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SPIN1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-125837A
    MS31 trihydrochloride

    		Epigenetic Reader Domain Cancer
    MS31 trihydrochloride is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine-containing peptides to SPIN1, and is not toxic to nontumorigenic cells [1].
    MS31 trihydrochloride
  • HY-RS13675
    SPIN1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SPIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for SPIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SPIN1 Human Pre-designed siRNA Set A
    SPIN1 Human Pre-designed siRNA Set A
  • HY-163460
    MS8535

    		Others Others
    MS8535 is a SPIN1 selective inhibitor, with an IC50 of 0.2 μM [1].
    MS8535
  • HY-125837
    MS31

    		Epigenetic Reader Domain Cancer
    MS31 is a potent, highly affinity and selective fragment-like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 potently inhibits binding of trimethyllysine-containing peptides to SPIN1. MS31 is not toxic to nontumorigenic cells [1].
    MS31
  • HY-161068
    hACE2/SP-IN-1

    		SARS-CoV Angiotensin-converting Enzyme (ACE) Infection
    hACE2/SP-IN-1 (compound 7a) is a dual inhibitor of hACE2 and coronavirus spike protein. hACE2/SP-IN-1 can bind to the spike protein and block cell entry, preventing SARS-CoV-2 from infecting human cells [1].
    hACE2/SP-IN-<em>1</em>

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