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Results for "

RBL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Complement System (1) COX (1) GnRH Receptor (1) Lipoxygenase (1) PERK (1) PKC (1) Small Interfering RNA (siRNA) (2) Syk (3) TNF Receptor (3) TRP Channel (1)
By Research Areas:	Cancer (1) Infection (2) Inflammation/Immunology (7)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-12504

Pyr6 1 Publications Verification N-[4-[3,5-Bis(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide	TRP Channel	Others
Pyr6 is a selective inhibitor of TRPC3 with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).

HY-RS11729

RBL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RBL1 Human Pre-designed siRNA Set A contains three designed siRNAs for RBL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RBL1 Human Pre-designed siRNA Set A RBL1 Human Pre-designed siRNA Set A

HY-RS11730

RBL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RBL2 Human Pre-designed siRNA Set A contains three designed siRNAs for RBL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RBL2 Human Pre-designed siRNA Set A RBL2 Human Pre-designed siRNA Set A

HY-N12116

Maceneolignan A	TNF Receptor	Cancer
Maceneolignan A is a natural product that can be isolated from mace, the aril of Myristica fragrans (Myristicaceae). Maceneolignan A inhibits the release of β-hexosaminidase in RBL-2H3 cells, with an IC₅₀ of 48.4 μM. Maceneolignan A inhibits the release of TNF-α in antigen stimulated RBL-2H3 cells, with an IC₅₀ of 63.7 μM .

HY-N8593

Undecane	TNF Receptor	Infection
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α ^[

HY-N2344

Procyanidin A1 1 Publications Verification Proanthocyanidin A1	PKC	Inflammation/Immunology
Procyanidin A1 (Proanthocyanidin A1) is a procyanidin dimer, which inhibits degranulation downstream of protein kinase C activation or Ca ²⁺ influx from an internal store in RBL-213 cells. Procyanidin A1 has antiallergic effects .

HY-105024

FPL 62064	Lipoxygenase COX	Inflammation/Immunology
FPL 62064 is a potent 5-lipoxygenase (5-LOX) and COX dual inhibitor, with IC₅₀ values of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin synthetase (cyclooxygenase), respectively. FPL 62064 has potent anti-inflammatory activity .

HY-N8593S

Undecane-d24	TNF Receptor	Infection
Undecane-d₂₄ is the deuterium labeled Undecane[1]. Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α[2].

HY-139247

pNPS-DHA	Others	Inflammation/Immunology
pNPS-DHA (Compound 19) is an orally active DHA-ethanolamide (DHEA) derivative that has antiallergic activity. pNPS-DHA inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) reaction in mice. pNPS-DHA has anti-degranulating activity in RBL-2H3 mast cells with an IC₅₀ of 15 μM .

HY-N2252

Licarin A (+)-Licarin A
Licarin A ((+)-Licarin A), a neolignan, significantly and dose-dependently reduces TNF-α production (IC₅₀=12.6 μM) in dinitrophenyl-human serum albumin (DNP-HSA)-stimulated RBL-2H3 cells. Anti-allergic effects. Licarin A reduces TNF-α and PGD2 production, and COX-2 expression .

HY-P1640

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

HY-13699

NBI-42902	GnRH Receptor PERK	Others
NBI-42902 is an orally active, potent functional and competitive antagonist of GnRH receptor with an IC₅₀ value of 0.79 nM, a K_i value of 0.56 nM, respectively. NBI-42902 inhibits GnRH-stimulated inositol phosphate (IP) accumulation, Ca ²⁺ flux, and ERK1/2 activation. NBI-42902 inhibits serum luteinizing hormone (LH) in castrated male macaques. NBI-42902 can be used for research on sex-hormone-related diseases .

HY-112390A

Syk Inhibitor II 1 Publications Verification	Syk 5-HT Receptor	Inflammation/Immunology
Syk Inhibitor II is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II shows less potent against other kinases and has anti-allergic effect .

HY-112390

Syk Inhibitor II dihydrochloride	5-HT Receptor Syk	Inflammation/Immunology
Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect .

HY-112390B

Syk Inhibitor II dihydrochloride dihydrate	Syk 5-HT Receptor	Inflammation/Immunology
Syk Inhibitor II dihydrochloride dihydrate is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II dihydrochloride dihydrate inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II dihydrochloride dihydrate shows less potent against other kinases and has anti-allergic effect .

(Trp63,Trp64)-C3a(63-77)	Complement System	Inflammation/Immunology
(Trp63,Trp64)-C3a(63-77) is a C3a synthetic analogue peptide, which exhibits Ca ²⁺ stimulating efficacy in human neutrophils and hC3aR or mC3aR expressing RBL-2H3 cells with EC₅₀ of 9.5, 2.0 and 0.8 nM, respectively .

Cat. No.	Product Name	Category	Target	Chemical Structure