggregation of ubiquitinated (Ub) proteins. Prostaglandin J2 is highly neurotoxic and potentially contributes to many neurodegenerative conditions, including Alzheimer's (AD) and Parkinson's diseases (PD) ^[2] .

HY-A0019

Paliperidone 1 Publications Verification 9-Hydroxyrisperidone	Structural Classification Natural Products Source classification Endogenous metabolite	Dopamine Receptor 5-HT Receptor Adrenergic Receptor
Paliperidone (9-Hydroxyrisperidone), the major active metabolite of Risperidone, is a dopamine D2 antagonist and *5-HT2A* antagonist. Paliperidone is also active as an antagonist at α1 and α2 adrenergic receptors and H1-histaminergic receptors. Paliperidone, a antipsychotic agent, shows efficacy against schizophrenia .

HY-N3945

Glaucine O,O-Dimethylisoboldine; S-(+)-Glaucine; NSC 34396	Infection Alkaloids other families Classification of Application Fields Source classification Plants Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Glaucium flavum Papaveraceae	Phosphodiesterase (PDE) Calcium Channel Adrenergic Receptor Dopamine Receptor Influenza Virus
Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with K_is of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca ²⁺ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities ^[2] .

HY-N0049

Nuciferine 4 Publications Verification	Structural Classification Alkaloids Aporphine Alkaloids other families Source classification Plants Isoquinoline Alkaloids	Parasite 5-HT Receptor Dopamine Receptor
Nuciferine is an antagonist at *5-HT_2A* (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and *5-HT_2B* (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-N0049R

Nuciferine (Standard)	Structural Classification Alkaloids other families Source classification Plants	5-HT Receptor Dopamine Receptor
Nuciferine (Standard) is the analytical standard of Nuciferine. This product is intended for research and analytical applications. Nuciferine is an antagonist at *5-HT_2A* (IC₅₀=478 nM), *5-HT_2C* (IC₅₀=131 nM), and *5-HT_2B* (IC₅₀=1 μM), an inverse agonist at 5-HT₇ (IC₅₀=150 nM), a partial agonist at D₂ (EC₅₀=64 nM), D₅ (EC₅₀=2.6 μM) and 5-HT₆ (EC₅₀=700 nM), an agonist at 5-HT_1A (EC₅₀=3.2 μM) and D₄ (EC₅₀=2 μM) receptor.

HY-N3180

Norbraylin	Toddalia asiatica (L.) Lam. Structural Classification Source classification Rutaceae Coumarins Phenylpropanoids Plants	Phosphodiesterase (PDE)
Norbraylin, a natural prenylated coumarin, is a *PDE4D2* inhibitor with an IC₅₀ value of 7.15 μM .

HY-113038

D-α-Hydroxyglutaric acid (R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid	Classification of Application Fields Neurological Disease Anti-aging Source classification Endocrine diseases Endogenous metabolite Immune System Disorder Ketones, Aldehydes, Acids Disease markers Nervous System Disorder Disease Research Fields Inflammation/Immunology Cancer	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid ((R)-2-Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling ^[2] .

HY-100542

D-α-Hydroxyglutaric acid disodium 2 Publications Verification Disodium (R)-2-hydroxyglutarate	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Ketones, Aldehydes, Acids Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields Cancer	Reactive Oxygen Species ATP Synthase mTOR Endogenous Metabolite
D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D-2-hydroxyglutaric aciduria. D-α-Hydroxyglutaric acid disodium is a weak competitive antagonist of α-ketoglutarate (α-KG) and inhibits multiple α-KG-dependent dioxygenases with a K_i of 10.87 mM. D-α-Hydroxyglutaric acid disodium increases reactive oxygen species (ROS) production. D-α-Hydroxyglutaric acid disodium binds and inhibits ATP synthase and inhibits mTOR signaling ^[2] .

HY-18572

2,4-D 2,4-Dichlorophenoxyacetic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields Biological Pesticide Research Agricultural Research	DNA/RNA Synthesis Apoptosis
2,4-D (2, 4-dichlorophenoxyacetic acid) is a selective herbicide that can be orally active for the control of broad-leaved weeds. 2,4-D can induce apoptosis. 2,4-D inhibits DNA and protein synthesis, thereby preventing normal plant growth and development ^[2] .

HY-122942

Moracin M	Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Moraceae Endogenous metabolite Inflammation/Immunology Disease Research Fields Morus alba Linn.	Phosphodiesterase (PDE) Endogenous Metabolite NF-κB Autophagy
Moracin M is a phenolic component that can be isolated from Mori Cortex, is a potent phosphodiesterase-4 (PDE4) inhibitor with IC₅₀ values of 2.9, 4.5, >40, and >100 μM for PDE4D2, PDE4B2, PDE5A1, and PDE9A2, respectively. Moracin M has anti-inflammatory activity ^[2].

Species:	Human (12) Mouse (1) Cynomolgus (1)
Tag:	SUMO (1) His (12) Tag Free (1) Myc (1) GST (4) Flag (2)
Source:	HEK293 (4) Sf9 insect cells (6) E. coli (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P72159

	CXCR4 Protein, Human (N-His-SUMO, C-Myc) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; SDF 1 receptor; SDF-1 receptor; WHIM; WHIMS	Human	E. coli
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (N-His-SUMO, C-Myc) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-10*His, C-Myc, N-SUMO labeled tag. The total length of CXCR4 Protein, Human (N-His-SUMO, C-Myc) is 50 a.a., with molecular weight of ~28 kDa.

HY-P72160

	CXCR4 Protein, Human (GST) C-X-C chemokine receptor type 4; CD184; CD184 antigen; Chemokine C X C motif; receptor 4; Chemokine CXC Motif Receptor 4; CXC-R4; CXCR-4; CXCR4; CXCR4_HUMAN; D2S201E; FB22; Fusin; HM89; HSY3RR; LAP 3; LAP3; LCR1; LESTR; Leukocyte derived seven transmembrane domain receptor; Leukocyte-derived seven transmembrane domain receptor; Lipopolysaccharide associated protein 3; Neuropeptide Y receptor Y3; NPY3R; NPYR; NPYRL; NPYY3; NPYY3R; Probable G protein coupled receptor lcr1 homolog; SDF 1 receptor; SDF-1 receptor; SEVEN-TRANSMEMBRANE-SEGMENT RECEPTOR; Stromal cell derived factor 1 receptor; Stromal cell-derived factor 1 receptor; WHIM; WHIMS	Human	E. coli
	The CXCR4 protein functions as a receptor for the CXC chemokine CXCL12/SDF-1, triggering an increase in intracellular calcium ions and activation of MAPK1/MAPK3. It is actively involved in AKT signaling, which is critical for regulating cell migration, especially in wound healing. CXCR4 Protein, Human (GST) is the recombinant human-derived CXCR4 protein, expressed by E. coli , with N-GST labeled tag. The total length of CXCR4 Protein, Human (GST) is 50 a.a., with molecular weight of ~32.6 kDa.

HY-P74615

	Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) Serine/threonine-protein kinase D2; PRKD2; PKD2; HSPC187	Human	Sf9 insect cells
	Protein kinase D2 (PRKD2) is a serine/threonine protein kinase that mediates various cellular processes downstream of PKC. It affects cell proliferation through MAPK1/3 (ERK1/2) signaling, activates NF-kappa-B under oxidative stress, inhibits HDAC7 transcriptional repression, and regulates T cell antigen receptor (TCR) signaling, cytokine production, Golgi trafficking, angiogenesis, particle release, and cell adhesion. Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) is the recombinant human-derived protein Kinase D2/PRKD2 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Protein Kinase D2/PRKD2 Protein, Human (sf9, His-GST) is 878 a.a., with molecular weight of ~120 kDa.

HY-P76779

	CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) Antigen-presenting glycoprotein CD1D2; Cd1D2; Beta-2-microglobulin	Mouse	HEK293
	The CD1D2 protein plays a crucial role as an antigen-presenting molecule, binding self and non-self glycolipids and presenting them to T-cell receptors on natural killer T-cells. In partnership with B2M, it mediates immune responses, and its interactions with MHC II and CD74 highlight its significance in the complex network of immune system regulation. CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived CD1D2-B2M Heterodimer protein, expressed by HEK293, with C-His labeled tag. CD1D2-B2M Heterodimer Protein, Mouse (HEK293, His), has molecular weight of ~33.7 & 11.7 KDa, respectively.

HY-P7773

	CCND2 Protein, Human (His) rHuCCND2, His; G1/S-specific cyclin-D2; CCND2	Human	E. coli
	CCND2 Protein, Human (His) is a D-type cyclin with key roles in cell cycle regulation, differentiation, and malignant transformation.

HY-P76955

	GLT8D2 Protein, Human (sf9, His) Glycosyltransferase 8 domain-containing protein 2; GALA4A	Human	Sf9 insect cells
	GLT8D2 is a member of the glycosyltransferase 8 family. GLT8D2 Protein, Human (sf9, His) is the recombinant human-derived GLT8D2 protein, expressed by Sf9 insect cells, with N-His labeled tag. The total length of GLT8D2 Protein, Human (sf9, His) is 325 a.a., with molecular weight of ~39.6 KDa.

HY-P76866

	DCUN1D2 Protein, Human (His) DCN1-like protein 2; DCNL2; C13orf17; DCUN1L2	Human	E. coli
	The DCUN1D2 protein transfers NEDD8 from NEDD8-conjugated E2 to the cullin-RBX complex and regulates SCF-type complex activity. DCUN1D2 Protein, Human (His) is the recombinant human-derived DCUN1D2 protein, expressed by E. coli , with N-His labeled tag. The total length of DCUN1D2 Protein, Human (His) is 259 a.a., with molecular weight of ~30 kDa.

HY-P76954

	GLT25D2 Protein, Human (sf9, His) Procollagen galactosyltransferase 2; ColGalT 2; COLGALT2; C1orf17; KIAA0584	Human	Sf9 insect cells
	GLT25D2 Protein, a beta-galactosyltransferase, crucially catalyzes beta-galactose transfer to collagen hydroxylysine residues, influencing collagen's structural diversity and functional properties. This glycosylation modulates collagen's biochemical and biomechanical characteristics, impacting tissue development, maintenance, and repair. Understanding GLT25D2's role enhances comprehension of collagen modification pathways, with potential therapeutic implications for collagen-related disorders. Further exploration promises insights into collagen biology, advancing knowledge and contributing to therapeutic strategy development. GLT25D2 Protein, Human (sf9, His) is the recombinant human-derived GLT25D2 protein, expressed by Sf9 insect cells, with C-His labeled tag. The total length of GLT25D2 Protein, Human (sf9, His) is 622 a.a., with molecular weight of ~68 kDa.

HY-P700838

	TNFRSF1A Protein, Cynomolgus (HEK293, His) TNF-R1; TNF-RI; FPF; TBP1; TNF-R55; TNFAR; TNFR60; p55; p60; MS5; p55-R; TNFR1-D2	Cynomolgus	HEK293
	TNFRSF1A Protein exhibits a deficiency in conserved residue(s) crucial for feature annotation propagation. TNFRSF1A Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived TNFRSF1A protein, expressed by HEK293 , with C-His labeled tag. The total length of TNFRSF1A Protein, Cynomolgus (HEK293, His) is 182 a.a., with molecular weight of 32-42 kDa.

HY-P71242

	PTGDS Protein, Human (HEK293, His) 1 Publications Verification Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS	Human	HEK293
	The PTGDS protein catalyzes the conversion of PGH2 to PGD2, a prostaglandin that affects smooth muscle activity and platelet aggregation. It plays a role in central nervous system functions such as sedation, sleep, and allodynia. PTGDS Protein, Human (HEK293, His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PTGDS Protein, Human (HEK293, His) is 168 a.a., with molecular weight of 20-29 kDa.

HY-P701367

	CDK6-CCND2 Heterodimer Protein, Human (Sf9) CDK6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND2 Heterodimer Protein, Human (Sf9) is a recombinant protein dimer complex containing human-derived CDK6-CCND2 Heterodimer protein, expressed by Sf9 insect cells , with tag free.

HY-P71242A

	PTGDS Protein, Human (HEK293, C-His) Prostaglandin-H2 D-Isomerase; Beta-Trace Protein; Cerebrin-28; Glutathione-Independent PGD Synthase; Lipocalin-Type Prostaglandin-D Synthase; Prostaglandin-D2 Synthase; PGD2 Synthase; PGDS; PGDS2; PTGDS; PDS	Human	HEK293
	The PTGDS protein serves a multifaceted role in various physiological processes. It catalyzes the conversion of PGH2 to PGD2, a prostaglandin with implications in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Beyond its involvement in these vascular functions, PTGDS plays a crucial role in diverse central nervous system (CNS) activities, including sedation, NREM sleep, and PGE2-induced allodynia, and may exhibit an anti-apoptotic function in oligodendrocytes. Notably, PTGDS has a broad substrate-binding capacity, interacting with small non-substrate lipophilic molecules such as biliverdin, bilirubin, retinal, retinoic acid, and thyroid hormone. This suggests its potential role as a scavenger for harmful hydrophobic molecules and as a transporter for secretory retinoids and thyroid hormones. Additionally, PTGDS is implicated in the development and maintenance of various blood barriers, including the blood-brain, blood-retina, blood-aqueous humor, and blood-testis barriers, indicating its significance in barrier function. Furthermore, it plays essential roles in the maturation and maintenance of the central nervous system and the male reproductive system, as well as participates in PLA2G3-dependent maturation of mast cells, further emphasizing its intricate involvement in diverse biological processes. PTGDS Protein, Human (HEK293, C-His) is the recombinant human-derived PTGDS protein, expressed by HEK293 , with C-10*His labeled tag. The total length of PTGDS Protein, Human (HEK293, C-His) is 168 a.a., with molecular weight of ~21 kDa.

HY-P701368

	CDK6-CCND2 Heterodimer Protein, Human (Sf9, GST, FLAG, His) CDK6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2	Human	Sf9 insect cells
	The CDK6ic complex is an important serine/threonine protein kinase that regulates cell cycle progression and differentiation, promoting the G1/S transition by phosphorylating substrates such as pRB/RB1 and NPM1. It interacts with D-type G1 cyclins during interphase to form active pRB/RB1 kinase, which controls cell cycle entry. CDK6-CCND2 Heterodimer Protein, Human (Sf9, GST, FLAG, His) is a recombinant protein dimer complex containing human-derived CDK6-CCND2 Heterodimer protein, expressed by Sf9 insect cells , with N-Flag, N-8*His, N-GST labeled tag.

HY-P702687

	CDK6-CCND1 Protein, Human (sf9, GST, Flag, His) CDK6; CCND2; Cyclin-dependent kinase 6; Cell division protein kinase 6; Serine/threonine-protein kinase PLSTIRE; G1/S-specific cyclin-D2	Human	Sf9 insect cells

Cat. No.	Product Name	Chemical Structure

HY-Y0127S

D(-)-2-Aminobutyric acid-d6

D(-)-2-Aminobutyric acid-d₆ is the deuterium labeled D(-)-2-Aminobutyric acid. D(-)-2-Aminobutyric acid is a substrate of D-amino acid oxidase.
HY-41912AS

D-2-Aminohexanoic acid-d9

D-2-Aminohexanoic acid-d₉ is the deuterium labeled D-2-Aminohexanoic acid.
HY-139952S

Prostaglandin D2 Dopamine-d4

Prostaglandin D2 Dopamine-d₄ is the deuterium labeled Prostaglandin D2 Dopamine[1].
HY-B1812S1

Veratrole-d2

Veratrole-d₂ is the deuterium labeled Veratrole. Veratrole-d₂ is an naturally occurring insect attractant ^[2].

HY-121636S

Resolvin D2-d5
Resolvin D2-d₅ is the deuterium labeled Resolvin D2. Resolvin D2 is a metabolite of docosahexaenoic acid (DHA), with anti-inflammatory, anti-infective activities. Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Resolvin D2 is a remarkably potent inhibitor of TRPV1 (IC50 = 0.1 nM) and TRPA1 (IC50 = 2 nM) in primary sensory neurons[1][2][3].

HY-136820S1

Taurultam-d2 hydrochloride

Taurultam-d₂ (hydrochloride) is deuterium labeled Taurultam.
HY-N0453S1

Hypericin-d2

Hypericin-d₂ is deuterium labeled Hypericin.
HY-132383S

24,25-Dihydroxy Vitamin D2-d3

24,25-Dihydroxy Vitamin D2-d₃ is the deuterium labeled 24,25-Dihydroxy Vitamin D2[1].
HY-13631ES3

Deruxtecan-d2

Deruxtecan-d2 is the deuterium labeled Potassium oleate .

HY-101988S1

Prostaglandin D2-d9
Prostaglandin D2-d₉ is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

HY-101988S

Prostaglandin D2-d4
Prostaglandin D2-d₄ is the deuterium labeled Prostaglandin D2. Prostaglandin D2 (PGD2) is one of the major PGs actively produced in the brain of various mammals[1]. Prostaglandin D2 is one of the most potent endogenous sleep promoting substances[2]. PGD2 plays a protective role by suppressing inflammation[3].

HY-113150S1

Hexanoylglycine-d2

Hexanoylglycine-d₂ is the deuterium labeled Hexanoylglycine[1].
HY-W115763S

Dodecanoate-d2 potassium

Dodecanoate-d₂ (potassium) is the deuterium labeled Dodecanoate[1].
HY-W115788S

Tetradecanoate-d2 potassium

Tetradecanoate-d₂ (potassium) is the deuterium labeled Tetradecanoate[1].
HY-W133986S

Stearate-d2 potassium

Stearate-d₂ (potassium) is the deuterium labeled Stearate[1].
HY-W134007S2

Hexadecanoate-d2 potassium

Hexadecanoate-d₂ (potassium) is the deuterium labeled Hexadecanoate[1].
HY-Y0384S

Iodochloromethane-d2

Iodochloromethane-d₂ is the deuterium labeled Iodochloromethane[1].
HY-N0090S1

Guanosine-d2 hydrate

Guanosine-d₂ (hydrate) is the deuterium labeled Guanosine Hydrate[1].
HY-151017S

Mequitazine-d2 hydrochloride

Mequitazine-d₂ (hydrochloride) is the deuterium labeled Mequitazine hydrochloride[1].
HY-B1403S

Dienestrol-d2

Dienestrol-d₂ is a deuterium labeled Dienestrol (HY-B1403).
HY-B1449S8

Uridine-d2-1

Uridine-d₂-1 is the deuterium labeled Uridine[1].
HY-158085S

N-Undecanoylglycine-d2

N-Undecanoylglycine-d₂ is the deuterated labeled N-Undecanoylglycine .
HY-158084S

N-Nonanoylglycine-d2

N-Nonanoylglycine-d₂ is the deuterated labeled N-Nonanoylglycine .

HY-A0042S

Rufinamide-d2
Rufinamide-d₂ (CGP 33101-d₂) is the deuterium labeled Rufinamide. Rufinamide (E 2080) is a new antiepileptic agent that differs structurally from other antiepileptic drugs and is approved as adjunctive therapy for Lennox-Gastaut syndrome (LGS).

HY-W016221S1

6-Hydroxy Chlorzoxazone-15N,d2

6-Hydroxy Chlorzoxazone-15N,d2 is 15N labeled 6-Hydroxy Chlorzoxazone-d2 (HY-W016221S) .

HY-76542S

Vitamin D2-d6
Vitamin D2-d₆ is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

HY-113119S1

N-Butyrylglycine-d2

N-Butyrylglycine-d₂ is the deuterium labeled N-Butyrylglycine[1].
HY-Y0978S1

Boc-Glycine-d2

Boc-Glycine-d₂ is the deuterium labeled Boc-Glycine[1].
HY-W141928S1

N-Isobutyrylglycine-d2

N-Isobutyrylglycine-d₂ is the deuterium labeled N-Isobutyrylglycine[1].
HY-W012889S4

DL-Valine-d2

DL-Valine-d₂ is the deuterium labeled DL-Valine[1].
HY-W087983S

N-Methylethanamine-d2

N-Methylethanamine-d₂ is the deuterium labeled N-Methylethanamine[1].

HY-W013812S2

Ethyl linoleate-d2
Ethyl linoleate-d₂ (Linoleic Acid ethyl ester-d₂; Mandenol-d₂) is the deuterium labeled Ethyl linoleate (HY-W013812). Ethyl linoleate (Linoleic Acid ethyl ester) inhibit the development of atherosclerotic lesions and the expression of inflammatory mediators ^[2].

HY-W130305S1

1-Iodooctane-d2

1-Iodooctane-d₂ is the deuterium labeled 1-Iodooctane[1].
HY-116028S1

15-deoxy-Δ12,14-Prostaglandin D2-d4

15-deoxy-Δ12,14-Prostaglandin D2-d₄ is the deuterium labeled 15-deoxy-Δ12,14-Prostaglandin D2[1].
HY-152070S

Demethylmaprotiline-d2

Demethylmaprotiline-d₂ is the deuterium labeled Demethylmaprotiline[1].
HY-W013652S

N-Tigloylglycine-2,2-d2

N-Tigloylglycine-2,2-d₂ is the deuterium labeled N-Tigloylglycine-2,2.
HY-W005355S1

Sodium 2-oxobutanoate-d2 hydrate

Sodium 2-oxobutanoate-d₂ (hydrate) is the deuterium labeled Sodium 2-oxobutanoate hydrate[1].
HY-N8440S1

Gibberellin A4-d2

Gibberellin A4-d2 is the deuterium labeled Gibberellin A4 (HY-N8440) .

HY-Y0069S1

N-Acetylglycine-d2
N-Acetylglycine-d₂ (Aceturic acid-d₂; Acetamidoacetic acid-d₂) is the deuterated labeled N-Acetylglycine (HY-Y0069). N-Acetylglycine (Aceturic acid) is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics .

HY-17605S

Bictegravir-15N,d2
Bictegravir- ¹⁵N,d₂ (GS-9883- ¹⁵N,d₂) is the ¹⁵N and deuterium labeled Bictegravir (HY-17605) . Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC₅₀ of 7.5 nM ^[2].

HY-W141770S

DL-Phenylmercapturic acid-d2

DL-Phenylmercapturic acid-d₂ is the deuterium labeled DL-Phenylmercapturic acid[1].
HY-W035361S

(Aminomethyl)phosphonic acid-d2

(Aminomethyl)phosphonic acid-d₂ is the deuterium labeled (Aminomethyl)phosphonic acid[1].
HY-W099646S1

N-Octanoylglycine-2,2-d2

N-Octanoylglycine-2,2-d₂ is the deuterium labeled N-Octanoylglycine-2,2[1].
HY-132960S

N-Propionylglycine-2,2-d2

N-Propionylglycine-2,2-d₂ is the deuterium labeled N-Propionylglycine-2,2[1].
HY-W032015S1

1-Bromooctane-1,1-d2

1-Bromooctane-1,1-d₂ is the deuterium labeled 1-Bromooctane[1].
HY-B0249S

Didanosine-d2

Didanosine-d₂ is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

HY-D0187S5

L-Glutathione reduced-d2
L-Glutathione reduced-d₂ (GSH-d₂; γ-L-Glutamyl-L-cysteinyl-glycine-d₂) is deuterated-labeled L-Glutathione reduced (HY-D0187). L-Glutathione reduced is an endogenous antioxidant and oxygen free radical scavenger.

HY-W004283S2

Pentadecanoic acid-d2

Pentadecanoic acid-d₂ is the deuterium labeled Pentadecanoic acid. Pentadecylic acid is a saturated fatty acid with a 15-carbon backbone.
HY-N0059S4

D-Arabinose-d2

D-Arabinose-d₂ is the deuterium labeled D-arabinose. D-arabinose is an endogenous metabolite[1].
HY-B1449S5

Uridine-d2

Uridine-d₂ is the deuterium labeled Uridine[1].

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