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PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects .
PAP-IN-2 (Compound 35) is a purple acid phosphatase (PAP) inhibitor (Kis: 186 nM). PAP-IN-2 can be used for development of anti-osteoporotic compounds .
PAP-IN-1 (compound 28) is an inhibitor of purple acid phosphatases(PAPs), a ubiquitous binuclear metallohydrolase. PAP-IN-1 inhibits mammalian PAP with Ki value of 168 nM. PAP-IN-1 targets to pig PAP with Kic value of 0.17 μM. PAP inhibitors can be used for research of anti-osteoporotic drugs .
PAP 248–286 is a biological active peptide. (Prostatic Acid Phosphatase (248-286), PAP (248-286) peptide is a semen-derived enhancer of viral infection (SEVI) factor found in semen. This peptide greatly increases HIV infection through enhanced virion attachment to target cells.)
Adenosine 3'-phosphate 5'-phosphosulfate triethylamine, is a universal sulfuryl donor for sulfation. Adenosine 3'-phosphate 5'-phosphosulfate triethylamine (PAPS) is synthesized in the cytosol and subsequently translocated into the Golgi lumen via a PAPS transporter (PAPST) .
5-Br-PAPS is a highly specific Zn 2+ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn 2+ by forming a deeply colored red Zn 2+ complex .
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
5-Br-PAPS is a highly specific Zn 2+ metallochromic indicator. 5-Br-PAPS is used in assays for measuring free Zn 2+ by forming a deeply colored red Zn 2+ complex .
Nitro-PAPS disodium dihydrate is a highly sensitive colometric reagent for Fe(II) detection with a maximal absorption wavelength of 592 nm. Nitro-PAPS disodium dihydrate is suitable for the determination of Fe(II) in serum and also be used to determine micro molar levels of Cu, Zn, Ni, Co and V .
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
Adenosine 3'-phosphate 5'-phosphosulfate lithium is a co-substrate used for the sulfonation of glycans. Adenosine 3'-phosphate 5'-phosphosulfate lithium can be used for Golgi-resident PAP-specific 3'-phosphatase-coupled sulfotransferase assays, which as donor substrate to transfer a sulfonate group .
PAP 248–286 is a biological active peptide. (Prostatic Acid Phosphatase (248-286), PAP (248-286) peptide is a semen-derived enhancer of viral infection (SEVI) factor found in semen. This peptide greatly increases HIV infection through enhanced virion attachment to target cells.)
Acid prostatic phosphatase (ACPP) is an enzyme that catalyzes the conversion of orthophosphate monoesters into alcohol and orthophosphate. ACPP is regulated by androgens and secreted by prostate epithelial cells. Prostatic acid phosphatase/ACPP Protein, Human (HEK293, His) is the recombinant human-derived Prostatic acid phosphatase/ACPP protein, expressed by HEK293 , with C-His labeled tag. The total length of Prostatic acid phosphatase/ACPP Protein, Human (HEK293, His) is 350 a.a., with molecular weight of 43-55 kDa.
PPAP protein, a nonspecific tyrosine phosphatase, has anticancer and antiproliferative activities. The PPAP protein dephosphorylates a variety of substrates under acidic conditions (pH 4-6), resulting in the inactivation of lysophosphatidic acid in seminal plasma. The PPAP protein is also a common biomarker for prostate cancer and can inhibit tumor development. Prostatic acid phosphatase/ACPP Protein, Human (354a.a, HEK293, His, solution) is the recombinant human-derived Prostatic acid phosphatase/ACPP protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Prostatic acid phosphatase/ACPP Protein, Human (354a.a, HEK293, His, solution) is 354 a.a., with molecular weight of ~50.0 kDa.
REG-3 beta/REG3B Protein, a bactericidal C-type lectin, combats intestinal Gram-positive and Gram-negative bacteria, except S.typhimurium. It inhibits S.enteritidis translocation, safeguarding against infection. Beyond antibacterial action, REG-3 beta functions hormonally, activating EXTL3 receptor for cell-specific signaling. In the pancreas, it notably stimulates cell proliferation. REG-3 beta/REG3B Protein, Mouse (HEK293, His) is the recombinant mouse-derived REG-3 beta/REG3B protein, expressed by HEK293, with C-His labeled tag. The total length of REG-3 beta/REG3B Protein, Mouse (HEK293, His) is 175 a.a., with molecular weight of ~19 kDa.
REG-3 alpha/REG3A Protein, a bactericidal C-type lectin, selectively targets Gram-positive bacteria by binding to peptidoglycan carbohydrate moieties. Its antimicrobial action extends to membrane phospholipid binding, forming pores that contribute to bacterial elimination. As a hormone, REG-3 alpha responds to IL17A and gut microbiome signals. Upon secretion, it activates EXTL3 receptor, initiating cell-specific pathways. In keratinocytes, REG-3 alpha regulates proliferation and differentiation through EXTL3-PI3K-AKT after skin injury, while in the pancreas, it stimulates beta-cell proliferation. REG-3 alpha/REG3A Protein, Human (HEK293, His) is the recombinant human-derived REG-3 alpha/REG3A protein, expressed by HEK293, with C-His labeled tag. The total length of REG-3 alpha/REG3A Protein, Human (HEK293, His) is 149 a.a., with molecular weight of ~18 kDa.
PAP proteins play a dual regulatory role in cell growth, exhibiting different effects depending on the specific growth factors involved. In fibroblasts, it exerts a positive regulatory effect by enhancing PDGFA-stimulated cell growth. PAP Protein, Human (His) is the recombinant human-derived PAP protein, expressed by E. coli , with N-6*His labeled tag. The total length of PAP Protein, Human (His) is 181 a.a., with molecular weight of ~30.0 kDa.
The acid prostatic phosphatase (ACPP) protein, encapsulated in virus-like particles (VLPs), is an acid tyrosine phosphatase that skillfully dephosphorylates a variety of substrates. ACPP-VLP possesses lipid phosphatase activity and inactivates lysophosphatidic acid. ACPP/Prostatic Acid Phosphatase Protein, Mouse (HEK293, His) is the recombinant mouse-derived ACPP/Prostatic Acid Phosphatase protein, expressed by HEK293 , with C-His labeled tag. The total length of ACPP/Prostatic Acid Phosphatase Protein, Mouse (HEK293, His) is 350 a.a., with molecular weight of 44-55 kDa.
Prostatic acid phosphatase (ACPP) operates as a versatile tyrosine phosphatase under acidic conditions (pH 4-6), dephosphorylating various substrates, including orthophosphate monoesters. With lipid phosphatase activity, ACPP inactivates lysophosphatidic acid in seminal plasma. In prostate cancer, it acts as a tumor suppressor by dephosphorylating ERBB2, deactivating MAPK signaling, and controlling cancer-related processes. ACPP also exhibits ecto-5'-nucleotidase activity in dorsal root ganglion neurons, suggesting a role in pain modulation by generating adenosine from AMP. Prostatic acid Phosphatase/ACPP Protein, Human (HEK293, GFP-His) is the recombinant human-derived Prostatic acid Phosphatase/ACPP protein, expressed by HEK293, with C-His, GFP labeled tag. The total length of Prostatic acid Phosphatase/ACPP Protein, Human (HEK293, GFP-His) is 350 a.a., with molecular weight of 70.6 kDa.
Prostatic acid phosphatase (ACPP) operates as a versatile tyrosine phosphatase under acidic conditions (pH 4-6), dephosphorylating various substrates, including orthophosphate monoesters. With lipid phosphatase activity, ACPP inactivates lysophosphatidic acid in seminal plasma. In prostate cancer, it acts as a tumor suppressor by dephosphorylating ERBB2, deactivating MAPK signaling, and controlling cancer-related processes. ACPP also exhibits ecto-5'-nucleotidase activity in dorsal root ganglion neurons, suggesting a role in pain modulation by generating adenosine from AMP. Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His) is the recombinant human-derived Prostatic acid Phosphatase/ACPP protein-VLP, expressed by HEK293, with N-10*His labeled tag. The total length of Prostatic acid Phosphatase/ACPP Protein-VLP, Human (386a.a, HEK293, His) is 386 a.a., with molecular weight of 47.5 kDa.
Annexin A2 (ANXA2) is a calcium-regulated membrane-binding protein with heightened calcium affinity in the presence of anionic phospholipids. Known for its potential involvement in the heat-stress response, ANXA2 operates as a heterotetramer, comprising two light chains of S100A10/p11 and two heavy chains of ANXA2/p36. It inhibits PCSK9-enhanced LDLR degradation, potentially through translational mechanisms, while also competing with LDLR for PCSK9 binding. ANXA2 interacts with various proteins, including ATP1B1, DYSF, COCH, and CEACAM1, with the latter interaction being regulated by CEACAM1 phosphorylation. Moreover, ANXA2 interacts with PCSK9, forming a complex that hinders LDLR degradation. Additionally, it associates with APPL2 and APPL1, facilitating the targeting of APPL2 to endosomes in parallel with RAB5A. The intricate network of ANXA2 interactions underscores its versatile role in cellular processes and regulatory pathways. Annexin A2/ANXA2 Protein, Mouse (His) is the recombinant mouse-derived Annexin A2/ANXA2 protein, expressed by E. coli , with N-His labeled tag. The total length of Annexin A2/ANXA2 Protein, Mouse (His) is 338 a.a., with molecular weight of ~39.6 kDa.
REG-3 α/REG3A proteins exhibit identical protein-binding, oligosaccharide-binding, and peptidoglycan-binding activities. It negatively regulates keratinocyte differentiation and positively regulates keratinocyte proliferation and wound healing, emphasizing its role in skin-related processes. REG-3 alpha/REG3A Protein, Mouse (HEK293, His) is the recombinant mouse-derived REG-3 alpha/REG3A protein, expressed by HEK293 , with C-His labeled tag. The total length of REG-3 alpha/REG3A Protein, Mouse (HEK293, His) is 149 a.a., with molecular weight of ~18 kDa.
REG-3 alpha/REG3A Protein, a bactericidal C-type lectin lacking the EPN motif, functions as a hormone responding to stimuli like IL17A and the gut microbiome. Secreted by various cell types, it activates receptor EXTL3, initiating cell-specific signaling pathways. Induced by IL17A in keratinocytes, it regulates proliferation and differentiation post-skin injury, inhibiting skin inflammation by suppressing IL6 and TNF. In the pancreas, REG-3 alpha/REG3A permeabilizes beta-cell membranes, stimulating proliferation. REG-3 alpha/REG3A Protein, Rat (HEK293, Fc) is the recombinant rat-derived REG-3 alpha/REG3A protein, expressed by HEK293, with C-hFc labeled tag. The total length of REG-3 alpha/REG3A Protein, Rat (HEK293, Fc) is 174 a.a., with molecular weight of ~44 kDa.
REG-3 alpha/REG3A Protein, a bactericidal C-type lectin lacking the EPN motif, functions as a hormone responding to stimuli like IL17A and the gut microbiome. Secreted by various cell types, it activates receptor EXTL3, initiating cell-specific signaling pathways. Induced by IL17A in keratinocytes, it regulates proliferation and differentiation post-skin injury, inhibiting skin inflammation by suppressing IL6 and TNF. In the pancreas, REG-3 alpha/REG3A permeabilizes beta-cell membranes, stimulating proliferation. REG-3 alpha/REG3A Protein, Rat (HEK293, His) is the recombinant rat-derived REG-3 alpha/REG3A protein, expressed by HEK293, with C-His labeled tag. The total length of REG-3 alpha/REG3A Protein, Rat (HEK293, His) is 149 a.a., with molecular weight of ~17 kDa.
Regenerating islet-derived protein 3-gamma; REG-3-gamma; Pancreatitis-associated protein 1B; REG3G; PAP-1B; Regenerating islet-derived protein III-gamma
REG-3 gamma/REG3G protein is a bactericidal C-type lectin that specifically targets Gram-positive bacteria by binding to the peptidoglycan surface moiety, mediating bacterial killing. It limits bacterial colonization of intestinal epithelial surfaces and limits microbiota-induced adaptive immune responses. REG-3 gamma/REG3G Protein, Human (HEK293, Fc) is the recombinant human-derived REG-3 gamma/REG3G protein, expressed by HEK293 , with C-hFc labeled tag. The total length of REG-3 gamma/REG3G Protein, Human (HEK293, Fc) is 149 a.a., with molecular weight of ~44-50.0 kDa.
Regenerating islet-derived protein 3-gamma; REG-3-gamma; Pancreatitis-associated protein 1B; REG3G; PAP-1B; Regenerating islet-derived protein III-gamma
REG-3 gamma/REG3G protein is a bactericidal C-type lectin that specifically targets Gram-positive bacteria by binding to the peptidoglycan surface moiety, mediating bacterial killing. It limits bacterial colonization of intestinal epithelial surfaces and limits microbiota-induced adaptive immune responses. REG-3 gamma/REG3G Protein, Human (149a.a, HEK293, His) is the recombinant human-derived REG-3 gamma/REG3G protein, expressed by HEK293 , with C-6*His labeled tag. The total length of REG-3 gamma/REG3G Protein, Human (149a.a, HEK293, His) is 149 a.a., with molecular weight of 17-19 kDa.
The FIP1L1 protein is an important component of the CPSF complex and is responsible for the formation of the 3' end of pre-mRNA. FIP1L1 Protein, Human (Sf9, His, GST) is the recombinant human-derived FIP1L1 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of FIP1L1 Protein, Human (Sf9, His, GST) is 593 a.a., .
