Search Result
Results for "
replacement
" in MedChemExpress (MCE) Product Catalog:
1
Biochemical Assay Reagents
4
Isotope-Labeled Compounds
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Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-148140
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Others
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Others
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Cross-linked dextran G 25 is a dextran chromatography medium. Sephadex G-25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .
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- HY-W021448
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Guanidinoacetic acid
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Endogenous Metabolite
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Others
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Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.
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- HY-N3018
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6-O-α-D-Glucopyranosyl-D-glucose; D-Isomaltose
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Endogenous Metabolite
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Metabolic Disease
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Isomaltose is composed of two glucose units and suitable as a non-cariogenic sucrose replacement and is favorable in products for diabetics and prediabetic dispositions.
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- HY-153592
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Others
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Others
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Therapeutic agent-1 is a heteroaryl compound that can be used in Gaucher disease glucocerebrosidase activity enzyme replacement therapy .
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- HY-108721
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Others
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Metabolic Disease
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Velaglucerase alfa is produced through gene activation technology and is identical to wild-type enzyme. Velaglucerase alfa targets accumulated glucocerebroside primarily within the lysosome of the macrophages in the affected organs and systems. Velaglucerase alfa is an enzyme replacement therapy (ERT) for type 1 Gaucher disease (GD) .
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- HY-B0672
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β-Estradiol 17-valerate
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Estrogen Receptor/ERR
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Endocrinology
Cancer
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Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
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- HY-W021448S
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Guanidinoacetic acid-d2
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Endogenous Metabolite
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Others
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Glycocyamine-d2 is the deuterium labeled Glycocyamine. Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.
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- HY-146753
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HIV
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Infection
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HIV-1 inhibitor-20 is a potent HIV-1 inhibitor by non-classical isosteric replacement of amide to 1,2,4-oxadiazoles .
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- HY-10269
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Factor Xa
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Cardiovascular Disease
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LY-517717 is a potent and orally active FXa inhibitor. LY-517717 shows antithrombotic and anticoagulant activity. LY-517717 has the potential for the research of venous thromboembolism after hip or knee replacement .
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- HY-B0672S
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- HY-B0672S1
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β-Estradiol 17-valerate-d4
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Isotope-Labeled Compounds
Estrogen Receptor/ERR
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Endocrinology
Cancer
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Estradiol valerianate-d4 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
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- HY-W021448S1
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Endogenous Metabolite
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Others
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Glycocyamine- 15N, 13C2 is the 13C and 15N labeled Glycocyamine[1]. Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird[2].
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- HY-E70216
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Others
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Others
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Bsu DNA polymerase, Large fragment is a polymerase derived from Bacillus subtilis. Bsu DNA polymerase, Large fragment is a DNA isothermal amplification polymerase with chain replacement activity, which used in RPA recombinase polymerase amplification technology .
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- HY-Y0308
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Disodium phosphate is commonly used as a food additive, buffer and laboratory reagent. Disodium phosphate has unique chemical properties that make it an important ingredient in the manufacture of fertilizers, detergents and water treatment products. Additionally, it is used in various medical applications such as osmotic laxatives and electrolyte replacement solutions.
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- HY-B0672R
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β-Estradiol 17-valerate (Standard)
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Estrogen Receptor/ERR
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Endocrinology
Cancer
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Estradiol valerianate (Standard) is the analytical standard of Estradiol valerianate. This product is intended for research and analytical applications. Estradiol valerate (β-Estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
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- HY-160230
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Toll-like Receptor (TLR)
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Infection
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ssRNA41 sodium is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. It derives from ssRNA40 by replacement of all U nucleotides with adenosine. ssRNA41 sodium is unable to induce the production of type IFNs, and therefore can be used as a negative control for ssRNA40 .
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- HY-D2160
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Fluorescent Dye
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Others
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AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye. The maximum excitation wavelength is 648 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling.
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- HY-141591
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Others
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Others
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CYT296 is a target chromatin de-condensation compound. CYT296 can improve the induction of induced pluripotent stem cell (iPSCs) mediated by defined factors (OSKM) and induce an open chromatin state in Mouse Embryonic Fibroblast (MEFs) to facilitate somatic cell reprogramming. CYT296 can be used for cell replacement therapies and drug screening research .
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- HY-160231
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Toll-like Receptor (TLR)
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Inflammation/Immunology
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ssRNA42 (sodium) is a 20-mer phosphothioate protected single-stranded RNA oligonucleotide. ssRNA42 (sodium) derives from ssRNA40 by replacement of all G nucleotides with adenosine. ssRNA42 activated human PBMCs to secrete IFN-α, TNF-a, IL- 12p40, and IL-6, but ssRNA42 failed to stimulated murine pDCs and PBMCs.
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- HY-160281
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Others
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Metabolic Disease
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CCD-2 is a conventional detergent and is readily degraded. CCD-2 can efficiently solubilize and stabilize diverse G protein-coupled receptors (GPCRs). CCD-2 is amenable to the β-barrel protein research. The chemical cleavage of CCD-2 is rapid, complete and biorthogonal and should facilitate a chemical methodology for in situ detergent replacement in diverse membrane proteins (MPs) studies .
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- HY-P5601
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Bacterial
Fungal
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Infection
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Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
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- HY-P5601A
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Bacterial
Fungal
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Infection
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Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
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- HY-107845
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SCR7 pyrazine
Maximum Cited Publications
10 Publications Verification
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CRISPR/Cas9
DNA/RNA Synthesis
Apoptosis
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Cancer
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SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
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- HY-12742
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DNA/RNA Synthesis
CRISPR/Cas9
Apoptosis
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Cancer
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SCR7 is an unstable form that can be autocyclized into a stable form SCR7 pyrazine. SCR7 pyrazine is a DNA ligase IV inhibitor that blocks nonhomologous end-joining (NHEJ) in a ligase IV-dependent manner. SCR7 pyrazine is also a CRISPR/Cas9 enhancer which increases the efficiency of Cas9-mediated homology-directed repair (HDR). SCR7 pyrazine induces cell apoptosis and has anticancer activity .
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- HY-153264
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Others
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Others
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TAS2R14 agonist is a potent TAS2R14 partial agonist with an EC50 of 116.6 ±23.6 nM .
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| Cat. No. |
Product Name |
Type |
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- HY-D2160
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Fluorescent Dyes/Probes
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AF 647 carboxylic acid is a derivative of the far-infrared dye AF 647. AF 647 is often used as a replacement for Cy5 dye. The maximum excitation wavelength is 648 nm and the maximum emission wavelength is 671 nm. AF 647 carboxylic acid has a carboxylic acid group and can be coupled to biomolecules with amino groups to achieve dye labeling.
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| Cat. No. |
Product Name |
Type |
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- HY-Y0308D
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Disodium hydrogen phosphate, meets analytical specification of Ph. Eur. BP USP FCC E339
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Biochemical Assay Reagents
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Sodium phosphate dibasic is commonly used as a food additive, buffer and laboratory reagent. Sodium phosphate dibasic has unique chemical properties that make it an important ingredient in the manufacture of fertilizers, detergents and water treatment products. Additionally, it is used in various medical applications such as osmotic laxatives and electrolyte replacement solutions .
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-P5601A
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Bacterial
Fungal
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Infection
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Thanatin TFA is an inducible cationic antimicrobial peptide. Thanatin TFA s a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin TFA displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin TFA has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
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- HY-P5373
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Peptides
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Others
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Ser-parafluoroPhe-Aad-Leu-Arg-Asn-Pro-NH2 is a biological active peptide. (Structure-activity studies of thrombin receptor-tethered ligand SFLLRNP have revealed
the importance of the Phe-2-phenyl group in receptor recognition and the replacement of the
Phe-2 by para-fluorophenylalanine [(p-F)Phe] was found to enhance its activity)
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- HY-P5601
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Bacterial
Fungal
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Infection
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Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption .
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- HY-P5519
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Peptides
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Others
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[Thr28, Nle31]-Cholecystokinin (25-33) is a biological active peptide. (Cholecystokinin (CCK) acts both as a hormone and a neurotransmitter and is found in the GI system and the central nervous system. It is a satiety peptide that inhibits food intake.This Cholecystokinin (CCK) analog retains all the bioactivities of CCK8, but was found to be remarkably more stable in acidic media and unaffected by air oxidation due to Met replacements (Thr 28 and Nle31 were substituted for Methionine). The predominant conformation contains a gamma-turn centered on Thr4, separated by Gly5 from a helical segment that comprises the C-terminal residues.)
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| Cat. No. |
Product Name |
Target |
Research Area |
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- HY-108786
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ENB-0040
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Inhibitory Antibodies
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Metabolic Disease
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Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2 −/− knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP) .
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- HY-108794
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BMN 110; Chondrosulfatase; Chondroitinase; Chondrosulfatases; Chondroitin sulfatase
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Inhibitory Antibodies
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Others
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Elosulfase alfa (BMN 110) is a recombinant form of human N-acetylgalactosamine-6-sulfatase (GALNS). Elosulfase alfa is used as an enzyme replacement therapy for mucopolysaccharidosis IVA (MPS IVA), also known as Morquio A syndrome .
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| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
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- HY-W021448S
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Glycocyamine-d2 is the deuterium labeled Glycocyamine. Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird.
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- HY-W021448S1
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Glycocyamine- 15N, 13C2 is the 13C and 15N labeled Glycocyamine[1]. Glycocyamine (Guanidinoacetic acid), a precursor of creatine, is a replacement of dietary arginine and could support overall energy homeostasis of the bird[2].
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- HY-B0672S
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Estradiol valerianate-d9 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
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- HY-B0672S1
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Estradiol valerianate-d4 is the deuterium labeled Estradiol valerianate. Estradiol valerianate (β-estradiol 17-valerate) is a synthetic estrogen widely used in combination with other steroid hormones in hormone replacement therapy agents.
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