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NLRP3-IN-32

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-161329
    NLRP3-IN-32

    		NOD-like Receptor (NLR) Reactive Oxygen Species NF-κB IKK Inflammation/Immunology
    NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling .
    <em>NLRP3-IN-32</em>

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