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UDP-GlcNAz disodium is a substrate for UDP-GlcNAc:polypeptidyltransferase. UDP-GlcNAz serves as a sugar donor for the process catalyzed by the OGT enzyme and labels proteins through this process .
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .
UDP-sugar pyrophosphorylase (BlUSP) is the enzyme capable of activating glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc). UDP-sugar pyrophosphorylase (BlUSP) catalyzes a reversible transfer of the uridyl group from UTP to sugar-1-phosphate, producing UDP-sugar and pyrophosphate (PPi) .
UDP-rhamnose is one of the substrates for pectin synthesis in cell wall. UDP-rhamnose can be identified in fungi, it is one of the most common sugar donor in plants .
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .
UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT) .
UDP-β-D-glucose disodium is a the stereoisomer of UDP-α-D-glucose. UDP-β-D-glucose disodium is an oligosaccharide that can be used to synthesize glycoproteins and glycolipids. UDP-β-D-glucose disodium can be used as a substrate .
UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O[1][2].
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) Tris is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) disodium is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .
UDP-xylose is a natural product that could be isolated from Cryptococcus laurentii (NRRL Y-1401). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi .
UDP-Galactose is a monosaccharide involved in nucleotide sugar metabolism. UDP-Galactose and its derivatives act as a natural agonist for Gi protein-conjugated P2Y14 receptors in the immune system (IC50=0.67 μM, hP2Y14) .
UDP-xylose disodium is a natural product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi ..
UDP-Galactose disodium is a monosaccharide and a P2Y14 receptor agonist with an EC50 value of 0.67 μM. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5) .
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .
UDP-glucuronic acid trisodium (Uridine-5'-diphosphoglucuronic acid trisodium salt) is a critical precursor for essential glycoconjugates across biological kingdoms, ranging from mammalian glycosaminoglycans and plant cell wall polysaccharides to bacterial capsule glycoglycerolipids.
Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR .
Uridine 5′-diphosphoglucose- 13C (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycop
Uridine 5′-diphosphoglucose- 13C6 (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].
6-Azido-N-acetylgalactosamine-UDP (compound 5) is an active sugar donor in the beta-1, 3-N-Acetylhexaminyltransferase (LgtA)-catalyzed glycosylation of lactose .
JH-LPH-28, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-28 displays outstanding antibiotic activity with a MIC value of 0.83 μg/mL .
JH-LPH-33, a sulfonyl piperazine analog, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. JH-LPH-33 displays outstanding antibiotic activity with a MIC value of 0.66 μg/mL .
LpxH-IN-AZ1, a sulfonyl piperazine compound, is a potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor. LpxH-IN-AZ1 is a potent inhibitor of Klebsiella pneumoniae LpxH with IC50 of 0.36 μM .
LpxC-IN-5 is a potent non-hydroxamate LpxC (UDP-3-O-acyl-N-acetylglucosamine deacetylase) inhibitor with an IC50 of 20 nM. LpxC-IN-5 shows antibacterial activity against E. coli ATCC25922, P. aeruginosa ATCC27853, K. pneumoniae ATCC13883 and P. aeruginosa 5567 with MIC of 16, 4, 64, and 4 μg/mL, respectively .
PF-04753299 is a potent and selective UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitor. PF-04753299 is bactericidal for the gonococcal isolates. PF-04753299 inhibits E. coli, P. aeruginosa and K. pneumoniae strains with MIC90 values of 2 μg/ml, 4 μg/ml and 16 μg/ml, respectively. PF-04753299 is used for the study of gram-negative bacteria infection .
Nikkomycin Z, a nucleoside-peptide, is a selective competitive chitin synthesis inhibitor. Nikkomycin Z has antifungal effects and acts as a competitive analogue of the chitin synthase substrate UDP-N-acetylglucosamine .
Hecogenin is a steroid saponin isolated from Agave sisalana and is a selective inhibitor of human UDP-glucuronosyltransferases. Hecogenin has a wide spectrum of pharmacological activities, including anti-inflammatory, antifungal and gastroprotective effects .
D,L-erythro-PDMP is an erythro isomer of PDMP. D,L-erythro-PDMP causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .
UGM-IN-3 (compound 10a) is a UDP-galactopyranose mutase (UGM) inhibitor with a Kd of 66 μM. UGM-IN-3 inhibits the growth of Mycobacterium tuberculosis with a MIC value of 6.2 μg/mL .
D,L-erythro-PDMP hydrochloride is an erythro isomer of PDMP. D,L-erythro-PDMP hydrochloride causes growth inhibition of cultured rabbit skin fibroblasts. PDMP is an effective inhibitor of UDP-glucose:ceramide glucosyltransferase .
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
L-threo-PPMP is a GlcT (UDP-Glc: Ceramide β1,1glucosyltransferase) inhibitor. L-threo-PPMP inhibits glycosphingolipid biosynthesis and induces apoptosis. L-threo-PPMP has anti-cancer activity .
PSB 0474 (3-phenacyl-UDP) is a selective and potent P2Y6 receptor agonist with an EC50 of 70 nM . PSB 0474 inhibits cell proliferation, increases NO release in astrocytes and microglia cells. PSB 0474 induces astrocytes apoptosis .
Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule .
Antituberculosis agent-5 (compound 52) is a nitrofuranylamide derivative, inhibits M. tuberculosisUDP-Gal mutase. Antituberculosis agent-5 inhibits Glf activity with an IC50 value of 99 μM/mL and resists tuberculosis (TB) with a MIC value of 1.6 μg/mL .
beta-1,4-Galactosyltransferase 1 (Y285L) can enzymatic synthesis of the LacdiNAc motif. beta-1,4-Galactosyltransferase 1 (Y285L) can transfer of GalNAc from UDP-GalNAc .
beta-1, 3-N-Acetylhexaminyltransferase (LgtA) is a glycosyltransferase, is often used in biochemical studies. beta-1, 3-N-Acetylhexaminyltransferase (LgtA) catalyzes the transfer of N-acetylglucosamine from UDP-GlcNAc to N-acetyllactosamine and lactose .
N-Acetylglucosaminyltransferase V (MGAT4B) is the enzyme that catalyzes the formation of the β1,6-GlcNAc branch of N-glycans in the Golgi apparatus using UDP-GlcNAc as the donor substrate. N-Acetylglucosaminyltransferase V is involved in cancer malignancy and autoimmune disease etiology .
GlcNAc 1-P uridyltransferase (CjGlmU) is a sugar nucleotidyltransferase (SNT). GlcNAc 1-P uridyltransferase (CjGlmU) utilizes UTP and GlcNAc-1-P as its natural substrates, synthesizes UDP-GlcNAc. GlcNAc 1-P uridyltransferase (CjGlmU) has the potential for the research of antimicrobial agents .
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
beta-1,4-Galactosyltransferase (LgtB) (EC 2.4.1.90) (B4GALT1 (LgtB)) is often used in biochemical studies. beta-1,4-Galactosyltransferase (LgtB) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine .
Glucosylceramide synthase-IN-2 (compound T-690) is a potent, brain-penetrant and orally active glucosylceramide synthase (GCS) inhibitor with IC50s of 15 nM and 190 nM for human GCS and mouse GCS, respectively.Glucosylceramide synthase-IN-2 exhibits noncompetitive type inhibition with C8-ceramide and UDP-glucose.Glucosylceramide synthase-IN-2 can be used for Gaucher's disease research .
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation .
alpha-1,3-Galactosyltransferase (GTB) (alpha 1,3GT) catalyzes the synthesis of the xenoantigen or α-galactose (α-Gal) epitope. alpha-1,3-Galactosyltransferase (GTB) transfers galactose from UDP-Gal to type 1 or type 2, αFuc1→2βGal-R (H)-terminating acceptors .
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .
N-acetylglucosamine-1-P uridyltransferase (AGX1) (EC 2.3.1.157) (GlcNAc1pUT) is a bifunctional acetyltransferase/uridyltransferase. N-acetylglucosamine-1-P uridyltransferase (AGX1) binds GlcNAc-1-P and UTP, and catalyzes an uridyltransfer reaction to synthesize UDP-GlcNAc. N-acetylglucosamine-1-P uridyltransferase (AGX1) is a bifunctional enzyme exclusive to prokaryotes .
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer promotes the Wnt/β-catenin signaling pathway through abnormal O-glycosylation of CD44, thereby enhancing malignancy. N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .
alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species .
4-Hydroxyretinoic acid (4-HRA) is a naturally occurring retinoid derivative with diverse biological effects. 4-Hydroxyretinoic acid is formed from retinol catalyzed by cytochrome P-450 isozyme(s), and is mainly metabolized by the liver in the body. 4-Hydroxyretinoic acid also serves as the substrate for human liver microsomal UDP-glucuronosyltransferase(s) and recombinant UGT2B7. 4-Hydroxyretinoic acid regulates gene expression and cell differentiation via binding to nuclear receptor RAR (Retinoic Acid Receptor), and activates RARs and RXR-alpha, to induce cancer cell apoptosis. In addition, 4-Hydroxyretinoic acid is also involved in various physiological processes such as immune regulation, neuroprotection, and anti-oxidation .
UDP-GlcNAz disodium is a substrate for UDP-GlcNAc:polypeptidyltransferase. UDP-GlcNAz serves as a sugar donor for the process catalyzed by the OGT enzyme and labels proteins through this process .
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .
UDP-Glc dehydrogenase (UGDH) catalyzes is a NAD+-dependent enzyme that catalyzes the two-fold oxidation of UDP-glucose (UDP-Glc) to produce UDP-glucuronic acid. UDP-Glc dehydrogenase (UGDH) is a key enzyme in the nucleotide-sugar interconversion pathway necessary for biosynthesis of many cell-wall polysaccharides .
UDP-sugar pyrophosphorylase (BlUSP) is the enzyme capable of activating glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc). UDP-sugar pyrophosphorylase (BlUSP) catalyzes a reversible transfer of the uridyl group from UTP to sugar-1-phosphate, producing UDP-sugar and pyrophosphate (PPi) .
UDP-Glc 4-epimerase (GalE) is catalytically active enzyme. UDP-Glc 4-epimerase (GalE) catalyzes the reversible conversion of abundantly available UDP-glucose to UDP-galactose .
UDP-sugar pyrophosphorylase (AtUSP) is a broad substrate enzyme that synthesizes nucleotide sugars. UDP-sugar pyrophosphorylase catalyzes the conversion of various monosaccharide 1-phosphates to the respective UDP-sugars in the salvage pathway .
UDP-Galactose disodium is a monosaccharide and a P2Y14 receptor agonist with an EC50 value of 0.67 μM. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5) .
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .
GlcNAc 1-P uridyltransferase (PmGlmU) catalyzes high efficient synthesis of UDP-GlcNAc from GlcNAc-1-P and UTP. GlcNAc 1-P uridyltransferase (PmGlmU) is used to break down the pyrophosphate formed in the PmGlmU reaction to inorganic phosphate to shift the equilibrium of the coupled enzymatic reactions towards the formation of UDP-GlcNA .
beta-1,4-Galactosyltransferase (LgtE) (EB4GALT1 (LgtE)) catalyzes the reaction involving UDP-galactose and N-acetylglucosamine for the production of galactose beta-1,4-N-acetylglucosamine .
β-1,4-Galactosyltransferase 7 has exclusive specificity for the donor substrate UDP-galactose and all transfer galactose in a β-1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. .
GlcNAc 1-P uridyltransferase (CjGlmU) is a sugar nucleotidyltransferase (SNT). GlcNAc 1-P uridyltransferase (CjGlmU) utilizes UTP and GlcNAc-1-P as its natural substrates, synthesizes UDP-GlcNAc. GlcNAc 1-P uridyltransferase (CjGlmU) has the potential for the research of antimicrobial agents .
alpha-1,3-Galactosyltransferase (GTB) (alpha 1,3GT) catalyzes the synthesis of the xenoantigen or α-galactose (α-Gal) epitope. alpha-1,3-Galactosyltransferase (GTB) transfers galactose from UDP-Gal to type 1 or type 2, αFuc1→2βGal-R (H)-terminating acceptors .
alpha-1,3-Galactosyltransferase (a1,3GalT) (GGTA1) catalyzes the generation of the α-gal glycan via the transfer of a galactose (Gal) in α1-3 linkage, from a uridyl-diphosphate (UDP) donor onto the N-acetyllactosamine (Galβ1,4GlcNAc-R) of glycoproteins. alpha-1,3-Galactosyltransferase (a1,3GalT) is responsible for the synthesis of the α-galactose (α-Gal) epitope found in most mammalian species .
O-Linked GlcNAc transferase substrate is a biological active peptide. (A peptide substrate of O-linked GlcNAc transferase (OGT), a eukaryotic glycosyltransferase that uses UDP-GlcNAc as a glycosyl donor.)
MUC5AC-13 is a biological active peptide. (This glycopeptide is an N-acetyl galactosamine (GalNAc)-modified MUC5AC mucin peptide containing the single site of threonine 13 labeled with GalNAc (T*). Polypeptide N-acetylgalactosaminyltransferase (ppGaNTase) catalyzes the transfer of GalNAc from the nucleotide sugar UDP-GalNAc to threonine. The MUC5AC gene is mainly expressed in gastric and tracheo-bronchial mucosae, and some tumors.)
UDP-GalNAc (UDP-N-acetyl-D-galactosamine) disodium is a sugar nucleotide and a substrate of EpsC115. EpsC115 is an exopolymeric substances (EPS) N-terminal deletion mutant with the residue 1-115 deletion. UDP-GalNAc UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor .
UDP-rhamnose is one of the substrates for pectin synthesis in cell wall. UDP-rhamnose can be identified in fungi, it is one of the most common sugar donor in plants .
UDP-glucosamine (UDP-GlcNAc) disodium is a substrate for O-GlcNAc transferase, which catalyzes the attachment of O-GlcNAc to proteins. O-GlcNAcase catalyzes the removal of O-GlcNAc from proteins. UDP-glucosamine (UDP-GlcNAc) disodium is the end product of the hexosamine biosynthesis pathway, which is regulated primarily by glucose-6-phosphate-Glutamine:fructose-6-phosphate amidotransferase (GFAT) .
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) Tris is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .
UDP-3-O-acyl-GlcNAc (UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine) disodium is an E. coli metabolite that is involved in 3-deoxy-D-manno-octulosonate (KDO) biosynthesis pathway .
UDP-xylose is a natural product that could be isolated from Cryptococcus laurentii (NRRL Y-1401). UDP-xylose is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi .
UDP-Galactose is a monosaccharide involved in nucleotide sugar metabolism. UDP-Galactose and its derivatives act as a natural agonist for Gi protein-conjugated P2Y14 receptors in the immune system (IC50=0.67 μM, hP2Y14) .
UDP-xylose disodium is a natural product that could be isolated from Cryptococcus laurentii (N RRL Y-1401). UDP-xylose disodium is a sugar donor for the synthesis of glycoproteins, polysaccharides, various metabolites, and oligosaccharides in plants, vertebrates, and fungi ..
UDP-Galactose disodium is a monosaccharide and a P2Y14 receptor agonist with an EC50 value of 0.67 μM. UDP-Galactose disodium is a substrate for the transferase beta-1, 4 galactosyltransferase V (B4GALT5) .
Uridine diphosphate glucuronic acid (UDP-GlcA) ammonium is a cofactor that is formed by the catalytic activity of UDP-glucose dehydrogenase. Uridine diphosphate glucuronic acid (ammonium) is a central precursor in sugar nucleotide biosynthesis and common substrate for C4-epimerases and decarboxylases releasing UDP-galacturonic acid (UDP-GalA) and UDP-pentose products, respectively. Uridine diphosphate glucuronic acid (ammonium), as a glucuronic acid donor, can be used for for the research of the conjugation of bilirubin in the endoplasmic recticulum .
Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR .
CMP-Sialic acid (CMP-Neu5Ac) sodium salt is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid sodium salt provides a substrate for Golgi sialyltransferases. CMP-Sialic acid sodium salt is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates .
Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule .
Gitogenin is a natural steroid isolated from the whole plant of Tribulus longipetalus. Gitogenin is a selective inhibitor of UDP-glucuronosyltransferase 1A4 (UGT1A4) and enzyme α-glucosidase with IC50 values of 0.69 μM (use trifluoperazine as a substrate) and 37.2 μM, respectively, and does not inhibit the activities of major human cytochrome P450 isoforms .
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC50 and Ki values lower than 5 μM) .
α-Angelica lactone is a naturally occurring anticarcinogen and an vinylogous nucleophile. α-Angelica lactone can give the chiral δ-amino γ,γ-disubstituted butenolide carbonyl derivatives and exhibitselectrophilic trapping at the γ-carbon. α-Angelica lactone exerts strong chemoprotective effects by selective enhancement of glutathione-S-thansferase (GST) and UDP-glucononosyltransferase (UGT) detoxification enzymes .
GALE proteins catalyze the reversible epimerization of UDP-glucose to UDP-galactose, and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. UDP-glucose 4-epimerase/GALE Protein, Human (His) is the recombinant human-derived UDP-glucose 4-epimerase/GALE protein, expressed by E. coli , with N-6*His labeled tag. The total length of UDP-glucose 4-epimerase/GALE Protein, Human (His) is 348 a.a., with molecular weight of ~38.23 kDa.
The GALNT7 protein serves as an indispensable glycopeptidyl transferase for O-linked oligosaccharide biosynthesis. Its enzymatic activity involves catalyzing the transfer of N-acetyl-D-galactosamine residues to pre-existing glycosylated peptides. GALNT7 Protein, Human (HEK293, His) is the recombinant human-derived GALNT7 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GALNT7 Protein, Human (HEK293, His) is 628 a.a., with molecular weight of 65-80 kDa.
SLC35A2 is a key transmembrane protein that acts as an antiporter to transport uridine diphosphate galactose (UDP-galactose) into the Golgi apparatus. The process involves the exchange of UDP-galactose with UMP and exhibits versatility through exchange with AMP and CMP. SLC35A2 Protein, Human (Sf9, His, MBP, FLAG) is the recombinant human-derived SLC35A2 protein, expressed by Sf9 insect cells , with N-MBP, C-Flag, N-8*His labeled tag. The total length of SLC35A2 Protein, Human (Sf9, His, MBP, FLAG) is 395 a.a., .
UGCG proteins play a key role in the glucosphingolipid (GSL) synthesis pathway based on glucosylceramide in the Golgi apparatus, catalyzing the key step of transferring glucose to ceramide to form glucosylceramide (GlcCer). GSLs have effects on membrane microdomains, affecting processes such as membrane trafficking and signal transduction. UGCG Protein, Human (Cell-Free, His) is the recombinant human-derived UGCG protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGCG Protein, Human (Cell-Free, His) is 394 a.a., with molecular weight of 47.7 kDa.
The UGT2B17 protein is a key UDP-glucuronosyltransferase (UGT) that directs phase II biotransformation by conjugating lipophilic substrates with glucuronic acid. This process enhances water solubility and promotes excretion of metabolites into urine or bile. UGT2B17 Protein, Human (Cell-Free, His) is the recombinant human-derived UGT2B17 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGT2B17 Protein, Human (Cell-Free, His) is 507 a.a., with molecular weight of 64.5 kDa.
LpxC protein serves as a key enzyme in lipid A biosynthesis by catalyzing the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine, marking a key and crucial step in this important pathway. Through this enzymatic process, LpxC promotes the conversion of its substrate into UDP-3-O-myristoylglucosamine and acetate, making a significant contribution to lipid A biosynthesis. LpxC Protein, E.coli (His) is the recombinant E. coli-derived LpxC protein, expressed by E. coli , with N-His labeled tag. The total length of LpxC Protein, E.coli (His) is 305 a.a., with molecular weight of ~38.0 kDa.
The UGT1A7 protein is a UDP-glucuronosyltransferase (UGT) that plays a key catalytic role in phase II reactions, conjugating lipophilic substrates with glucuronic acid to enhance water solubility and promote excretion. This enzymatic activity is critical for the elimination of drugs, xenobiotics, and endogenous compounds. UGT1A7 Protein, Human (Cell-Free, His) is the recombinant human-derived UGT1A7 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGT1A7 Protein, Human (Cell-Free, His) is 505 a.a., with molecular weight of 60.0 kDa.
UGT1A8 protein is a key UDP-glucuronosyltransferase (UGT) that plays a vital role in phase II biotransformation by catalyzing the conjugation of lipophilic substrates with glucuronic acid, enhancing water solubility, and promoting excretion. role. UGT1A8 Protein, Human (Cell-Free, His) is the recombinant human-derived UGT1A8 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of UGT1A8 Protein, Human (Cell-Free, His) is 505 a.a., with molecular weight of 59.9 kDa.
The UGT1A1 protein is an important UDP-glucuronosyltransferase (UGT) that drives phase II biotransformation by conjugating lipophilic substrates with glucuronic acid, enhancing water solubility, and promoting excretion. UGT1A1 is critical for the elimination of drugs, xenobiotics, and endogenous compounds and exhibits multiple substrate specificities, glucuronidating estrogens, bilirubin, phytoestrogens such as genistein and daidzein, and SN -38. UGT1A1 Protein, Human (P.pastoris, His) is the recombinant human-derived UGT1A1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of UGT1A1 Protein, Human (P.pastoris, His) is 508 a.a., with molecular weight of ~70.0 kDa.
ALG13 protein is suggested to be a multifunctional enzyme with glycosyltransferase and deubiquitinase activities, playing a role in the second step of the dolichol-linked oligosaccharide pathway for protein N-glycosylation. This implies ALG13's involvement in vital cellular processes, bridging glycosylation and deubiquitination activities and highlighting its potential significance in regulating protein modifications and cellular pathways. ALG13 Protein, Human is the recombinant human-derived ALG13 protein, expressed by E. coli , with tag free. The total length of ALG13 Protein, Human is 152 a.a., .
ALG13 protein is suggested to be a multifunctional enzyme with glycosyltransferase and deubiquitinase activities, playing a role in the second step of the dolichol-linked oligosaccharide pathway for protein N-glycosylation. This implies ALG13's involvement in vital cellular processes, bridging glycosylation and deubiquitination activities and highlighting its potential significance in regulating protein modifications and cellular pathways. ALG13 Protein, Human (His) is the recombinant human-derived ALG13 protein, expressed by E. coli , with N-6*His labeled tag. The total length of ALG13 Protein, Human (His) is 152 a.a., .
GALNT3 Protein initiates O-linked oligosaccharide biosynthesis by transferring an N-acetyl-D-galactosamine residue to serine or threonine on protein receptors, including HIV envelope glycoproteins (gp120), EA2, MUC2, MUC1A, MUC5AC, and possibly fibronectin. GALNT3 also glycosylates FGF23 in vivo. GALNT3 Protein, Human (HEK293, His) is the recombinant human-derived GALNT3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GALNT3 Protein, Human (HEK293, His) is 596 a.a., with molecular weight of ~80.0 kDa.
Putative Polypeptide N-Acetylgalactosaminyltransferase-Like Protein 1; Polypeptide GalNAc Transferase-Like Protein 1; GalNAc-T-Like Protein 1; pp-GaNTase-Like Protein 1; Protein-UDP Acetylgalactosaminyltransferase-Like Protein 1; UDP-GalNAc:Polypeptide N-Acety
GALNTL1 protein plays a pivotal role in O-linked oligosaccharide biosynthesis by catalyzing the crucial initial step—the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. This enzymatic activity is fundamental for the glycosylation processes that modulate the structure and function of various proteins, impacting diverse cellular functions. GALNTL1 Protein, Human (HEK293, His) is the recombinant human-derived GALNTL1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GALNTL1 Protein, Human (HEK293, His) is 532 a.a., with molecular weight of 62-65 kDa.
The POMGNT1 protein crucially directs O-mannosyl glycosylation, which adds N-acetylglucosamine to O-linked mannose residues on glycoproteins. It catalyzes GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr on α-dystroglycan and other O-mannosylated proteins, laying the foundation for subsequent carbohydrate addition. POMGNT1 Protein, Human (HEK293, His) is the recombinant human-derived POMGNT1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of POMGNT1 Protein, Human (HEK293, His) is 602 a.a., with molecular weight of ~74.0 kDa.
Uridine 5′-diphosphoglucose- 13C6 (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt[1]. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycoproteins, and glycolipids in animal tissues and in some microorganisms. Uridine-5′-diphosphoglucose is an agonist of the P2Y14 receptor, a neuroimmune system GPCR[2].
UDP-GlcNAc- 13C (disodium) is the 13C labeled UDP-GlcNAc Disodium Salt. UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (O[1][2].
Uridine 5′-diphosphoglucose- 13C (disodium) is the 13C labeled Uridine 5′-diphosphoglucose disodium salt. Uridine 5′-diphosphoglucose disodium salt (UDP-D-Glucose disodium salt) is the precursor of glucose-containing oligosaccharides, polysaccharides, glycop
UDP-GalNAz disodium (UDP-N-azidoacetylgalactosamine disodium) is the analogue of UDP-GalNAc. UDP-GalNAc is the donor substrate of many N-acetylgalactosaminyltransferases, enzymes which transfer GalNAc from the nucleotide sugar to a saccharide or peptide acceptor . UDP-GalNAz (disodium) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
UDP-GlcNAz disodium is a substrate for UDP-GlcNAc:polypeptidyltransferase. UDP-GlcNAz serves as a sugar donor for the process catalyzed by the OGT enzyme and labels proteins through this process .
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