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SGK3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (2) PI3K (1) PROTAC Linkers (4) PROTACs (1) SGK (2) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (7)

Inhibitors & Agonists

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

*PROTAC SGK3* degrader-1** 2 Publications Verification SGK3-PROTAC1	PROTACs SGK	Cancer
PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent *SKG3* degrader based on von Hippel-Lindau ligand. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1 (an SGK3 substrate) .

PEG3-C4-OBn	PROTAC Linkers	Cancer
PEG3-C4-OBn is a polyethylene glycol (PEG)-based PROTAC linker. PEG3-C4-OBn can be used in the synthesis of the PROTAC SGK3 degrader-1 (HY-125878). PROTAC SGK3 degrader-1 is a potent SKG3 degrader based on PROTAC .

SGK3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Human Pre-designed siRNA Set A SGK3 Human Pre-designed siRNA Set A

Sgk3 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sgk3 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk3 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sgk3 Mouse Pre-designed siRNA Set A Sgk3 Mouse Pre-designed siRNA Set A

SGK3 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SGK3 Rat Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

SGK3 Rat Pre-designed siRNA Set A SGK3 Rat Pre-designed siRNA Set A

Ald-CH2-PEG3-CH2-Boc	PROTAC Linkers	Cancer
Ald-CH2-PEG3-CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker can be used in the synthesis of SGK3 kinase PROTAC degrader .

OTs-C6-OBn	PROTAC Linkers	Cancer
OTs-C6-OBn is an alkyl chain-based PROTAC linker can be used in the synthesis of PROTAC SGK3 degrader-1 (HY-125878) .

Vps34-IN-1 Maximum Cited Publications 6 Publications Verification	PI3K Autophagy	Cancer
Vps34-IN-1 is a potent and selective inhibitor of class III Vps34 PI3K. Vps34-IN-1 inhibits phosphorylation of PtdIns by recombinant insect cell expressed Vps34-Vps15 complex with an IC₅₀ of ~25 nM. Vps34-IN-1 can suppress SGK3 activation by reducing PtdIns(3)P levels via lowering phosphorylation of T-loop and hydrophobic motifs. Vps34-IN-1 modulates autophagy ^[3].

HaloPROTAC-E 1 Publications Verification	SGK Autophagy	Cancer
HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, *SGK3* and VPS34, with a DC₅₀ of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14).

Boc-C1-PEG3-C4-OBn	PROTAC Linkers	Cancer
Boc-C1-PEG3-C4-OBn (PROTAC Linker 15) is a PROTAC linker, which refers to the PEG composition. Boc-C1-PEG3-C4-OBn can be used in the synthesis of a series of PROTACs, such as PROTAC SGK3 degrader-1 (HY-125878). PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins .

Recombinant Proteins Recommended:

Cat. No.	Compare	Product Name	Species	Source

	SGK3 Protein, Human (sf9, GST) Serine/threonine-protein kinase SGK3; Cytokine-independent survival kinase; SGK3; CISK; SGKL	Human	Sf9 insect cells
	The SGK3 protein is an important serine/threonine protein kinase that complexly controls diverse ion channels, transporters, and key cellular processes, affecting growth, proliferation, survival, and migration. SGK3 exhibits multiple effects by upregulating channels such as Na(+), K(+), epithelial Ca(2+), chloride, and transporters such as creatine. SGK3 Protein, Human (sf9, GST) is the recombinant human-derived SGK3 protein, expressed by Sf9 insect cells , with GST tag.


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