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Naphthoquinone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Autophagy (1) Bacterial (5) CXCR (1) Dihydroorotate Dehydrogenase (1) DNA/RNA Synthesis (1) Endogenous Metabolite (2) Fungal (4) GnRH Receptor (2) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) Monoamine Oxidase (2) NF-κB (1) Parasite (6) Somatostatin Receptor (1) Topoisomerase (3) Urotensin Receptor (1)
By Research Areas:	Cancer (10) Cardiovascular Disease (2) Endocrinology (4) Infection (11) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (3)

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Peptides

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Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W015490

1,4-Naphthoquinone 2 Publications Verification	Monoamine Oxidase	Cancer
1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity .

HY-115243

2-Chloro-1,4-naphthoquinone	Others	Others
2-Chloro-1,4-naphthoquinone is an reactive intermediate. 2-Chloro-1,4-naphthoquinone can be used for the research of various biochemical studies .

HY-N8139

2-Amino-3-carboxy-1,4-naphthoquinone	Others	Metabolic Disease
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria .

HY-N7116

Lawsone methyl ether 2-Methoxy-1,4-Naphthoquinone	Fungal Bacterial	Infection
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities .

HY-W015490S

*1,4-Naphthoquinone-d6*	Monoamine Oxidase	Cancer
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-N3036

(rac)-Isovalerylshikonin

Others Others

(rac)-Isovalerylshikonin (compound 372) is a naphthoquinone pigment present in hexane extracts of safflower roots .
HY-121632

Quinoclamine

2 Publications Verification

NF-κB Cancer

Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity .
HY-N10200

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone

Others Others

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .

(rac)-Isovalerylshikonin	Others	Others
(rac)-Isovalerylshikonin (compound 372) is a naphthoquinone pigment present in hexane extracts of safflower roots .

Quinoclamine 2 Publications Verification	NF-κB	Cancer
Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity .

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone	Others	Others
2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .

HY-B0332

Menadione Maximum Cited Publications 14 Publications Verification Vitamin K3	Endogenous Metabolite	Others
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-108011

Naftazone	Others	Cardiovascular Disease
Naftazone is a naphthoquinone derivative, it can be used for the research of venous insufciency. Naftazone protects blood vessels, increases venous tonicity and capillary resistance, and improves lymphatic and venous circulation .

HY-N3488

Isodiospyrin	Topoisomerase Bacterial Fungal	Infection Cancer
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-U00094

INO5042

Others Inflammation/Immunology

INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .

INO5042	Others	Inflammation/Immunology
INO5042, a thiazole fused 1,4-naphthoquinone compound, and exhibits anti-inflammation activity .

HY-N6961

Lapachol 1 Publications Verification	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite	Infection Inflammation/Immunology Cancer
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-149938

Antimalarial agent 25	Parasite	Infection
Antimalarial agent 25 is an orally active 1,4-naphthoquinones derivative with antimalarial activity. Antimalarial agent 25 shows cytotoxicity against P. falciparum. Antimalarial agent 25 inhibits P. burghei induced parasitemia in vivo .

HY-149939

Antimalarial agent 26	Parasite	Infection
Antimalarial agent 26 is an orally active 1,4-naphthoquinones derivative with antimalarial activities. Antimalarial agent 26 shows cytotoxicity against P. falciparum and selectivity over mammalian cell lines. Antimalarial agent 26 inhibits P. burghei induced parasitemia in vivo .

HY-N2188

Beta-Acetoxyisovalerylshikonin

1 Publications Verification

Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma .

Beta-Acetoxyisovalerylshikonin 1 Publications Verification
Beta-Acetoxyisovalerylshikonin is a naphthoquinone derivative isolated from Arnebia euchroma .

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-Naphthoquinone	Apoptosis	Neurological Disease Cancer
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-N1497

Plumbagin 1 Publications Verification 2-Methyljuglone
Plumbagin (2-Methyljuglone) is a naphthoquinone isolated from Plumbago zeylanica, exhibits anticancer and antiproliferative activities .

HY-B0332S

Menadione-d3 Vitamin K3-d₃	Endogenous Metabolite	Others
Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-N2552

Vitamin K5 hydrochloride	Others	Infection
Vitamin K5 (hydrochloride) is a naphthoquinones compound, shows trichomonacidal activity in vitro. Vitamin K5(hydrochloride) can be used for the research of anti-infection .

HY-N2493S

Lawsone-d4	Isotope-Labeled Compounds Fungal	Infection
Lawsone-d₄ is the deuterium labeled Lawsone. Lawsone is a naphthoquinone dye isolated from leaves of Lawsonia inermis that shows antimicrobial and antioxidant activity[1].

HY-13555

β-Lapachone 5+ Cited Publications ARQ-501; NSC-26326	Topoisomerase Autophagy Apoptosis	Cancer
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-N3550

Catalponol	Others	Cancer
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N8248

Eleutherin (+)-Eleutherin	Others Topoisomerase	Cardiovascular Disease
Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong) .

HY-N2493

Lawsone 1 Publications Verification	Fungal Apoptosis	Infection
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-19738

NQTrp
NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide ( ⁴¹GCWMLY ⁴⁶ within the N-terminus of γD-crystallin) as well as full-length γD-crystallin .

HY-N5112B

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	HIF/HIF Prolyl-Hydroxylase	Cancer
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity .

HY-P0009A

Cetrorelix Acetate 1 Publications Verification SB-75 acetate	GnRH Receptor	Neurological Disease Endocrinology
Cetrorelix Acetate (SB-75 acetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM .

HY-P0009B

Cetrorelix diacetate SB-75 diacetate	GnRH Receptor	Neurological Disease Endocrinology
Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM .

HY-P0171

Motixafortide 2 Publications Verification BKT140 (4-fluorobenzoyl); BL-8040; TF14016	CXCR	Endocrinology Cancer
Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC₅₀ vakue of ～1 nM.

HY-146489

Anti-infective agent 3	Bacterial Parasite	Infection
Anti-infective agent 3 (compound 3l) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 0.47 and 0.13 μM, respectively. Anti-infective agent 3 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 4 μg/mL .

HY-146487

Anti-infective agent 1	Bacterial Parasite	Infection
Anti-infective agent 1 (compound 3a) is a potent and selective antiprotozoal and antimycobacterial agent. Anti-infective agent 1 shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 10.95 and 0.06 μM, respectively. Anti-infective agent 1 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 8 μg/mL .

HY-146488

Anti-infective agent 2	Parasite Bacterial	Infection
Anti-infective agent 2 (compound 3k) shows antiparasitic activity against P. falciparum and T. brucei rhodesiense, with IC₅₀ values of 0.07 and 2.20 μM, respectively. Anti-infective agent 2 shows antimycobacterial activity against Mycobacterium smegmatis with a MIC of 32 μg/mL .

HY-P4452

PRL 2915

Somatostatin Receptor Urotensin Receptor Endocrinology

PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst₂) antagonist with a K_i of 12 nM .

PRL 2915	Somatostatin Receptor Urotensin Receptor	Endocrinology
PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst₂) antagonist with a K_i of 12 nM .

Motixafortide 2 Publications Verification BKT140 (4-fluorobenzoyl); BL-8040; TF14016	CXCR	Endocrinology Cancer
Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC₅₀ vakue of ～1 nM.

PRL 2915	Somatostatin Receptor Urotensin Receptor	Endocrinology
PRL 2915 is a potent human somatostatin subtype 2 receptor (hsst₂) antagonist with a K_i of 12 nM .

Cetrorelix diacetate SB-75 diacetate	GnRH Receptor	Neurological Disease Endocrinology
Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC₅₀ of 1.21 nM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N8139

2-Amino-3-carboxy-1,4-naphthoquinone	Alkaloids Quinones Classification of Application Fields Source classification Rubiaceae Metabolic Disease Plants Naphthalene Quinones Disease Research Fields Rubia cordifolia L.	Others
2-Amino-3-carboxy-1,4-naphthoquinone is the electron transfer mediator. 2-Amino-3-carboxy-1,4-naphthoquinone changes glucose metabolism of the homofermentative lactic acid bacteria .

HY-N7116

Lawsone methyl ether 2-Methoxy-1,4-Naphthoquinone	Infection Quinones Classification of Application Fields Source classification Impatiens balsamina Linn. Balsaminaceae Plants Naphthalene Quinones Disease Research Fields	Fungal Bacterial
Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities .

HY-B0332

Menadione Maximum Cited Publications 14 Publications Verification Vitamin K3	Quinones Structural Classification Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Naphthalene Quinones Disease Research Fields	Endogenous Metabolite
Menadione is a naphthoquinone that is converted into active vitamin K2 in the body. Menadione is a potential anticancer agent and radiosensitizer .

HY-N3036

(rac)-Isovalerylshikonin	Quinones Structural Classification Alkanna tinctoria (L.) Tausch Source classification Plants Naphthalene Quinones Boraginaceae	Others
(rac)-Isovalerylshikonin (compound 372) is a naphthoquinone pigment present in hexane extracts of safflower roots .

HY-N10200

2,7-Dimethoxy-6-(1-acetoxyethyl)juglone	Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Source classification Other Diseases Phenols Disease Research Fields	Others
2,7-Dimethoxy-6-(1-acetoxyethyl)juglone is a naphthoquinone derivative found in the fungus Kirschsteiniothelia species .

HY-N3488

Isodiospyrin	Quinones Structural Classification other families Diospyros virginiana L. Source classification Benzene Quinones Plants	Topoisomerase Bacterial Fungal
Isodiospyrin, a natural dimeric naphthoquinone, is a human DNA topoisomerase I (Topoisomerase) inhibitor. Isodiospyrin can prevent both DNA relaxation and kinase activities of human topoisomerase I. Isodiospyrin shows anticancer, antibacterial and antifungal activities .

HY-N6961

Lapachol 1 Publications Verification	Infection Quinones Structural Classification Classification of Application Fields Tabebuia avellanedae Plants Bignoniaceae Naphthalene Quinones Inflammation/Immunology Disease Research Fields	Dihydroorotate Dehydrogenase DNA/RNA Synthesis Parasite
Lapachol, a natural naphthoquinone, is an orally active, potent DHODH inhibitor. Lapachol has immunosuppressive activity on lymphocytes through its direct ability to block DHODH activity and inhibit pyrimidine synthesis. Lapachol is a vitamin K antagonist with antitumor activity and can inhibit DNA and RNA synthesis in neoplastic cells. Lapachol has anti-Leishmania activity .

HY-N7526

Naphthazarin 1 Publications Verification DHNQ; 5,8-Dihydroxy-1,4-Naphthoquinone	Quinones Structural Classification other families Source classification Phenols Polyphenols Plants Naphthalene Quinones	Apoptosis
Naphthazarin (DHNQ) is a naturally occurring compound. Naphthazarin is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, interference with lysosomal function and p53-dependent p21 activation. Naphthazarin triggers apoptosis and has anti-tumor effects .

HY-13555

β-Lapachone 5+ Cited Publications ARQ-501; NSC-26326	Quinones Structural Classification other families Classification of Application Fields Source classification Plants Naphthalene Quinones Disease Research Fields Cancer	Topoisomerase Autophagy Apoptosis
β-Lapachone (ARQ-501;NSC-26326) is a naturally occurring O-naphthoquinone, acts as a topoisomerase I inhibitor, and induces apoptosis by inhibiting cell cycle progression.

HY-N3550

Catalponol	Other Terpenoids Catalpa ovata G. Don Classification of Application Fields Terpenoids Source classification Plants Bignoniaceae Disease Research Fields Cancer	Others
Catalponol is a naphthoquinone derivative. Catalponol enhances dopamine biosynthesis by inducing tyrosine hydroxylase activity. Catalponol also increases the levels of cAMP and tyrosine hydroxylase phosphorylation in PC12 cells .

HY-N8248

Eleutherin (+)-Eleutherin	Quinones Structural Classification Iridaceae Classification of Application Fields Anthraquinones Source classification Eleutherine plicata Herb. Plants Disease Research Fields Cancer	Others Topoisomerase
Eleutherin is a type of naphthoquinone derivative with the protective effect against the injury ofhuman umbilical vein endothelial cells (HUVECs), which can be isolated from the edible bulbs of Eleutherine americana (Hong-Cong) .

HY-N2493

Lawsone 1 Publications Verification	Infection Quinones Structural Classification Lythraceae Lawsonia inermis L. Classification of Application Fields Source classification Plants Naphthalene Quinones Disease Research Fields	Fungal Apoptosis
Lawsone is an orally active naphthoquinone dye that can be isolated from the leaves of Lawsonia inermis. Lawsone can induce apoptosis. Lawsone has antibacterial, antitumor and antioxidant activities. Lawsone can be used in anti-tumor drug research .

HY-N5112B

β,β-Dimethylacrylshikonin 1 Publications Verification Isoarnebin I	Quinones Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Lithospermum erythrorhizon Sieb. et Zucc. Naphthalene Quinones Disease Research Fields Boraginaceae Cancer	HIF/HIF Prolyl-Hydroxylase
β,β-Dimethylacrylshikonin (Isoarnebin I) is a naphthoquinone derivative isolated from Lithospermum erythrorhizon Sieb. et Zucc. , promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway.β,β-Dimethylacrylshikonin has anti-tumor activity .

Cat. No.	Product Name	Chemical Structure

HY-B0332S

Menadione-d3

Menadione-d₃ is the deuterium labeled Menadione. Menadione, a synthetic naphthoquinone, can be converted to active vitamin K2 in vivo.

HY-W015490S

*1,4-Naphthoquinone-d6*
1,4-Naphthoquinone-d₆ is the deuterium labeled 1,4-Naphthoquinone[1]. 1,4-Naphthoquinone is a potential pharmacophore for inhibition of both MAO (monoamine oxidase) and DNA topoisomerase activities, this latter associated with antitumor activity[2].

HY-N2493S

Lawsone-d4

Lawsone-d₄ is the deuterium labeled Lawsone. Lawsone is a naphthoquinone dye isolated from leaves of Lawsonia inermis that shows antimicrobial and antioxidant activity[1].

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Naphthoquinone

Inhibitors & Agonists

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Isotope-Labeled Compounds

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