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Results for "

pinal

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PIN1 (9) Amyloid-β (1) Bacterial (2) Biochemical Assay Reagents (2) Endogenous Metabolite (1) Fluorescent Dye (1) GABA Receptor (1) MicroRNA (2) Monoamine Oxidase (1) Small Interfering RNA (siRNA) (2) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (14) Infection (3) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (2)

Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
Products

Targets Recommended: PIN1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139361

Sulfopin 1 Publications Verification PIN1-3	PIN1	Cancer
Sulfopin (PIN1-3) is a highly selective covalent inhibitor of *Pin1* with an apparent K_i of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors .

HY-123847

KPT-6566	PIN1	Cancer
KPT-6566 is a selective and covalent prolyl isomerase *PIN1* inhibitor, covalently binds to the catalytic site of PIN1, selectively inhibits and degrades *PIN1. KPT-6566 shows an IC₅₀* value of 640 nM and a K_i value of 625.2 nM for PIN1 PPIase domain. KPT-6566 can be used for the research of cancer .

HY-143902

*ZL-Pin01*	PIN1	Cancer
ZL-Pin01 is a high potent covalent *Pin1* (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) inhibitor. ZL-Pin01 shows potent disruption of the Pin1-substrate interaction with an IC₅₀ of 1.33 μM .

HY-147710

PIN1 inhibitor 2	MicroRNA	Cancer
PIN1 inhibitor 2 (compound 12) is a potent *PIN1* inhibitor. PIN1 inhibitor 2 shows antitumor activity with an IC₅₀ of 9.55 µM for MCF7 cells. PIN1 inhibitor 2 has the potential for the research of breast cancer .

HY-143903

*ZL-Pin13*	PIN1	Cancer
ZL-Pin13 is a high potent cell-active covalent inhibitor targeting the *Pin1* (Peptidyl-Prolyl Isomerase NIMA-Interacting-1) with an IC₅₀ of 67 nM. ZL-Pin13 effectively inhibits the proliferation and downregulated the Pin1 substrates in MDA-MB-231 cells .

HY-145880

Elongation factor P-IN-1	Bacterial	Infection
Elongation factor P-IN-1 is a potent inhibitor elongation factor P (EFP). Elongation factor P-IN-1 is a β-lysine derivative compound. Elongation factor P-IN-1 affects the proliferation rates of E. coli .

HY-145881

Elongation factor P-IN-2	Bacterial	Infection
Elongation factor P-IN-2 is a potent inhibitor elongation factor P (EFP). Elongation factor P-IN-2 is a β-lysine derivative compound. Elongation factor P-IN-2 affects the proliferation rates of E. coli .

HY-116716

PIN1 inhibitor API-1	MicroRNA	Cancer
PIN1 inhibitor API-1 is a specific *Pin1* (peptidyl-prolyl cis-trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC₅₀ of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis-trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development .

HY-P4202

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-128034

PPIase-Parvulin inhibitor

PIN1 Cancer

PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases Pin1 and Pin4 with IC₅₀s of 1.5 and 1.0 µM, respectively .

PPIase-Parvulin inhibitor	PIN1	Cancer
PPIase-Parvulin Inhibitor is a cell-permeable inhibitor of the PPIases *Pin1* and *Pin4* with IC₅₀s of 1.5 and 1.0 µM, respectively .

HY-P4202A

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

HY-RS10557

PIN1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)
PIN1 Human Pre-designed siRNA Set A contains three designed siRNAs for PIN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIN1 Human Pre-designed siRNA Set A PIN1 Human Pre-designed siRNA Set A

HY-RS10558

PIN4 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
PIN4 Human Pre-designed siRNA Set A contains three designed siRNAs for PIN4 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

PIN4 Human Pre-designed siRNA Set A PIN4 Human Pre-designed siRNA Set A

HY-153675

BCPA	PIN1	Metabolic Disease
BCPA is a *Pin1* regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research .

HY-49597

Pin1 modulator 1	Wnt β-catenin	Cancer
Pin1 modulator 1 (compound IIb-219) is a modulator that specifically targets β-Catenin and inhibits the Wnt pathway. Pin1 modulator 1 can be used in the study of Wnt-mediated related diseases, such as cancer .

HY-146695

S100P-IN-1

Others Cancer

S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC₅₀ of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells .

S100P-IN-1	Others	Cancer
S100P-IN-1 (Compound 4) is a S100P inhibitor with an IC₅₀ of 22.7 nM. S100P-IN-1 shows anti-metastatic effects on pancreatic cancer cells .

HY-W008566

Norharmane Norharman; β-Carboline	Monoamine Oxidase Endogenous Metabolite	Infection Neurological Disease Cancer
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

HY-P3480

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA	Fluorescent Dye	Others
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins .

HY-P4359

Suc-AEPF-AMC

PIN1 Others

Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .

Suc-AEPF-AMC	PIN1	Others
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .

HY-137122

3-Pyridine toxoflavin	PIN1	Inflammation/Immunology
3-Pyridine toxoflavin (compound 49) is a *PIN1* inhibitor. 3-Pyridine toxoflavin can be used for the research of immune disease proliferative disorder .

HY-131062

yGsy2p-IN-1	Others	Metabolic Disease
yGsy2p-IN-1 is a potent inhibitor for yeast glycogen synthase 2 (yGsy2p). yGsy2p-IN-1 is a competitive human glycogen synthase 1 (hGYS1) inhibitor with an IC₅₀ of 2.75 µM and a K_i of 1.31 µM for wild-type hGYS1. yGsy2p-IN-H23 a pyrazole inhibitor, is used for glycogen storage diseases (GSDs) .

HY-128592

TAB29	PIN1	Cancer
TAB29 is a potent inhibitor of peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) with an IC₅₀ of 874 nM, possesses therapeutic potential for human cancers .

HY-19771

amyloid P-IN-1	Amyloid-β	Cancer
amyloid P-IN-1 is used in the research of diseases or disorders wherein depletion of serum amyloid P component (SAP), including amyloidosis, Alzheimer's disease, type 2 diabetes mellitus and osteoarthritis.

HY-W003836

7-Methyl-1-naphthyl acetic acid 7-Methoxy-NAA	Others	Others
7-Methyl-1-naphthyl acetic acid is a potent inhibitor of auxin action in plants. 7-Methyl-1-naphthyl acetic acid inhibits AUX1, PIN, and ABCB protein-mediated auxin transport expressed in yeast. 7-Methyl-1-naphthyl acetic acid can be used in auxin dependent development .

HY-11048

NS11394 3 Publications Verification	GABA Receptor	Neurological Disease
NS11394 is an orally active and unique subtype-selective GABA_A positive allosteric receptor (PAM), with a K_i of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABA_A-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties .

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Chromogenic Substrates
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

Suc-Ala-Glu-Pro-Phe-pNA Suc-AEPF-pNA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA) is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

Suc-Ala-Glu-Pro-Phe-pNA TFA Suc-AEPF-pNA TFA	Biochemical Assay Reagents	Others
Suc-Ala-Glu-Pro-Phe-pNA (Suc-AEPF-pNA ) TFA is a chromogenic substrate for the peptidylprolyl isomerase Pin1. Suc-Ala-Glu-Pro-Phe-pNA TFA can be used to evaluate the inhibitory effect of the target compound on Pin1, and catalytic activity of Pin1, etc .

H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA	Fluorescent Dye	Others
H-Trp-Phe-Tyr-Ser(PO3H2)-Pro-Arg-pNA is a chromogenic substrate for Pin1. Pin1 is an essential and conserved mitotic peptidyl-prolyl isomerase, and can recognize the phosphoserine-proline bonds present in mitotic phosphoproteins .

Suc-AEPF-AMC	PIN1	Others
Suc-AEPF-AMC is a peptide substrate of Pin1 and Par14 peptidyl prolyl isomerase .

AGR	Peptides	Cancer
AGR is a peptide. AGR recognizes lymphatic vessels in fully developed prostate tumors but not in the pre-malignant lesions .

REA	Peptides	Cancer
REA is a peptide. REA recognizes lymphatics of a premalignant stage, but not to the tumor lymphatic vessels .

Norharmane Norharman; β-Carboline	Structural Classification Neurological Disease Classification of Application Fields Source classification Pyridine Alkaloids Endogenous metabolite Biological Pesticide Research Indole Alkaloids Agricultural Research Infection Alkaloids Microorganisms Disease Research Fields Cancer	Monoamine Oxidase Endogenous Metabolite
Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC₅₀ values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings .

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