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teratogenic

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By Targets:	Akt (1) Antibiotic (4) Apoptosis (4) Autophagy (2) Bacterial (6) DNA/RNA Synthesis (2) EBV (1) Endogenous Metabolite (2) Fungal (1) Hedgehog (1) Isotope-Labeled Compounds (4) Ligands for E3 Ligase (1) mAChR (2) Molecular Glues (1) nAChR (2) Parasite (1) Smo (1)
By Research Areas:	Cancer (11) Infection (7) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-147251

SRI 6409-94	Others	Others
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. SRI 6409-94 serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity .

HY-N7027

Macrozamin

Others Neurological Disease Cancer

Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .
HY-128683

Cycloposine

Others Others

Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound .

Macrozamin	Others	Neurological Disease Cancer
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

Cycloposine	Others	Others
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound .

HY-W010593

Ethylenethiourea	Others	Cancer
Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active .

HY-14658A

(S)-Thalidomide (S)-(-)-Thalidomide	Molecular Glues Ligands for E3 Ligase Autophagy Apoptosis	Metabolic Disease Inflammation/Immunology
(S)-Thalidomide ((S)-(-)-Thalidomide) is the S-enantiomer of Thalidomide. (S)-Thalidomide has immunomodulatory, anti-inflammatory, antiangiogenic and pro-apoptotic effects . (S)-Thalidomide induces teratogenic effects by binding to cereblon (CRBN) .

HY-138793

2-(2,6-Dioxopiperidin-3-yl)phthalimidine EM-12	Others	Cancer
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12), a teratogenic Thalidomide analogue, is more active than Thalidomide and is much more stable for hydrolysis. 2-(2,6-Dioxopiperidin-3-yl)phthalimidine enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas .

HY-N6779

Patulin 3 Publications Verification Terinin	Bacterial Apoptosis Autophagy Antibiotic	Infection
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-N0836

Jervine 2 Publications Verification 11-Ketocyclopamine	Hedgehog Smo	Inflammation/Immunology Cancer
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-146459

Akt1-IN-1	Akt	Cancer
Akt1-IN-1 (compound 5b) is a potent and selective Akt1 inhibitor with an IC₅₀ value of 18.79 nM in MIA Paca-2 cells. Akt1-IN-1 does not exhibit obvious teratogenicity, hepatotoxicity and cardiotoxicity (No Observed Adverse Effect Level > 100 µM). Akt1-IN-1 can be used for researching anticancer .

HY-N6643

Rubropunctamine	EBV Fungal Bacterial	Infection Inflammation/Immunology
Rubropunctamine is a redMonascus pigment. Not only Rubropunctamine exerts antibiotic action against bacteria but also against some yeast and filamentous fungi strains. Rubropunctamine has potential embryotoxicity and teratogenicity .

HY-W010593S

Ethylenethiourea-d4	Isotope-Labeled Compounds	Cancer
Ethylenethiourea-d₄ is the deuterium labeled Ethylenethiourea[1]. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active[2][3].

HY-75308

Azetidine-2-carboxylic acid	Others	Cancer
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent .

HY-N6697

Aflatoxin G1	Bacterial Antibiotic Parasite	Infection Cancer
Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .

HY-N6725

Sterigmatocystine	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N6725R

Sterigmatocystine (Standard)	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite	Infection Cancer
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N1952S

Isoeugenol-d3 iso-Eugenol-d₃	Bacterial Isotope-Labeled Compounds	Infection
Isoeugenol-d₃ is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N6779S

Patulin-13C7 Terinin-¹³C₇	Isotope-Labeled Compounds	Infection
Patulin- ¹³C₇ (Terinin- ¹³C₇) is the ¹³C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-N6697S

Aflatoxin G1-13C17	Isotope-Labeled Compounds	Cancer
Aflatoxin G1- ¹³C₁₇ is the ¹³C labeled Aflatoxin G1 (HY-N6697) . Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .

HY-121027

Anagyrine (-)-Anagyrine; Monolupine; Rhombinine	mAChR nAChR	Neurological Disease
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR .

HY-121027A

Anagyrine hydrochloride (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride	mAChR nAChR	Neurological Disease
Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7027

Macrozamin	Liliaceae Source classification Smilacis Glabrae Rhizoma Plants Saccharides	Others
Macrozamin is a major constituent principle of Cycads. Macrozamin has carcinogenic, mutagenic, teratogenic and neurotoxic properties .

HY-128683

Cycloposine	Structural Classification Liliaceae Classification of Application Fields Veratrum californicum Other Diseases Plants Disease Research Fields Steroids	Others
Cycloposine is a steroidal alkaloid that can be found in the roots and rhizomes of Veratrum californicum. Cycloposine is also a teratogenic compound .

HY-N6779

Patulin 3 Publications Verification Terinin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Bacterial Apoptosis Autophagy Antibiotic
Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, causes chromosome breakage, mutation, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-N0836

Jervine 2 Publications Verification 11-Ketocyclopamine	Alkaloids Piperidine Alkaloids Veratrum nigrum Linn. Liliaceae Classification of Application Fields Source classification Plants Inflammation/Immunology Disease Research Fields	Hedgehog Smo
Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC₅₀ of 500-700 nM . Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties .

HY-N6643

Rubropunctamine	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Source classification Pigments Isoquinoline Alkaloids Inflammation/Immunology Disease Research Fields Food Research	EBV Fungal Bacterial
Rubropunctamine is a redMonascus pigment. Not only Rubropunctamine exerts antibiotic action against bacteria but also against some yeast and filamentous fungi strains. Rubropunctamine has potential embryotoxicity and teratogenicity .

HY-75308

Azetidine-2-carboxylic acid	Structural Classification Classification of Application Fields Source classification Amino acids Beta vulgaris Linn. Plants Disease Research Fields Cancer Chenopodiaceae	Others
Azetidine-2-carboxylic acid is a non proteinogenic amino acid homologue of proline. Found in common beets. Azetidine-2-carboxylic acid can be misincorporated into proteins in place of proline in many species, including humans. Toxic and teratogenic agent .

HY-N6697

Aflatoxin G1	Infection Structural Classification Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Source classification Coumarins Phenylpropanoids Endogenous metabolite Disease Research Fields Cancer	Bacterial Antibiotic Parasite
Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .

HY-N6725

Sterigmatocystine	Infection Structural Classification Monophenols Microorganisms Xanthones Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N6725R

Sterigmatocystine (Standard)	Infection Structural Classification Microorganisms Classification of Application Fields Source classification Phenols Disease Research Fields	DNA/RNA Synthesis Bacterial Apoptosis Antibiotic Endogenous Metabolite
Sterigmatocystine (Standard) is the analytical standard of Sterigmatocystine. This product is intended for research and analytical applications. Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-121027

Anagyrine (-)-Anagyrine; Monolupine; Rhombinine	Alkaloids Piperidine Alkaloids Structural Classification Classification of Application Fields Leguminosae Source classification Plants Disease Research Fields Lupinus albus Linn. Cancer	mAChR nAChR
Anagyrine ((-)-Anagyrine) is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine binds to muscarinic and nicotinic acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine is a potent and effective desensitizer of nAChR, and Anagyrine can directly, without metabolism, desensitize nAChR .

HY-121027A

Anagyrine hydrochloride (-)-Anagyrine hydrochloride; Monolupine hydrochloride; Rhombinine hydrochloride	Structural Classification Alkaloids Piperidine Alkaloids Leguminosae Source classification Plants Sophora flavescens Aiton	mAChR nAChR
Anagyrine ((-)-Anagyrine) hydrochloride is a quinolizidine alkaloid that has been found in Lupinus albus. Anagyrine hydrochloride binds to muscarinic and nicotinic acetylcholine receptors with IC₅₀ values of 132 and 2096 µM respectively. Anagyrine hydrochloride is a potent and effective desensitizer of nAChR, and Anagyrine hydrochloride can directly, without metabolism, desensitize nAChR .

Cat. No.	Product Name	Chemical Structure

HY-W010593S

Ethylenethiourea-d4
Ethylenethiourea-d₄ is the deuterium labeled Ethylenethiourea[1]. Ethylenethiourea is a degradation product of the ethylenebisthiocarbamate group of fungicides. Ethylenethiourea is tumorigenic and teratogenic. Ethylenethiourea is orally active[2][3].

HY-N1952S

Isoeugenol-d3
Isoeugenol-d₃ is deuterated labeled Sterigmatocystine (HY-N6725). Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor . Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals .

HY-N6779S

Patulin-13C7
Patulin- ¹³C₇ (Terinin- ¹³C₇) is the ¹³C labeled Patulin (HY-N6779) . Patulin (Terinin) is a mycotoxin produced by fungi including the Aspergillus, Penicillium, and Byssochlamys species, is suspected to be clastogenic, mutagenic, teratogenic and cytotoxic. Patulin induces autophagy-dependent apoptosis through lysosomal-mitochondrial axis, and causes DNA damage .

HY-N6697S

Aflatoxin G1-13C17
Aflatoxin G1- ¹³C₁₇ is the ¹³C labeled Aflatoxin G1 (HY-N6697) . Aflatoxin G1 is one type of aflatoxins occuring in nature. It is produced by molds, such as Aspergillus flavus and Aspergillus parasiticus. Aflatoxins are hepatogenic, teratogenic, imunosuppressive, and carcinogenic fungal metabolites found in feeds, nuts, wine-grapes, spices, and other grain crops .

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teratogenic

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products