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pro-oxidant

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By Targets:	Apoptosis (2) Caspase (1) Endogenous Metabolite (2) Ferroptosis (1) Isotope-Labeled Compounds (1) Parasite (2) Reactive Oxygen Species (3)
By Research Areas:	Cancer (5) Infection (2) Inflammation/Immunology (1) Metabolic Disease (1)

9

Inhibitors & Agonists

1

Peptides

6

Natural
Products

1

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Iron sucrose Iron saccharate
Iron sucrose (Iron saccharate) is a intravenous iron preparation and a pro-oxidant agent. Iron sucrose has the potential for iron deficiency anemia treatment .

Rufigallol	Reactive Oxygen Species Parasite	Infection
Rufigallol is one of the earliest systems reported to form columnar mesophases. Rufigallol is also an oxidant agent. Rufigallol acts in a pro-oxidant fashion to produce oxygen radicals inside parasitized erythrocytes. Rufigallol has vitamin K activity and antimalarial activity .

L-Selenocystine-77Se2	Isotope-Labeled Compounds	Others
Selenocystine-77Se2 is a stable isotope labelled amino acid. L-Selenocystine is a diselenide-bridged amino acid. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions.

PAA5	Ferroptosis Endogenous Metabolite Reactive Oxygen Species	Cancer
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .

Ganoderic acid T1	Apoptosis Caspase	Inflammation/Immunology Cancer
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

Atherosperminine Atherospermine	Parasite	Infection
Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC₅₀ of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC₅₀ of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis .

Theaflavin-3-gallate	Others	Cancer
Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner .

Theaflavin-3'-gallate	Others	Cancer
Theaflavin-3'-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3'-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3'-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner .

β-Carotene 1 Publications Verification provitamin A; beta-Carotene	Endogenous Metabolite Apoptosis Reactive Oxygen Species	Metabolic Disease Cancer
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

Theaflavin-3-gallate	Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae	Others
Theaflavin-3-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner .

Theaflavin-3'-gallate	Structural Classification Flavonoids Classification of Application Fields Flavanols Source classification Phenols Polyphenols Plants Camellia sinensis (L.) O. Ktze. Disease Research Fields Cancer Theaceae	Others
Theaflavin-3'-gallate, a black tea theaflavin monomer, is regarded as the biologically important active component of black tea and provides health benefits. Theaflavin-3'-gallate acts as prooxidants and induces oxidative stress in the carcinoma cells. Theaflavin-3'-gallate reacts directly with reduced glutathione (GSH) in a time- and concentration-dependent manner .

PAA5	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields Cancer	Ferroptosis Endogenous Metabolite Reactive Oxygen Species
PAA5 is a methide carbon-centered polynuclear Au(I) cluster. PAA5 can release Au(I) causing Pro-oxidant response and accelerated ferroptosis. PAA5 increases the expression of pH2AX in a time-dependent manner. PAA5 has anticancer activity .

Ganoderic acid T1	Triterpenes Structural Classification Microorganisms Terpenoids Source classification	Apoptosis Caspase
Ganoderic acid T1 is a deacetylated derivative of Ganoderic acid T. Ganoderic acid T1 attenuates antioxidant defense system and induces apoptosis of cancer cells. Ganoderic acid T1 decreases mitochondrial membrane potential and activates caspase-9 and caspase-3, to trigger apoptosis. Ganoderic acid T1 also increases the generation of intracellular ROS to produce pro-oxidant activities and cytotoxicity .

Atherosperminine Atherospermine	Infection Alkaloids Classification of Application Fields Source classification Fissistigma glaucescens Plants Annonaceae Disease Research Fields	Parasite
Atherosperminine（Atherospermine）is a nature occurring alkaloid, has antiplasmodial activities in vitro, with an IC₅₀ of 5.80 μM. Atherosperminine is a good reductant with the ability to chelate metals. Atherosperminine has scavenging activity towards the free radical DPPH, with an IC₅₀ of 29.56 µg/mL. Atherosperminine exerts a non-specific relaxant effect on the trachealis .

β-Carotene 1 Publications Verification provitamin A; beta-Carotene	Classification of Application Fields Source classification Metabolic Disease Endocrine diseases Plants Endogenous metabolite Food Research Other Terpenoids other families Immune System Disorder Terpenoids Disease markers Pigments Disease Research Fields Cancer	Endogenous Metabolite Apoptosis Reactive Oxygen Species
β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities .

Cat. No.	Product Name	Chemical Structure

L-Selenocystine-77Se2
Selenocystine-77Se2 is a stable isotope labelled amino acid. L-Selenocystine is a diselenide-bridged amino acid. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions.

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