retinoblastoma

By Targets:	Akt (1) Apoptosis (2) Autophagy (1) CDK (4) CRFR (1) DNA/RNA Synthesis (1) Histone Demethylase (1) HPV (1) mTOR (1) PI3K (1) Raf (1) Ser/Thr Protease (1) TRP Channel (1)
By Research Areas:	Cancer (8) Inflammation/Immunology (2) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

D-erythro-Sphingosine hydrochloride 2 Publications Verification Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	TRP Channel	Neurological Disease
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

RRD-251	Raf Apoptosis	Cancer
RRD-251 is an inhibitor of retinoblastoma tumor suppressor protein (Rb)-Raf-1 interaction, with potent anti-proliferative, anti-angiogenic and anti-tumor activities .

TPCK 1 Publications Verification L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK	Ser/Thr Protease HPV	Inflammation/Immunology Cancer
TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) is a potent serine protease inhibitor that reacts with the retinoblastoma protein (RB)-binding core of HPV-18 E7 protein and abolish its RB-binding capability. TPCK is able to modify E7 protein in live keratinocytes following its addition to the culture medium .

CDK-IN-9	CDK Apoptosis DNA/RNA Synthesis	Cancer
CDK-IN-9 (compound 24) is a potent CDK inhibitor, also as a molecular glue inducing an interaction between CDK12 and DDB1, with an IC₅₀ values of 4 nM for CDK2/E. CDK-IN-9 leads to polyubiquitination of cyclin K and its subsequent degradation. CDK-IN-9 induce apoptosis through dephosphorylation of retinoblastoma protein and RNA polymerase II .

BMS-665053	CRFR	Neurological Disease
BMS-665053 is a corticotropin-releasing factor-1 (CRF1) receptor antagonist (IC₅₀ = 1.0 nM). BMS-665053)11 is a potent inhibitor of CRF-stimulated cyclic adenosine monophosphate (cAMP) production in human Y-79 retinoblastoma cells (IC₅₀ = 4.9 nM) .

CDK4/6-IN-15	CDK	Cancer
CDK4/6-IN-15 is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 potently inhibits cancer cells growth. CDK4/6-IN-15 arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression .

KDM5-C70 3 Publications Verification	Histone Demethylase	Cancer
KDM5-C70 is an ethyl ester derivative of KDM5-C49 and a potent, cell-permeable and pan-KDM5 histone demethylase inhibitor. KDM5-C70 has an antiproliferative effect in myeloma cells, leading to genome-wide elevation of H3K4me3 levels .

CDK4/6-IN-14	CDK	Cancer
CDK4/6-IN-14 is a potent and highly selective CDK4 and CDK6 (CDK) inhibitor with IC₅₀s of 10 nM and 16 nM, respectively. CDK4/6-IN-14 exhibits more than 60-fold selectivity over CDKs 1, 2, 7, and 9, and shows high selectivity among other 205 kinases .

BS-194	CDK	Cancer
BS-194 is an orally active, selective and potent CDK inhibitor. BS-194 inhibits CDK2, CDK1, CDK5, CDK7, CDK9 (IC₅₀s: 3, 30, 30, 250, and 90 nM respectively). BS-194 potently inhibits cancer cells proliferation. BS-194 can be used in the research of cancers like breast cancer, colon cancer .

Methyl Eugenol	Autophagy PI3K mTOR Akt	Inflammation/Immunology Cancer
Methyl Eugenol is a bait that has oral activity against oriental fruit fly (Hendel).Methyl Eugenol has anti-cancer and anti-inflammatory activities. Methyl Eugenol can induce Autophagy in cells. Methyl Eugenol can be used in the study of intestinal ischemia/reperfusion injury .

Cat. No.	Product Name	Category	Target	Chemical Structure

D-erythro-Sphingosine hydrochloride 2 Publications Verification Erythrosphingosine hydrochloride; erythro-C18-Sphingosine hydrochloride; trans-4-Sphingenine hydrochloride	Animals Source classification	TRP Channel
D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation .

Methyl Eugenol	Asarum sieboldii Miq. Structural Classification Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Phenylpropanoids Plants Disease Research Fields Aristolochiaceae	Autophagy PI3K mTOR Akt
Methyl Eugenol is a bait that has oral activity against oriental fruit fly (Hendel).Methyl Eugenol has anti-cancer and anti-inflammatory activities. Methyl Eugenol can induce Autophagy in cells. Methyl Eugenol can be used in the study of intestinal ischemia/reperfusion injury .

Cat. No.	Product Name	Application	Reactivity

HY-P81301

Phospho-Rb (Thr356) Antibody (YA1029)

RB1; retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
WB, IHC-P, IP Human, Rat
HY-P81301A

Phospho-Rb (Ser780) Antibody (YA1030)

RB1; retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
WB, IP Human, Rat
HY-P81301B

Phospho-Rb (Ser811) Antibody (YA1031)

RB1; retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
WB Human, Hamster
HY-P81301C

Phospho-Rb (Ser608) Antibody (YA1032)

RB1; retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
WB, IHC-P Human, Rat
HY-P81301D

Phospho-Rb (Thr252) Antibody (YA1033)

RB1; retinoblastoma-associated protein; p105-Rb; pRb; Rb; pp110
WB, IHC-P Human, Rat

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inhibitors & Agonists

Name
Email *

	Sorry, but the email address you supplied was invalid.