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Results for "

DHODH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Dihydroorotate Dehydrogenase (53) Apoptosis (1) Autophagy (3) Bacterial (2) Dengue virus (1) DNA/RNA Synthesis (28) Endogenous Metabolite (6) Ferroptosis (1) Flavivirus (1) FXR (2) Influenza Virus (2) Interleukin Related (2) MDM-2/p53 (3) Nucleoside Antimetabolite/Analog (4) Parasite (7) Prostaglandin Receptor (1) Reactive Oxygen Species (1) ROR (3) SARS-CoV (1) Sirtuin (3) Small Interfering RNA (siRNA) (3) VEGFR (1) Virus Protease (1)
By Research Areas:	Cancer (30) Infection (18) Inflammation/Immunology (18) Metabolic Disease (4)

By Targets:

Dihydroorotate Dehydrogenase (53)

Apoptosis (1)

Autophagy (3)

Bacterial (2)

Dengue virus (1)

DNA/RNA Synthesis (28)

Endogenous Metabolite (6)

Ferroptosis (1)

Flavivirus (1)

FXR (2)

Influenza Virus (2)

Interleukin Related (2)

MDM-2/p53 (3)

Nucleoside Antimetabolite/Analog (4)

Parasite (7)

Prostaglandin Receptor (1)

Reactive Oxygen Species (1)

ROR (3)

SARS-CoV (1)

Sirtuin (3)

Small Interfering RNA (siRNA) (3)

VEGFR (1)

Virus Protease (1)

By Research Areas:

Cancer (30)

Infection (18)

Inflammation/Immunology (18)

Metabolic Disease (4)

Inhibitors & Agonists

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

DHODH-IN-16	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
DHODH-IN-16 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 0.396 nM for human DHODH .

DHODH-IN-1	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-1 (compound 18d) is a potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC₅₀ of 25 nM. DHODH-IN-1 is an inhibitor of pyrimidine biosynthesis pathway .

DHODH-IN-11	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology
DHODH-IN-11 (Compound 14b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pK_a of 5.03 .

DHODH-IN-24	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
DHODH-IN-24 (compound 16) is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 91 nM .

DHODH-IN-13	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology
DHODH-IN-13 (Compound 7a) is a hydroxyfurazan analog of A771726. DHODH-IN-13 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 4.3 μM for rat liver DHODH. DHODH-IN-13 can be used for rheumatoid arthritis .

DHODH-IN-12	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology
DHODH-IN-12 (Compound 12b) is a Leflunomide derivative and a weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pK_a of 5.07 .

DHODH-IN-14	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology
DHODH-IN-14 (Compound 7l) is a hydroxyfurazan analog of A771726. DHODH-IN-14 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 0.49 μM for rat liver DHODH. DHODH-IN-14 can be used for rheumatoid arthritis .

DHODH-IN-15	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology
DHODH-IN-15 (Compound 7b) is a hydroxyfurazan analog of A771726. DHODH-IN-15 is a dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 11 μM for rat liver DHODH. DHODH-IN-15 can be used for rheumatoid arthritis .

DHODH-IN-8	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-8 (Compound 27) is an inhibitor of human and **Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC₅₀s of 0.13 μM and 47.4 μM, and K_i*s of 0.016 μM and 5.6 μM, respectively. DHODH*-IN-8 has antimalarial activity .

DHODH-IN-19	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology Cancer
DHODH-IN-19 is a potent inhibitor of *DHODH. DHODH* is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-19 inhibits tumor growth. DHODH-IN-19 has the potential for the research of cancer and inflammation disease (extracted from patent WO2021238881A1, compound 1) .

DHODH-IN-20	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology Cancer
DHODH-IN-20 (Compound 133) is a potent inhibitor of *DHODH. DHODH* is present in the inner membrane of human mitochondria and is an iron-containing flavin-dependent enzyme. DHODH-IN-20 inhibits tumor growth. DHODH-IN-20 has the potential for the research of acute myelogenous leukemia .

DHODH-IN-21	Dihydroorotate Dehydrogenase	Cancer
DHODH-IN-21 (compound 19) is an orally active selective dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ value of 1.1 nM. DHODH-IN-21 has anticancer activity and can be used in studies of acute myeloid leukaemia (AML) .

DHODH-IN-25	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
DHODH-IN-25 (Compound 25) is an orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ value of 5.4 nM for human *DHODH. DHODH*-IN-25 can be used for the study of acute myeloid leukemia (AML) .

DHODH-IN-18	Dihydroorotate Dehydrogenase	Cancer
DHODH-IN-18 is a human *DHODH* inhibitor (IC₅₀ = 0.2 nM).

DHODH-IN-3	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection
DHODH-IN-3 (compound 3) is a potent inhibitor of Human Dihydroorotate Dehydrogenases (HsDHODH) with an IC₅₀ value of 261 nM. DHODH-IN-3 binds to the the ubiquinone binding cavities in DHODH with a K_i ^app of 32 nM. DHODH-IN-3 has the potential for malaria treatment .

DHODH-IN-22	Dihydroorotate Dehydrogenase	Cancer
DHODH-IN-22 is a potent, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ value of 0.3 nM. DHODH-IN-22 can be used for researching acute myelogenous leukemia (AML) .

DHODH-IN-23	Dihydroorotate Dehydrogenase	Cancer
DHODH-IN-23 (Compound A) is an orally active *DHODH* inhibitor that can be used for the research of cancer .

DHODH-IN-17	Dihydroorotate Dehydrogenase	Cancer
DHODH-IN-17, a 2-anilino nicotinic acid, is a human *DHODH* inhibitor (IC₅₀=0.40 μM). DHODH-IN-17 can be used for theresearch of acute myeloid leukemia (AML) .

DHODH-IN-26	Dihydroorotate Dehydrogenase Reactive Oxygen Species Ferroptosis	Cancer
DHODH-IN-26 (compound B2) is a mitochondria-targeting *DHODH* inhibitor. DHODH-IN-26 shows anticancer activity, triggers the formation of reactive oxygen species (ROS), promots mitochondrial lipid peroxidation, and induces ferroptosis .

DHODH-IN-4	Parasite Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Infection Inflammation/Immunology
DHODH-IN-4 (compound 17) is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor, with IC₅₀ values of 4 μM and 0.18 μM for PfDHODH and HsDHODH, respectively. DHODH-IN-4 (compound 17) possess antimalarial activity .

DHODH Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DHODH Human Pre-designed siRNA Set A contains three designed siRNAs for DHODH gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dhodh Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dhodh Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dhodh gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dhodh Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dhodh Rat Pre-designed siRNA Set A contains three designed siRNAs for Dhodh gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

*RORγt/DHODH-IN-1*	ROR Dihydroorotate Dehydrogenase	Inflammation/Immunology
RORγt/DHODH-IN-1 (compound (R)-14d) is a potent and orally active dual RORγt/DHODH inhibitor, with IC₅₀s of 0.083 μM and 0.172 μM, respectively. RORγt/DHODH-IN-1 exhibits remarkable in vivo anti-inflammatory activity .

*RORγt/DHODH-IN-2*	ROR Dihydroorotate Dehydrogenase	Inflammation/Immunology
RORγt/DHODH-IN-2 (compound 1) is a potent dual RORγt/DHODH inhibitor. RORγt/DHODH-IN-2 can be used for inflammatory bowel disease (IBD) research .

*RORγt/DHODH-IN-3*	ROR Dihydroorotate Dehydrogenase	Inflammation/Immunology
RORγt/DHODH-IN-3 (compound (S)-14d) is a dual RORγt/DHODH inhibitor, with IC₅₀s of 0.098 μM and 0.432 μM, respectively. RORγt/DHODH-IN-3 exhibits remarkable in vivo anti-inflammatory activity .

DSM502	Dihydroorotate Dehydrogenase Parasite	Infection
DSM502 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM502 exhibits nanomolar potency againsts Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs .

DSM705 hydrochloride	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 hydrochloride, an orally active antimalarial compound, is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 hydrochloride exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites (IC₅₀=95, 52 nM for P. falciparum and P. vivax DHODH, respectively), with no inhibition of mammalian DHODHs .

DSM705	Dihydroorotate Dehydrogenase Parasite	Infection
DSM705 is a pyrrole-based Dihydroorotate Dehydrogenase (DHODH) inhibitor. DSM705 exhibits nanomolar potency against Plasmodium DHODH and Plasmodium parasites, with no inhibition of mammalian DHODHs. DSM705 is a potent antimalarial compound .

hDHODH-IN-7	DNA/RNA Synthesis Influenza Virus Dihydroorotate Dehydrogenase	Infection
DHODH-IN-9 (Compound 10k) is an azine-bearing analogue and is a human dihydroorotate dehydrogenase inhibitor. DHODH-IN-9 has antiviral effect with a pMIC₅₀ of 7.4 .

AG-636	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
AG-636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC₅₀ of 17 nM. AG-636 has strong anticancer effects .

CHIKV-IN-2	Flavivirus Dengue virus Dihydroorotate Dehydrogenase	Infection
CHIKV-IN-2 is a potent inhibitor against Chikungunya virus (CHIKV), with excellent cellular antiviral activity (EC₉₀=270 nM) and improved liver microsomal stability. CHIKV-IN-2 shows inhibitory activity against a cellular target Dihydroorotate Dehydrogenase (DHODH), which interacts with various viruses and regulate their replication via depleting intracellular pyrimidine pools .

Lapachol 1 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol, a natural naphthoquinone, is an orally active, potent *DHODH* inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

Farudodstat 2 Publications Verification ASLAN003	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Apoptosis	Cancer
Farudodstat (ASLAN003) is an orally active and potent Dihydroorotate Dehydrogenase (DHODH) inhibitor with an IC₅₀ of 35 nM for human DHODH enzyme. Farudodstat inhibits protein synthesis via activation of AP-1 transcription factors. Farudodstat induces apoptosis and substantially prolongs survival in acute myeloid leukemia (AML) xenograft mice .

hDHODH-IN-5	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
DHODH-IN-7 is a human dihydroorotate dehydrogenase (DHODH) inhibitor, with an IC₅₀ of 0.91 μM. DHODH-IN-7 induces differentiation in acute myeloid leukemia .

hDHODH-IN-4	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Influenza Virus	Infection
hDHODH-IN-4 is a potent human dihydroorotate dehydrogenase (DHODH) inhibitor, with a pIC₅₀ of 7.8 for human recombinant DHODH. hDHODH-IN-4 inhibits measles virus replication, with a pMIC₅₀ of 8.8 .

Brequinar Maximum Cited Publications 13 Publications Verification DUP785; NSC 368390	Dihydroorotate Dehydrogenase SARS-CoV Virus Protease DNA/RNA Synthesis	Infection Inflammation/Immunology Cancer
Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC₅₀ of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.

Indoluidin E	Dihydroorotate Dehydrogenase	Cancer
Indoluidin E selectively inhibits *DHODH* and suppresses cancer cell growth.

BAY-2402234 5 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Cancer
BAY-2402234 is a selective dihydroorotate dehydrogenase *(DHODH)* inhibitor for the treatment of myeloid malignancies.

P1788	Dihydroorotate Dehydrogenase DNA/RNA Synthesis	Inflammation/Immunology Cancer
P1788 is a dihydroorotate dehydrogenase (DHODH) inhibitor. P1788 induces DNA damage .

Leflunomide 5+ Cited Publications HWA486; RS-34821; SU101	Dihydroorotate Dehydrogenase Endogenous Metabolite Bacterial	Cancer
Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.

hDHODH-IN-12	DNA/RNA Synthesis Dihydroorotate Dehydrogenase	Cancer
hDHODH-IN-12 is a potent *DHODH* inhibitor with an IC₅₀ value of 0.421 μM. DHODH is the rate-limiting enzyme in the de novo synthesis of pyrimidine which is essential in DNA/RNA Synthesis. hDHODH-IN-12 is present in the inner membrane of human mitochondria.hDHODH-IN-12 can be used for the research of lung cancer .

(E/Z)-Ginkgolic acid C17:2	Dihydroorotate Dehydrogenase	Others
(E/Z)-Ginkgolic acid C17:2, isolated from Ginkgo biloba, can bind with human dihydroorotate dehydrogenase (DHODH) tightly .

Leflunomide (Standard)	Dihydroorotate Dehydrogenase Endogenous Metabolite Bacterial	Cancer
Leflunomide (Standard) is the analytical standard of Leflunomide. This product is intended for research and analytical applications. Leflunomide is a pyrimidine synthesis inhibitor, inhibiting dihydroorotate dehydrogenase (DHODH), and acts as a disease-modifying antirheumatic agent.

BRD9185	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection
BRD9185 is a Dihydroorotate dehydrogenase (DHODH) inhibitor, with an EC₅₀ of 16 nM against multidrug-resistant blood-stage parasites in vitro and is curative after just three doses in a P. berghei mouse model .

UCK2 Inhibitor-2	Dihydroorotate Dehydrogenase	Cancer
UCK2 Inhibitor-2 is a non-competitive uridine-cytidine kinase 2 (UCK2) inhibitor with an IC₅₀ value of 3.8 µM. UCK2 Inhibitor-2 can suppress uridine salvage in cells .

Cat. No.	Compare	Product Name	Species	Source

HY-P78957

	Dihydroorotate Dehydrogenase Protein, Human (His) Dihydroorotate dehydrogenase (quinone), mitochondrial; DHODH; DHOdehase; Dihydroorotate oxidase; Dihydroorotate Dehydrogenase	Human	E. coli
	Dihydroorotate dehydrogenase is a key enzyme that utilizes quinones as electron acceptors to catalyze the key conversion of dihydroorotate to orotic acid. This enzyme activity is essential for the de novo biosynthesis of UMP (uridine monophosphate), an essential component of nucleotide metabolism. Dihydroorotate Dehydrogenase Protein, Human (His) is the recombinant human-derived Dihydroorotate Dehydrogenase protein, expressed by E. coli , with N-His labeled tag. The total length of Dihydroorotate Dehydrogenase Protein, Human (His) is 365 a.a., with molecular weight of ~41 kDa.

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