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Results for "

TPPS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (2) Biochemical Assay Reagents (2) Fungal (1) HSP (4) Liposome (1) Mitochondrial Metabolism (3) PD-1/PD-L1 (2) Reactive Oxygen Species (2) Ser/Thr Protease (1) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (12) Infection (2) Metabolic Disease (1) Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W075353

TPPS

Others Cancer

TPPS can be used as a non-cytotoxic probe for detecting tumor location .

*TPPS*	Others	Cancer
TPPS can be used as a non-cytotoxic probe for detecting tumor location .

HY-135868

Mito-apocynin (C2)	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C2), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C2) exhibits antineuroinflammatory effect .

HY-W127806

TPPS dihydrochloride	Biochemical Assay Reagents	Others
TPPS dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-151342

*Ser@TPP@CUR*	Others	Others
Ser@TPP@CUR is a Curcumin (HY-N0005) derivative. Ser@TPP@CUR effectively ameliorates injured renal tubular epithelial cells and improves renal functions of acute kidney injury (AKI) mice. Ser@TPP@CUR can be used for the research of AKI .

HY-157933

SF-C5-TPP	Mitochondrial Metabolism	Infection
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM ^>[1].

HY-P3139

TPP-1	PD-1/PD-L1	Cancer
TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function .

HY-P3139A

TPP-1 TFA	PD-1/PD-L1	Cancer
TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function .

HY-150070

Butabindide UCL-1397	Others	Neurological Disease
Butabindide (UCL-1397) is a potent, selective *tripeptidvl peptidase II (TPP* II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide inhibits TPP II to protect CCK-8 against inactivation .

HY-107759

Butabindide oxalate UCL-1397 oxalate	Others	Neurological Disease
Butabindide (UCL-1397) oxalate is a potent, selective *tripeptidvl peptidase II (TPP* II) inhibitor with K_i** values of 7 nM and 10 μM for TPP II and TPP I, respectively. Butabindide oxalate inhibits TPP II to protect CCK-8 against inactivation .

HY-144831

6BrCaQ-C10-TPP	HSP	Cancer
6BrCaQ-C10-TPP is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity in various human cancer cells (IC₅₀=0.008-0.30 μM). 6BrCaQ-C10-TPP can also induces mitochondrial membrane disturbance .

HY-102007

Gamitrinib TPP

HSP Cancer

Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.

Gamitrinib TPP	HSP	Cancer
Gamitrinib TPP is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.

HY-102007A

*Gamitrinib TPP* hexafluorophosphate** 5+ Cited Publications	HSP	Cancer
Gamitrinib TPP hexafluorophosphate is a Gamitrinib (GA) mitochondrial matrix inhibitor. Gamitrinib TPP hexafluorophosphate is a mitochondrial targeted HSP90 inhibitor with anti-cancer activity.

HY-W111141

BCN-OH endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne	Biochemical Assay Reagents	Others
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

HY-RS14942

TPP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TPP1 Human Pre-designed siRNA Set A contains three designed siRNAs for TPP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TPP1 Human Pre-designed siRNA Set A TPP1 Human Pre-designed siRNA Set A

HY-RS14943

TPP2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
TPP2 Human Pre-designed siRNA Set A contains three designed siRNAs for TPP2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

TPP2 Human Pre-designed siRNA Set A TPP2 Human Pre-designed siRNA Set A

HY-100116A

Mitoquinone mesylate Maximum Cited Publications 91 Publications Verification MitoQ mesylate; MitoQ10 mesylate	Reactive Oxygen Species	Metabolic Disease Cancer
Mitoquinone mesylate is a TPP-based, mitochondrially targeted antioxidant in order to protect against oxidative damage .

HY-135869

Mito-apocynin (C11) 2 Publications Verification	Mitochondrial Metabolism	Neurological Disease
Mito-apocynin (C11), an orally active mitochondria-targeted triphenylphosphonium (TPP)-based compound, is synthesized by conjugating the Apocynin moiety with a TPP ⁺ cation. Mito-apocynin (C11) selectively targets mitochondria, and shows neuroprotective effect. Mito-apocynin (C11) prevents hyposmia and corrects deficits in motor function .

HY-144768

(R)-Chol-TPP

Liposome Others

(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

(R)-Chol-TPP	Liposome	Others
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

HY-103656

Tetraphenylporphyrin TPP; Tetraphenylporphine; meso-Tetraphenylporphyrin	Others	Cancer
Tetraphenylporphyrin (TPP) is a symmetrically substituted porphyrin-based heterocyclic compound and used as a structural block for supramolecular synthesis. Tetraphenylporphyrin derivatives can be used for cancer research .

HY-161048

PDH E1-IN-1

Others Others

PDH E1-IN-1 (compound 24) is a selective TPP-competitive PDH E1 with an IC₅₀ value of 0.99 μM .

PDH E1-IN-1	Others	Others
PDH E1-IN-1 (compound 24) is a selective TPP-competitive PDH E1 with an IC₅₀ value of 0.99 μM .

HY-144830

6BrCaQ	HSP	Cancer
6BrCaQ is a potent mitochondrial heat shock protein TRAP1 inhibitor, with antiproliferative activity. 6BrCaQ can be used in the synthesis of 6BrCaQ-TPP conjugates .

HY-151404

Antitumor agent-76

Apoptosis Cancer

Antitumor agent-76 (Compound TP-P1) is an orally active, rapid-release and water-soluble Triptolide (HY-32735) proagent with antitumor activity .
HY-P4470

Phe-Pro-Ala-pNA

Ser/Thr Protease Cancer

Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

Antitumor agent-76	Apoptosis	Cancer
Antitumor agent-76 (Compound TP-P1) is an orally active, rapid-release and water-soluble Triptolide (HY-32735) proagent with antitumor activity .

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

HY-144825

Chol-CTPP	Apoptosis Reactive Oxygen Species	Cancer
Chol-CTPP is a ligand with dual targeting effect on blood-brain barrier (BBB) and glioma cells. Lip-CTPP can be gained by Chol-CTPP and another mitochondria targeting ligand (Chol-TPP). Lip-CTPP is a promising potential carrier to exert the anti-glioma effect of doxorubicin (DOX) and lonidamine (LND) collaboratively. Lip-CTPP elevates the inhibition rate of tumor cell proliferation, migration and invasion, promote apoptosis and necrosis, and interfere with mitochondrial function .

HY-151556

Antifungal agent 45	Fungal	Infection
Antifungal agent 45 is with fungicidal activities. Antifungal agent 45 shows excellent characteristics superior to Kresoxim-methyl (HY-125776), in which the activity enhancement against Phytophthora capsici was the most remarkable, with an EC₅₀ value of about 5 μM .

BCN-OH endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne	Biochemical Assay Reagents
BCN-OH (endo-9-Hydroxymethylbicyclo[6.1.0]non-4-yne) is a mitochondrial probe based on the lyophilic bidentate bicyclic ligand BCN and is a control reagent for BCN-TPP. The TPP group is a reactive sulfenic acid probe that targets mitochondria. BCN-TPP is known to affect mitochondrial energy, causing a sharp decrease in basal respiration, causing it to exhibit faster reaction kinetics with sulfonated proteins. BCN-OH does not contain hydrophobic triphenylphosphonium (TPP) ions. Using BCN-OH as a control allows the TPP group to be safely introduced when designing sulfenic acid traps .

(R)-Chol-TPP	Drug Delivery
(R)-Chol-TPP a mitochondria targeting liposome ligand could be used in pH-redox responsive .

TPPS dihydrochloride	Biochemical Assay Reagents
TPPS dihydrochloride is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

TPP-1	PD-1/PD-L1	Cancer
TPP-1 is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function .

Phe-Pro-Ala-pNA	Ser/Thr Protease	Cancer
Phe-Pro-Ala-pNA is a chromogenic substrate of tripeptidyl peptidase. Phe-Pro-Ala-pNA can be used to test tripeptidyl peptidase activity .

TPP-1 TFA	PD-1/PD-L1	Cancer
TPP-1 TFA is a potent inhibitor of the PD-1/PD-L1 interaction. TPP-1 TFA binds specifically to PD-L1 with a high affinity (K_D=95 nM). TPP-1 TFA inhibits human tumor growth in vivo via reactivating T-cell function .

FRETS-VWF73	Peptides	Others
FRETS-VWF73 is a biological active peptide. (FRETS-VWF73 is a very powerful Fluorescence-Quenching Substrate for the VWF cleaving protease ADAMTS-13. It is commonly used as a useful tool for the rapid measurement of ADAMTS-13 activity in plasma and is a predictive marker for various thrombotic diseases like TPP. Our new substrate FRETS-VWF73 can be easily used with a 96-well format in commercial plate readers.)

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