EB | MedChemExpress (MCE) Life Science Reagents

By Targets:	Adrenergic Receptor (2) AMPK (1) Apoptosis (2) Autophagy (2) COX (1) Dopamine Transporter (3) Endogenous Metabolite (1) Eukaryotic Initiation Factor (eIF) (1) Glucosidase (3) HIV (1) HPV (1) HSV (1) Interleukin Related (1) Isotope-Labeled Compounds (1) LRRK2 (1) MNK (1) mTOR (1) NAMPT (1) PARP (2) Phospholipase (1) Serotonin Transporter (3) VD/VDR (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (1) Endocrinology (2) Infection (4) Inflammation/Immunology (5) Metabolic Disease (2) Neurological Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-108631

EB-47 dihydrochloride 2 Publications Verification	PARP	Inflammation/Immunology
EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC₅₀ value of 45 nM, shows modest potency against ARTD5 with an IC₅₀ value of 410 nM. EB-47 mimics the substrate NAD ⁺ and extends from the nicotinamide to the adenosine subsite .

HY-145273

EB-0150	Glucosidase	Infection
EB-0150 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC₅₀s of 0.73 and 0.0337 μM, respectively. EB-0150 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0150 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses .

HY-145275

EB-0176	Glucosidase	Infection
EB-0176 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC₅₀s of 0.6439 and 0.0011 μM, respectively. EB-0176 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0176 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses .

HY-145274

EB-0156	Glucosidase	Infection
EB-0156 is a potent inhibitor of ER α-glucosidases (α-Glu) Iand II with IC₅₀s of 0.0479 and less than 0.001 μM, respectively. EB-0156 is a N-substituted derivative of valiolamine with broad-spectrum antiviral. EB-0156 has the potential for the reseach of broad-spectrum agent against the existing and emerging viruses .

HY-15046

EB-47	PARP	Cardiovascular Disease Inflammation/Immunology
EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC₅₀ value of 45 nM, shows modest potency against ARTD5 with an IC₅₀ value of 410 nM. EB-47 mimics the substrate NAD ⁺ and extends from the nicotinamide to the adenosine subsite .

HY-115463

EB-3D 1 Publications Verification	AMPK Apoptosis	Cancer
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC₅₀ of 1 μM for ChoKα1. EB-3D exerts effects on ChoKα expression, AMPK activation, apoptosis, endoplasmic reticulum stress and lipid metabolism. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity .

HY-142647

EB-42486

LRRK2 Neurological Disease

EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC₅₀ < 0.2 nM).

EB-42486	LRRK2	Neurological Disease
EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC₅₀ < 0.2 nM).

HY-146805

EB1	MNK Eukaryotic Initiation Factor (eIF) Apoptosis	Cancer
EB1 is the inhibitor of kinases MNK with IC₅₀s of 0.69 μM (MNK1) and 9.4 μM (MNK2). EB1 selectively inhibits the growth of cancer cells, but not normal cells. EB1 also increases cell apoptosis and suppresses eIF4E phosphorylation .

HY-17485

Alminoprofen EB-382	Phospholipase COX	Inflammation/Immunology
Alminoprofen (EB-382) is a nonsteroidal anti-inflammatory agent (NSAID) of the phenylpropionic acid class. Alminoprofen possesses a dual anti-inflammatory action, by inhibiting both secretory phospholipase A₂ (sPLA₂) and COX-2 .

HY-32341

Seocalcitol 1 Publications Verification EB 1089	VD/VDR	Cancer
Seocalcitol is a vitamin D analog, binds vitamin D receptor protein from human osteosarcoma MG-63 cells with K_d of 0.27 nM.

HY-16736A

Centanafadine hydrochloride EB-1020 hydrochloride	Adrenergic Receptor Dopamine Transporter Serotonin Transporter	Neurological Disease Endocrinology
Centanafadine (hydrochloride) is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC₅₀s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

HY-16736

Centanafadine EB-1020	Adrenergic Receptor Dopamine Transporter Serotonin Transporter	Neurological Disease Endocrinology
Centanafadine is dual norepinephrine (NE)/dopamine (DA) transporter inhibitor, also inhibits serotonin transporter, with IC₅₀s of 6 nM, 38 nM and 83 nM for human NE, DA and serotonin transporter , respectively.

HY-18332A

Amitifadine hydrochloride DOV-21947 hydrochloride; EB-1010 hydrochloride	Serotonin Transporter Dopamine Transporter	Neurological Disease
Amitifadine hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

HY-10080

Teglarinad chloride GMX1777; EB-1627	NAMPT	Cancer
Teglarinad chloride (GMX1777) is a proagent of GMX1778 (a nicotinamide phosphoribosyl transferase inhibitor). Teglarinad chloride exhibits antitumor activity in mice can be attributed to inhibition of NAMPT. Teglarinad chloride also enhances radiation efficacy, mediated by interference with DNA repair and antiangiogenesis .

HY-N0866

20-Deoxyingenol 1 Publications Verification	Autophagy	Inflammation/Immunology
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-W010255

Phenylglyoxylic acid Benzoylformic acid	Endogenous Metabolite	Metabolic Disease
Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

HY-124582

NEO214	Autophagy mTOR	Cancer
NEO214 is an autophagy inhibitor and a covalent conjugate of the PDE4 inhibitor Rolipram (HY-16900) and perillyl alcohol (HY-N7000). It has anti-cancer activity and blood-brain barrier (BBB) permeability. Over sex. NEO214 prevents autophagy-lysosome fusion, thereby blocking autophagic flux and triggering glioma cell death. The process involves mTOR activation, andTFEB(Transcription Factor EB) aggregation. NEO214 inhibitionMacroautophagy/autophagy in glioblastoma cells has the potential to overcome chemotherapy resistance in glioblastoma .

HY-W010255S

Phenylglyoxylic acid-d5 Benzoylformic acid-d₅	Isotope-Labeled Compounds	Metabolic Disease
Phenylglyoxylic acid-d₅ (Benzoylformic acid-d₅) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

HY-W010255A

Phenylglyoxylic acid sodium Benzoylformic acid sodium	Others	Others
Phenylglyoxylic acid (sodium) is the sodium salt form of Phenylglyoxylic acid. Phenylglyoxylic acid as a biomarker of exposure to ethylbenzene and styrene (EB/S) .

HY-148230

TFEB Decoy ODN sodium	Others	Others
TFEB Decoy ODN (sodium) is a synthetic oligonucleotide with a hairpin ring structure, which were designed to inhibit Transcription factor EB (TFEB).

HY-107801

Inosine pranobex 1 Publications Verification Imunovir; Delimmun; Groprinosin	Interleukin Related HSV HIV HPV	Infection Inflammation/Immunology
Inosine pranobex is an orally active immunomodulator. Inosine pranobex has broad-spectrum antiviral activity. Inosine pranobex inhibits human immunodeficiency virus (HIV), herpes simplex virus (HSV), vaccinia virus (VACV), human tumor virus (HPV), Cytomegalovirus, influenza virus (INFV), parainfluenza virus (PIV), and Epstein-Barr virus .

Cat. No.	Product Name	Type

HY-E70060

beta-1,4-Galactosyltransferase (LgtE) EB4GALT1 (LgtE)	Biochemical Assay Reagents
beta-1,4-Galactosyltransferase (LgtE) (EB4GALT1 (LgtE)) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine .

Cat. No.	Product Name	Target	Research Area

HY-P4118

EB1 peptide Penetrating analog	Peptides	Others
EB1 peptide (Penetrating analog), a Penetratin peptide derivative, is an amphipathic cell-penetrating peptide (CPP). EB1 peptide has the potential for intracellular drug delivery research .

Cat. No.	Product Name

HY-K1007

Red Nucleic Acid Gel Stain (10,000×) 1 Publications Verification
Red Nucleic Acid Gel Stain (10,000×) is a nucleic acid stain that can be used as a safer alternative to the traditional ethidium bromide (EB) stain for detecting nucleic acids in agarose gels or polyacrylamide gels.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0866

20-Deoxyingenol 1 Publications Verification	Classification of Application Fields Terpenoids Source classification Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	Autophagy
20-Deoxyingenol, a diterpene, is isolated from the roots of Euphorbia kansui. 20-Deoxyingenol can promote autophagy and lysosomal biogenesis by promoting the nuclear translocation of transcription factor EB (TFEB) in vitro. 20-Deoxyingenol can be used for the research of osteoarthritis (OA) .

HY-W010255

Phenylglyoxylic acid Benzoylformic acid	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

Species:	Human (2)
Tag:	His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P75275

	EB3/MAPRE3 Protein, Human (His) Microtubule-associated protein RP/EB family member 3; EBF3; EB3; RP3; MAPRE3	Human	E. coli
	The EB3/MAPRE3 protein is a plus-end tracking protein (+TIP) that dynamically regulates microtubule cytoskeletal dynamics by binding to the plus-end of microtubules. It promotes microtubule growth, stabilizes it at the centrosome, and regulates minus-end microtubule organization. EB3/MAPRE3 Protein, Human (His) is the recombinant human-derived EB3/MAPRE3 protein, expressed by E. coli , with N-His labeled tag. The total length of EB3/MAPRE3 Protein, Human (His) is 281 a.a., with molecular weight of ~34 kDa.

HY-P71823

	KIR2DS1 Protein, Human (P.pastoris, His) KIR2DS1; CD158 antigen-like family member H; MHC class I NK cell receptor EB6 ActI	Human	P. pastoris
	KIR2DS1, on NK cells, acts as a receptor for specific HLA-C alleles, like w6, without inhibiting NK cell activity. Interacting with the adapter protein TYROBP/DAP12, their collaboration enhances KIR2DS1 stability at the cell surface. This dynamic interplay highlights the intricate regulatory mechanisms associated with KIR2DS1, contributing to the modulation of NK cell responses. KIR2DS1 Protein, Human (P.pastoris, His) is the recombinant human-derived KIR2DS1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of KIR2DS1 Protein, Human (P.pastoris, His) is 224 a.a., with molecular weight of ~34 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-W010255S

Phenylglyoxylic acid-d5
Phenylglyoxylic acid-d₅ (Benzoylformic acid-d₅) is a deuterium labeled Phenylglyoxylic acid (HY-W010255). Phenylglyoxylic acid (Benzoylformic acid) is a metabolite of ethylbenzene and styrene (EB/S) and can be used as a biomarker of exposure to EB/S in human .

Cat. No.	Product Name	Application	Reactivity

HY-P82030

EB3 Antibody (YA1775)

EB3; EBF3; MAPRE3; RP/EB Family; RP3
WB, IHC-P, ICC/IF, FC Human, Mouse, Rat
HY-P83521

Transcription Factor EB Antibody (YA3266)

TFEB; BHLHE35; Transcription factor EB; Class E basic helix-loop-helix protein 35; bHLHe35
WB, IHC-F, IHC-P, ICC/IF, IP Human

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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EB

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

EB

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

MCE Kits

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Natural
Products