UGT1A1

By Targets:	Autophagy (1) Cytochrome P450 (1) Estrogen Receptor/ERR (2) HBV (1) HIV (2) HIV Integrase (2) Prostaglandin Receptor (1) Small Interfering RNA (siRNA) (1) UGT (3)
By Research Areas:	Cancer (1) Endocrinology (3) Infection (3) Inflammation/Immunology (1) Metabolic Disease (4)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111832

1,2,3,6-Tetragalloylglucose TeGG	UGT	Metabolic Disease
1,2,3,6-Tetragalloylglucose is a potent UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) inhibitor, with a K_i of 1.68 μM .

HY-RS15426

UGT1A1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
UGT1A1 Human Pre-designed siRNA Set A contains three designed siRNAs for UGT1A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

UGT1A1 Human Pre-designed siRNA Set A UGT1A1 Human Pre-designed siRNA Set A

HY-160250

UGT1A1-IN-1	UGT	Metabolic Disease
UGT1A1-IN-1 (compound 2) is a non-competitive inhibitor of *UGT1A1, which can inhibit the 1-O-glucuronidation process mediated by UGT1A1* with a K_i value of 5.02 μM. UGT1A1-IN-1 (compound 2) can bind on *UGT1A1* at the same ligand-binding site as bilirubin (HY-N0323). UGT1A1-IN-1 can serve as a ‘turn-on’ fluorescent probe substrate for UGT1A1 .

HY-100319

UK-157147

UGT Metabolic Disease

UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a K_m value of 105 μM.

UK-157147	UGT	Metabolic Disease
UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a K_m value of 105 μM.

HY-124364

RO6889678	HBV Cytochrome P450	Infection Metabolic Disease
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation .

HY-135581

Raloxifene 6-glucuronide	Estrogen Receptor/ERR	Endocrinology
Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC₅₀ of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression .

HY-N0372

Licochalcone A Maximum Cited Publications 8 Publications Verification Licochalcone-A	Autophagy	Cancer
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium	Estrogen Receptor/ERR	Endocrinology
Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].

HY-15592A

Cabotegravir sodium 5 Publications Verification GSK-1265744 sodium; S/GSK1265744 sodium	HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) sodium is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir sodium is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir sodium can be used to research AIDS .

HY-15592

Cabotegravir 5 Publications Verification GSK-1265744; S/GSK1265744	HIV HIV Integrase	Infection
Cabotegravir (GSK-1265744) is a orally active and long-acting HIV integrase strand transfer inhibitor and organic anion transporter 1/3 (OAT1/OAT3) inhibitor with IC₅₀ values of 2.5 nM, 0.41 μM and 0.81 μM for HIV_ADA, OAT3 and OAT1, respectively. Cabotegravir is primarily metabolized by uridine diphosphate glucuronosyltransferase (UGT) 1A1, with low potential to interact with other antiretroviral agents (ARVs). Cabotegravir can be used to research AIDS .

HY-111539

BAY-1316957	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
BAY-1316957 is a potent, selective and orally active prostaglandin E2 receptor subtype 4 (EP4-R) antagonist with an IC₅₀ of 15.3 nM for human EP4-R. BAY-1316957 has excellent agent metabolism and pharmacokinetics properties, and can be used for endometriosis research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-111832

1,2,3,6-Tetragalloylglucose TeGG	Structural Classification other families Classification of Application Fields Source classification Phenols Polyphenols Metabolic Disease Plants Disease Research Fields	UGT
1,2,3,6-Tetragalloylglucose is a potent UDP glucuronosyltransferase 1 family, polypeptide A1 (UGT1A1) inhibitor, with a K_i of 1.68 μM .

HY-N0372

Licochalcone A 5+ Cited Publications Licochalcone-A	Structural Classification Chalcones Flavonoids Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer	Autophagy
Licochalcone A (LCA), a flavonoid isolated, presents obvious anti-cancer effects, displays broad-spectrum inhibition against UDP-glucuronosyltransferases (UGTs) . Licochalcone A (LCA) exhibits strong inhibitory effects against UGT1A1, 1A3, 1A4, 1A6, 1A7, 1A9, and 2B7 (both IC₅₀ and K_i values lower than 5 μM) .

Cat. No.	Compare	Product Name	Species	Source

HY-P72277

	UGT1A1 Protein, Human (P.pastoris, His) BILIQTL1; UDP-glucuronosyltransferase 1-1	Human	P. pastoris
	The UGT1A1 protein is an important UDP-glucuronosyltransferase (UGT) that drives phase II biotransformation by conjugating lipophilic substrates with glucuronic acid, enhancing water solubility, and promoting excretion. UGT1A1 is critical for the elimination of drugs, xenobiotics, and endogenous compounds and exhibits multiple substrate specificities, glucuronidating estrogens, bilirubin, phytoestrogens such as genistein and daidzein, and SN -38. UGT1A1 Protein, Human (P.pastoris, His) is the recombinant human-derived UGT1A1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of UGT1A1 Protein, Human (P.pastoris, His) is 508 a.a., with molecular weight of ~70.0 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-135581S1

Raloxifene 6-glucuronide-d4 lithium
Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].

Raloxifene 6-glucuronide-d4 lithium

Raloxifene 6-glucuronide-d₄ (lithium) is deuterium labeled Raloxifene 6-glucuronide. Raloxifene 6-glucuronide is a primary metabolite of Raloxifene. Raloxifene 6-glucuronide is mediated mostly by UGT1A1 and UGT1A8. Raloxifene 6-glucuronide binds to estrogen receptor with an IC50 of 290 μM. Raloxifene is a selective and nonsteroidal estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[1][2][3].

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