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Results for "

chymase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cathepsin (1) Elastase (1) ERK (3)
By Research Areas:	Cardiovascular Disease (5) Inflammation/Immunology (4) Metabolic Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109059

Fulacimstat 1 Publications Verification BAY1142524	Others	Cardiovascular Disease
Fulacimstat is an orally available *chymase* inhibitor, with IC₅₀s of 4, 3 nM for human and hamster chymase enzyme, respectively.

HY-12370

TY-51469

Others Inflammation/Immunology

TY-51469 is a chymase inhibitor with IC₅₀s for simian and human chymases of 0.4 and 7.0 nM, respectively.
HY-U00282

Chymase-IN-2

Others Inflammation/Immunology

Chymase-IN-2 is a chymase modulator which is useful in the treatment of inflammatory and serine protease mediated disorders.
HY-100269

Chymase-IN-1

Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC₅₀ of 29 nM.

TY-51469	Others	Inflammation/Immunology
TY-51469 is a *chymase* inhibitor with IC₅₀s for simian and human chymases of 0.4 and 7.0 nM, respectively.

Chymase-IN-2	Others	Inflammation/Immunology
Chymase-IN-2 is a chymase modulator which is useful in the treatment of inflammatory and serine protease mediated disorders.

Chymase-IN-1
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell *chymase* with an IC₅₀ of 29 nM.

HY-122161

JNJ-10311795 RWJ-355871	Cathepsin	Inflammation/Immunology
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (K_i = 38 nM) and mast cell *chymase* (K_i = 2.3 nM), exhibits noteworthy antiinflammatory activity .

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159

Endothelin-1 (1-31) (Human)	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159A

Endothelin-1 (1-31) (Human) TFA 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .

HY-126988

SP-Chymostatin B α-MAPI	Elastase	Others
SP-Chymostatin B (α-MAPI) is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, H, and L. SP-Chymostatin B weakly inhibits human leucocyte elastase .

Cat. No.	Product Name	Type

HY-131162

*Chymase*	Biochemical Assay Reagents
Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies .

Cat. No.	Product Name	Target	Research Area

HY-16707

CH 5450 Z-Ile-Glu-Pro-Phe-Ome	Peptides	Inflammation/Immunology
CH 5450 (Z-Ile-Glu-Pro-Phe-Ome) is a selective short peptide human cardiac *chymase* inhibitor. CH-5450 inhibits the action of rat MAB elastase 2 on substrate Ang I with an IC₅₀ value of 49 µM and N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide with an IC₅₀ value of 4.8 µM .

HY-P1347A

RETF-4NA TFA

Peptides Metabolic Disease

RETF-4NA TFA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M .
HY-P1347

RETF-4NA

Peptides Metabolic Disease

RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M .

RETF-4NA TFA	Peptides	Metabolic Disease
RETF-4NA TFA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M .

RETF-4NA	Peptides	Metabolic Disease
RETF-4NA, a chymase-specific substrate, is a sensitive and selective substrate for chymase when free or bound to α₂M .

HY-P4159B

Endothelin-1 (1-31) (Human) acetate	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) acetate is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) acetate is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159

Endothelin-1 (1-31) (Human)	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) is derived from the selective hydrolysis of big ET-1 by chymase .

HY-P4159A

Endothelin-1 (1-31) (Human) TFA 1 Publications Verification	ERK	Cardiovascular Disease
Endothelin-1 (1-31) (Human) TFA is a potent vasoconstrictor and hypertensive agent. Endothelin-1 (1-31) (Human) TFA is derived from the selective hydrolysis of big ET-1 by chymase .

Species:	Human (1) Mouse (1)
Tag:	His (2)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74252

	Chymase/CMA1 Protein, Human (sf9, His) Alpha-chymase; Mast cell chymase 1; Mast cell protease 5; mMCP-5	Human	Sf9 insect cells
	Chymase/CMA1 Protein, a secreted protease from mast cells, plays a significant role in generating vasoactive peptides, degrading the extracellular matrix, and regulating gland secretion. Chymase/CMA1 Protein, Human (sf9, His) is the recombinant human-derived Chymase/CMA1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of Chymase/CMA1 Protein, Human (sf9, His) is 247 a.a., with molecular weight of ~33 kDa.

HY-P72290

	Chymase/CMA1 Protein, Mouse (His) Alpha-chymase; Mast cell chymase 1; Mast cell protease 5; mMCP-5; Mast cell protease I	Mouse	E. coli
	Chymase/CMA1 Protein, a prominent secreted protease in mast cells, is implicated in various physiological processes, including the generation of vasoactive peptides, extracellular matrix degradation, and the regulation of gland secretion. Chymase/CMA1 Protein, Mouse (His) is the recombinant mouse-derived Chymase/CMA1 protein, expressed by E. coli , with N-His labeled tag. The total length of Chymase/CMA1 Protein, Mouse (His) is 225 a.a., with molecular weight of ~29.2 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P81884

Mast Cell Chymase Antibody (YA1629)

chymase 1; chymase; CMA1; CYH; CYM; Mcp-5; MCP3P; Mcpt5; MCT1; MMCP-5
WB, IHC-P Human

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