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Results for "

NADPH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	NADPH Oxidase (21) Adrenergic Receptor (1) Akt (2) Aldehyde Dehydrogenase (ALDH) (1) Antibiotic (2) Apoptosis (4) Autophagy (1) Bacterial (4) Biochemical Assay Reagents (1) COX (1) Cytochrome P450 (1) DNA Alkylator/Crosslinker (1) Drug Metabolite (1) Endogenous Metabolite (11) Fatty Acid Synthase (FASN) (2) Ferroptosis (4) Fluorescent Dye (1) Formyl Peptide Receptor (FPR) (5) Influenza Virus (1) Integrin (1) Isocitrate Dehydrogenase (IDH) (1) Isotope-Labeled Compounds (1) NO Synthase (5) PARP (1) PDI (1) Phospholipase (1) PI3K (2) PKC (1) Ras (1) Reactive Oxygen Species (11) Toll-like Receptor (TLR) (2) TRP Channel (1)
By Research Areas:	Cancer (15) Cardiovascular Disease (9) Endocrinology (1) Infection (4) Inflammation/Immunology (27) Metabolic Disease (14) Neurological Disease (8)

By Targets:

NADPH Oxidase (21)

Adrenergic Receptor (1)

Akt (2)

Aldehyde Dehydrogenase (ALDH) (1)

Antibiotic (2)

Apoptosis (4)

Autophagy (1)

Bacterial (4)

Biochemical Assay Reagents (1)

COX (1)

Cytochrome P450 (1)

DNA Alkylator/Crosslinker (1)

Drug Metabolite (1)

Endogenous Metabolite (11)

Fatty Acid Synthase (FASN) (2)

Ferroptosis (4)

Fluorescent Dye (1)

Formyl Peptide Receptor (FPR) (5)

Influenza Virus (1)

Integrin (1)

Isocitrate Dehydrogenase (IDH) (1)

Isotope-Labeled Compounds (1)

NO Synthase (5)

PARP (1)

PDI (1)

Phospholipase (1)

PI3K (2)

PKC (1)

Ras (1)

Reactive Oxygen Species (11)

Toll-like Receptor (TLR) (2)

TRP Channel (1)

By Research Areas:

Cancer (15)

Cardiovascular Disease (9)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (27)

Metabolic Disease (14)

Neurological Disease (8)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: NADPH Oxidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-F0003

NADPH tetrasodium salt 5+ Cited Publications	Ferroptosis Endogenous Metabolite	Cancer
NADPH tetrasodium salt functions as an important cofactor in a variety of metabolic and biosynthetic pathways. NADPH tetrasodium salt plays a vital role in the biosynthesis of agents, chiral alcohols, fatty acids and biopolymers, while also being required for lipid biosynthesis, biomass formation, and cell replication. The demand for NADPH tetrasodium salt is particularly high in proliferating cancer cells, where it acts as a cofactor for the synthesis of nucleotides, proteins, and fatty acids. NADPH tetrasodium salt is also essential for the neutralization of the dangerously high levels of reactive oxygen species (ROS) generated by increased metabolic activity. NADPH tetrasodium salt is an endogenous inhibitor of ferroptosis .

HY-F0003A

NADPH tetracyclohexanamine

5+ Cited Publications

Ferroptosis Endogenous Metabolite Others

NADPH tetracyclohexanamine is a ubiquitous cofactor and biological reducing agent.

NADPH tetracyclohexanamine 5+ Cited Publications	Ferroptosis Endogenous Metabolite	Others
NADPH tetracyclohexanamine is a ubiquitous cofactor and biological reducing agent.

HY-152026

NADPH oxidase-IN-1	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-113325

*NADP* 4 Publications Verification	Endogenous Metabolite	Others
NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .

HY-E70002

Deamino-NADPH

Biochemical Assay Reagents Others

Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .

Deamino-NADPH	Biochemical Assay Reagents	Others
Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .

HY-P2906

Cytochrome P450 reductase	Cytochrome P450	Others
Cytochrome P450 reductase is a NADPH-cytochrome reductase. Cytochrome P450 reductase has a role in promoting aromatase conformation optimal for substrate binding .

HY-F0002

NADP sodium salt 4 Publications Verification Sodium NADP	Endogenous Metabolite	Others
NADP sodium salt is the sodium salt form of NADP (HY-113325). NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .

HY-F0002A

NADP disodium salt 4 Publications Verification Disodium NADP	Endogenous Metabolite	Others
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism	Endogenous Metabolite	Metabolic Disease Cancer
Glucose-6-phosphate dehydrogenase, Microorganism is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer .

HY-W015422

1,5-Isoquinolinediol	PARP	Metabolic Disease
1,5-Isoquinolinediol is a potent PARP inhibitor, with an IC₅₀ of 0.18-0.37 µM. 1,5-Isoquinolinediol attenuates diabetes-induced NADPH oxidase-derived oxidative stress in retina .

HY-121097

Diapocynin Dehydrodiacetovanillone	NADPH Oxidase	Neurological Disease Inflammation/Immunology
Diapocynin (Dehydrodiacetovanillone), a dimeric derivative of Apocynin, is an orally active NADPH oxidase inhibitor. Diapocynin has anti-inflammatory, neuroprotection and antioxidant activities .

HY-113325A

NADP sodium hydrate 4 Publications Verification	Endogenous Metabolite	Others
NADP sodium hydrate, a β-Nicotinamide adenine dinucleotide phosphate sodium salt, is a redox cofactor. NADP sodium hydrate is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH) .

HY-126213

1-Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium 18:1 Lyso-PS	Others	Inflammation/Immunology
Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium (18:1 Lyso-PS) is a modified PS product generated following activation of the NADPH oxidase and lyso-PS signaling. Oleoyl-2-hydroxy-sn-glycero-3-phospho-L-serine sodium through the macrophage G2A functions to enhance existing receptor/ligand systems for resolution of neutrophilic inflammation .

HY-101499

GKT136901 1 Publications Verification	NADPH Oxidase	Neurological Disease Metabolic Disease Inflammation/Immunology
GKT136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 is also a selective and direct scavenger of peroxynitrite. GKT136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 also has anti-inflammatory activity .

HY-101499A

GKT136901 hydrochloride 1 Publications Verification	NADPH Oxidase	Neurological Disease Metabolic Disease
GKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with K_is of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity .

HY-W107464

G6PDi-1	PDI	Metabolic Disease Inflammation/Immunology
G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀ of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytokine production in T cells .

HY-12804

VAS2870

10+ Cited Publications

NADPH Oxidase Cardiovascular Disease

VAS2870 is a NADPH oxidase (NOX) inhibitor.

VAS2870 10+ Cited Publications	NADPH Oxidase	Cardiovascular Disease
VAS2870 is a NADPH oxidase (NOX) inhibitor.

HY-12325

GSK2194069 2 Publications Verification	Fatty Acid Synthase (FASN)	Cancer
GSK2194069 is a potent inhibitor of β-ketoyl reductase (KR) of fatty acid synthase (FASN), with an IC₅₀ value of 7.7 nM. GSK2194069 shows specifically inhibitory effect on FAS expressing cancer cells, by acting potent efficacy on acetoacetyl-CoA, NADPH with IC₅₀ or K_i values of 4.8 nM and 5.6 nM, respectively .

HY-18950

GSK2795039 Maximum Cited Publications 49 Publications Verification	NADPH Oxidase Reactive Oxygen Species Apoptosis	Cancer
GSK2795039 is a NADPH oxidase 2 (NOX2) inhibitor with a mean pIC₅₀ of 6 in different cell-free assays. GSK2795039 inhibits reactive oxygen species (ROS) production and NADPH consumption . GSK2795039 reduces apoptosis .

HY-P5381

gp91 ds-tat

NADPH Oxidase Others

gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)

gp91 ds-tat	NADPH Oxidase	Others
gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)

HY-14572

PR-104A SN 27858	DNA Alkylator/Crosslinker Drug Metabolite	Cancer
PR-104A (SN 27858) is the alcohol metabolite of phosphate proagent PR-104. PR-104A is a hypoxia-selective DNA cross-linking agent/DNA-damaging agent and cytotoxin. Antitumor Activity . PR-104A is metabolized under hypoxia by the 1-electron NADPH:cytochrome P450 oxidoreductase. PR-104A can be used for the research of relapsed/refractory T-lineage acute lymphoblastic leukemia (T-ALL) .

HY-12298

Setanaxib 20+ Cited Publications GKT137831; GKT831	NADPH Oxidase Ferroptosis	Cardiovascular Disease
Setanaxib (GKT137831) is a selective NADPH oxidase (NOX1/4) inhibitor with K_is of 140 and 110 nM, respectively.

HY-B0203B

(Rac)-Nebivolol (Rac)-R 065824	Adrenergic Receptor NADPH Oxidase	Cardiovascular Disease
(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC₅₀ value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity .

HY-P3186

Glucose dehydrogenase, recombinant Microorganisms	Endogenous Metabolite	Metabolic Disease
Glucose dehydrogenase, recombinant Microorganisms is a oxidoreductase. Glucose dehydrogenase (GDH) catalyzes the oxidation of β-D-glucose to β-D-glucono-1,5-lactone with simultaneous reduction of the cofactor NADP ⁺ to NADPH or, to a lesser extent, NAD ⁺ to NADH. Glucose dehydrogenase (GDH) accepts both NAD ⁺ and NADP ⁺ as cofactors and can be used for the regeneration of NADH and NADPH .

HY-100965

Diphenyleneiodonium chloride 30+ Cited Publications DPI	TRP Channel NADPH Oxidase Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Diphenyleneiodonium chloride is a NADPH oxidase (NOX) inhibitor and also functions as a TRPA1 activator with an EC₅₀ of 1 to 3 μM. Diphenyleneiodonium chloride selectively inhibits intracellular reactive oxygen species.

HY-N0088S

Apocynin-d3 Acetovanillone-d₃	Apoptosis Autophagy	Cancer
Apocynin-d₃ is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

HY-D0937

Methoxy-PMS 2 Publications Verification 1-Methoxy PMS; 1-Methoxyphenazine methosulfate	Reactive Oxygen Species	Others
Methoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is stable electron-transport mediator between NAD(P)H and tetrazolium dyes .

HY-100111

GLX351322 25+ Cited Publications	NADPH Oxidase	Metabolic Disease
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC₅₀ of 5 μM.

HY-108537

L 012 sodium salt	Reactive Oxygen Species	Inflammation/Immunology
L 012 sodium salt a luminol-based chemiluminescent (CL) probe, is widely used in vitro and in vivo to detect NADPH oxidase (Nox)-derived superoxide (O2 ^•−) and identify Nox inhibitors .

HY-116482

Desmedipham	Others	Others
Desmedipham is a selective systemic phenyl-carbamate herbicide. Desmedipham acts by disrupting CO₂ fixation and the production of intermediary energy components-ATP and NADPH₂ and inhibition of Hill reaction .

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-157445

CBR1-IN-3

Others Metabolic Disease

CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM .

CBR1-IN-3	Others	Metabolic Disease
CBR1-IN-3 (compound 13h) is a potent inhibitor of carbonyl reductase 1 (CBR1), with IC₅₀ value of 0.034 μM .

HY-128799

CL097	Toll-like Receptor (TLR) Reactive Oxygen Species	Inflammation/Immunology
CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages . CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production .

HY-128799A

CL097 hydrochloride	Toll-like Receptor (TLR) Reactive Oxygen Species	Inflammation/Immunology
CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages . CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production .

HY-160524

NOX2-IN-3

NADPH Oxidase Cancer

NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813) .

NOX2-IN-3	NADPH Oxidase	Cancer
NOX2-IN-3 (compound 3) is an inhibitor of NOX2 (NADPH Oxidase 2). NOX2-IN-3 sensitizes tumor cells to MRTX1133 (HY-134813) .

HY-N0699

Daphnoretin 1 Publications Verification Dephnoretin; Thymelol	PKC Influenza Virus	Infection
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity . Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst .

HY-111447

VAS 3947	NADPH Oxidase Apoptosis	Cardiovascular Disease Cancer
VAS 3947, a specific NADPH oxidase (NOX) inhibitor, exerts a potent antiplatelet effect. VAS3947 induces apoptosis independently of anti-NOX activity, via UPR activation, mainly due to aggregation and misfolding of proteins .

HY-P1120

WKYMVM	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-P1120A

WKYMVM TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-E70014

Glucose dehydrogenase, pseudomonas sp FAD-GDH; Glucose 1-dehydrogenase	Endogenous Metabolite	Others
Glucose 1-dehydrogenase (EC 1.1.5.9), or glucose dehydrogenase (FAD)/Pseudomonas glucose dehydrogenase. Glucose 1-dehydrogenase is an enzyme used as a regeneration cofactor to convert glucose and NAD(P) into NAD(P)H and gluconic acid .

HY-12803

Fulvene-5	NADPH Oxidase Reactive Oxygen Species	Cancer
Fulvene-5 is a potent NADPH oxidase 4 (NOX4) inhibitor with antioxidant properties. Fulvene-5 is a reactive oxygen species (ROS) modifying agent and a potent radioprotector. Fulvene-5 has antitumor activity .

HY-P2947

ALDH Aldehyde dehydrogenase (NAD(P))	Aldehyde Dehydrogenase (ALDH)	Others
ALDH (Aldehyde dehydrogenase (NAD(P))) catalyzes the oxidation of aldehydes into their corresponding carboxylic acids with the concomitant reduction of the cofactor NAD(P) into NAD(P)H, is often used in biochemical studies. The ALDHs are one of many enzyme systems the body utilizes to alleviate aldehyde stress .

HY-P2993

Isocitrate dehydrogenase, Porcine heart ICDH; IDH	Isocitrate Dehydrogenase (IDH)	Metabolic Disease
Isocitrate dehydrogenase, Porcine heart (ICDH) is a citric acid or tricarboxylic acid cycle enzyme, is often used in biochemical studies. Isocitrate dehydrogenase catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate and reduces NAD(P) ⁺ to NAD(P)H, it plays important roles in cellular metabolism .

HY-P1121A

WKYMVM-NH2 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-W004520

Phenazine methylsulfate 1 Publications Verification 5-Methylphenazinium methylsulfate	Bacterial Antibiotic Apoptosis	Others
Phenazine methylsulfate is a free radical generator. Phenazine methylsulfate has been used as an electron transfer reactant in cell viability assays. Phenazine methylsulfate induces ssDNA break formation in the presence of the reducing agent NADPH. Phenazine methylsulfate induces oxidative DNA damage in an alkaline comet assay and apoptosis.

HY-100986

L-NIO dihydrochloride 1 Publications Verification	NO Synthase	Cardiovascular Disease
L-NIO dihydrochloride is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO dihydrochloride induces a consistentfocal ischemic infarctin rats .

HY-119576

Phox-I2	NADPH Oxidase Reactive Oxygen Species	Inflammation/Immunology
Phox-I2 is a selective inhibitor of p67 ^phox-Rac1 interaction, binds to p67 ^phox with high affinity with a K_d of ~150 nM. Phox-I2 is a NADPH oxidase 2 (NOX2) inhibitor and inhibits reactive oxygen species (ROS) production .

HY-100986B

L-NIO	NO Synthase	Cardiovascular Disease
L-NIO is a potent, non-selective and NADPH-dependent nitric oxide synthase (NOS) inhibitor, with K_is of 1.7, 3.9, 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS), respectively . L-NIO induces a consistentfocal ischemic infarctin rats .

HY-12805

ML171 10+ Cited Publications 2-Acetylphenothiazine; 2-APT	NADPH Oxidase	Cardiovascular Disease
ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC₅₀ of 0.25 μM in HEK293-Nox1 confirmatory assay.

Cat. No.	Product Name	Target	Research Area

HY-P1118

Ac9-25	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P2996

NAD(P)H-Nitrate reductase	Peptides	Others
NAD(P)H-Nitrate reductase is isolated from Aspergillus niger that catalyses the reduction of nitrate to nitrite via a two-electron transfer. In plants, the electron donor for Nitrate reductase is NADPH is NADH:Nitrate reductase and a bispecific NAD(P)H: Nitrate reductase .

HY-P2906

Cytochrome P450 reductase	Cytochrome P450	Others
Cytochrome P450 reductase is a NADPH-cytochrome reductase. Cytochrome P450 reductase has a role in promoting aromatase conformation optimal for substrate binding .

HY-P5381

gp91 ds-tat

NADPH Oxidase Others

gp91 ds-tat is a biological active peptide. (NADPH oxidase assembly peptide inhibitor)
HY-P1908

sgp91 ds-tat Peptide 2, scrambled

Peptides Cardiovascular Disease Cancer

sgp91 ds-tat Peptide 2, scrambled is a scrambled sequence of NADPH oxidase inhibitor gp91 ds-tat peptide .

HY-P1118A

Ac9-25 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
Ac9-25 TFA, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR .

HY-P1120

WKYMVM	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-P1120A

WKYMVM TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM (TFA) is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-P1121A

WKYMVM-NH2 TFA	Formyl Peptide Receptor (FPR)	Inflammation/Immunology
WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase .

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease
NoxA1ds is a highly efficacious and selective Nox1 (NADPH oxidase isoform 1) inhibitor. NoxA1ds establishes a critical interaction site for Nox1-NOXA1 binding required for enzyme activation. NoxA1ds can be used for the research of hypertension, atherosclerosis and neoplasia .

HY-P1116

PBP10	Bacterial	Infection Inflammation/Immunology
PBP10 is a cell permeable and selective gelsolin-derived peptide inhibitor of formyl peptide receptor 2 (FPR2) over FPR1 . PBP10 is a 10-AA peptide with rhodamine conjugated at its N terminus, exerts bactericidal activity against gram-positive and gram-negative bacteria and limits microbial-induced inflammatory effects .

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cancer
NoxA1ds TFA is a potent and selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA exhibits selectivity for NOX1 over NOX2, NOX4, NOX5 and xanthine oxidase. NoxA1ds TFA inhibits NOX1-derived O2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113325

*NADP* 4 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .

HY-F0002A

NADP disodium salt 4 Publications Verification Disodium NADP	Structural Classification other families Microorganisms Classification of Application Fields Animals Ketones, Aldehydes, Acids Source classification Other Diseases Plants Disease Research Fields	Endogenous Metabolite
NADP disodium salt is the disodium salt form of NADP (HY-113325). NADP, a nicotinamide adenine dinucleotide, is a redox cofactor. NADP is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH). NADPH is the universal electron donor in cellular reductive biosyntheses and detoxification processes, and also plays a key role in oxidative defense system .

HY-125863

Glucose-6-phosphate dehydrogenase, Microorganism	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite
Glucose-6-phosphate dehydrogenase, Microorganism is the rate-limiting enzyme of the pentose phosphate pathway. Glucose-6-phosphate dehydrogenase is a major source of NADPH that is required by many essential cellular systems including the antioxidant pathways, nitric oxide synthase, NADPH oxidase, cytochrome p450 system, and others. Glucose-6-phosphate dehydrogenase can be used for the research of diabetes, aldosterone-induced endothelial dysfunction, and cancer .

HY-113325A

NADP sodium hydrate 4 Publications Verification	Structural Classification Natural Products Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	Endogenous Metabolite
NADP sodium hydrate, a β-Nicotinamide adenine dinucleotide phosphate sodium salt, is a redox cofactor. NADP sodium hydrate is a key cofactor for electron transfer in the metabolism, being alternately oxidized (NADP ⁺) and reduced (NADPH) .

HY-N0699

Daphnoretin 1 Publications Verification Dephnoretin; Thymelol	Infection Monophenols Classification of Application Fields Thymelaeaceae Source classification Coumarins Phenols Phenylpropanoids Plants Disease Research Fields Wikstroemia indica	PKC Influenza Virus
Daphnoretin (Dephnoretin), isolated from Wikstroemia indica, possesses antiviral activity . Daphnoretin likes PMA, may direct activation of protein kinase C which in turn activated NADPH oxidase and elicited respiratory burst .

HY-N0088

Apocynin Maximum Cited Publications 15 Publications Verification Acetovanillone	Structural Classification Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Orchidaceae Source classification Phenols Anoectochilus roxburghii (Wall.) Lindl. Plants Disease Research Fields Cancer	NADPH Oxidase
Apocynin is a selective *NADPH-oxidase* inhibitor with an IC₅₀ of 10 μM . Apocynin improves acute lung inflammation in Carrageenan (HY-125474)-induced pleurisy mice model . Apocynin can also be used for cancer research . Apocynin reverses the aging process in mesenchymal stem cells to promote osteogenesis and increases bone mass .

HY-N9480

Vinaxanthone SM-345431	Structural Classification Microorganisms Xanthones Classification of Application Fields Source classification Phenols Disease Research Fields Cancer	Phospholipase Bacterial
Vinaxanthone (SM-345431) is a potent and selective semaphorin3A, phospholipase C (PLC) and FabI inhibitor, with IC₅₀s of 0.1-0.2 μM and 0.9 mM for semaphorin3A and FabI. Vinaxanthone inhibits the substrate (t-o-NAC thioester) and the cofactor (NADPH) with K_is of 3.1 μM and 1.0 μM, respectively. Vinaxanthone can be used to handle infections caused by multidrug-resistant pathogens .

HY-N1356A

(R)-Reticuline	Structural Classification Alkaloids Source classification Plants Lauraceae Isoquinoline Alkaloids Lindera aggregata (Sims) Kosterm.	Others
(R)-Reticuline is an isomer of Reticuline (HY-N1356). Reticuline displays anti-inflammatory and cardiovascular effects through JAK2/STAT3 and NF-κB signaling pathways. Salutaridine is a key intermediate in morphine biosynthesis. Salutaridine can be converted from (R)-Reticuline in the poppy plant. The conversion system relies on membrane-bound cytochrome P-450 enzymes and also requires reducing cofactors NADPH, molecular oxygen, etc .

HY-125365

Rifamycin S 1 Publications Verification	Infection Quinones Structural Classification Monophenols Microorganisms Classification of Application Fields Source classification Phenols Naphthalene Quinones Disease Research Fields	Bacterial Reactive Oxygen Species Antibiotic
Rifamycin S, a quinone, is an antibiotic against Gram-positive bacteria (including MRSA). Rifamycin S is the oxidized forms of a reversible oxidation-reduction system involving two electrons. Rifamycin S generates reactive oxygen species (ROS) and inhibits microsomal lipid peroxidation. Rifamycin S can be used for tuberculosis and leprosy .

Species:	Human (7) Mouse (1)
Tag:	His (10) Tag Free (2)
Source:	E. coli Cell-free (2) P. pastoris (2) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P75605

	CBR3 Protein, Human (His) Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3; CBR3	Human	E. coli
	The CBR3 protein uses NADPH to convert carbonyl compounds into alcohols. CBR3 Protein, Human (His) is the recombinant human-derived CBR3 protein, expressed by E. coli , with N-His labeled tag. The total length of CBR3 Protein, Human (His) is 277 a.a., with molecular weight of ~37 kDa.

HY-P701871

	GRE3 Protein, Saccharomyces cerevisiae GRE3; NADPH-dependent aldose reductase GRE3; AR; Genes de respuesta a estres protein 3; NADPH-dependent aldo-keto reductase GRE3; Xylose reductase	Others	E. coli
	The GRE3 protein is an aldose reductase that reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde, especially under stress conditions. MG is synthesized from dihydroxyacetone phosphate and is involved in cell cycle regulation and stress adaptation. GRE3 Protein, Saccharomyces cerevisiae is the recombinant GRE3 protein, expressed by E. coli , with tag free. The total length of GRE3 Protein, Saccharomyces cerevisiae is 327 a.a., .

HY-P702387

	NOX1 Protein, Human (Cell-Free, His) NADPH oxidase 1; Mitogenic oxidase 1; MOX-1; NADH/NADPH mitogenic oxidase subunit P65-MOX; NOH-1	Human	E. coli Cell-free
	The NOX1 protein contains two isoforms with different functions. NOH-1S acts as a voltage-gated proton channel, manages H(+) currents in quiescent phagocytes and tissues, affects cellular pH, and is inhibited by zinc. NOX1 Protein, Human (Cell-Free, His) is the recombinant human-derived NOX1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NOX1 Protein, Human (Cell-Free, His) is 564 a.a., with molecular weight of 67.7 kDa.

HY-P701872

	GRE3 Protein, Saccharomyces cerevisiae (His) GRE3; NADPH-dependent aldose reductase GRE3; AR; Genes de respuesta a estres protein 3; NADPH-dependent aldo-keto reductase GRE3; Xylose reductase	Others	E. coli
	The GRE3 protein is an aldose reductase that reduces the cytotoxic compound methylglyoxal (MG) to acetol and (R)-lactaldehyde, especially under stress conditions. MG is synthesized from dihydroxyacetone phosphate and is involved in cell cycle regulation and stress adaptation. GRE3 Protein, Saccharomyces cerevisiae (His) is the recombinant GRE3 protein, expressed by E. coli , with N-6*His labeled tag. The total length of GRE3 Protein, Saccharomyces cerevisiae (His) is 327 a.a., .

HY-P702388

	NOX4 Protein, Pongo abelii (Cell-Free, His) NADPH oxidase 4	Others	E. coli Cell-free
	NOX4 protein generates intracellular superoxide by forming a complex with CYBA/p22phox. NOX4 Protein, Pongo abelii (Cell-Free, His) is the recombinant NOX4 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of NOX4 Protein, Pongo abelii (Cell-Free, His) is 578 a.a., with molecular weight of 69.7 kDa.

HY-P74405A

	Azoreductase/NQO1 Protein, Human NQO1; DIA4; NAD(P)H dehydrogenase [quinone] 1; Azoreductase; DTD; QR1	Human	E. coli
	Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone. It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components. Azoreductase/NQO1 Protein, Human is the recombinant human-derived Azoreductase/NQO1 protein, expressed by E. coli , with tag free. The total length of Azoreductase/NQO1 Protein, Human is 274 a.a., with molecular weight of ~33 kDa.

HY-P74405

	Azoreductase/NQO1 Protein, Human (His) NQO1; DIA4; NAD(P)H dehydrogenase [quinone] 1; Azoreductase; DTD; QR1	Human	E. coli
	Azo reductase/NQO1 protein is a flavin-containing quinone reductase that uses NADH or NADPH to catalyze the two-electron reduction of quinone to hydroquinone. It regulates cellular redox status by detoxifying quinones and reducing plasma membrane redox components. Azoreductase/NQO1 Protein, Human (His) is the recombinant human-derived Azoreductase/NQO1 protein, expressed by E. coli , with N-His labeled tag. The total length of Azoreductase/NQO1 Protein, Human (His) is 274 a.a., with molecular weight of ~33 kDa.

HY-P700629

	CYP102A1 Protein, Priestia megaterium (P. pastoris, His) Bifunctional cytochrome P450; NADPH--P450 reductase; Cytochrome P450BM-3; Fatty acid monooxygenase; Flavocytochrome P450 BM3	Others	P. pastoris
	The CYP102A1 protein acts as a fatty acid monooxygenase, catalyzing the hydroxylation of fatty acids at various positions. The protein also exhibits NADPH-dependent reductase activity, promoting electron transfer within its domain. CYP102A1 Protein, Priestia megaterium (P. pastoris, His) is the recombinant CYP102A1 protein, expressed by P. pastoris , with C-6*His labeled tag. The total length of CYP102A1 Protein, Priestia megaterium (P. pastoris, His) is 471 a.a., with molecular weight of 55.2 kDa.

HY-P71831

	Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) Nqo1; Dia4; Nmo1; Nmor1; NAD(P)H dehydrogenase [quinone] 1; EC 1.6.5.2; Azoreductase; DT-diaphorase; DTD; Phylloquinone reductase; Quinone reductase 1; QR1	Mouse	P. pastoris
	The azoreductase/NQO1 protein reduces quinones to hydroquinone using NADH or NADPH as an electron donor. Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived Azoreductase/NQO1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Azoreductase/NQO1 Protein, Mouse (P.pastoris, His) is 273 a.a., with molecular weight of ~33 kDa.

HY-P76172

	BLVRB Protein, Human (His) Flavin reductase (NADPH); Biliverdin reductase B; FR; BVR-B; GHBP; FLR	Human	E. coli
	BLVRB Protein, a broad-specificity oxidoreductase, catalyzes NADPH-dependent reduction of various substrates, including flavins, biliverdins, methemoglobin, and PQQ. Crucial in heme catabolism, it metabolizes linear tetrapyrroles and reduces complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, BLVRB Protein plays a vital role in converting biliverdin to bilirubin, contributing to metabolic processes and maintaining redox balance. BLVRB Protein, Human (His) is the recombinant human-derived BLVRB protein, expressed by E. coli, with N-His labeled tag. The total length of BLVRB Protein, Human (His) is 205 a.a., with molecular weight of ~25 KDa.

HY-P72228

	HMGCR Protein, Human (His) 3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase NADPH; ; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hmgcr; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269; Red	Human	E. coli
	As a key enzyme in cholesterol biosynthesis, HMGCR protein plays a central role in regulating cellular cholesterol levels. It catalyzes the conversion of HMG-CoA to mevalonate, a key step in the synthesis of cholesterol and other isoprenoids. HMGCR Protein, Human (His) is the recombinant human-derived HMGCR protein, expressed by E. coli , with N-6*His labeled tag. The total length of HMGCR Protein, Human (His) is 300 a.a., with molecular weight of ~38 kDa.

HY-P70290

	Neutrophil cytosol factor 1 Protein, Human (His) rHuNeutrophil cytosol factor 1/NCF1, His; NCF-1; 47 kDa autosomal chronic granulomatous disease protein/47 kDa neutrophil oxidase factor; NCF-47K; Neutrophil NADPH oxidase factor 1; Nox organizer 2; Nox-organizing protein 2/SH3 and PX domain-containing protein 1A; p47-phox	Human	E. coli
	Neutrophil cytoplasmic factor 1 (NCF1) is essential for activation of the NADPH oxidase complex, which is essential for superoxide production. It cooperates with NCF2 to form a core association in the complex, interacting with NCF4, CYBB and CYBA. Neutrophil cytosol factor 1 Protein, Human (His) is the recombinant human-derived Neutrophil cytosol factor 1 protein, expressed by E. coli , with C-6*His labeled tag. The total length of Neutrophil cytosol factor 1 Protein, Human (His) is 390 a.a., with molecular weight of 45-50 kDa.

Cat. No.	Product Name	Chemical Structure

HY-107855S

DL-Mevalonolactone-d7
DL-Mevalonolactone-d₇ is the deuterium labeled DL-Mevalonolactone. DL-Mevalonolactone ((±)-Mevalonolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (∆Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

HY-N0088S

Apocynin-d3

Apocynin-d₃ is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

HY-107855S1

DL-Mevalonolactone-d3

DL-Mevalonolactone-d3 is the deuterium labeled DL-Mevalonolactone[1]. DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential ( Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[2][3].

HY-121246S

Fluorofenidone-d3
Fluorofenidone-d₃ is deuterium labeled Fluorofenidone. Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].

Cat. No.	Product Name	Application	Reactivity

HY-P80762

NADPH Oxidase 4 Antibody NADPH oxidase 4; Kidney oxidase-1; KOX-1; KOX1; Kidney superoxide-producing NADPH oxidase; Renal NAD(P)H-oxidase; NOX4; RENOX	WB, IHC-P, ICC/IF, IP	Human, Mouse, Rat
NADPH Oxidase 4 Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 67 kDa, targeting to NADPH Oxidase 4. It can be used for WB,IHC-P,ICC/IF,IP assays with tag free, in the background of Human, Mouse, Rat.

HY-P82650

CBR3 Antibody (YA2395)

CBR3; Carbonyl reductase [NADPH] 3; NADPH-dependent carbonyl reductase 3
WB Human

HY-P80590

CBR1 Antibody (YA810) 15 hydroxyprostaglandin dehydrogenase [NADP ]; 15-hydroxyprostaglandin dehydrogenase [NADP ]; Carbonyl reductase [NADPH] 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1; Prostaglandin 9 ketoreduc	WB, ICC/IF	Human
CBR1 Antibody (YA810) is a non-conjugated and Mouse origined monoclonal antibody about 30 kDa, targeting to CBR1 (2C9). It can be used for WB,ICC/IF assays with tag free, in the background of Human.

HY-P81195

NOX2 Antibody AMCBX2; CGD; CGD91-phox; CY24B_HUMAN; CYBB; Cytochrome b 245, beta polypeptide; Cytochrome b(558) beta chain; Cytochrome b(558) subunit beta; Cytochrome b-245 heavy chain; Cytochrome b558 subunit beta; GP91 PHOX; gp91-1; gp91-phox; GP91PHOX; Heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; Neutrophil cytochrome b 91 kDa polypeptide; p22 phagocyte B-cytochrome; P91 PHOX; p91-PHOX; Superoxide-generating NADPH oxidase heavy chain subunit.	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse, Rat(predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit)
NOX2 Antibody is an unconjugated, approximately 65 kDa, rabbit-derived, anti-NOX2 polyclonal antibody. NOX2 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, rat, and predicted: chicken, dog, pig, cow, horse, rabbit background without labeling.

HY-P81197

HMGCR Antibody 3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; Hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269; Red.	ELISA; IHC-P; IHC-F; Flow-Cyt; IF	Human, Mouse, Rat(predicted: Dog, Pig, Cow, Rabbit)
HMGCR Antibody is an unconjugated, approximately 97 kDa, rabbit-derived, anti-HMGCR polyclonal antibody. HMGCR Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, rabbit background without labeling.

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