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overload

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By Targets:	Apoptosis (1) Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (4) Endogenous Metabolite (1) Ferroptosis (6) HCV (1) Isotope-Labeled Compounds (2) NF-κB (1) PPAR (1) TRP Channel (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (7) Inflammation/Immunology (2) Metabolic Disease (1) Neurological Disease (1)

15

Inhibitors & Agonists

3

Natural
Products

2

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Deferasirox 5 Publications Verification ICL 670	Bacterial Ferroptosis	Cancer
Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

Deferitrin GT-56-252	Others	Cardiovascular Disease
Deferitrin (GT-56-252), a desferrithiocin (DFT) analogue, is an orally active trident iron chelator. Deferitrin is used for chronic iron overload due to transfusional therapy. Deferitrin has the potential for beta-thalassemia major .

HY-114837

HBED

Ferroptosis Cancer

HBED is a potent iron chelator. HBED can be used to study transfusional iron overload .

Deferiprone-d3	Isotope-Labeled Compounds HCV Ferroptosis	Cardiovascular Disease Cancer
Deferiprone-d₃ is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating agent to be used therapeutically in conditions of transfusional iron overload[1][2].

Deferasirox-d4	Isotope-Labeled Compounds Bacterial Ferroptosis	Cancer
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

HY-U00354

CP-060

Calcium Channel Cardiovascular Disease

CP-060 is a potent Ca ²⁺ antagonist, inhibits Ca ²⁺ overload and possesses antioxidant and cardioprotective activities.

Deferasirox (Standard) ICL 670 (Standard)	Bacterial Ferroptosis	Cancer
Deferasirox (Standard) is the analytical standard of Deferasirox. This product is intended for research and analytical applications. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload .

SOICR-IN-1	Calcium Channel	Cardiovascular Disease
SOICR-IN-1 (compound 32) is a store-overload induced calcium release (SOICR) inhibitor with an IC₅₀ value of 14.6 μM. SOICR-IN-1 can be used for the research of cardiac arrhythmias .

Ammonium iron(III) citrate 5+ Cited Publications Ammonium ferric citrate; FAC	Ferroptosis	Cancer
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis . Ammonium iron(III) citrate can enhance protein production .

KS370G	Others	Cardiovascular Disease
KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy .

Tiron	Biochemical Assay Reagents Apoptosis	Metabolic Disease Inflammation/Immunology Cancer
Tiron is a non-toxic chelator of a variety of metals. Tiron is cell permeable analog of vitamin E and function as hydroxyl radical and superoxide scavenger. Tiron is an orally active antioxidant. Tiron can be used to alleviate acute metal overload in animals .

Englerin A	TRP Channel	Cancer
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca ²⁺ influx and Ca ²⁺ cell overload .

(17R,18S)-Epoxyeicosatetraenoic acid 17(R),18(S)-EETeTr	Calcium Channel	Cardiovascular Disease
(17R,18S)-Epoxyeicosatetraenoic acid (17(R),18(S)-EETeTr) is a cytochrome P450 epoxygenase metabolite of eicosapentaenoic acid (HY-B0660). (17R,18S)-Epoxyeicosatetraenoic acid shows exerts negative chronotropic effects and protects neonatal rat cardiomyocytes against Ca ²⁺ overload. (17R,18S)-Epoxyeicosatetraenoic acid has the potential for the research of antiarrhythmic agent .

Folic acid disodium Vitamin B9 disodium; Vitamin M disodium	Endogenous Metabolite	Others Neurological Disease Cancer
Folic acid disodium (Vitamin B9 disodium; Vitamin M disodium) is an orally active disodium salt form of Folic acid (HY-16637) with an intrinsic dissolution rate (IDR) of 4.96·10 ⁵ g/s . Folic acid disodium serves as cofactor in single-carbon transfer reactions and exhibits protective effects against neural tube defects, ischemic events, and cancer. Folate acid disodium overload leads to impaired brain development in embryogenesis and promotes growth of precancerous altered cells. Folic acid deficiency leads to megaloblastic anemia .

Ophiopogonin D	PPAR NF-κB Calcium Channel	Cardiovascular Disease Inflammation/Immunology
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

Cat. No.	Product Name	Category	Target	Chemical Structure

Ammonium iron(III) citrate 5+ Cited Publications Ammonium ferric citrate; FAC	Ketones, Aldehydes, Acids Source classification Rutaceae Plants Disease Research Fields Citrus reticulata Blanco Cancer	Ferroptosis
Ammonium iron(III) citrate (Ammonium ferric citrate), a physiological form of nonetransferrin-bound iron, induces intracellular iron overload to cause ferroptosis . Ammonium iron(III) citrate can enhance protein production .

Englerin A	other families Classification of Application Fields Terpenoids Sesquiterpenes Source classification Plants Disease Research Fields Cancer	TRP Channel
Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC₅₀s of 11.2 and 7.6 nM, respectively. Englerin A can induce renal carcinoma cells death by elevated Ca ²⁺ influx and Ca ²⁺ cell overload .

Ophiopogonin D	Cardiovascular Disease Ophiopogon japonicus (L. f.) Ker-Gawl. Liliaceae Classification of Application Fields Source classification Plants Disease Research Fields Steroids	PPAR NF-κB Calcium Channel
Ophiopogonin D, isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C₂₉ steroidal glycoside . Ophiopogonin D is a CYP2J3 inducer that significantly inhibits Ang II induced NF-κB nuclear translocation, IκBα down-regulation, intracellular Ca ²⁺ overload and activation of pro-inflammatory cytokines by increasing the expression of CYP2J2/EETs and PPARα in human umbilical vein endothelial cells (HUVECs). Ophiopogonin D has been used to treat inflammatory and cardiovascular diseases for thousands of years .

Cat. No.	Product Name	Chemical Structure

Deferiprone-d3
Deferiprone-d₃ is the deuterium labeled Deferiprone. Deferiprone is the only orally active iron-chelating agent to be used therapeutically in conditions of transfusional iron overload[1][2].

Deferasirox-d4
Deferasirox-d₄ is the deuterium labeled Deferasirox. Deferasirox (ICL 670) is an orally available iron chelator used for the management of transfusional iron overload[1][2][3].

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