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Results for "

sEH

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Cholinesterase (ChE) (5) COX (2) Epoxide Hydrolase (40) FAAH (2) FLAP (2) Fluorescent Dye (2) HDAC (1) PPAR (1) Small Interfering RNA (siRNA) (1)
By Research Areas:	Cancer (5) Cardiovascular Disease (16) Infection (2) Inflammation/Immunology (20) Metabolic Disease (8) Neurological Disease (8)

Inhibitors & Agonists

Fluorescent Dye

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-120494

sEH inhibitor-1	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-1 (compound TCPU ) is a potent and oral active inhibitor of *sEH* (soluble epoxide hydrolase) with IC₅₀s of 0.4 and 5.3 nM in human and murine, respectively .

HY-156329

sEH/FLAP-IN-1	Epoxide Hydrolase FLAP	Inflammation/Immunology
sEH/FLAP-IN-1 (Compound 46A) is a *sEH/FLAP* inhibitor. sEH/FLAP-IN-1 inhibits 5-LOX product formation in SACM-stimulated PBMCs (EC₅₀: 11 nM). sEH/FLAP-IN-1 inhibit sEH (EC₅₀: 18 nM) and thromboxane production. sEH/FLAP-IN-1 can be used for research of inflammatory diseases .

HY-143294

sEH inhibitor-2	Epoxide Hydrolase	Cardiovascular Disease
sEH inhibitor-2 (compound 5l) is an orally active (predicted percentage absorption: 71.2-88.4%) soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 0.9 nM. sEH inhibitor-2 can maintain epoxyeicosatrienoic acids (EETs) serum level in high concentrations. sEH inhibitor-2 can be used in study of cardiovascular protection .

HY-145831

sEH/AChE-IN-1	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
sEH/AChE-IN-1 (Compound 12a) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-1 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-1 has the potential for the research of Alzheimer's disease (AD) .

HY-151621

sEH inhibitor-13

Epoxide Hydrolase Inflammation/Immunology

sEH inhibitor-13 (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 0.4 μM .

sEH inhibitor-13	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-13 (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 0.4 μM .

HY-145832

sEH/AChE-IN-2	Cholinesterase (ChE)	Neurological Disease Inflammation/Immunology
sEH/AChE-IN-2 (Compound 12b) is a dual inhibitor of the enzymes soluble epoxide hydrolase (sEH) and acetylcholinesterase (AChE). sEH/AChE-IN-2 provides cumulative effects against neuroinflammation and memory impairment. sEH/AChE-IN-2 has the potential for the research of Alzheimer's disease (AD) .

HY-155029

sEH inhibitor-16	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC₅₀ of 2 nM. sEH inhibitor-16 reduces the inflammatory damage in Cerulein (HY-A0190)-induced acute pancreatitis (AP) in mice and can be used for inflammation/immunology research .

HY-160676

sEH-IN-1	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
sEH-IN-1 (example 67) is a soluble epoxide hydrolase (sEH) inhibitor. sEH-IN-1 can be used in the research of sEH-mediated diseases such as hypertension, cardiovascular disease, inflammation, diabetes, and so on .

HY-146643

sEH inhibitor-3	Epoxide Hydrolase	Neurological Disease
sEH inhibitor-3 (compound 35) is a potent and orally active soluble epoxide hydrolase (sEH) inhibitor with a K_i of 0.75 nM for human sEH .

HY-148136

sEH inhibitor-7	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-7 (compound c-2) is an inhibitor of soluble epoxide hydrolase (sEH) with IC₅₀s of 0.15 μM (mouse sEH) and 6.2 μM (human sEH), respectively. soluble epoxide hydrolase (sEH) plays an important role in the metabolism of endogenous chemical mediators involved in the regulation of blood pressure and inflammation .

HY-151617

sEH inhibitor-11	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-11 (compound 35) is a *sEH* inhibitor with an IC₅₀ value of 0.3 μM. sEH inhibitor-11 can be used for the research of inflammation .

HY-151616

sEH inhibitor-10	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
sEH inhibitor-10 (Compound 37) is a selective soluble epoxide hydrolase (sEH) inhibitor (IC₅₀=0.5 μM). sEH inhibitor-10 maintains high cycloeicosatrienoic acid (EETs) levels by inhibiting *sEH, thereby reducing inflammation, regulating endothelial tone, improving mitochondrial function, and reducing oxidative stress. sEH* inhibitor-10 has good research potential in metabolic, renal and cardiovascular diseases .

HY-148573

sEH inhibitor-14	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease Inflammation/Immunology
sEH inhibitor-14 (compound 33) is a benzoxazolone-5-urea analogue. In addition, sEH inhibitor-14 is a soluble Epoxide Hydrolase (sEH) inhibitor (IC₅₀=0.39 nM) .

HY-151619

sEH inhibitor-12	Epoxide Hydrolase	Inflammation/Immunology
sEH inhibitor-12 (compound 34) is a *sEH* inhibitor with an IC₅₀ value of 0.7 μM. sEH inhibitor-12 inhibits the 5-lipoxygenase-activating protein (FLAP)-mediated leukotriene (LT) biosynthesis with an IC₅₀ value of 2.9 μM. sEH inhibitor-12 can be used for the research of inflammation .

HY-148000

sEH inhibitor-6	Epoxide Hydrolase	Cardiovascular Disease Inflammation/Immunology
sEH inhibitor-6 (Compound 3g) is a soluble epoxide hydrolase (sEH) inhibitor with an IC₅₀ of 0.5 nM .

HY-147733

sEH inhibitor-5

Cholinesterase (ChE) Inflammation/Immunology

sEH inhibitor-5 (compound D016) is a potent sEH (soluble epoxide hydrolase) inhibitor with an IC₅₀ value of 0.1 nM .

sEH inhibitor-5	Cholinesterase (ChE)	Inflammation/Immunology
sEH inhibitor-5 (compound D016) is a potent sEH (soluble epoxide hydrolase) inhibitor with an IC₅₀ value of 0.1 nM .

HY-163207

sEH/HDAC6-IN-1	Epoxide Hydrolase HDAC	Neurological Disease
sEH/HDAC6-IN-1 (compound M9) is a selective, orally active dual inhibitor for *sEH* and HDAC6, with IC₅₀s of 2 nM, 0.72 nM and 5 nM, for human sEH, murine sEH and HDAC6, respectively. sEH/HDAC6-IN-1 reveals analgesic and anti-inflammatory effects .

HY-147732

sEH inhibitor-4	Epoxide Hydrolase	Inflammation/Immunology
Intensive structural modification resulted in the identification of compound B15 as an effective sEH inhibitor with a value of 0.03 ± 0.01 nm, and the presence of soluble epoxide hydrolase (SEH) can reduce inflammation and pain.

HY-145833A

sEH/AChE-IN-4	Epoxide Hydrolase Cholinesterase (ChE)	Neurological Disease Cancer
sEH/AChE-IN-4 (compound (+)-15) is a potent and BBB-penetrated dual inhibitor of *sEH* (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC₅₀ values of 3.1 nM (hsEH), 1660 nM (hAChE), 179 nM (hBChE, human butyrylcholinesterase), 14.5 nM (msEH), and 102 nM (mAChE), respectively .

HY-145833

sEH/AChE-IN-3	Epoxide Hydrolase Cholinesterase (ChE)	Neurological Disease Cancer
sEH/AChE-IN-3 (compound (−)-15) is a potent and BBB-penetrated dual inhibitor of *sEH* (soluble epoxide hydrolase) and AChE (acetylcholinesterase), with IC₅₀ values of 0.4 nM (hsEH), 1.94 nM (hAChE), 615 (hBChE, human butyrylcholinesterase), 4.3 nM (msEH), and 2.61 nM (mAChE), respectively .

HY-RS12629

SEH1L Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SEH1L Human Pre-designed siRNA Set A contains three designed siRNAs for SEH1L gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SEH1L Human Pre-designed siRNA Set A SEH1L Human Pre-designed siRNA Set A

HY-146704

*COX-2/sEH-IN-1*	Epoxide Hydrolase COX	Cardiovascular Disease
COX-2/sEH-IN-1 (Compound 9c) is an orally active, dual COX-2 and *sEH* (soluble epoxide hydrolase) inhibitor with IC₅₀ values of 1.24 µM and 0.40 nM against COX-2 and sEH, respectively. COX-2/sEH-IN-1 shows improved anti-inflammatory activity and highly reduced cardiovascular risks .

HY-101294

TPPU Maximum Cited Publications 7 Publications Verification	Epoxide Hydrolase	Inflammation/Immunology
TPPU is a soluble epoxide hydrolase (sEH) inhibitor with IC₅₀ values of 37 and 3.7 nM for monkey and human sEH, respectively.

HY-144738

*Dual FAAH/sEH-IN-1*	Epoxide Hydrolase FAAH	Inflammation/Immunology
Dual FAAH/sEH-IN-1 (compound 3) is a high affinity dual *sEH* (soluble epoxide hydrolase) and FAAH (fatty acid amide hydrolase) inhibitor, with IC₅₀ values of 9.6 and 7 nM, respectively. Dual FAAH/sEH-IN-1 shows antinociception against the inflammatory phase .

HY-113974

trans-AUCB 1 Publications Verification t-AUCB	Epoxide Hydrolase	Cancer
trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC₅₀s of 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has anti-glioma activity .

HY-108570

AUDA 2 Publications Verification	Epoxide Hydrolase	Inflammation/Immunology
AUDA (compound 43) is a potent soluble epoxide hydrolase (sEH) inhibitor with IC₅₀s of 18 and 69 nM for the mouse and human sEH, respectively . AUDA has anti-inflammatory activity .

HY-113862

PHOME	Fluorescent Dye	Others
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) .

HY-121538

CUDA	Epoxide Hydrolase PPAR	Cardiovascular Disease
CUDA is a potent inhibitor of soluble epoxide hydrolase (sEH), with IC₅₀s of 11.1 nM and 112 nM for mouse sEH and human sEH, respectively . CUDA selectively increases peroxisome proliferator-activated receptor (PPAR) alpha activity. CUDA may be valuable for the research of cardiovascular disease .

HY-N12528

10,11-EDT	Epoxide Hydrolase	Cardiovascular Disease
10,11-EDT, a soluble epoxide hydrolase (sEH) substrate, is a metabolic product of adrenic acid. 10,11-EDT is an endothelium-derived hyperpolarizing factor with strong vasorelaxant effects .

HY-135653

EC5026 1 Publications Verification BPN-19186	Epoxide Hydrolase	Neurological Disease
EC5026 (BPN-19186) is a first-in-class, non-opioid and orally active soluble Epoxide Hydrolase (sEH) inhibitor. EC5026 shows efficacy for inflammatory and neuropathic pain .

HY-135653A

(Rac)-EC5026 (Rac)-BPN-19186	Epoxide Hydrolase	Neurological Disease
(Rac)-EC5026 ((Rac)-BPN-19186) is a potent piperidine inhibitor of soluble epoxide hydrolase (sEH) extracted from patent WO2019156991A1, page 39, has a K_i of 0.06 nM. (Rac)-EC5026 can be used for the research of Parkinson's disease and dementia with Lewy Bodies (DLB) .

HY-19644

GSK2256294A 2 Publications Verification GSK 2256294	Epoxide Hydrolase	Cardiovascular Disease
GSK2256294A (GSK 2256294) is a selective and orally active inhibitor of soluble epoxide hydrolase (sEH). GSK2256294A inhibits recombinant human sEH, rat sEH orthologs and murine sEH orthologs with IC₅₀s of 27, 61 and 189 pM, respectively. GSK2256294A can be used for the research of chronic obstructive pulmonary disease (COPD) and cardiovascular disease .

HY-126326

SWE101	Epoxide Hydrolase	Metabolic Disease
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC₅₀s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH .

HY-111151

AR-9281 APAU	Epoxide Hydrolase	Infection Metabolic Disease
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC₅₀ values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes .

HY-121941

Epoxy Fluor 7	Fluorescent Dye	Others
Epoxy Fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used for human and mouse enzymes. Epoxy Fluor 7 is hydrolyzed to yield fluorescence used for monitoring the activity of sEH.

HY-163401

Epoxykynin

Epoxide Hydrolase Cancer

Epoxykynin is a potent epoxide hydrolase (sEH) inhibitor .

Epoxykynin	Epoxide Hydrolase	Cancer
Epoxykynin is a potent epoxide hydrolase (sEH) inhibitor .

HY-162120

FZQ-21	Epoxide Hydrolase	Infection
FZQ-21 (Compound 70P) is a soluble epoxide hydrolase (sEH) inhibitor, with an IC₅₀ of 4 nM. FZQ-21 exhibits equal IC₅₀ (1.5 nM) on inhibiting human sEH as EC5026 (HY-135653) (1.7 nM). FZQ-21 can be used for research of sepsis .

HY-114266

UC-1728 t-TUCB	Epoxide Hydrolase	Cardiovascular Disease Inflammation/Immunology
UC-1728 is a potent rabbit soluble epoxide hydrolase *(sEH)* inhibitor, with an IC₅₀ of 2 nM on rabbit liver.

HY-122591

PTUPB

COX Metabolic Disease Cancer

PTUPB is a potent and dual sEH and COX-2 enzymes inhibitor with IC₅₀ of 0.9 nM and 1.26 μM, respectively .

PTUPB	COX	Metabolic Disease Cancer
PTUPB is a potent and dual *sEH* and COX-2 enzymes inhibitor with IC₅₀ of 0.9 nM and 1.26 μM, respectively .

HY-128171

Diflapolin 1 Publications Verification	FLAP Epoxide Hydrolase	Inflammation/Immunology
Diflapolin is a highly active dual 5-lipoxygenase-activating protein (FLAP)/soluble epoxide hydrolase *(sEH)* inhibitor with marked anti-inflammatory efficacy and high target selectivity. Diflapolin inhibits 5-LOX product formation in intact human monocytes and neutrophils with IC₅₀s of 30 and 170 nM, respectively, and suppressed the activity of isolated sEH (IC₅₀=20 nM) .

HY-124063

BI-1935

Epoxide Hydrolase Cardiovascular Disease

BI-1935 is a potent soluble epoxide hydrolase (sEH) inhibitor. BI-1935 can be used for the research of cardiovascular disease .

BI-1935	Epoxide Hydrolase	Cardiovascular Disease
BI-1935 is a potent soluble epoxide hydrolase (sEH) inhibitor. BI-1935 can be used for the research of cardiovascular disease .

HY-121549

S-NEPC 4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate	Epoxide Hydrolase	Others
S-NEPC (4-Nitrophenyl-2S,3S-epoxy-3 phenylpropyl carbonate) is a colorimetric substrate used to measure epoxide hydrolase activity .

HY-U00453

Soluble epoxide hydrolase inhibitor	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease
Soluble epoxide hydrolase inhibitor is an inhibitor of soluble epoxide hydrolase, and inhibits human soluble epoxide hydrolase (h-sEH) with pIC₅₀ of 8.4, extracted from patent WO 2010096722 A1, example 57.

HY-W013989

1,3-Dicyclohexylurea	Epoxide Hydrolase	Cardiovascular Disease
1,3-Dicyclohexylurea (DCU) is an orally active and potent *sEH* (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats .

HY-155773

VU534	FAAH Epoxide Hydrolase	Cardiovascular Disease
VU534 is a NAPE-PLD activator, with an EC₅₀ of 0.30 μM. VU534 is dual inhibitors of FAAH and *sEH* (IC₅₀ of 1.2 μM). VU534 increases efferocytosis in a NAPE-PLD dependent manner. VU534 has the potential for cardiometabolic diseases study ^[1].

HY-W013989R

1,3-Dicyclohexylurea (Standard)	Epoxide Hydrolase	Cardiovascular Disease
1,3-Dicyclohexylurea (Standard) is the analytical standard of 1,3-Dicyclohexylurea. This product is intended for research and analytical applications. 1,3-Dicyclohexylurea (DCU) is an orally active and potent *sEH* (soluble epoxide hydrolase) inhibitor. Oral Delivery of 1,3-Dicyclohexylurea nanosuspension enhances exposure and lowers blood pressure in hypertensive Rats .

HY-135795

1-Cyclohexyl-3-dodecyl urea CDU; N-Cyclohexyl-N-dodecyl urea; NCND	Epoxide Hydrolase	Cardiovascular Disease Metabolic Disease
1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) is a highly selective soluble epoxide hydrolase (sEH) inhibitor. 1-Cyclohexyl-3-dodecyl urea (CDU; N-Cyclohexyl-N-dodecyl urea; NCND) increases epoxyeicosatrienoic acids (EETs) levels and lowers blood pressure in angiotensin II (Ang II) hypertension .

Cat. No.	Product Name	Type

HY-113862

PHOME	Dyes
PHOME is a fluorogenic substrate for sEH. sEH can hydrolyze the epoxy ring in the PHOME substrate. PHOME can be used for fluorescent epoxide hydrolase assay (extracted from patent CN113402447A) .

HY-121941

Epoxy Fluor 7	Fluorescent Dyes/Probes
Epoxy Fluor 7 is a sensitive fluorescent substrate for soluble epoxide hydrolase (sEH) that can be used for human and mouse enzymes. Epoxy Fluor 7 is hydrolyzed to yield fluorescence used for monitoring the activity of sEH.

Cat. No.	Compare	Product Name	Species	Source

HY-P71807

	Enterotoxin type H Protein, S. aureus (P.pastoris, His) entH; sEHEnterotoxin type H; sEH	Staphylococcus aureus	P. pastoris
	Enterotoxin (ETH) activates the host immune system by binding as a raw molecule to major histocompatibility complex class II and T-cell receptor (TCR) molecules, specifically through its alpha domain, specifically TRAV27 . This interaction forms a ternary complex that activates a large number of T lymphocytes and triggers the widespread release of proinflammatory cytokines. Enterotoxin type H Protein, S. aureus (P.pastoris, His) is the recombinant Staphylococcus aureus-derived Enterotoxin type H protein, expressed by P. pastoris , with N-His labeled tag. The total length of Enterotoxin type H Protein, S. aureus (P.pastoris, His) is 217 a.a., with molecular weight of ~27.1 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P83150

Epoxide Hydrolase 1 Antibody (YA2895)

CEH; sEH; ABHD20
WB Human, Mouse
HY-P82174

SEH1L Antibody (YA1919)

GATOR complex protein sEH1; Nup107-160 subcomplex subunit sEH1
WB, IP Human, Mouse, Rat

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