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Results for "

diABZI

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-112921A
    diABZI STING agonist-1
    Maximum Cited Publications
    20 Publications Verification

    		 STING Inflammation/Immunology
    diABZI STING agonist-1 is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    <em>diABZI</em> STING agonist-1
  • HY-112921B
    diABZI STING agonist-1 trihydrochloride
    Maximum Cited Publications
    20 Publications Verification

    		 STING Inflammation/Immunology Cancer
    diABZI STING agonist-1 (trihydrochloride) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    <em>diABZI</em> STING agonist-1 trihydrochloride
  • HY-137320
    diABZI-C2-NH2

    		STING Cancer
    diABZI-C2-NH2, an active analogue containing a primary amine functionality, is a STING agonist .
    <em>diABZI</em>-C2-NH2
  • HY-112921
    diABZI STING agonist-1 (Tautomerism)

    		STING Inflammation/Immunology
    diABZI STING agonist-1 Tautomerism (compound 3) is a selective stimulator of interferon genes (STING) receptor agonist, with EC50s of 130, 186 nM for human and mouse, respectively.
    <em>diABZI</em> STING agonist-1 (Tautomerism)
  • HY-158048
    UNC9036

    		PROTACs STING Inflammation/Immunology
    UNC9036 is a PROTAC-based STING degrader, with a DC50 of 227 nM. UNC9036-mediated STING degradation is proteasome and VHL dependent (Srtucture Note: Red, STING agonist diABZI (HY-112921A); Blue, VHL ligand VH032 (HY-120217); Black, linker) .
    UNC9036
  • HY-103665
    STING agonist-3
    5+ Cited Publications

    		 STING Cancer
    STING agonist-3, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pIC50 of 7.5 and 9.5, respectively. STING agonist-3 has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
    STING agonist-3
  • HY-103665A
    STING agonist-3 trihydrochloride
    5+ Cited Publications

    		 STING Cancer
    STING agonist-3 trihydrochloride, extracted from patent WO2017175147A1 (example 10), is a selective and non-nucleotide small-molecule STING agonist with a pEC50 and pEC50 of 7.5 and 9.5, respectively. STING agonist-3 trihydrochloride has durable anti-tumor effect and tremendous potential to improve treatment of cancer .
    STING agonist-3 trihydrochloride
  • HY-123943
    STING agonist-4
    4 Publications Verification

    		 STING Cancer
    STING agonist-4 is an stimulator of Interferon Genes (STING) receptor agonist with an apparent inhibitory constant (IC50) of 20 nM. STING agonist-4 is a two symmetry-related amidobenzimidazole (ABZI)-based compound to create linked ABZIs (diABZIs) with enhanced binding to STING and cellular function .
    STING agonist-4

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