Smad3

By Targets:	Anaplastic lymphoma kinase (ALK) (1) Antibiotic (1) DNA/RNA Synthesis (1) DYRK (1) Endogenous Metabolite (1) Fungal (1) HIF/HIF Prolyl-Hydroxylase (1) Integrin (1) NF-κB (1) PROTACs (1) Proton Pump (1) Small Interfering RNA (siRNA) (1) TGF-beta/Smad (8) TGF-β Receptor (2)
By Research Areas:	Cancer (3) Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (8) Metabolic Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13013

SIS3 Maximum Cited Publications 72 Publications Verification	TGF-beta/Smad	Inflammation/Immunology
(E)-SIS3 is a potent and selective inhibitor of *Smad3* with an IC₅₀ of 3 μM for Smad3 phosphorylation. (E)-SIS3 inhibits the myofibroblast differentiation of fibroblasts by TGF-β1 .

HY-N2033

Chebulinic acid 1 Publications Verification	DNA/RNA Synthesis TGF-beta/Smad Proton Pump	Infection
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-RS13394

SMAD3 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMAD3 Human Pre-designed siRNA Set A contains three designed siRNAs for SMAD3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMAD3 Human Pre-designed siRNA Set A SMAD3 Human Pre-designed siRNA Set A

HY-W108953

Myristoyl tetrapeptide-12	TGF-beta/Smad	Metabolic Disease
Myristoyl tetrapeptide-12 directly activates *SMAD2* and induces the linking of SMAD3 with DNA. Myristoyl tetrapeptide-12 is capable of stimulating hair growth, especially at the level of eyelashes .

HY-W803134

(E/Z)-SIS3 free base	TGF-beta/Smad	Inflammation/Immunology
E/Z-SIS3 free base exhibits an inhibitory efficacy against *smad3, exhibits an anti-fibrotic and anti-inflammatory effect through a TGF-β/smad3* signaling pathway .

HY-128439

BT173	DYRK	Cancer
BT173 is a potent homeodomain interacting protein kinase 2 (HIPK2) inhibitor. BT173 binds to HIPK2 does not inhibit HIPK2 kinase activity but rather, interfered allosterically with the ability of HIPK2 to associate with Smad3. BT173 attenuates renal fibrosis through suppression of the TGF-β1/Smad3 pathway .

HY-147025

(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine 1 Publications Verification	PROTACs TGF-beta/Smad HIF/HIF Prolyl-Hydroxylase	Inflammation/Immunology
(S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine is a dual target PROTAC that can not only target to the ubiquitination and degradation of *Smad3* but also improve the HIF-α protein level. (S,R,S)-AHPC-C2-amide-benzofuranylmethyl-pyridine has a multi-path anti-fibrosis function and a renal protection function for research of renal anemia .

HY-144043

ALK5-IN-8	TGF-β Receptor	Cancer
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5). ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1) .

HY-114495

Caerulomycin A 1 Publications Verification Cerulomycin; Caerulomycin	Fungal Antibiotic	Infection Inflammation/Immunology
Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases .

HY-100444

SIS3 free base Maximum Cited Publications 72 Publications Verification
SIS3 free base is a potent and selective inhibitor of *Smad3* phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2 .

HY-47888

PLN-1474	Integrin	Inflammation/Immunology
PLN-1474 (compound 1) is an orally active and selective ανβ1 integrin inhibitor with an IC50 value of <50 nM. PLN-1474 reduces levels of pSMAD3/SMAD3 in liver, hepatic collagen gene expression and hepatic OHP concentration in liver fibrosis mouse model. PLN-1474 can be used for the research of preventing, delaying or researching a fibrotic or cirrhotic disease or disorder.

HY-W012977

3,3-Dimethyl-1-butanol DMB; Neohexanol	TGF-beta/Smad NF-κB Endogenous Metabolite	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and *TGF-β1/Smad3*. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) ^[3].

HY-12953

R-268712	TGF-β Receptor TGF-beta/Smad Anaplastic lymphoma kinase (ALK)	Cardiovascular Disease Inflammation/Immunology Cancer
R-268712 is an orally active and selective ALK-5 inhibitor, with an IC₅₀ of 2.5 nM. R-268712 inhibits the phosphorylation of *Smad3* in a dose-dependent manner with an IC₅₀ of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer .

HY-146434

TGFβ-IN-2	TGF-beta/Smad	Inflammation/Immunology
TGFβ-IN-2 (Compound 9d) inhibits TGF-β-induced total collagen accumulation in NRK-49F cells with the IC₅₀ of 4.31 μM. TGFβ-IN-2 suppresses the TGF-β-induced protein expression of COL1A1, α-SMA, and p-Smad3 in vitro. TGFβ-IN-2 can be used as a potential effective compound for anti-fibrosis in vivo by oral administration .

HY-18758

IN-1130
IN-1130 is a highly selective transforming growth factor-β type I receptor kinase (ALK5) inhibitor with an IC₅₀ of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC₅₀=36 nM) and p38α mitogen-activated protein kinase (IC₅₀=4.3 μM). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis .

HY-114683

KS370G	Others	Cardiovascular Disease
KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .

Cat. No.	Product Name	Target	Research Area

HY-W108953

Myristoyl tetrapeptide-12	TGF-beta/Smad	Metabolic Disease
Myristoyl tetrapeptide-12 directly activates *SMAD2* and induces the linking of SMAD3 with DNA. Myristoyl tetrapeptide-12 is capable of stimulating hair growth, especially at the level of eyelashes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2033

Chebulinic acid 1 Publications Verification	Infection Structural Classification Classification of Application Fields Combretaceae Source classification Phenols Polyphenols Terminalia chebula Retz. Plants Disease Research Fields	DNA/RNA Synthesis TGF-beta/Smad Proton Pump
Chebulinic acid is a potent natural inhibitor of M. tuberculosis DNA gyrase, also can inhibit SMAD-3 phosphorylation, inhibit H+ K+-ATPase activity.

HY-114495

Caerulomycin A 1 Publications Verification Cerulomycin; Caerulomycin	Structural Classification Microorganisms Anti-inflammation/Immunoregulatory Classification of Application Fields Antibiotics Source classification Antibacterial Disease Research Anticancer Inflammation/Immunology Disease Research Fields Other Antibiotics	Fungal Antibiotic
Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases .

HY-W012977

3,3-Dimethyl-1-butanol DMB; Neohexanol	Structural Classification Natural Products Classification of Application Fields Source classification Metabolic Disease Endogenous metabolite Inflammation/Immunology Disease Research Fields	TGF-beta/Smad NF-κB Endogenous Metabolite
3,3-Dimethyl-1-butanol (DMB) is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO). 3,3-Dimethyl-1-butanol inhibits the signaling pathway of p65 NF-κB and *TGF-β1/Smad3*. 3,3-Dimethyl-1-butanol has potential applications in cardiovascular disease (CVD) ^[3].

Recombinant Proteins Recommended:

SMAD3

Species:	Human (1) Rat (1)
Tag:	His (2) GST (1) Flag (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P71323

	SMAD3 Protein, Human (Flag-His) 1 Publications Verification Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; Smad family member 3; Smad 3; Smad3; hSmad3; Smad3; MADH3	Human	E. coli
	The SMAD3 protein acts as a receptor-regulated SMAD (R-SMAD), transducing signals from TGF-β and activin type 1 receptor kinase. After being activated by antigen-presenting cells, SMAD3 binds to the TRE element in the gene promoter and forms a complex with SMAD4 to activate transcription. SMAD3 Protein, Human (Flag-His) is the recombinant human-derived SMAD3 protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of SMAD3 Protein, Human (Flag-His) is 424 a.a., with molecular weight of 50-60 kDa.

HY-P73636

	SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) Mothers against decapentaplegic homolog 3; mMad3; Smad3; Madh3	Rat	Sf9 insect cells
	The SMAD3 protein is an R-SMAD that acts as an intracellular signal transducer activated by TGF-β and activin type 1 receptor kinase. It binds TRE elements and regulates TGF-β target genes. SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) is the recombinant rat-derived SMAD3 protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of SMAD3 Protein, Human/Mouse/Rat (sf9, His-GST) is 425 a.a., with molecular weight of ~75.9 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P80854

*Phospho-Smad3* (Ser423/425) Antibody** Smad3; MADH3; Mothers against decapentaplegic homolog 3; MAD homolog 3; Mad3; Mothers against DPP homolog 3; hMAD-3; JV15-2; Smad family member 3; Smad 3; Smad3; hSmad3	WB, IHC-P, ICC/IF	Human, Mouse
Phospho-Smad3 (Ser423/425) Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 48 kDa, targeting to Phospho-Smad3 (Ser423/425). It can be used for WB,IHC-P,ICC/IF assays with tag free, in the background of Human, Mouse.

HY-P80325

Smad3 Antibody	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
Smad3 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 58 kDa, targeting to Smad3. It can be used for WB,ICC/IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.

HY-P80477

*Phospho-Smad3* (Ser423/Ser425) Antibody**	WB, ICC/IF, IHC-P	Human, Mouse
Phospho-Smad3 (Ser423/Ser425) Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 48 kDa, targeting to Phospho-Smad3(S423/S425). It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

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Smad3

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