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Results for "

plasma kallikrein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Kallikrein (19) Endogenous Metabolite (1) Factor Xa (1) Ser/Thr Protease (1)
By Research Areas:	Cardiovascular Disease (11) Endocrinology (1) Inflammation/Immunology (4) Metabolic Disease (4) Neurological Disease (1)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Recombinant Proteins

Antibodies

Targets Recommended: Kallikrein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-153115

Plasma kallikrein-IN-4	Kallikrein	Cardiovascular Disease Inflammation/Immunology
Plasma kallikrein-IN-4 (Example 153) is a **plasma kallikrein inhibitor with an IC₅₀** of 0.016 μM against human plasma kallikrein .

HY-150052

Plasma kallikrein-IN-3	Kallikrein	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-3 is a **plasma kallikrein inhibitor (IC₅₀*: 0.15 μM). Plasma* kallikrein-IN-3 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-163464

Plasma kallikrein-IN-5	Kallikrein	Cardiovascular Disease
Plasma kallikrein-IN-5 (Compound 20) is a potent covalent inhibitor of plasma potassium kinin peptide (Pka) with IC₅₀ values of 66 nM and 70 pM at 1 minute and 24 hours, respectively. Plasma kallikrein-IN-5 can be used IN the study of hereditary angioedema (HAE) .

HY-143476

Plasma kallikrein-IN-2	Kallikrein	Cardiovascular Disease Metabolic Disease
Plasma kallikrein-IN-2 (Compound 198) is a potent plasma kallikrein (PKal) inhibitor with an IC₅₀ of 0.1 nM. Plasma kallikrein-IN-2 can be used for hereditary angioedema, diabetic macular edema, and diabetic retinopathy research .

HY-139888

Plasma kallikrein-IN-1

Kallikrein Endocrinology

Plasma kallikrein-IN-1 is a PKK inhibitor with an IC₅₀ value of 0.5 nM.

Plasma kallikrein-IN-1	Kallikrein	Endocrinology
Plasma kallikrein-IN-1 is a PKK inhibitor with an IC₅₀ value of 0.5 nM.

HY-132830

Sebetralstat KVD900	Kallikrein	Metabolic Disease
Sebetralstat (KVD900) is a **plasma kallikrein** inhibitor (WO2016083820). Sebetralstat can be used for the research of metabolic diseases .

HY-123133

PKSI-527	Kallikrein	Inflammation/Immunology
PKSI-527 is a new, highly selective plasma kallikrein inhibitor. PKSI-527 can suppress collagen-induced arthritis (CIA) by modifying the kallikrein-kinin system .

HY-19101

ONO-3307	Kallikrein	Cardiovascular Disease
ONO-3307 is a protease inhibitor that competitively inhibits a variety of proteases including trypsin, thrombin, plasma kallikrein, plasmin, pancreatic kallikrein, and chymotrypsin. ONO-3307 alleviates endotoxin-induced experimental disseminated intravascular coagulation (DIC) in rats. ONO-3307 can be used in the study of thrombosis and protease-mediated diseases .

HY-122543A

PPACK II

Kallikrein Cardiovascular Disease

PPACK II is an irreversible and specific glandular and plasma kallikreins inhibitor .
HY-122543

PPACK II diTFA

Kallikrein Cardiovascular Disease

PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor .

PPACK II	Kallikrein	Cardiovascular Disease
PPACK II is an irreversible and specific glandular and plasma *kallikreins* inhibitor .

PPACK II diTFA	Kallikrein	Cardiovascular Disease
PPACK II diTFA is an irreversible and specific glandular and plasma *kallikreins* inhibitor .

HY-109127A

Berotralstat dihydrochloride 1 Publications Verification BCX7353 dihydrochloride	Kallikrein	Others
Berotralstat dihydrochloride is a low toxicity, effective, highly specific, second-generation, synthetic and orally active **plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat dihydrochloride works by blocking the enzymatic activity of plasma kallikrein** in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .

HY-109127

Berotralstat 1 Publications Verification BCX7353	Kallikrein	Others
Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active **plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein** in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .

HY-16735

Avoralstat 4 Publications Verification BCX4161	Kallikrein	Others
Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research .

HY-145568

Feniralstat KVD-824	Kallikrein	Cardiovascular Disease Metabolic Disease
Feniralstat (compound 30), a pyrazole derivative, is a potent *kallikrein* inhibitor with an IC₅₀ of 6.7 nM for Human plasma kallikrein (pKal). Feniralstat has no inhibition on Human KLKl, Human FXIa, Human Factor Xlla (all IC₅₀>40 μM).

HY-P4245

D-Pro-Phe-Arg-Chloromethylketone	Factor Xa Kallikrein	Cardiovascular Disease Neurological Disease
D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma *kallikrein*, plays an important role in thrombosis and inflammation .

HY-P2795

Kallikrein, Porcine pancreas kininogenase; SK-827	Endogenous Metabolite	Others
Kallikrein, Porcine pancreas (kininogenase) is capable of forming the kallikrenase kalinin system (KKS) in plasma and tissues, producing bradykinin and kalin peptides, respectively .

HY-109127R

Berotralstat (Standard)	Ser/Thr Protease	Others
Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is a low toxicity, effective, highly specific, second-generation, synthetic and orally active **plasma kallikrein inhibitor used for the research of hereditary angioedema (HAE) attacks. Berotralstat works by blocking the enzymatic activity of plasma kallikrein** in releasing bradykinin, the major biologic peptide that promotes swelling and pain associated with attacks of HAE .

HY-108814

Ecallantide DX-88	Kallikrein	Cardiovascular Disease
Ecallantide (DX-88) is a specific plasma *kallikrein* inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema .

HY-108814A

Ecallantide TFA DX-88 TFA	Kallikrein	Cardiovascular Disease
Ecallantide (DX-88) TFA is a specific recombinant plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide may be used to prevent acute attacks of angioedema .

HY-126378

LSP-249	Kallikrein	Inflammation/Immunology
LSP-249 (example 35), extracted from patent WO2016011209A1, is a plasma *kallikrein* inhibitor under the study for angioedema, with an EC₅₀ less than 100 nM in cell .

HY-P99110

Lanadelumab SHP643; DX-2930	Kallikrein	Inflammation/Immunology
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K_i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .

Cat. No.	Product Name	Target	Research Area

HY-P4245

D-Pro-Phe-Arg-Chloromethylketone	Factor Xa Kallikrein	Cardiovascular Disease Neurological Disease
D-Pro-Phe-Arg-Chloromethylketone, a inhibitor of coagulation factor XII and plasma *kallikrein*, plays an important role in thrombosis and inflammation .

HY-108814A

Ecallantide TFA DX-88 TFA	Kallikrein	Cardiovascular Disease
Ecallantide (DX-88) TFA is a specific recombinant plasma kallikrein inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide may be used to prevent acute attacks of angioedema .

HY-108814

Ecallantide DX-88	Kallikrein	Cardiovascular Disease
Ecallantide (DX-88) is a specific plasma *kallikrein* inhibitor. Ecallantide inhibits the production of bradykinin. Ecallantide can be used to prevent acute attacks of angioedema .

Cat. No.	Product Name	Target	Research Area

HY-P99110

Lanadelumab SHP643; DX-2930	Kallikrein	Inflammation/Immunology
Lanadelumab (SHP643) is a human IgG1 monoclonal antibody against plasma kallikrein (pKal) with an K_i value of 0.12 nM. Lanadelumab inhibits both free and HMWK (high molecular weight kininogen)-bound pKal. Lanadelumab has the potential for the research of hereditary angioedema .

Species:	Human (2) Mouse (1) Rat (1) Cynomolgus (1)
Tag:	His (5)
Source:	HEK293 (4) P. pastoris (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P70249

	Plasma kallikrein/KLKB1 Protein, Human (HEK293, His, solution) rHuplasma kallikrein/KLKB1, His; plasma kallikrein; Fletcher factor; Kininogenin; plasma prekallikrein; KLKB1; KLK3	Human	HEK293
	Plasma kallikrein (KLKB1) serves as an enzyme, cleaving Lys-Arg and Arg-Ser bonds to release bradykinin from HMW kininogen. It plays a crucial role in the reciprocal activation of factor XII, especially upon binding to a negatively charged surface. Besides its role in the kinin system, KLKB1 may contribute to the renin-angiotensin system by converting prorenin into renin. Plasma kallikrein/KLKB1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Plasma kallikrein/KLKB1 Protein, Human (HEK293, His, solution) is 619 a.a., with molecular weight of 72-80 kDa.

HY-P77973

	Plasma kallikrein/KLKB1 Protein, Mouse (HEK293, His) plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin	Mouse	HEK293
	Plasma kallikrein/KLKB1 enzymatically cleaves Lys-Arg and Arg-Ser bonds, triggering factor XII activation upon binding to a negatively charged surface. It liberates bradykinin from HMW kininogen and is implicated in the renin-angiotensin system, potentially converting prorenin into renin. This underscores the diverse and essential functions of Plasma kallikrein/KLKB1 in various physiological processes. Plasma kallikrein/KLKB1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Plasma kallikrein/KLKB1 Protein, Mouse (HEK293, His) is 619 a.a., with molecular weight of 75-85 kDa.

HY-P700772

	Plasma kallikrein/KLKB1 Protein, Cynomolgus (HEK293, His) plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin	Cynomolgus	HEK293
	Plasma kallikrein (KLKB1) serves as an enzyme, cleaving Lys-Arg and Arg-Ser bonds to release bradykinin from HMW kininogen. It plays a crucial role in the reciprocal activation of factor XII, especially upon binding to a negatively charged surface. Besides its role in the kinin system, KLKB1 may contribute to the renin-angiotensin system by converting prorenin into renin. Plasma kallikrein/KLKB1 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Plasma kallikrein/KLKB1 Protein, Cynomolgus (HEK293, His) is 619 a.a., with molecular weight of 70-90 kDa.

HY-P70249A

	Plasma kallikrein/KLKB1 Protein, Human (HEK293, His) plasma kallikrein; PKK; KLK3; KLKB1; Fletcher factor; Kininogenin	Human	HEK293
	Plasma kallikrein (KLKB1) serves as an enzyme, cleaving Lys-Arg and Arg-Ser bonds to release bradykinin from HMW kininogen. It plays a crucial role in the reciprocal activation of factor XII, especially upon binding to a negatively charged surface. Besides its role in the kinin system, KLKB1 may contribute to the renin-angiotensin system by converting prorenin into renin. Plasma kallikrein/KLKB1 Protein, Human (HEK293, His) is the recombinant human-derived Plasma kallikrein/KLKB1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Plasma kallikrein/KLKB1 Protein, Human (HEK293, His) is 619 a.a., with molecular weight of 72-80 kDa.

HY-P71748

	Plasma kallikrein/KLKB1 Protein, Rat (P.pastoris, His) Klkb1; Klk3; Pkplasma kallikrein; EC 3.4.21.34; Fletcher factor; Kininogenin	Rat	P. pastoris
	Plasma kallikrein/KLKB1 enzymatically cleaves Lys-Arg and Arg-Ser bonds, triggering factor XII activation upon binding to a negatively charged surface. It liberates bradykinin from HMW kininogen and is implicated in the renin-angiotensin system, potentially converting prorenin into renin. This highlights the protein's multifaceted role in various physiological processes. Plasma kallikrein/KLKB1 Protein, Rat (P.pastoris, His) is the recombinant rat-derived Plasma kallikrein/KLKB1 protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of Plasma kallikrein/KLKB1 Protein, Rat (P.pastoris, His) is 248 a.a., with molecular weight of ~34 kDa.


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HY-P83618

	Plasma Kallikrein Antibody (YA3363) Fletcher factor; kallikrein B plasma; kallikrein B1; Kininogenin; KLK3; KLKB1; PKK; PKKD; plasma kallikrein light chain; PPK; Prekallikrein	WB, IHC-P, IP	Human, Rat


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