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OB-1 is a stomatin-like protein-3 (STOML3) oligomerization blocker. OB-1 is an effective inhibitor of the self-association of Stomatin, STOML1 and STOML2, but not podocin .
OB-24 is a potent inhibitor of heme oxygenase-1 (HO-1). Heme oxygenase-1, a member of the heat shock protein family, plays a key role as a sensor and regulator of oxidative stress. OB-24 significantly inhibited cell proliferation in vitro and tumor growth and lymph node/lung metastases in vivo. OB-24 has potential for the research of advanced prostate cancer (PCA) .
Otilonium bromide (OB) is an orally active mAChR inhibitor and smooth muscle relaxant which can interfere with the mobilization of calcium in intestinal smooth muscle, OB can be used for research of irritable bowel syndrome .
Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent.
Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT .
Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells .
[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes .
[Pro3]-GIP (Mouse) is a GIP receptor antagonist (IC50: 2.6 μM). [Pro3]-GIP (Mouse) improves glucose tolerance and insulin sensitivity in ob/ob mice. [Pro3]-GIP (Mouse) can be used for research of type 2 diabetes .
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .
Fatostatin hydrobromide (125B11 hydrobromide), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin hydrobromide binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin hydrobromide decreases the transcription of lipogenic genes in cells. Fatostatin hydrobromide possesses antitumor properties, and lowers hyperglycemia in ob/ob mice .
PF-5006739 is a potent and selective inhibitor of CK1δ/ε with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1δ/ε and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner . PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity .
[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes .
OB3, a derivative of Leptin, show more effective than leptin in reducing obesity and diabetes in mouse models. OB3 can reduce Leptin-related inflammation and proliferation in hepatocellular carcinoma cells .
[Pro3]-GIP (Mouse) is a GIP receptor antagonist (IC50: 2.6 μM). [Pro3]-GIP (Mouse) improves glucose tolerance and insulin sensitivity in ob/ob mice. [Pro3]-GIP (Mouse) can be used for research of type 2 diabetes .
Leptin is an important energy regulator that regulates appetite, metabolism, and immune responses through its central receptor LEPR. In the hypothalamus, it reduces food intake, affects neuropeptides, and affects bone mass and reproductive function. Leptin Protein, Human (His) is the recombinant human-derived Leptin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Leptin Protein, Human (His) is 146 a.a., with molecular weight of ~17 kDa.
Leptin R/LEPR protein, as a receptor for the hormone LEP/leptin, mediates central and peripheral effects by activating various signaling pathways (such as JAK2/STAT3 and MAPK cascade/FOS). In the hypothalamus, it regulates appetite, energy expenditure, bone mass, and hormone secretion. Leptin R/LEPR Protein, Mouse (HEK293, His) is the recombinant mouse-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Leptin R/LEPR Protein, Mouse (HEK293, His) is 818 a.a., with molecular weight of 120-150 kDa.
Leptin R/LEPR protein, as the receptor of LEP/leptin, plays a key role in mediating central and peripheral effects through multiple signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, it regulates appetite, influencing orexigenic factors and inhibiting orexigenic neuropeptides. Leptin R/LEPR Protein, Human (HEK293, His) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-10*His labeled tag. The total length of Leptin R/LEPR Protein, Human (HEK293, His) is 818 a.a., with molecular weight of 100-130 kDa.
Leptin is a key regulator of energy balance and body weight and binds to LEPR receptors in multiple tissues. It controls appetite in the hypothalamus and affects bone mass, hormone regulation, and reproductive function. Leptin Protein, Mouse (His) is the recombinant mouse-derived Leptin protein, expressed by E. coli , with N-6*His labeled tag. The total length of Leptin Protein, Mouse (His) is 146 a.a., with molecular weight of 16-17 kDa.
Leptin protein plays a pivotal role in regulating energy balance and body weight. It binds to its receptor, LEPR, in various tissues, activating signaling pathways that regulate energy homeostasis. Leptin Protein, Carassius auratus (P.pastoris, His) is the recombinant Leptin protein, expressed by P. pastoris , with N-8*His labeled tag. The total length of Leptin Protein, Carassius auratus (P.pastoris, His) is 150 a.a., with molecular weight of ~17.0 kDa.
PSAP/prosaposin protein is a multifunctional protein involved in various cellular processes. It serves as a precursor to four different saponin proteins involved in lipid metabolism and lysosomal function. Leptin R/LEPR Protein, Human (HEK293, His-Fc) is the recombinant human-derived Leptin R/LEPR protein, expressed by HEK293 , with C-hFc, C-8*His labeled tag. The total length of Leptin R/LEPR Protein, Human (HEK293, His-Fc) is 818 a.a., with molecular weight of 130-180 kDa.
Cadherin-11 Protein, Human (HEK293, His) is a recombinant human Cadherin-11 produced in HEK293 cells, with His tag. Cadherin-11 is a classical cadherin adhesion molecule that mediates homophilic cell-to-cell adhesion.
Siglec-6 Protein, a putative adhesion molecule, facilitates sialic acid-dependent binding to cells, specifically binding to alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Siglec-6 interacts with LEP. Siglec-6 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-6 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-6 Protein, Human (HEK293, Fc) is 305 a.a., with molecular weight of 70-90 kDa.
Siglec-F Protein, a putative adhesion molecule, crucially mediates sialic-acid dependent binding to cells with a preferential affinity for alpha-2,3-linked sialic acid. Notably, its sialic acid recognition site may be concealed through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Siglec-5 protein, expressed by HEK293, with C-His labeled tag. The total length of Siglec-5 Protein, Mouse (HEK293, His) is 423 a.a., with molecular weight of 65-68 kDa.
Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (Biotinylated, HEK293, Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-5 Protein, Human (Biotinylated, HEK293, Fc) is 418 a.a., with molecular weight of 90-115 kDa.
Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Siglec-5 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Siglec-5 Protein, Human (HEK293, His-Avi) is 418 a.a., with molecular weight of 68-78 kDa.
Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived Siglec-5 protein, expressed by HEK293, with C-Avi, C-His labeled tag. The total length of Siglec-5 Protein, Human (Biotinylated, HEK293, His-Avi) is 418 a.a., with molecular weight of 70-80 kDa.
Siglec-6 Protein, a putative adhesion molecule, facilitates sialic acid-dependent binding to cells, specifically binding to alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Siglec-6 interacts with LEP. Siglec-6 Protein, Human (HEK293, His-Avi) is the recombinant human-derived Siglec-6 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of Siglec-6 Protein, Human (HEK293, His-Avi) is 305 a.a., with molecular weight of 55-70 kDa.
Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Siglec-5 Protein, Human (HEK293, Fc) is 418 a.a., with molecular weight of 90-110 kDa.
Siglec-5 Protein, a putative adhesion molecule, participates in sialic-acid dependent cellular binding, showing equal affinity for alpha-2,3-linked and alpha-2,6-linked sialic acid. Its sialic acid recognition site may be masked through cis interactions with sialic acids on the same cell surface. Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is the recombinant human-derived Siglec-5 protein, expressed by HEK293 , with C-hFc, C-Flag, C-6*His labeled tag. The total length of Siglec-5 Protein, Human (HEK293, His-Flag-Fc) is 418 a.a., with molecular weight of 90-110 kDa.
HOPX Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 8 kDa, targeting to HOPX. It can be used for WB, IP assays with tag free, in the background of Human.
![[D-Leu-4]-<em>OB</em>3](http://file.medchemexpress.com/product_pic/hy-p3342.gif)
![[Pro3]-GIP (Mouse)](http://file.medchemexpress.com/product_pic/hy-p1434.gif)
