Search Result
Results for "
THP
" in MedChemExpress (MCE) Product Catalog:
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
- HY-138315
-
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PROTAC Linkers
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Cancer
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Ms-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138337
-
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PROTAC Linkers
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Cancer
|
MS-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138338
-
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PROTAC Linkers
|
Cancer
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Benzyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138341
-
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PROTAC Linkers
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Cancer
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Benzyl-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138344
-
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PROTAC Linkers
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Cancer
|
MS-PEG10-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138360
-
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PROTAC Linkers
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Cancer
|
Benzyl-PEG18-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138371
-
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PROTAC Linkers
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Cancer
|
MS-PEG12-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138372
-
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PROTAC Linkers
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Cancer
|
Br-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138385
-
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PROTAC Linkers
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Cancer
|
MS-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138442
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PROTAC Linkers
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Cancer
|
Benzyl-PEG16-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138477
-
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PROTAC Linkers
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Cancer
|
Benzyl-PEG24-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-138482
-
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PROTAC Linkers
|
Cancer
|
MS-PEG1-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W096066
-
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PROTAC Linkers
|
Cancer
|
Benzyl-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W096071
-
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PROTAC Linkers
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Cancer
|
Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W096074
-
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PROTAC Linkers
|
Cancer
|
MS-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-W096075
-
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PROTAC Linkers
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Cancer
|
Benzyl-PEG5-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
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- HY-132106
-
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PROTAC Linkers
|
Cancer
|
Benzyl-PEG7-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-132105
-
|
PROTAC Linkers
|
Cancer
|
Benzyl-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-132107
-
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PROTAC Linkers
|
Cancer
|
MS-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
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- HY-132055
-
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PROTAC Linkers
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Cancer
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Azido-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG8-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-138325
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PROTAC Linkers
|
Cancer
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Azido-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-138374
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PROTAC Linkers
|
Cancer
|
Azido-PEG12-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG12-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-138472
-
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PROTAC Linkers
|
Cancer
|
Azido-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-130819
-
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PROTAC Linkers
|
Cancer
|
Tos-PEG4-THP is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523) .
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- HY-119698
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SD 8339; N-Benzyl-9-(tetrahydro-2h-pyran-2-yl)adenine
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Others
|
Others
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BAP9THP is a synthetic cytokinin derivative and a growth regulator. BAP9THP promotes chlorophyll retention (and senescence delay) in plant tissues exceptionally strongly, and growth of tobacco callus almost as strongly as 6-Benzylaminopurine (BAP). BAP9THP induces adventitious shoot formation ignificantly more strongly than N6-isopentenyladenine or Kinetin .
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- HY-150732
-
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IRAK
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Inflammation/Immunology
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IRAK4-IN-18 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease .
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- HY-150733
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IRAK
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Inflammation/Immunology
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IRAK4-IN-19 is a potent interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor with an IC50 value of 4.3 nM. IRAK4-IN-19 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-19 can be used for researching arthritis disease .
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- HY-112349
-
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p38 MAPK
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Inflammation/Immunology
|
SB 203580 sulfone is an analog of p38 MAP kinase inhibitor SB 203580, which inhibits the IL-1 production in monocytes with an IC50 of 0.2 μM and binds competitively with CSAID binding proteins (CSBP), inhibits it mediated stress response signaling with an IC50 of 0.03 μM .
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- HY-104073
-
-
- HY-N12469
-
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Others
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Others
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Gypsogenin 3-O-glucuronide is a glucuronide that can be isolated from Gypsophila. Gypsogenin 3-O-glucuronide has cytotoxic effect on THP-1 cells .
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- HY-N8390
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Others
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Cancer
|
3-Epidehydropachymic acid, a lanostane triterpenoid, shows totoxicity effect against human acute monocytic leukemia cell line THP-1 (IC50=52.51 μM) .
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- HY-144168A
-
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STING
|
Inflammation/Immunology
|
STING agonist-8 dihydrochloride (compound 5-AB) is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells .
|
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- HY-N12186
-
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Others
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Inflammation/Immunology
|
Sibiricine (Compound 8) is an isoquinoline alkaloid derived from the medicinal plant Corydalis crispa. Sibiricine has significant anti-inflammatory activity on TNF-α production by LPS-activated THP-1 cells .
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- HY-144168
-
|
STING
|
Inflammation/Immunology
|
STING agonist-8 is a potent STING agonist with an EC50 of 27 nM in THP1-Dual KI-hSTING-R232 cells (WO2021239068A1, compound 5-AB) .
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- HY-157554
-
-
- HY-148645
-
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STING
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Inflammation/Immunology
|
STING modulator-4 (compound AIH05) is a competitive STING modulator with a Ki of 0.0933 μM for R232H STING. STING modulator-4 has an EC50 of >10 μM for p-IRF3 in THP-1 cell .
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- HY-122941
-
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Others
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Inflammation/Immunology
|
Viscidulin II (FL6) is a flavone. Viscidulin II can be isolated from the root of Scutellaria baicalensis. Viscidulin II significantly suppresses P. acnes-induced IL-8 and IL-1β production in THP-1 cells .
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- HY-N8304
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(+)-Shegansu B; Parvifolol D
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Interleukin Related
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Inflammation/Immunology
|
Shegansu B is an inhibitor of IL-1β. Shegansu B 6 inhibits IL-1β expression on LPS-induced THP-1 cells with 64.74% inhibition. Shegansu B has anti-inflammatory activity .
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- HY-15544
-
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CCR
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Inflammation/Immunology
|
CCR1 antagonist 10 (example 1) is a potent and orally active CCR1 antagonist. CCR1 antagonist 10 inhibits 125I-MIP-1α binding to THP-1 cell membranes with an Ki value of 2.3 nM .
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- HY-145861
-
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Histone Demethylase
Apoptosis
|
Cancer
|
LSD1-IN-14 is a potent and selective LSD1 inhibitor (IC50=0.89 μM). LSD1-IN-14 can significantly inhibit the proliferation of A549 and THP-1 cells and induce the apoptosis of tumor cells .
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- HY-146581
-
|
Cathepsin
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Inflammation/Immunology
|
Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC50 values of 203.4 and 177.6 nM, respectively .
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- HY-146580
-
|
Cathepsin
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Inflammation/Immunology
|
Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC50 values of 101.5 and 86.5 nM, respectively .
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- HY-108670
-
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P2X Receptor
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Inflammation/Immunology
|
AZ11645373 is a highly selective and potent antagonist at human but not rat P2X7 receptors,AZ11645373 inhibits ATP-evoked IL-1β release from lipopolysaccharide-activated THP-1 cells , with an IC50 value of 90 nM .
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- HY-149816
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- HY-14926
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(S)-(-)-Nadifloxacin; WCK 771
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Antibiotic
Bacterial
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Infection
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Levonadifloxacin ((S)-(-)-Nadifloxacin; WCK 771) is a broad-spectrum anti-staphylococcal agent. Levonadifloxacin shows antibacterial activity against Methicillin (HY-121544)-susceptible Staphylococcus aureus (MSSA) and Methicillin-resistant S. aureus (MRSA) strains, with a reduction of which phagocytized in THP-1 monocytes .
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- HY-148606
-
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STING
|
Cancer
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STING modulator-3 is a STING inhibitor. STING modulator-3 inhibits R232 STING with an Ki value of 43.1 nM in scintillation proximity assay. STING modulator-3 has no effect on IRF-3 activation or TNF-β induction in THP-1 cells .
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- HY-18739
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PMA; TPA; Phorbol myristate acetate
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PKC
SphK
NF-κB
|
Inflammation/Immunology
|
Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator . Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells .
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- HY-148643
-
|
STING
|
Inflammation/Immunology
|
STING modulator-5 (compound 38) is a STING modulator with a pIC50 value of 9.5. STING modulator-5 antagonizes peripheral blood mononuclear cells (PBMC) with a pIC50 value of 8.1. STING modulator-5 is a antagonist of THP-1 cells, it can be used for immunological disease research .
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- HY-W080443
-
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Others
|
Others
|
O-allylvanillin is O-allylchalcone derivative with anti-cancer effects . O-allylvanillin inhibits THP-1, HL60, Hep-G2, MCF-7 cells growth with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively .
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- HY-161325
-
|
Parasite
|
Infection
|
Antileishmanial agent-26 (Compound 69) is a guanidine-containing compound with anti-Leishmania donovani activity. Its IC50 value against Leishmania donovani is 5.67 μM, and its CC50 value against THP-1 is 3.79 μM. Antileishmanial agent-26 can be used in the research of tropical diseases .
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- HY-131454
-
|
STING
|
Inflammation/Immunology
Cancer
|
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
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- HY-131945
-
CU-115
2 Publications Verification
|
Toll-like Receptor (TLR)
|
Inflammation/Immunology
|
CU-115 is a potent TLR8 antagonist (IC50=1.04 µM), and shows selective for TLR8 over TLR7 (IC50=>50 µM). CU-115 decreases TNF-α and IL-1β production activated by R-848 in THP-1 cells .
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- HY-147506
-
|
NOD-like Receptor (NLR)
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Inflammation/Immunology
|
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC50 of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .
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- HY-155463
-
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NOD-like Receptor (NLR)
Interleukin Related
|
Inflammation/Immunology
|
NLRP3-IN-25 (compound 32) is an orally available NLRP3 inhibitor with anti-inflammatory activity. NLRP3-IN-25 attenuates renal injury in doxorubicin-induced glomerulonephritis in mice. NLRP3-IN-25 inhibits IL-1β secretion in THP-1 cells with an IC50 of 21 nM .
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- HY-131454A
-
|
STING
|
Inflammation/Immunology
Cancer
|
SR-717 free acid is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity .
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- HY-P2036A
-
|
Toll-like Receptor (TLR)
MMP
HSV
Antibiotic
|
Infection
|
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .
|
-
- HY-151132
-
IsoQC-IN-1
|
Others
|
Cancer
|
Glutaminyl cyclases-IN-1 (IsoQC-IN-1) is a potent glutaminyl cyclases (QC) inhibitor with IC50 values of 12 nM and 73 nM for human QC and isoQC, respectively. Glutaminyl cyclases-IN-1 can selectively interfere with the interaction of CD47/SIRPα through isoQC inhibition, and enhances the increased phagocytic activity of both THP-1 and U937 macrophages .
|
-
- HY-155151
-
|
RIP kinase
|
Inflammation/Immunology
|
RIPK2/3-IN-1 is a potent dual RIPK2/3 kinases inhibitor with IC50 values of 3 nM and 117 nM, respectively. RIPK2/3-IN-1 is against RIPK2 with IC50 value 14 nM in 14-TriLAN-Gly/NOD1 THP-1 cell-based NF-κB reporter assay .
|
-
- HY-163280
-
|
NAMPT
|
Neurological Disease
|
JGB-1-155 is a positive allosteric modulators (N-PAMs), which enhances the activity of nicotinamide phosphoribosyltransferase NAMPT with EC50 of 3.29 μM. JGB-1-155 counteracts the oxidative stress, through upregulating the NAD + in THP-1 human monocytes. JGB-1-155 attenuates TNFα-induced ROS in HT-22 cells .
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- HY-146283
-
|
Histone Demethylase
|
Cancer
|
LSD1-IN-18 (compound 7) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.156 μM and KD of 0.075 μM, respectively. LSD1-IN-18 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.16 and 0.21 μM, respectively .
|
-
- HY-146284
-
|
Histone Demethylase
|
Cancer
|
LSD1-IN-19 (compound 29) is a potent, non-covalent and selective LSD1 inhibitor, with Ki of 0.108 μM and KD of 0.068 μM, respectively. LSD1-IN-19 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.17 and 0.40 μM, respectively .
|
-
- HY-135453
-
|
Bacterial
|
Infection
|
(-)-Pinocembrin exhibits anti-mycobacterium activity against mycobacteriuum tuberculosis H37Ra with an IC50 value of 1.11 mg/mL in dormant phase and 1.21 mg/mL in active phase, respectively. (-)-Pinocembrin has potent antiproliferative activity with IC50 values of 1.88-11.00 mg/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines .
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-
- HY-146285
-
|
Histone Demethylase
Histone Methyltransferase
|
Cancer
|
LSD1-IN-20 (compound 1) is a potent dual non-covalent LSD1/G9a inhibitor, with Ki values of 0.44 and 0.68 μM, respectively. LSD1-IN-20 shows antiproliferative activity in THP-1 leukemia cells and MDA-MB-231 breast cancer cells, with IC50 (72 h) of 0.51 and 1.60 μM, respectively .
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- HY-123942
-
|
Toll-like Receptor (TLR)
TNF Receptor
p38 MAPK
NF-κB
|
Inflammation/Immunology
Cancer
|
Diprovocim is a potent TLR1/TLR2 agonist. Diprovocim elicits full agonist activity in human THP-1 cells (EC50=110 pM). Diprovocim stimulates the release of TNF-α from mouse macrophages (EC50=1.3 nM). Diprovocim activates downstream MAPK and NF-κB signaling pathway. Diprovocim displays strong adjuvant activity in mice, particularly abetting cellular immune responses .
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- HY-130481
-
|
PROTAC Linkers
|
Cancer
|
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells . Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-131040
-
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
NLRP3-IN-NBC6 is a potent, selective NLRP3 inflammasome inhibitor (IC50= 574 nM) that acts independently of Ca 2+. NLRP3-IN-NBC6 inhibits Nigericin (HY-127019)-induced inflammasome activation in THP-1 cells and Imiquimod (HY-B0180)-induced IL-1β release from LPS-primed bone marrow-derived macrophages (BMDMs) .
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- HY-155245
-
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CDK
Bcl-2 Family
|
Cancer
|
A09-003 is a CDK-9 inhibitor (IC50: 16 nM). A09-003 inhibits leukemia cell proliferation (IC50: 1.90, 0.86, 2.49, 1.84, 0.48 μM for BDCM, Molm-14, THP-1, U937, MV4-11 cells). A09-003 induces apoptosis and decreases Mcl-1 expression through Thr163 dephosphorylation .
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-
- HY-162122
-
|
PPAR
|
Inflammation/Immunology
|
PPARα/γ agonist 3 (Compound 4) is a dual agonist of PPARα/γ. PPARα/γ agonist 3 has anti-inflammatory activity, significantly reducing inflammatory markers such as IL-6 and MCP-1 on THP-1 macrophages through NF-κB activation. PPARα/γ agonist 3 can be used in the study of metabolic syndrome and metabolic dysfunction-related fatty liver disease (MAFLD) .
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-
- HY-156415
-
-
- HY-127102
-
DDD01305143
|
Parasite
Proteasome
|
Infection
|
GSK3494245 (DDD01305143) is a potent, orally active, and selective inhibitor of the chymotrypsin-like activity of the parasite proteasome binding in a site sandwiched between the β4 and β5 subunits (IC50=0.16 μM for WT L. donovani proteasomes). GSK3494245 moderately inhibits chymotrypsin-like activity of human proteasome (IC50: purified 26S=13 µM; enriched THP-1 extracts IC50=40µM). GSK3494245 exhibits attractive biological and biosafety properties .
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- HY-144226
-
|
NOD-like Receptor (NLR)
AIM2
Pyroptosis
|
Inflammation/Immunology
|
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with differential species specific effects against NLRP3 and AIM2 inflammasome-dependent pyroptosis. NLRP3/AIM2-IN-3 shows inhibitory efficacy against pyroptosis in THP-1 macrophages stimulated with LPS/nigericin, with an IC50 of 0.077 ± 0.008 μM. NLRP3/AIM2-IN-3 disturbs the interaction of NLRP3 or AIM2 with the adaptor protein ASC and inhibited ASC oligomerization .
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- HY-149781
-
|
STING
|
Cancer
|
STING agonist-34 (Compound 12L) is a potent STING agonist with an IC50 value of 1.15 μM and an EC50 of 0.38 μM in THP1 cells. STING agonist-34 could be used in cancer research .
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-
- HY-120048
-
|
NOD-like Receptor (NLR)
|
Inflammation/Immunology
|
NBC19 is an NLRP3 inflammasome inhibitor with an IC50 of 60 nM in differentiated THP1 cells. NBC19 inhibits nigericin- and ATP-induced IL-1β release with IC50s of 80 nM and 850 nM, respectively .
|
-
- HY-100688
-
|
Dihydroorotate Dehydrogenase
|
Cancer
|
ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models .
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-
- HY-N7489
-
|
Parasite
|
Infection
Inflammation/Immunology
|
β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively .
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-
- HY-N12720
-
|
Others
|
Cancer
|
Cynanoside J is a C21 steroidal glycosides that can be obtained from Cynanchum taihangense. The IC50 values of Cynanoside J for HL-60, THP1, and Caco2 are 6.38, 5.82, and 6.76 μM, respectively. Cynanoside J can be used in cancer research .
|
-
- HY-100401A
-
CS-505
|
Acyltransferase
|
Cardiovascular Disease
|
Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively . Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .
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- HY-100401
-
CS-505 free base
|
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Pactimibe (CS-505 free base) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505 free base) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively . Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .
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- HY-144129
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Apoptosis
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Cancer
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hGGPPS-IN-2 (Compound 16g) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-2 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-2 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .
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- HY-144130
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Apoptosis
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Cancer
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hGGPPS-IN-3 (Compound 13h) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-3 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-3 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .
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- HY-144128
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Apoptosis
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Cancer
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hGGPPS-IN-1 (Compound 18b) is a potent inhibitor of the human geranylgeranyl pyrophosphate synthase (hGGPPS). hGGPPS-IN-1 is an analogue of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs). hGGPPS-IN-1 induces target-selective apoptosis of multiple myeloma (MM) cells and exhibits antimyeloma activity in vivo .
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- HY-156622
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HMC-C-01-A; MBS2320
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Mitochondrial Metabolism
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Cancer
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Leramistat (HMC-C-01-A; MBS2320) is a mitochondrial complex 1 inhibitor, involving in cell metabolism immune metabolism regulation. Leramistat also inhibits ATP production in Thp1 human monocytes (IC50: 0.63 μM). Leramistat inhibits atopic dermatitis and other skin diseases autoimmune diseases, inflammatory diseases, cancer; and also inhibits osteoclast mediated disease .
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- HY-149522
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Bcl-2 Family
Apoptosis
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Cancer
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BCL6-IN-10 (Compound WK499) is a BCL6 inhibitor. BCL6-IN-10 interrupts the binding of BCL6 to SMRT protein. BCL6-IN-10 induces cell apoptosis, cell cycle arrest and DNA damage. BCL6-IN-10 inhibits AML cell proliferation (IC50s: 0.91, 1.63, 1.026, 7.42, 0.87, 0.85μM for OCl-AML3, THP1, MOLM13, HL60, KG1, NB4 cell respectively) .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P2036A
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Toll-like Receptor (TLR)
MMP
HSV
Antibiotic
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Infection
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FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection . FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells .
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P99273
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Anti-Human CD70 Recombinant Antibody
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Inhibitory Antibodies
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Cancer
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Vorsetuzumab (Anti-Human CD70 Recombinant Antibody) is a human anti-CD70 antibody. Vorsetuzumab enhances macrophage-related phagocytosis of renal carcinoma cells, shows inhibitory efficacy against Burkitt’s lymphoma .
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Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
Cat. No. |
Product Name |
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Classification |
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- HY-138334
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PROTAC Synthesis
Alkynes
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Propargyl-PEG1-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG1-THP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-138459
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PROTAC Synthesis
Alkynes
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Propargyl-PEG9-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Propargyl-PEG9-THP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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- HY-132055
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PROTAC Synthesis
Azide
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Azido-PEG8-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG8-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-138325
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PROTAC Synthesis
Azide
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Azido-PEG6-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG6-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-138374
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Azide
PROTAC Synthesis
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Azido-PEG12-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG12-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-138472
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PROTAC Synthesis
Azide
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Azido-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG4-THP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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- HY-130481
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PROTAC Synthesis
Alkynes
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Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells . Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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