ammonia

By Targets:	Apoptosis (1) Bacterial (3) Biochemical Assay Reagents (2) Drug Metabolite (1) Endogenous Metabolite (3) Fluorescent Dye (1) NO Synthase (1) Reactive Oxygen Species (1) Sigma Receptor (1) TMV (1)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (1) Infection (4) Inflammation/Immunology (2) Metabolic Disease (7)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents	Endocrinology
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-B0543

Allylthiourea

Thiosinamine; N-Allylthiourea
Reactive Oxygen Species Metabolic Disease

Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

Allylthiourea Thiosinamine; N-Allylthiourea	Reactive Oxygen Species	Metabolic Disease
Allylthiourea is a metabolic inhibitor that selective inhibits ammonia oxidation.

HY-N11886

5-NH2-Baicalein	Drug Metabolite	Others
5-NH2-Baicalein is an aminated metabolite of Baicalein (HY-N0196). 5-NH2-Baicalein can be used for research of ammonia and ammonia-associated chronic diseases .

HY-E70002

Deamino-NADPH

Biochemical Assay Reagents Others

Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .
HY-107792

Benurestat

Bacterial Infection

Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research .
HY-P2876

Tryptophanase

Bacterial Infection

Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

Deamino-NADPH	Biochemical Assay Reagents	Others
Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .

Benurestat	Bacterial	Infection
Benurestat is an orally active urease inhibitor. Benurestat can be used for infected ureolysis research .

Tryptophanase	Bacterial	Infection
Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

HY-134230

L-2-Aminooxy-3-phenylpropanoic acid L-α-aminooxy-β-phenylpropionic acid; AOPP	Others	Metabolic Disease
L-2-Aminooxy-3-phenylpropanoic acid is a potent inhibitor of L-phenylalanine ammonia-lyase .

HY-134230A

L-2-Aminooxy-3-phenylpropanoic acid hydrobromide L-α-aminooxy-β-phenylpropionic acid hydrobromide; AOPP hydrobromide	Others	Metabolic Disease
L-2-Aminooxy-3-phenylpropanoic acid hydrobromide is a potent inhibitor of L-phenylalanine ammonia-lyase .

HY-P2767

Urease, Jack bean	Bacterial	Others
Urease, Jack bean is derived from jack bean and Catalyzes hydrolysis of urea to carbon dioxide and ammonia. Urease, Jack bean is useful in the determination of urea in body fluids.

HY-B2087

Glycerol phenylbutyrate HPN-100	Sigma Receptor	Cardiovascular Disease
Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pK_i of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger agent .

HY-P2987

L-Amino acid oxidase	Endogenous Metabolite	Metabolic Disease
L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia .

HY-P2736

Amidase	Endogenous Metabolite	Metabolic Disease
Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .

HY-D2166

AF 594 NHS ester	Fluorescent Dye	Others
AF 594 NHS ester is a derivative of the red fluorescent dye AF 594 with high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 NHS ester can form an ester bond by reacting the NHS group with ammonia.

HY-A0282

L-Ornithine L-aspartate	Others	Metabolic Disease Inflammation/Immunology
L-Ornithine L-aspartate is a stable salt of two natural nonessential L-amino acids with oral activity: ornithine and aspartic acid. L-Ornithine L-aspartate lowers blood ammonia concentration and to eliminate symptoms of hepatic encephalopathy associated with liver cirrhosis. L-Ornithine L-aspartate also improves mitochondrial functions .

HY-B1529A

Citric acid triammonium 2 Publications Verification Triammonium citrate	Endogenous Metabolite Apoptosis	Infection Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Citric acid triammonium (Triammonium citrate) is formed by Citric acid (HY-N1428) reacting with ammonia in a molar ratio of 1:3. Citric acid triammonium can be used as the carbon source to prepare carbon quantum dots (CDs). Citric acid triammonium with higher nitrogen components might promote the nitrogen-based functional groups in CDs, leading to a more efficient emission-color tunability .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	NO Synthase	Others
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-N1836

3-Acetonyl-3-hydroxyoxindole 3-Hydroxy-3-acetonyloxindole	TMV	Infection
3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .

Cat. No.	Product Name

HY-L064

Glutamine Metabolism Compound Library	917 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH. Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment. MCE owns a unique collection of 917 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Glutamine Metabolism Compound Library

917 compounds

Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.

Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.

MCE owns a unique collection of 917 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.

Cat. No.	Product Name	Type

HY-D2166

AF 594 NHS ester	Fluorescent Dyes/Probes
AF 594 NHS ester is a derivative of the red fluorescent dye AF 594 with high fluorescence quantum yield and high photostability (maximum absorption wavelength of 586 nm, maximum emission wavelength of 613 nm). AF 594 NHS ester can form an ester bond by reacting the NHS group with ammonia.

Cat. No.	Product Name	Type

HY-E70003

Glutamate dehydrogenase	Biochemical Assay Reagents
Glutamate dehydrogenase is an enzyme in both prokaryotes and eukaryotic mitochondria. Glutamate dehydrogenase can be used for the enzymatic determination of ammonia, alpha-ketoglutaric acid, L-glutamate and urease .

HY-P2951

*Phenylalanine ammonia-lyase*	Biochemical Assay Reagents
Phenylalanine ammonia-lyase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-E70002

Deamino-NADPH

Biochemical Assay Reagents

Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .
HY-P2876

Tryptophanase

Biochemical Assay Reagents

Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

Deamino-NADPH	Biochemical Assay Reagents
Deamino-NADPH is a 2'-phosphorylated coenzyme. Deamino-NADPH can be used in ammonia determination .

Tryptophanase	Biochemical Assay Reagents
Tryptophanase, a bacterial enzyme, catalyzes degradation of tryptophan to indole, pyruvate and ammonia .

HY-P2987

L-Amino acid oxidase	Biochemical Assay Reagents
L-Amino acid oxidase is a homodimeric proteins containing flavin adenine dinucleotide. L-Amino acid oxidase can catalyze the stereospecific oxidative deamination of L-amino acids to α-keto acids and ammonia .

HY-P2736

Amidase	Biochemical Assay Reagents
Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .

HY-P2965

L-Lysine α-oxidase	Biochemical Assay Reagents
L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity .

HY-B1529A

Citric acid triammonium 2 Publications Verification Triammonium citrate	Biochemical Assay Reagents
Citric acid triammonium (Triammonium citrate) is formed by Citric acid (HY-N1428) reacting with ammonia in a molar ratio of 1:3. Citric acid triammonium can be used as the carbon source to prepare carbon quantum dots (CDs). Citric acid triammonium with higher nitrogen components might promote the nitrogen-based functional groups in CDs, leading to a more efficient emission-color tunability .

Cat. No.	Product Name	Target	Research Area

HY-P2951

*Phenylalanine ammonia-lyase*	Peptides	Others
Phenylalanine ammonia-lyase is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-P2736

Amidase	Endogenous Metabolite	Metabolic Disease
Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes .

HY-W142169

N-Formyl-L-histidine Formyl-L-histidine	Peptides	Others
N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a K_i value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a K_i value of 4.26 mM .

HY-P2965

L-Lysine α-oxidase	Peptides	Cancer
L-Lysine α-oxidase is a potent anticancer agent. L-Lysine α-oxidase also a L-amino acid oxidase, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. L-Lysine α-oxidase shows cytotoxicity and anticancer activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B1529A

Citric acid triammonium 2 Publications Verification Triammonium citrate	Infection Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Apoptosis
Citric acid triammonium (Triammonium citrate) is formed by Citric acid (HY-N1428) reacting with ammonia in a molar ratio of 1:3. Citric acid triammonium can be used as the carbon source to prepare carbon quantum dots (CDs). Citric acid triammonium with higher nitrogen components might promote the nitrogen-based functional groups in CDs, leading to a more efficient emission-color tunability .

HY-B1142

Lipoamide 5 Publications Verification (±)-α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Other Diseases Endogenous metabolite Disease Research Fields	NO Synthase
Lipoamide ((±)-α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway .

HY-N11886

5-NH2-Baicalein	Structural Classification Flavonoids Classification of Application Fields Animals Flavones Source classification Other Diseases Endogenous metabolite Disease Research Fields	Drug Metabolite
5-NH2-Baicalein is an aminated metabolite of Baicalein (HY-N0196). 5-NH2-Baicalein can be used for research of ammonia and ammonia-associated chronic diseases .

HY-N1836

3-Acetonyl-3-hydroxyoxindole 3-Hydroxy-3-acetonyloxindole	Infection Alkaloids Acanthaceae Classification of Application Fields Source classification Baphicacanthus cusia (Nees) Bremek. Plants Disease Research Fields Indole Alkaloids	TMV
3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .

Species:	Human (2)
Tag:	His (3) Flag (1)
Source:	E. coli (3)

Cat. No.	Compare	Product Name	Species	Source

HY-P70294

	Glutamine synthetase/GLUL Protein, Human (His) rHuGlutamine synthetase/GLUL, His; Glutamine Synthetase; GS; Glutamate Decarboxylase; Glutamate--ammonia Ligase; GLUL; GLNS	Human	E. coli
	GLUL proteins catalyze the conversion of glutamate and ammonia to glutamine. Glutamine synthetase/GLUL Protein, Human (His) is the recombinant human-derived Glutamine synthetase/GLUL protein, expressed by E. coli , with C-6*His labeled tag. The total length of Glutamine synthetase/GLUL Protein, Human (His) is 372 a.a., with molecular weight of 40-50 kDa.

HY-P702095

	TAL Protein, Rhodotorula glutinis (FLAG, His) TAL; Tyrosine ammonia lyase	Others	E. coli
	TAL protein is an important member of the PAL/histidinase family and participates in important biological processes. As part of this family, TALs may have conserved features that may contribute to enzymatic activity in histidine metabolism. TAL Protein, Rhodotorula glutinis (FLAG, His) is the recombinant TAL protein, expressed by E. coli , with N-6*His, N-Flag labeled tag. The total length of TAL Protein, Rhodotorula glutinis (FLAG, His) is 693 a.a., .

HY-P71445

	CPS1/CPSase I Protein, Human (His) Carbamoyl phosphate synthase; Carbamoyl phosphate synthase mitochondrial; Carbamoyl phosphate synthase; Carbamoyl phosphate synthetase 1; Carbamoyl phosphate synthetase 1 mitochondrial; Carbamoyl phosphate synthetase I; Carbamoyl-phosphate synthase [ammonia]; Carbamoyl-phosphate synthetase I; Carbamoylphosphate synthase; Carbamoylphosphate synthetase 1; Carbamoylphosphate synthetase I; CPS 1; Cps1; CPSase 1; CPSase I; CPSASE1; mitochondrial; MS738	Human	E. coli
	The CPS1/CPSase I protein is critical in participating in the urea cycle and is essential for the elimination of excess ammonia in urea-bearing animals. This essential enzyme converts toxic ammonia (a byproduct of amino acid catabolism) into urea, promoting safe excretion. CPS1/CPSase I Protein, Human (His) is the recombinant human-derived CPS1/CPSase I protein, expressed by E. coli , with N-His labeled tag. The total length of CPS1/CPSase I Protein, Human (His) is 147 a.a., with molecular weight of ~20.5 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

ammonia

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Recombinant Proteins

Natural
Products