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Results for "

Orphenadrine

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

4

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-157959
    Orphenadrine

    (±)-Orphenadrine

    		 iGluR Cytochrome P450 Cholinesterase (ChE) Neurological Disease Cancer
    Orphenadrine ((±)-Orphenadrine) is a skeletal muscle relaxant and NMDA antagonist that also has antiparkinsonian, antihistamine, antitremor, antispasmodic, and analgesic effects. Orphenadrine inhibits the binding of [3H]MK-801 to the phencyclidine (PCP) binding site of the NMDA receptor. Orphenadrine is also an anticholinergic and cytochrome P450 (CYP) 2B inducer. Orphenadrine may exert pro-tumor effects, causing CAR nuclear translocation, resulting in microsomal reactive oxygen species (ROS) production and oxidative stress. Orphenadrine also exerts neuronal protection, protecting rat cerebellar granule cells (CGC) from 3-NPA-induced death and has inhibitory potential against neurodegenerative diseases mediated by NMDA receptor overactivation .
    <em>Orphenadrine</em>
  • HY-143861S
    Orphenadrine-d3

    		Isotope-Labeled Compounds Others
    Orphenadrine-d3 is the deuterium labeled Orphenadrine[1].
    <em>Orphenadrine</em>-d3
  • HY-B1126
    Orphenadrine hydrochloride

    		iGluR Neurological Disease
    Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .
    <em>Orphenadrine</em> hydrochloride
  • HY-B1126S
    Orphenadrine-d3 hydrochloride

    		iGluR Neurological Disease
    Orphenadrine-d3 (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride[1]. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases[2][3].
    <em>Orphenadrine</em>-d3 hydrochloride
  • HY-B0369AS
    Orphenadrine-d3 citrate

    		iGluR Neurological Disease
    Orphenadrine-d3 (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.
    <em>Orphenadrine</em>-d3 citrate
  • HY-B0369A
    Orphenadrine citrate

    		iGluR Neurological Disease
    Orphenadrine citrate is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .
    <em>Orphenadrine</em> citrate
  • HY-144142S
    Orphenadrine impurity 6-d3 hydrochloride

    		Drug Metabolite Isotope-Labeled Compounds Others
    Orphenadrine impurity 6-d3 (hydrochloride) is the deuterium labeled Orphenadrine impurity 6 hydrochloride[1].
    <em>Orphenadrine</em> impurity 6-d3 hydrochloride

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