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Skp2

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By Targets:	Apoptosis (2) Bacterial (1) c-Myc (1) E1/E2/E3 Enzyme (7) EGFR (1) Fatty Acid Synthase (FASN) (1) PPAR (1) SARS-CoV (1) Sirtuin (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (8) Infection (2) Metabolic Disease (1)

10

Inhibitors & Agonists

1

Natural
Products

1

Recombinant Proteins

1

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Skp2 inhibitor 2	E1/E2/E3 Enzyme	Cancer
Skp2 inhibitor 2 (14f) is an inhibitor of F-box protein S-phase kinase-associated protein 2 (Skp2), with an IC₅₀ value of 10.2 μM (Skp2-Cks1). Skp2 is a part of cullin-RING ligases, which recruits and ubiquitinates substrates, involving in proteolytic and non-proteolytic process .

Skp2 Inhibitor C1 5+ Cited Publications Skpin C1	E1/E2/E3 Enzyme	Cancer
Skp2 Inhibitor C1 (SKPin C1) is an S-phase kinase-related protein 2 (Skp2) inhibitor with an inhibitory effect on metastatic melanoma cells. Skp2 Inhibitor C1 slows the cell cycle, inhibits cell proliferation, and triggers apoptosis .

SZL P1-41 Maximum Cited Publications 9 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
SZL P1-41 is a specific *Skp2* inhibitor, binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. SZL P1-41, like Skp2 deficiency, augments p27-mediated apoptosis/senescence, while it impairs Akt-driven glycolysis. Anti-tumor activities ^[2].

SMIP004 3 Publications Verification	E1/E2/E3 Enzyme Apoptosis	Cancer
SMIP004 is a SKP2 E3 ligase inhibitor, which downregulates SKP2 and to stabilise p27. SMIP004 is a cancer cell selective apoptosis inducer of human prostate cancer cells ^[2].

SKP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SKP2 Human Pre-designed siRNA Set A contains three designed siRNAs for SKP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SKP2 Human Pre-designed siRNA Set A SKP2 Human Pre-designed siRNA Set A

SARS-CoV-2-IN-39	SARS-CoV	Infection
SARS-CoV-2-IN-39 (compound 21) is a *SARS-CoV-2* inhibitor with an EC₅₀ of 1 μM. SARS-CoV-2-IN-39 against SARS-CoV-2 by inhibiting of SKP2 protein and stabilizing BECN1 .

NSC689857 1 Publications Verification	EGFR E1/E2/E3 Enzyme	Cancer
NSC689857 is a potent EGFR and SCF ^SKP2 inhibitor with an IC₅₀ value of 36 μM for Skp2-Cks1. NSC689857 can inhibit p27 ubiquitylation (IC₅₀=30 μM). NSC689857 has varied activity across cancer types, with more activity against leukemia cell lines than others ^[2].

Ubiquitination-IN-1	E1/E2/E3 Enzyme	Cancer
Ubiquitination-IN-1 (compound 24) is a ubiquitination and *Cksl-Skp2* protein-protein interaction (IC₅₀=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors .

SCFSkp2-IN-2	E1/E2/E3 Enzyme	Cancer
SCFSkp2-IN-2 (Compound AAA-237) is a *Skp2* inhibitor with a K_D of 28.77 μM. AAA-237 induces apoptosis of NSCLC cells and shows antitumor activities .

Agrimol B	Sirtuin PPAR Fatty Acid Synthase (FASN) c-Myc Bacterial	Infection Metabolic Disease Cancer
Agrimol B, a polyphenol, is an orally active and potent SIRT1 activator. Agrimol B shows anti-adipogenic and anticancer activity. Agrimol B shows antibacterial activity against plant pathogens. Agrimol B dramatically inhibits 3T3-L1 adipocyte differentiation by reducing PPARγ, C/EBPα, FAS, UCP-1, and apoE expression. The action of Agrimol B on the cancer cells is likely derived from its effect on c-MYC, *SKP2* and p27 ^[2] .

Cat. No.	Compare	Product Name	Species	Source

	SKP2 Protein, Human (His-SUMO) CDK2/Cyclin A associated protein p45; Cyclin A/CDK2 associated protein p45; Cyclin-A/CDK2-associated protein p45; F box protein Skp2; F box/LRR repeat protein 1; F-box protein Skp2; F-box/LRR-repeat protein 1; FBL 1; FBL1; FBXL 1; FBXL1; FLB 1; FLB1; MGC1366; p45; p45Skp2	Human	E. coli
	SKP2 serves as a substrate recognition component in the SCF E3 ubiquitin-protein ligase complex, directing ubiquitination and proteasomal degradation of key proteins in the cell cycle, signaling, and transcription. It crucially recognizes phosphorylated CDKN1B/p27kip and regulates the G1/S transition. SKP2 Protein, Human (His-SUMO) is the recombinant human-derived SKP2 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag. The total length of SKP2 Protein, Human (His-SUMO) is 424 a.a., with molecular weight of ~63.8 kDa.

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