STAT-1

Isoforms Recommended:	STAT1

By Targets:	STAT (9) Antibiotic (1) Apoptosis (5) CDK (3) CXCR (1) DNA/RNA Synthesis (1) Early 2 Factor (E2F) (1) Fungal (1) Glucocorticoid Receptor (2) IFNAR (2) JAK (1) NF-κB (1) NO Synthase (2) Nucleoside Antimetabolite/Analog (1) PI3K (1) Reactive Oxygen Species (2) RIP kinase (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (12) Endocrinology (1) Infection (2) Inflammation/Immunology (7)

Targets Recommended: STAT

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0069

Fludarabine Maximum Cited Publications 39 Publications Verification F-ara-A; NSC 118218	Nucleoside Antimetabolite/Analog DNA/RNA Synthesis STAT Apoptosis	Cancer
Fludarabine (NSC 118218) is a DNA synthesis inhibitor and a fluorinated purine analogue with antineoplastic activity in lymphoproliferative malignancies. Fludarabine inhibits the cytokine-induced activation of STAT1 and STAT1-dependent gene transcription in normal resting or activated lymphocytes ^[1] .

HY-W013523

2-NP 2 Publications Verification	STAT	Cancer
2-NP is a selective enhancer of *STAT1* transcription. 2-NP can enhance the ability of IFN-γ to inhibit the proliferation of human breast cancer and fibrosarcoma cells ^[1].

HY-RS13886

STAT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
STAT1 Human Pre-designed siRNA Set A contains three designed siRNAs for STAT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

STAT1 Human Pre-designed siRNA Set A STAT1 Human Pre-designed siRNA Set A

HY-122891

SB02024	PI3K CXCR STAT	Cancer
SB02024 is a potent and orally active VPS34 inhibitor. SB02024 inhibits Vps34 kinase activity. SB02024 induces CCL5 and CXCL10 via *STAT1/IRF7*. SB02024 shows anticancer activity ^[1] .

HY-N8107

Matairesinol monoglucoside	Others	Others
Matairesinol monoglucoside, a lignan compound, exhibits low activity on *IFN-γ/STAT1* and *IL-6/STAT3* signaling pathways with inhibition ratio of 5.8% and 7.0%, respectively ^[1].

HY-W035137

5,15-Diphenylporphyrin 5,15-DPP	STAT	Cancer
5,15-Diphenylporphyrin (5,15-DPP) is a selective *STAT3-SH2* antagonist (IC₅₀s of 0.28 µM and 10 µM for STAT3 and STAT1, respectively) ^[1].

HY-115594

Erasin	STAT Apoptosis	Cancer
Erasin is a potent Erlotinib (HY-50896)-resistance antagonizing *STAT3* inhibitor with IC₅₀s of 9.7 and 24 μM against STAT3 and STAT1, respectively. Erasin induces cancer cells apoptosis ^[1].

HY-161060

Zharp1-211	RIP kinase	Inflammation/Immunology
Zharp1-211 is a potent inhibitor of RIPK1 kinase. Zharp1-211 significantly reduces the expression of *JAK/STAT1*-mediated chemokines and MHC class II molecules in intestinal epithelial cells ^[1].

HY-114495

Caerulomycin A 1 Publications Verification Cerulomycin; Caerulomycin	Fungal Antibiotic	Infection Inflammation/Immunology
Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases ^[1].

HY-119347

Cirsilineol 1 Publications Verification	IFNAR STAT	Inflammation/Immunology Cancer
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 ⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice ^[1].

HY-146666

STAT3-IN-9	Apoptosis STAT	Cancer
STAT3-IN-9 is a potent *STAT3* inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase ^[1].

HY-107429

Abrocitinib 4 Publications Verification PF-04965842	JAK	Inflammation/Immunology
Abrocitinib (PF-04965842) is a potent, orally active and selective *JAK1* inhibitor, with IC₅₀s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC₅₀, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease ^[1].

HY-149974

CDK8-IN-13	Apoptosis CDK	Cancer
CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC₅₀ value of 51.9 nM. CDK8-IN-13 induces Apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity ^[1].

HY-149007

STAT3-IN-11 1 Publications Verification	STAT Apoptosis	Cancer
STAT3-IN-11 (7a) is a selective *STAT3* inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers ^[1].

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function ^[1].

HY-149209

LL-K8-22	CDK STAT Early 2 Factor (E2F)	Cancer
LL-K8-22 is a potent, selective and durable CDK8-cyclin C dual degrader, with DC₅₀ values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research ^[1].

HY-111388A

SEL120-34A monohydrochloride 5 Publications Verification	CDK	Cancer
SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC₅₀s of 4.4 nM and 10.4 nM, respectively, with a K_d of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC₅₀=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726 ^[1]. Has anti-tumor activity ^[1].

HY-13571A

Beclometasone dipropionate 3 Publications Verification Beclomethasone dipropionate	Glucocorticoid Receptor Reactive Oxygen Species NO Synthase	Inflammation/Immunology Endocrinology
Beclometasone dipropionate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate can be used for asthma ^[1] .

HY-13571B

Beclometasone dipropionate monohydrate	Glucocorticoid Receptor Reactive Oxygen Species NO Synthase	Inflammation/Immunology Cancer
Beclometasone dipropionate monohydrate, the proagent of Beclometasone, is an orally active and potent glucocorticoid recepter agonist. Beclometasone dipropionate monohydrate acts via a glucocorticoid receptor and suppresses inflammation and hyperproliferation. Beclometasone dipropionate monohydrate can be used for asthma ^[1] .

HY-N3548

Catalpalactone	NF-κB	Inflammation/Immunology
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and *IFN-β/STAT-1* activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities ^[1] .

Cat. No.	Product Name

HY-L008

*JAK/STAT* Compound Library**	423 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

423 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 423 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

Cat. No.	Product Name	Target	Research Area

HY-P99666

Interferon alfa	IFNAR	Infection
Albinterferon alfa-2b is a type I interferon that activates novel genes and exerts potent antiviral and antiproliferative activity on target cells. Signaling by Albinterferon alfa-2b requires receptor-dependent activation of Stat1 and Stat2 to form a heterodimeric STAT that binds to the DNA-binding protein IRF-9 (p48) and forms ISGF-3 (IFN-stimulated gene factor 3). The driver genes are then further activated by ISGF-3 to achieve antiviral function ^[1].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-114495

Caerulomycin A 1 Publications Verification Cerulomycin; Caerulomycin	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Fungal Antibiotic
Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases ^[1].

HY-119347

Cirsilineol 1 Publications Verification	Laburnum anagyroides Medic. Flavonoids Monophenols Classification of Application Fields Flavones Source classification Phenols Plants Compositae Disease Research Fields Inflammation/Immunology	IFNAR STAT
Cirsilineol, a natural flavone compound, selectively inhibits IFN-γ/STAT1/T-bet signaling in intestinal CD4 ⁺ T cells. Cirsilineol has potent immunosuppressive and anti-tumor properties. Cirsilineol significantly ameliorates trinitro-benzene sulfonic acid (TNBS)-induced T-cell-mediated experimental colitis in mice ^[1].

HY-N8107

Matairesinol monoglucoside	Monophenols other families Classification of Application Fields Source classification Lignans Other Diseases Phenols Phenylpropanoids Plants Disease Research Fields	Others
Matairesinol monoglucoside, a lignan compound, exhibits low activity on *IFN-γ/STAT1* and *IL-6/STAT3* signaling pathways with inhibition ratio of 5.8% and 7.0%, respectively ^[1].

HY-N3548

Catalpalactone	Structural Classification Natural Products Catalpa ovata G. Don Source classification Plants Bignoniaceae	NF-κB
Catalpalactone has anti-inflammatory effect. Catalpalactone inhibits LPS-induced NO production and iNOS expression in RAW264.7 cells, and also inhibits IRF3, NF-κB, and *IFN-β/STAT-1* activation. Catalpalactone also inhibits dopamine biosynthesis by reducing tyrosine hydroxylase (TH) and aromatic-l-amino acid decarboxylase (AADC) activities ^[1] .

Species:	Human (2)
Tag:	His (1) Tag Free (1) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73628

	STAT1 Protein, Human (sf9, His-GST) Signal Transducer and Activator of Transcription 1-Alpha/Beta; STAT1	Human	Sf9 insect cells
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human (sf9, His-GST) is the recombinant human-derived STAT1 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of STAT1 Protein, Human (sf9, His-GST) is 712 a.a., with molecular weight of ~105 kDa.

HY-P71335

	STAT1 Protein, Human Signal Transducer and Activator of Transcription 1-Alpha/Beta; Transcription Factor ISGF-3 Components p91/p84; STAT1	Human	E. coli
	STAT1 is a signal transducer and activator of transcription that responds to interferons, KITLG/SCF, and growth factors. After type I IFN binds, STAT1 and STAT2 form ISGF3, which translocates to the nucleus and activates ISG transcription. STAT1 Protein, Human is the recombinant human-derived STAT1 protein, expressed by E. coli , with tag free. The total length of STAT1 Protein, Human is 712 a.a., with molecular weight of ~85.0 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80855

*Phospho-STAT1* (Ser727) Antibody (YA149)** STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84	WB, IHC-P	Human, Mouse, Rat
Phospho-STAT1 (Ser727) Antibody (YA149) is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to Phospho-STAT1 (Ser727). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse, Rat.

HY-P80856

*Phospho-STAT1* (Tyr701) Antibody** STAT1; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84	ICC/IF, WB, IHC-F, IHC-P, IP, ELISA	Human, Mouse, Rat, Monkey
Phospho-STAT1 (Tyr701) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 87 kDa, targeting to Phospho-STAT1 (Tyr701). It can be used for ICC/IF,WB,IHC-F,IHC-P,IP,ELISA assays with tag free, in the background of Human, Mouse, Rat, Monkey.

HY-P80342

STAT1 alpha Antibody	WB, ICC/IF, IHC-P, IP, FC	Human
STAT1 alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to STAT1 alpha. It can be used for WB,ICC/IF,IHC-P,IP,FC assays with tag free, in the background of Human.

HY-P80340

STAT1 Antibody (YA059)	WB, IP, FC	Human, Mouse
STAT1 Antibody (YA059) is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to STAT1. It can be used for WB,IP,FC assays with tag free, in the background of Human, Mouse.

HY-P80341

STAT1 Antibody (YA667)	WB, ICC	Human, Mouse
STAT1 Antibody (YA667) is a non-conjugated and Mouse origined monoclonal antibody about 87kDa, targeting to STAT1. It can be used for WB,ICC assays with tag free, in the background of Human, Mouse.

HY-P80478

*Phospho-STAT1* (Ser727) Antibody (YA148)**	WB, IHC-P	Human, Mouse
Phospho-STAT1 (Ser727) Antibody (YA148) is a non-conjugated and Rabbit origined monoclonal antibody about 87 kDa, targeting to Phospho-STAT1(S727). It can be used for WB,IHC-P assays with tag free, in the background of Human, Mouse.

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