mismatch

By Targets:	Apoptosis (2) Autophagy (2) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (1) Endogenous Metabolite (1) Nucleoside Antimetabolite/Analog (2)
By Research Areas:	Cancer (6)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-116887

N6-Methyladenine	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis	Cancer
N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

HY-148503

5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)	Nucleoside Antimetabolite/Analog	Cancer
5'-ODMT cEt N-Bz A Phosphoramidite Amidite is a locked nucleic acid (LNA) analogue. 5'-ODMT cEt N-Bz A Phosphoramidite Amidite possesses hybridization and mismatch discrimination attributes similar to those of LNA and shows resistance to exonuclease digestion .

HY-17364

Temozolomide 110+ Cited Publications NSC 362856; CCRG 81045; TMZ	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

HY-17364S

Temozolomide-d3	DNA Alkylator/Crosslinker Autophagy Apoptosis	Cancer
Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

HY-153805

Z-NCTS

Others Cancer

Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA .

Z-NCTS	Others	Cancer
Z-NCTS is an RNA mismatch binding molecule that recognizes the 5’-r(XGG)-3’/5’-r(XGG)-3’ sequence (X=U or A) and acts as a molecular glue for RNA .

HY-17364R

Temozolomide (Standard)		Cancer
Temozolomide (Standard) is the analytical standard of Temozolomide. This product is intended for research and analytical applications. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-116887

N6-Methyladenine	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Endogenous Metabolite Nucleoside Antimetabolite/Analog DNA/RNA Synthesis
N6-Methyladenine is a modified purine that is widely present in prokaryotes. In prokaryotes, N6-Methyladenine plays an important role in distinguishing host DNA from exogenous DNA and controls many biological functions, such as DNA replication, transcription, mismatch repair, and chromosome replication .

Species:	Human (2)
Tag:	His (2) GST (1)
Source:	Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73803

	MSH2 Protein, Human (sf9, His-GST) DNA mismatch repair protein Msh2; hMSH2; MSH2	Human	Sf9 insect cells
	MSH2 protein is a key component of the DNA mismatch repair system, which can recognize and bind DNA mismatches to initiate repair. MSH2 forms heterodimers MutS α and MutS β that target various mismatches. MSH2 Protein, Human (sf9, His-GST) is the recombinant human-derived MSH2 protein, expressed by Sf9 insect cells , with C-His, N-GST labeled tag. The total length of MSH2 Protein, Human (sf9, His-GST) is 934 a.a., with molecular weight of ~132.6 kDa.

HY-P702783

TDG Protein, Human (His)

G/T mismatch-specific thymine DNA glycosylase; Thymine-DNA glycosylase; EC:3.2.2.29
Human E. coli


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Cat. No.	Product Name	Chemical Structure

HY-17364S

Temozolomide-d3
Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

Temozolomide-d3

Temozolomide-d₃ is the deuterium labeled Temozolomide. Temozolomide (NSC 362856) is an oral active DNA alkylating agent that crosses the blood-brain barrier. Temozolomide is also a proautophagic and proapoptotic agent. Temozolomide is effective against tumor cells that are characterized by low levels of O6-alkylguanine DNA alkyltransferase (OGAT) and a functional mismatch repair system. Temozolomide has antitumor and antiangiogenic effects[1][2].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82027

PMS2 Antibody (YA1772)

DNA mismatch repair gene; DNA mismatch repair protein PMS2; HNPCC4; PMS1 protein homolog 2
WB, IHC-P, ICC/IF Human

HY-P82011

	MSH6 Antibody (YA1756) MSH6; GTBP; DNA mismatch repair protein Msh6; hMSH6; G/T mismatch-binding protein; GTBP; GTMBP; MutS-alpha 160 kDa subunit; p160	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

HY-P82029

MSH2 Antibody (YA1774)

DNA mismatch repair protein Msh2; MutS protein homolog 2
WB Human, Rat

HY-P80753

	MLH1 Antibody (YA703) MLH1; COCA2; DNA mismatch repair protein Mlh1; MutL protein homolog 1	WB, ICC/IF	Human, Monkey
	MLH1 Antibody (YA703) is a non-conjugated and Mouse origined monoclonal antibody about 85 kDa, targeting to MLH1 (4C1). It can be used for WB,ICC/IF assays with tag free, in the background of Human, Monkey.

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