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47

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20

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Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-156376

    Cuproptosis Apoptosis Topoisomerase Cancer
    Cu(II)-Elesclomol is a Cu 2+ complex of Elesclomol (HY-12040). Cu(II)-Elesclomol induces cuproptosis. Cu(II)-Elesclomol also inducesapoptosis, causes a G1 cell cycle block and induces DNA double strand breaks in K562 cells. Cu(II)-Elesclomol also weakly inhibits DNA topoisomerase I. Cu(II)-Elesclomol has anticancer activity .
    Cu(II)-Elesclomol
  • HY-P10319

    PKA Cardiovascular Disease Cancer
    RI-STAD-2 is a high-affinity interfering peptide that regulates the subunit RI of protein kinase A (PKA). RI-STAD-2 interferes with the binding of AKAPs and PKA-RI by simulating the interaction between AKAPs' α-helix domain and PKA-RI's dimerization/anchoration (D/D) domain, thereby affecting PKA activity and intracellular localization. RI-STAD-2 can be used to study the role of AKAPs interaction with PKA-RI in pathological processes such as cardiovascular disease and cancer .
    RI-STAD-2
  • HY-P5740

    Bacterial Infection
    Cacaoidin is a glycosylated lantibiotic isolated from a Streptomyces cacaoi strain. Cacaoidin has potent antibacterial activity against Gram-positive pathogens including Clostridium difficile .
    Cacaoidin
  • HY-126677

    ADC Linker PROTAC Linkers Cancer
    Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA is a double claevable 3-unit and 4-unit PEG linker for antibody-agent-conjugation (ADC). Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA also is a PROTAC linker that can be used in the synthesis of PROTACs.
    Boc-NH-PEG3-C2-triazole-DBCO-PEG4-VC-PAB-DMEA
  • HY-129764A

    17-trans-PGF3α

    Others Inflammation/Immunology
    (17E)-Prostaglandin F3α (17-trans-PGF3α) is a double bond isomer of Prostaglandin F3α (HY-129764) and a potential metabolite of trans dietary fatty acids. (17E)-Prostaglandin F3α has anti-inflammatory activity .
    (17E)-Prostaglandin F3α
  • HY-145657

    BQQ

    Others Others
    Benzoquinoquinoxaline (BQQ) is a heterocyclic compound with an aminoalkyl side chain. Benzoquinoquinoxaline preferentially binds to DNA triplex structures, intercalates between the bases, thus, stabilising the triplex conformation. Conjugation of Benzoquinoquinoxaline to 1,10-phenanthroline specifically binds and cleaves double strand DNA at the site of formation of a triplex structure .
    Benzoquinoquinoxaline
  • HY-111183

    Zinostatin; Vinostatin

    DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Infection Cancer
    Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment .
    Neocarzinostatin
  • HY-110185

    DNA/RNA Synthesis Cancer
    NSC 617145 is a selective werner syndrome helicase (WRN) helicase inhibitor with an IC50 value of 230 nM. NSC 617145 inhibits WRN ATPase, and induces double-strand breaks (DSB) and chromosomal abnormalities. NSC 617145 shows selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases .
    NSC 617145
  • HY-Y0293

    L-(+)-Tartaric acid

    Endogenous Metabolite Cardiovascular Disease
    L-tartaric acid (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. L-Tartaric acid has vasodilatory and antihypertensive effects. L-Tartaric acid can be used as flavorings and antioxidants in a range of foods and beverages. L-Tartaric acid can be used in laser frequency doubling and optical limiting applications .
    L-Tartaric acid
  • HY-D0850

    Sodium tartrate dibasic dihydrate; Sodium tartrate dihydrate

    Phosphatase Endogenous Metabolite Cardiovascular Disease
    Tartaric acid disodium dehydrate (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. Tartaric acid disodium dehydrate has vasodilatory and antihypertensive effects. Tartaric acid disodium dehydrate can be used as flavorings and antioxidants in a range of foods and beverages. Tartaric acid disodium dehydrate can be used in laser frequency doubling and optical limiting applications .
    Tartaric acid disodium dihydrate
  • HY-W109973

    L-(+)-Tartaric acid diammonium

    Endogenous Metabolite Cardiovascular Disease
    L-Tartaric acid diammonium (L-(+) -tartaric acid) is an orally active weak organic acid that can be isolated from grapes. L-Tartaric acid diammonium has vasodilatory and antihypertensive effects. L-Tartaric acid diammonium can be used as flavorings and antioxidants in a range of foods and beverages. L-Tartaric acid diammonium can be used in laser frequency doubling and optical limiting applications .
    L-Tartaric acid diammonium
  • HY-120955

    Others Others
    Cloprostol, a synthetic derivative of prostaglandin F2α, is used as an ossified in veterinary medicine and the research of reproductive disorders in cattle, pigs and horses. (+)-5-trans Cloprostenol is a secondary impurity produced during the synthesis of (+) -cloprostenol .
    (+)-5-trans Cloprostenol
  • HY-12972

    PF-06747775

    EGFR Cancer
    Mavelertinib is a selective, orally available and irreversible EGFR tyrosine kinase inhibitor (EGFR TKI), with IC50s of 5, 4, 12 and 3 nM for Del, L858R, and double mutants T790M/L858R and T790M/Del, respectively. Mavelertinib can be used for the research of non-small-cell lung cancer (NSCLC) .
    Mavelertinib
  • HY-149003

    PARP Apoptosis Cancer
    PARP1-IN-10 (compound 12c) is a no-cytotoxicity and potent PARP1 inhibitor with an IC50 value of 50.62 nM in vitro. PARP1-IN-10 causes cell cycle arrest at G2/M phase and apoptosis, and enhances the cytotoxicity of temozolomide (TMZ) .
    PARP1-IN-10
  • HY-156989

    Others Cardiovascular Disease
    Butobendine, a double ester of 2-aminobutanol and trimethoxybenzoic acid, is an antiarrhythmic agent .
    Butobendine
  • HY-W040329

    Endogenous Metabolite Others
    2'-Deoxyadenosine is a nucleoside adenosine derivative, pairing with deoxythymidine (T) in double-stranded DNA.
    2'-Deoxyadenosine
  • HY-D1023

    5-Bromo-2'-deoxyuridine 5'-triphosphate sodium salt

    DNA/RNA Synthesis Others
    5-BrdUTP sodium salt is a TdT substrate which can be used to label the DNA double-strand breaks.
    5-BrdUTP sodium salt
  • HY-W009390

    Endogenous Metabolite Metabolic Disease
    DL-Homocystine is the double-bonded form of homocysteine and homocysteine is recognized as an important substance in the pathogenesis and pathophysiology of schizophrenia.
    DL-Homocystine
  • HY-135009

    DASPI

    G-quadruplex Others
    2-Di-1-ASP (DASPI; Compound 18a) is a mono-stryryl dye, and widely used as mitochondrial stain and groove-binding fluorescent probes for double-stranded DNA. 2-Di-1-ASP is selective for G-quadruplex (G4) and double-stranded DNA .
    2-Di-1-ASP
  • HY-161030

    EGFR Cancer
    EGFR-IN-92 (compound 15) is an allosteric T790M/L858R double mutant EGFR inhibitor. EGFR-IN-92 shows antiproliferative activity against H1975 non-small lung cancer (NSCLC) cancer cells expressing double mutant EGFR .
    EGFR-IN-92
  • HY-R04602A

    MicroRNA Others
    MicroRNA Agomir Negative Control is a chemically-modified double-strand miRNA mimic, and can be used as a negative control.
    MicroRNA Agomir Negative Control
    MicroRNA Agomir Negative Control
  • HY-157205

    Others Inflammation/Immunology
    Zeph is a small chemical group double heterologous hapten of Zep and combines with a specific antibody but lacks antigenicity of its own.
    Zeph
  • HY-160226

    STING Inflammation/Immunology
    ISD (interferon stimulatory DNA) Control sodium is a non-immunostimulatory single-stranded oligonucleotide with the same sequence as ISD, its double-stranded counterpart .
    ISD Control sodium
  • HY-136197

    Ras Cancer
    StRIP16, bioavailable StRIP3 analogue, is a double-stapled peptide which can bind to Rab8a GTPase, with a Kd of 12.7 μM .
    StRIP16
  • HY-143219

    Others Others
    SS-Inclisiran (sodium) is a sense strand of Inclisiran. Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9 .
    SS-Inclisiran sodium
  • HY-148078

    Endonuclease Others
    PFM03 is a MRE11 Endonuclease inhibitor. PFM03 regulates DNA double-strand break repair (DSBR) by nonhomologous end-joining (NHEJ) .
    PFM03
  • HY-N11702

    Others Others
    Kaempferol-3-O-robinoside-7-Oglucoside is a double-chain flavonol triglycoside can be extracted from Withania somnifera .
    Kaempferol-3-O-robinoside-7-O-glucoside
  • HY-E70220

    CRISPR/Cas9 Others
    AsCas12a Nuclease is a CRISPR nuclease, and can specifically cutting double-stranded DNA. AsCas12a Nuclease can be used for gene edited study .
    AsCas12a Nuclease
  • HY-160424

    Diethylamine NONOate sodium; Diethylamine nitric oxide sodium

    Others Others
    DEANO sodium is notric oxide donor. DEANO sodium potentiates the abilitv of hypoxanthine/xanthine oxidase to induce lipid peroxidation as well as DNA single- and double-strand breaks .
    DEANO sodium
  • HY-15558
    Hoechst 33258
    10+ Cited Publications

    bisBenzimide H 33258; H 33258

    Fluorescent Dye Cancer
    Hoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33258
  • HY-15559
    Hoechst 33342
    Maximum Cited Publications
    49 Publications Verification

    bisBenzimide H 33342; HOE 33342

    Autophagy Others
    Hoechst 33342 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33342
  • HY-15560

    HOE 34580

    Amyloid-β Neurological Disease
    Hoechst 34580 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 34580
  • HY-15619

    Nuclear yellow

    Fluorescent Dye Others
    Hoechst S 769121 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst S 769121
  • HY-15561

    meta-Hoechst

    Fluorescent Dye Cancer
    HOE-S 785026 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    HOE-S 785026
  • HY-15562

    Fluorescent Dye Others
    HOE 32021 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    HOE 32021
  • HY-15622

    DNA Stain Cancer
    meta-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    meta-iodoHoechst 33258
  • HY-15623
    Hoechst 33258 analog
    1 Publications Verification

    DNA Stain Others
    Hoechst 33258 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33258 analog
  • HY-15626

    Fluorescent Dye Others
    ortho-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    ortho-iodoHoechst 33258
  • HY-15627

    Fluorescent Dye Others
    Hoechst 33342 analog is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33342 analog
  • HY-15629

    DNA Stain Others
    HOE 32020 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    HOE 32020
  • HY-15632

    Fluorescent Dye Others
    para-iodoHoechst 33258 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    para-iodoHoechst 33258
  • HY-15559A
    Hoechst 33342 trihydrochloride
    Maximum Cited Publications
    49 Publications Verification

    bisBenzimide H 33342 trihydrochloride; HOE 33342 trihydrochloride

    Autophagy Others
    Hoechst 33342 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33342 trihydrochloride
  • HY-15561B

    meta-Hoechst trihydrochloride

    Fluorescent Dye Others
    HOE-S 785026 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    HOE-S 785026 trihydrochloride
  • HY-15560B
    Hoechst 34580 tetrahydrochloride
    2 Publications Verification

    HOE 34580 tetrahydrochloride

    Amyloid-β Neurological Disease
    Hoechst 34580 tetrahydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 34580 tetrahydrochloride
  • HY-15558A
    Hoechst 33258 trihydrochloride
    10+ Cited Publications

    bisBenzimide H 33258 trihydrochloride; H 33258 trihydrochloride

    Fluorescent Dye Cancer
    Hoechst 33258 trihydrochloride is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33258 trihydrochloride
  • HY-15563

    Fluorescent Dye Others
    HOE 33187 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    HOE 33187
  • HY-143220

    Others Cardiovascular Disease
    SS(no Galnac)-Inclisiran (sodium) is a single stran Inclisiran with no GalNAc. Inclisiran is a double-stranded small interfering RNA (siRNA) molecule that inhibits the transcription of PCSK-9 .
    SS(no Galnac)-Inclisiran sodium
  • HY-W250152

    Biochemical Assay Reagents Inflammation/Immunology
    Polycytidylic acid potassium is an immunostimulant and synthetic double-stranded RNA. Polycytidylic acid potassium can be used experimentally to model viral infections in vivo. Polycytidylic acid potassium is a common tool in immune system research .
    Polycytidylic acid potassium
  • HY-120996B

    cis-10-Pentadecenoic acid

    Biochemical Assay Reagents Others
    10(Z)-Pentadecenoic acid is an unsaturated fatty acid. Unsaturated fatty acids are an important class of lipid molecules whose chemical structure contains one or more double bonds.
    10(Z)-Pentadecenoic acid
  • HY-15624

    DNA Stain Cancer
    Hoechst 33258 analog 2 is a marker dye in Hoechst series. Hoechst is A live nuclear marker dye. Hoechst binds to the grooves in the DNA double strand, which tends to be A/ T-rich DNA strand. Although it binds to all nucleic acids, the A/ T-rich double strand DNA significantly enhances fluorescence intensity Therefore,Hoechst dye can be used for living cell labeling. The fluorescence intensity of Hoechst dye increases with the increase of pH of solution .
    Hoechst 33258 analog 2

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