Search Result

Results for "

transmembrane protein

" in MedChemExpress (MCE) Product Catalog:

By Targets:	CFTR (10) Apoptosis (2) Autophagy (4) Bacterial (3) Chloride Channel (3) Endogenous Metabolite (3) Endothelin Receptor (1) iGluR (2) Interleukin Related (1) Isotope-Labeled Compounds (1) Leukotriene Receptor (1) Ligands for Target Protein for PROTAC (1) Mitochondrial Metabolism (3) Mucin (1) Notch (1) P-glycoprotein (3) PI3K (1) Potassium Channel (3) Reactive Oxygen Species (1) SARS-CoV (1) Smo (1) STING (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (6) Endocrinology (2) Infection (1) Inflammation/Immunology (12) Metabolic Disease (3) Neurological Disease (6)

By Targets:

CFTR (10)

Apoptosis (2)

Autophagy (4)

Bacterial (3)

Chloride Channel (3)

Endogenous Metabolite (3)

Endothelin Receptor (1)

iGluR (2)

Interleukin Related (1)

Isotope-Labeled Compounds (1)

Leukotriene Receptor (1)

Ligands for Target Protein for PROTAC (1)

Mitochondrial Metabolism (3)

Mucin (1)

Notch (1)

P-glycoprotein (3)

PI3K (1)

Potassium Channel (3)

Reactive Oxygen Species (1)

SARS-CoV (1)

Smo (1)

STING (3)

By Research Areas:

Cancer (13)

Cardiovascular Disease (6)

Endocrinology (2)

Infection (1)

Inflammation/Immunology (12)

Metabolic Disease (3)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Targets Recommended: CFTR Enteropeptidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3540

Caraphenol A	Others	Inflammation/Immunology
Caraphenol A is a resveratrol trimer and is able to transiently reduce *interferon-induced transmembrane* (IFITM)** protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-109152

Navocaftor

GLPG 3067; ABBV-3067
CFTR Others

Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .

Navocaftor GLPG 3067; ABBV-3067	CFTR	Others
Navocaftor (GLPG 3067), as a cystic fibrosis transmembrane regulator (CFTR), is a protein modulator (US 20200377491 Al, example 1) .

HY-N10661

Ipomoeassin F Ipom-F	SARS-CoV	Infection Cancer
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-16587

Saridegib

IPI-926; Patidegib
Smo Cancer

Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

Saridegib IPI-926; Patidegib	Smo	Cancer
Saridegib is a potent and specific inhibitor of Smoothened (Smo), a key signaling transmembrane protein in the Hedgehog (Hh) pathway.

HY-148806

Zatonacaftor	CFTR	Inflammation/Immunology
Zatonacaftor is a modulator of *cystic fibrosis transmembrane* regulator (CFTR*) protein*. Zatonacaftor can be used for research of cystic fibrosis .

HY-109187A

Posenacaftor sodium 1 Publications Verification PTI-801 sodium	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) sodium is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor sodium is used for the research of cystic fibrosis (CF) .

HY-109187

Posenacaftor PTI-801	CFTR	Inflammation/Immunology
Posenacaftor (PTI-801) is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-109187B

(R)-Posenacaftor sodium (R)-PTI-801 sodium	CFTR	Inflammation/Immunology
(R)-Posenacaftor (R)-PTI-801) sodium is the R enantiomer of Posenacaftor. Posenacaftor is a cystic fibrosis transmembrane regulator (CFTR) protein modulator that corrects the folding and trafficking of CFTR protein. Posenacaftor is used for the research of cystic fibrosis (CF) .

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-100613

MONNA	Chloride Channel	Cardiovascular Disease
MONNA is a potent transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with an IC₅₀ of 80 nM. MONNA induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions .

HY-119981

Ani9	Chloride Channel	Neurological Disease Cancer
Ani9 is a potent and selective transmembrane protein 16A (TMEM16A, Anoctamin-1) blocker with IC₅₀ at 77 nM. Ani9 can be applied to the study of cancer and other diseases .

HY-108707

LY3130481 1 Publications Verification	iGluR	Neurological Disease
LY3130481 is an AMPA receptor antagonist that is dependent upon transmembrane AMPA receptor regulatory protein (TARP) γ-8, selective inhibits AMPA/TARP γ-8 with an IC₅₀ of 65 nM .

HY-P1985A

Notch 1 TFA	Notch	Cardiovascular Disease Cancer
Notch 1 TFA (Notch homolog 1, translocation-associated) can encode a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types .

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-126394B

Bamocaftor potassium VX-659 potassium	CFTR	Endocrinology
Bamocaftor potassium is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor potassium can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-126394

Bamocaftor VX-659	CFTR	Endocrinology
Bamocaftor (VX-659) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector designed to restore F508del-CFTR protein function. Bamocaftor can be used combine with Tezacaftor (HY-15448) and Ivacaftor (HY-13017) in cystic fibrosis research .

HY-100612

T16Ainh-A01 2 Publications Verification	Chloride Channel	Others
T16Ainh-A01, an aminophenylthiazole, is a potent transmembrane protein 16A (TMEM16A) inhibitor, inhibiting TMEM16A-mediated chloride currents with an IC₅₀ value of ~1 µM. TMEM16A (ANO1) functions as a calcium-activated chloride channel (CaCC) .

HY-W747565

Leukotriene B4-3-aminopropylamide LTB4-APA	Leukotriene Receptor	Inflammation/Immunology
Leukotriene B4-3-aminopropylamide (LTB4-APA) is a leukotriene immunomodulator. The study found that LTB4 can bind to the polar carboxylic acid group of LTB4 near the outer surface of BLT1 cells, and the hydrophobic LTB4 tail points to the transmembrane region of the receptor protein .

HY-15206

Glibenclamide Maximum Cited Publications 18 Publications Verification Glyburide	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glibenclamide (Glyburide) is an orally active ATP-sensitive K ⁺ channel (K_ATP) inhibitor and can be used for the research of diabetes and obesity . Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of K_ATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR) . Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability . Glibenclamide can induce autophagy .

HY-111751

JNJ-61432059 1 Publications Verification	iGluR	Neurological Disease
JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8, with a pIC₅₀ of 9.7 for GluA1/γ-8. Exhibits time- and dose-dependent AMPAR/γ-8 receptor occupancy in mouse hippocampus, resulting in robust seizure protection in corneal kindling and pentylenetetrazole (PTZ) anticonvulsant models .

HY-150407

TSPO ligand-1	Ligands for Target Protein for PROTAC Autophagy	Others Neurological Disease Cancer
TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration .

HY-15206S

Glyburide-d11	Isotope-Labeled Compounds Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S1

Glyburide-d3 Glyburide-d₃	Potassium Channel Mitochondrial Metabolism Autophagy CFTR P-glycoprotein	Metabolic Disease
Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-P9976

Isatuximab 1 Publications Verification	Apoptosis	Cancer
Isatuximab is a monoclonal antibody targeting the transmembrane receptor and ectoenzyme CD38, a protein highly expressed on hematological malignant cells, including those in multiple myeloma (MM). Isatuximab has antitumor activity via multiple biological mechanisms, including antibody-dependent cellular-mediated cytotoxicity, complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis, and direct induction of apoptosis without crosslinking. Isatuximab also directly inhibits CD38 ectoenzyme activity, which is implicated in many cellular functions .

HY-12326A

c-di-AMP disodium 2 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 2 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	STING Bacterial Endogenous Metabolite	Inflammation/Immunology
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-P99172

CC-90002	Interleukin Related	Cancer
CC-90002 is a humanized anti-CD47 monoclonal antibody (mAb). CC-90002 has a high affinity for binding to CD47 with a subnanomolar K_d value. CC-90002 can be used for the research of hematologic malignancies and solid tumors .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Product Name

HY-L150

Membrane Receptor-targeted Compound Library	4,674 compounds
Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules. There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery. MCE provides a unique collection of 4,674 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

Membrane Receptor-targeted Compound Library

4,674 compounds

Membrane receptors, also known cell surface receptors or transmembrane receptors, are transmembrane proteins embedded into the plasma membrane which play an essential role in maintaining communication between the internal processes within the cell and various types of extracellular signals. They act in cell signaling by receiving (binding to) extracellular molecules, which are also called ligands. These extracellular molecules include hormones, cytokines, growth factors, neurotransmitters, lipophilic signaling molecules such as prostaglandins, and cell recognition molecules.

There are three kinds of membrane receptors: ion channel-linked receptors, enzyme-linked receptors and G-protein-linked receptors. They play important roles in keeping human normal physiologic processes. GPCRs and ion channels are important drug targets in drug discovery.

MCE provides a unique collection of 4,674 compounds targeting a variety of membrane receptors. MCE Membrane reeptor-targeted Compound Library can be used for membrane receptor-focused screening and drug discovery.

HY-L016

Protein Tyrosine Kinase Compound Library	1,064 compounds
Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers. MCE designs a unique collection of 1,064 compounds that act as a useful tool for PTKs-related drug screening and disease research.

Protein Tyrosine Kinase Compound Library

1,064 compounds

Protein tyrosine kinases (PTKs) are key signaling molecules and important drug targets. Two classes of PTKs are present in cells: the transmembrane receptor PTKs (RTKs) and the nonreceptor PTKs. The RTK family includes the receptors for insulin and for many growth factors, such as EGFR, FGFR, PDGFR, VEGFR, and NGFR. RTKs are transmembrane glycoproteins that are activated by the binding of their ligands, and they transduce the extracellular signal to the cytoplasm by phosphorylating tyrosine residues on the receptors themselves (autophosphorylation) and on downstream signaling proteins. Their principal functions of PTKs involve the regulation of multicellular aspects of the organism. Cell to cell signals concerning growth, differentiation, adhesion, motility, and death are frequently transmitted through tyrosine kinases. In humans, tyrosine kinases have been demonstrated to play significant roles in the development of many disease states, including diabetes and cancers.

MCE designs a unique collection of 1,064 compounds that act as a useful tool for PTKs-related drug screening and disease research.

HY-L008

JAK/STAT Compound Library	424 compounds
The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID). MCE provides 424 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

JAK/STAT Compound Library

424 compounds

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway is central to signaling by cytokine receptors, a superfamily of more than 30 transmembrane proteins that recognize specific cytokines, and is critical in blood formation and immune response. Canonical JAK/STAT signaling begins with the association of cytokines and their corresponding transmembrane receptors. Activated JAKs then phosphorylate latent STAT monomers, leading to dimerization, nuclear translocation, and DNA binding. In mammals, there are four JAKs (JAK1, JAK2, JAK3, TYK2) and seven STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6). Since the JAK/STAT pathway plays a major role in many fundamental processes, such as apoptosis and inflammation, dysfunctional proteins in the pathway may lead to a number of diseases. For example, alterations in JAK/STAT signalling can result in cancer and diseases affecting the immune system, such as severe combined immunodeficiency disorder (SCID).

MCE provides 424 compounds that can be used in the study of the JAK/STAT signaling pathway and related diseases.

HY-L062

Neurotransmitter Receptor Compound Library	1,806 compounds
Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding. In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy. MCE designs a unique collection of 1,806 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

Neurotransmitter Receptor Compound Library

1,806 compounds

Neurotransmitter (NT) receptors, also known as neuroreceptors, are a broadly diverse group of membrane proteins that bind neurotransmitters for neuronal signaling. There are two major types of neurotransmitter receptors: ionotropic and metabotropic. Ionotropic receptors are ligand-gated ion channels, meaning that the receptor protein includes both a neurotransmitter binding site and an ion channel. The binding of a neurotransmitter molecule (the ligand) to the binding site induces a conformational change in the receptor structure, which opens, or gates, the ion channel. The term “metabotropic receptors” is typically used to refer to transmembrane G-protein-coupled receptors. Metabotropic receptors trigger second messenger-mediated effects within cells after neurotransmitter binding.

In some neurological diseases, the neurotransmitter receptor itself appears to be the target of the disease process. Many neuroactive drugs act by modifying neurotransmitter receptors. A better understanding of neurotransmitter receptor changes in disease may lead to improvements in therapy.

MCE designs a unique collection of 1,806 compounds targeting a variety of neurotransmitter receptors. MCE Neurotransmitter Receptor Compound Library is a useful tool for neurological diseases drug discovery.

N-Acetylglucosaminyltransferase 1 EC:2.4.1.101; MGAT1	Enzyme Substrates
N-Acetylglucosaminyltransferase1 (EC:2.4.1.101, MGAT1) shows typical features of a type II transmembrane protein. N-Acetylglucosaminyltransferase1 is believed to be essential for normal embryogenesis .

Cat. No.	Product Name	Target	Research Area

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) (TFA)	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P3333A

KSPWFTTL TFA	Peptides	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat Endothelin 3 (Rat,Human)	Peptides	Cardiovascular Disease Neurological Disease
Endothelin-3, human, mouse, rabbit, rat is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P0207

Endothelin-2 (49-69), human Endothelin-2 (human, canine); Human endothelin-2	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (Endothelin-2 (human, canine)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P3333

KSPWFTTL	Peptides	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P0207A

Endothelin-2 (49-69), human TFA Endothelin-2 (49-69) (human, canine) TFA; Human endothelin-2 TFA	Peptides	Cardiovascular Disease Cancer
Endothelin-2 (49-69), human (TFA) (Endothelin-2 (49-69) (human, canine) (TFA)) is a 21-amino acid vasoactive peptide that binds to G-protein-linked transmembrane receptors, ET-RA and ET-RB.

HY-P2508

MUC1, mucin core	Mucin	Cancer
MUC1, mucin core is the region of the MUC1 mucin core. MUC1 is a type I transmembrane glycoprotein, and is overexpressed and aberrantly glycosylated in carcinoma cells. MUC1, mucin core protein binds to domain 1 of ICAM-1 .

HY-P3051

CKS-17	Peptides	Inflammation/Immunology
CKS-17 is a synthetic retroviral envelope peptide. CKS-17 has the highly conserved amino acid sequences occurring within the transmembrane envelope protein of many animal and human retroviruses. CKS-17 acts as an immunomodulatory epitope and exhibits suppressive properties for numerous immune functions .

HY-P1925A

GO-203 TFA 2 Publications Verification	PI3K Reactive Oxygen Species Apoptosis	Cancer
GO-203 TFA is a potent MUC1-C oncoprotein inhibitor. GO-203 TFA is an all D-amino acid peptide that consists of a poly-R transduction domain linked to a CQCRRKN motif that binds to the MUC1-C cytoplasmic tail and blocks MUC1-C homodimerization. GO-203 TFA downregulates TIGAR (TP53-induced glycolysis and apoptosis regulator) protein synthesis by inhibiting the PI3K-AKT-S6K1 pathway. GO-203 TFA induces the production of ROS and loss of mitochondrial transmembrane potential. GO-203 TFA inhibits the growth of colon cancer cells in vitro and as xenografts in nude mice .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3540

Caraphenol A	Leguminosae Phenols Polyphenols Plants Caragana sinica (Buchoz) Rehd.	Others
Caraphenol A is a resveratrol trimer and is able to transiently reduce *interferon-induced transmembrane* (IFITM)** protein expression. Caraphenol A safely enhances lentiviral vector gene delivery to hematopoietic stem and progenitor cells . Caraphenol A also inhibits human cystathionine β-synthase (hCBS) and human cystathionine γ- lyase (hCSE) with IC₅₀s of 5.9 μM and 12.1 μM, respectively .

HY-12326A

c-di-AMP disodium 2 Publications Verification Cyclic diadenylate disodium; Cyclic-di-AMP disodium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-12326B

c-di-AMP diammonium 2 Publications Verification Cyclic diadenylate diammonium; Cyclic-di-AMP diammonium	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP diammonium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP diammonium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP diammonium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

HY-N10661

Ipomoeassin F Ipom-F	Structural Classification Natural Products Ipomoea squamosa Choisy Plants Convolvulaceae	SARS-CoV
Ipomoeassin F is a potent and selective endoplasmic reticulum (ER) protein-translocation inhibitor by targeting the pore-forming subunit of the Sec61 complex (Sec61α) at the ER membrane. Ipomoeassin F selectively inhibits the ER membrane translocation of SARS-CoV-2 proteins. Ipomoeassin F block the ER translocation of secretory proteins and type I transmembrane proteins (TMPs), but not type III TMPs .

HY-12326

c-di-AMP Cyclic diadenylate; Cyclic-di-AMP	Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Inflammation/Immunology Disease Research Fields	STING Bacterial Endogenous Metabolite
c-di-AMP (Cyclic diadenylate) is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP (Cyclic diadenylate) is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP (Cyclic diadenylate) acts as a potent mucosal adjuvant stimulating both humoral and cellular responses .

Species:	Human (70) Mouse (17) Bovine (1) Cynomolgus (3)
Tag:	SUMO (4) His (64) Avi (2) Myc (3) GST (1) MBP (1) Fc (24) Flag (2)
Source:	HEK293 (67) E. coli Cell-free (11) CHO (1) Sf9 insect cells (1) CHO (1) P. pastoris (2) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source

HY-P77244

	TMEM156 Protein, Human (HEK293, His) transmembrane protein 156; TMEM156	Human	HEK293
	TMEM156 Protein is a member of transmembrane proteins (TMEM) family. The expression levels of TMEM156 correlates with patient survival. TMEM156 is upregulated in tumor tissue. Many genes positively correlated with TMEM156 are involved in multiple immunological processes. Furthermore, genes negatively correlated with TMEM156 are linked with RHO GTPase effectors, which results in a poorer response to receptor activation, thus reducing cancer cell proliferation, survival, and migration. TMEM156 Protein, Human (HEK293, His) is the recombinant human-derived TMEM156 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMEM156 Protein, Human (HEK293, His) is 186 a.a., with molecular weight of ~23 KDa.

HY-P702473

	TMEM65 Protein, Human (Cell-Free, His, SUMO) transmembrane protein 65	Human	E. coli Cell-free
	The TMEM65 protein is critical for cardiac development, regulates GJA1 and affects gap junction communication. It contributes to the stability of GJA1 in cardiac intercalary disks, and there are indications that it is involved in mitochondrial function. TMEM65 Protein, Human (Cell-Free, His, SUMO) is the recombinant human-derived TMEM65 protein, expressed by E. coli Cell-free , with N-6*His, N-SUMO labeled tag. The total length of TMEM65 Protein, Human (Cell-Free, His, SUMO) is 178 a.a., with molecular weight of 35.1 kDa.

HY-P77245

	TMEM25 Protein, Human (HEK293, His) transmembrane protein 25; TMEM25	Human	HEK293
	TMEM25 Protein, crucial in neurons, modulates the degradation of the NMDA receptor GRIN2B subunit, influencing the intricate regulation of neuronal excitability. Its interaction with GRIN2B highlights its role in dynamic processes central to neurotransmission and synaptic function. TMEM25 Protein, Human (HEK293, His) is the recombinant human-derived TMEM25 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMEM25 Protein, Human (HEK293, His) is 198 a.a., with molecular weight of ~43 kDa.

HY-P702472

	TMEM59 Protein, Human (Cell-Free, His) transmembrane protein 59; Liver membrane-bound protein	Human	E. coli Cell-free
	TMEM59 Protein actively regulates autophagy during S.aureus infection by promoting LC3 activation through interaction with ATG16L1. This documented interaction facilitates LC3 lipidation, ultimately activating autophagy. Beyond autophagy, TMEM59 crucially modulates O-glycosylation and complex N-glycosylation in Golgi maturation, impacting proteins like APP, BACE1, SEAP, and PRNP. Notably, it hinders APP transport to the cell surface and shedding, forming a pivotal connection in autophagic and glycosylation processes through direct interaction with ATG16L1. TMEM59 Protein, Human (Cell-Free, His) is the recombinant human-derived TMEM59 protein, expressed by E. coli Cell-free, with C-10*His labeled tag. The total length of TMEM59 Protein, Human (Cell-Free, His) is 287 a.a., with molecular weight of 35.5 kDa.

HY-P76256

	CHODL Protein, Mouse (HEK293, His) Chondrolectin; transmembrane protein MT75; C21orf68	Mouse	HEK293
	CHODL proteins contribute significantly to nervous system development, particularly in neurite growth and elongation. There is evidence that it is involved in guiding motor axon growth and shaping the structural framework of the nervous system. CHODL Protein, Mouse (HEK293, His) is the recombinant mouse-derived CHODL protein, expressed by HEK293 , with C-His labeled tag. The total length of CHODL Protein, Mouse (HEK293, His) is 216 a.a., with molecular weight of ~34 KDa.

HY-P77854

	TMEM106B Protein, Mouse (HEK293, Fc) transmembrane protein 106B; Tmem106b	Mouse	HEK293
	The TMEM106B protein is a key player in neurons involved in trafficking to late endosomes/lysosomes and potentially affects dendritic morphogenesis and maintenance by regulating lysosomal trafficking. It may act as a molecular brake on retrograde transport by interacting with MAP6. TMEM106B Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEM106B protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEM106B Protein, Mouse (HEK293, Fc) is 157 a.a., with molecular weight of 65-68 kDa.

HY-P71629

	Collectrin Protein, Mouse (Myc, His-SUMO) Cltrn; Nx17; Tmem27Collectrin; transmembrane protein 27	Mouse	E. coli
	The Collectrin protein plays a crucial role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface transport and activity. Furthermore, it may affect the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Collectrin protein, expressed by E. coli , with N-His, C-Myc, N-SUMO labeled tag. The total length of Collectrin Protein, Mouse (Myc, His-SUMO) is 127 a.a., with molecular weight of ~34.5 kDa.

HY-P77246

	Collectrin/TMEM27 Protein, Human (HEK293, Fc) Collectrin; transmembrane protein 27; CLTRN; TMEM27	Human	HEK293
	Collectrin, also known as TMEM27, plays a key role in amino acid transport by binding to SLC6A18 and SLC6A19 and regulating their surface trafficking and amino acid transporter activity. Suggested to facilitate the trafficking of SLC3A1 and SLC7A9 to the renal cortical cell membrane. Collectrin/TMEM27 Protein, Human (HEK293, Fc) is the recombinant human-derived Collectrin/TMEM27 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Collectrin/TMEM27 Protein, Human (HEK293, Fc) is 127 a.a., with molecular weight of 53-57 kDa.

HY-P702474

TMEM72 Protein, Human (Cell-Free, His, Myc)

transmembrane protein 72; Kidney-specific secretory protein of 37 kDa
Human E. coli Cell-free

HY-P76255

	CHODL Protein, Mouse (216a.a, HEK293, Fc) Chondrolectin; transmembrane protein MT75; C21orf68	Mouse	HEK293
	CHODL proteins contribute significantly to nervous system development, particularly in neurite growth and elongation. There is evidence that it is involved in guiding motor axon growth and shaping the structural framework of the nervous system. CHODL Protein, Mouse (216a.a, HEK293, Fc) is the recombinant mouse-derived CHODL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CHODL Protein, Mouse (216a.a, HEK293, Fc) is 216 a.a., with molecular weight of ~60 KDa.

HY-P700470

	TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) TMEFF2; transmembrane protein with EGF like and two follistatin like domains 2; TR; HPP1; TPEF; TR-2; TENB2; CT120.2; tomoregulin-2; cancer/testis antigen family 120, member 2; hyperplastic polyposis protein 1; transmembrane protein TENB2; transmembrane protein with EGF-like and two follistatin-like domains	Human	HEK293
	TMEFF2/Tomoregulin-2 protein serves as a potential survival factor for hippocampal and midbrain neurons, supporting neuronal cell viability. In addition, its shed form may upregulate cancer cell proliferation by promoting ERK1/2 phosphorylation. TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is the recombinant human-derived TMEFF2/Tomoregulin-2 protein, expressed by HEK293 , with C-10*His labeled tag. The total length of TMEFF2/Tomoregulin-2 Protein, Human (HEK293, His) is 280 a.a., with molecular weight of 32.3 kDa.

HY-P77087

	MMGT1 Protein, Human (HEK293, His) ER membrane protein complex subunit 5; transmembrane protein 32; EMC5; TMEM32	Human	HEK293
	The MMGT1 protein is an important member of the endoplasmic reticulum membrane protein complex (EMC) and is essential for the independent insertion of newly synthesized membrane proteins into the endoplasmic reticulum (ER) membrane. Its preference for transmembrane domains with weak hydrophobicity or unstable characteristics guides co- and post-translational insertion processes. MMGT1 Protein, Human (HEK293, His) is the recombinant human-derived MMGT1 protein, expressed by HEK293 , with N-His labeled tag. The total length of MMGT1 Protein, Human (HEK293, His) is 66 a.a., with molecular weight of 23-29 kDa.

HY-P702471

	TMEM158 Protein, Human (Cell-Free, His) transmembrane protein 158; 40 kDa BINP-binding protein; p40BBP; Ras-induced senescence protein 1	Human	E. coli Cell-free
	TMEM158 Protein acts as a receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide. TMEM158 Protein, Human (Cell-Free, His) is the recombinant human-derived TMEM158 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TMEM158 Protein, Human (Cell-Free, His) is 280 a.a., with molecular weight of 29.9 kDa.

HY-P702433

	SGMS1 Protein, Human (Cell-Free, His) Phosphatidylcholine:ceramide cholinephosphotransferase 1; Medulla oblongata-derived protein; protein Mob; Sphingomyelin synthase 1; transmembrane protein 23	Human	E. coli Cell-free
	The SGMS1 protein is a key sphingomyelin synthase located in the Golgi apparatus and promotes sphingomyelin biosynthesis by transferring the phosphocholine moiety. This reversible reaction involves the conversion of phosphatidylcholine and ceramide into sphingomyelin and diacylglycerol. SGMS1 Protein, Human (Cell-Free, His) is the recombinant human-derived SGMS1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SGMS1 Protein, Human (Cell-Free, His) is 413 a.a., with molecular weight of 51.4 kDa.

HY-P702453

	STING1 Protein, Mouse (Cell-Free, His) Stimulator of interferon genes protein; Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; MMITA; transmembrane protein 173	Mouse	E. coli Cell-free
	STING1 is a promoter of innate immune signaling, a key sensor of bacterial and viral cytoplasmic DNA, and promotes the production of type I interferons (IFN-α and IFN-β). This innate immune response is triggered in response to non-CpG double-stranded DNA delivered to the cytoplasm from various pathogens. STING1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived STING1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of STING1 Protein, Mouse (Cell-Free, His) is 378 a.a., with molecular weight of 48.9 kDa.

HY-P77396

	IGFLR1 Protein, Human (HEK293, Fc) IGF-like family receptor 1; transmembrane protein 149; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, Fc) is the recombinant human-derived IGFLR1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IGFLR1 Protein, Human (HEK293, Fc) is 159 a.a., with molecular weight of ~58.9 & 47.6 kDa, respectively.

HY-P70938

	ITM2B Protein, Human (HEK293, His) Integral Membrane protein 2B; Immature BRI2; imBRI2; protein E25B; transmembrane protein BRI; Bri; ITM2B; BRI; BRI2	Human	HEK293
	The ITM2B protein regulates amyloid beta A4 precursor protein (APP) processing by inhibiting amyloid beta peptide aggregation and fibril deposition. In addition to its effects on the amyloid-β pathway, ITM2B also contributes to neurite outgrowth, affecting neurobiological processes. ITM2B Protein, Human (HEK293, His) is the recombinant human-derived ITM2B protein, expressed by HEK293 , with C-6*His labeled tag. The total length of ITM2B Protein, Human (HEK293, His) is 191 a.a., with molecular weight of 29-33 kDa.

HY-P76684

	TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) TR-1; H7365; transmembrane protein with EGF-like and one follistatin-like domain; C9orf2	Human	HEK293
	TMEFF1/Tomoregulin-1 protein may inhibit NODAL and BMP signaling in neural patterning, suggesting a regulatory role in neural development. It has been proposed as a tumor suppressor in brain cancer, emphasizing its importance in mitigating abnormal cell growth. TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Human (HEK293, Fc) is 291 a.a., with molecular weight of ~65 kDa.

HY-P77252

	TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) TR-1; H7365; transmembrane protein with EGF-like and one follistatin-like domain; C9orf2	Mouse	HEK293
	TMEFF1/Tomoregulin-1 Protein is a transmembrane protein involved in the physiological functions of the central nervous system, embryonic development, and other biological processes. TMEFF1 may inhibit NODAL and BMP signaling during neural patterning. And it may be a tumor suppressor in brain cancers. Additionally, the protein may interact with ST14, implying a molecular association that may contribute to its regulatory and signaling functions. TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TMEFF1/Tomoregulin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TMEFF1/Tomoregulin-1 Protein, Mouse (HEK293, Fc) is 298 a.a., with molecular weight of ~69 kDa.

HY-P70466

	PVRIG Protein, Cynomolgus (HEK293, His) C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463	Cynomolgus	HEK293
	The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived PVRIG protein, expressed by HEK293 , with C-6*His labeled tag. The total length of PVRIG Protein, Cynomolgus (HEK293, His) is 131 a.a., with molecular weight of 20-30 kDa.

HY-P70961

	PVRIG Protein, Mouse (HEK293, Fc) C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463	Mouse	HEK293
	PVRIG Protein, a member of the nectin and nectin-like family, is an immune checkpoint molecule with potential for development. PVRIG binds with high affinity to PVRL2 are inhibitory receptors on effector T cells, suppressing cytokine production and cytotoxic activity. PVRIG blocking antibodies significantly increased NK-cell cytotoxicity. PVRIG Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Mouse (HEK293, Fc) is 131 a.a., with molecular weight of 48-55 kDa.

HY-P71247

	PVRIG Protein, Human (HEK293, Fc) C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463	Human	HEK293
	The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, Fc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PVRIG Protein, Human (HEK293, Fc) is 131 a.a., with molecular weight of 45-50 kDa.

HY-P71248

	PVRIG Protein, Human (HEK293, mFc) C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463	Human	HEK293
	The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (HEK293, mFc) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-mFc labeled tag. The total length of PVRIG Protein, Human (HEK293, mFc) is 131 a.a., with molecular weight of 45-55 kDa.

HY-P72409

	PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) C7orf15; CD112R; PVRIG; transmembrane protein PVRIG; C7orf15MGC138295; MGC104322; MGC138297; MGC2463	Human	HEK293
	The PVRIG protein functions as a cell surface receptor for NECTIN2 and may serve as a co-inhibitory receptor capable of inhibiting T-cell receptor-mediated signaling. Upon interaction with NECTIN2, PVRIG inhibits T cell proliferation, suggesting its potential role in regulating immune responses. PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived PVRIG protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. The total length of PVRIG Protein, Human (Biotinylated, HEK293, Fc-Avi) is 131 a.a., with molecular weight of 50-60 kDa.

HY-P700616

	ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc) anoctamin 1, calcium activated chloride channel; oral cancer overexpressed 2, ORAOV2, TMEM16A, transmembrane protein 16A; anoctamin-1; DOG1; FLJ10261; TAOS2; oral cancer overexpressed 2; tumor-amplified and overexpressed sequence 2; discovered on gastrointestinal stromal tumors protein 1; transmembrane protein 16A (eight membrane-spanning domains); ORAOV2; TMEM16A	Human	E. coli
	ANO1/Anoctamin-1 protein, a calcium-activated chloride channel (CaCC), is involved in ion transport, smooth muscle contraction, and mucus secretion. ANO1/Anoctamin-1 Protein, Human (N-His, C-Myc) is the recombinant human-derived ANO1/Anoctamin-1 protein, expressed by E. coli , with C-Myc, N-10*His labeled tag.

HY-P700454

	IGFLR1 Protein, Human (HEK293, C-His) IGFLR1; IGF-like family receptor 1; TMEM149, transmembrane protein 149 , U2(RNU2) small nuclear RNA auxiliary factor 1 like 4 , U2AF1L4; FLJ22573; transmembrane protein 149; U2 small nuclear RNA auxiliary factor 1-like 4; U2(RNU2) small nuclear RNA auxiliary factor 1-like 4; TMEM149; U2AF1L4	Human	HEK293
	IGFLR1 protein, a probable cell membrane receptor, exhibits specific affinity for IGF-like family proteins IGFL1 and IGFL3, with higher binding affinity compared to others. This selective interaction profile suggests a key role for IGFLR1 in mediating cellular responses to these ligands, emphasizing its significance in the intricate network of cellular signaling pathways. IGFLR1 Protein, Human (HEK293, C-His) is the recombinant human-derived IGFLR1 protein, expressed by HEK293, with C-6*His labeled tag. The total length of IGFLR1 Protein, Human (HEK293, C-His) is 141 a.a., with molecular weight of 17.4 kDa.

HY-P702470

	TMC1 Protein, Mouse (Cell-Free, His) transmembrane channel-like protein 1; Beethoven protein; Deafness protein; transmembrane cochlear-expressed protein 1	Mouse	E. coli Cell-free
	The TMC1 protein is a possible ion channel critical for cochlear hair cell function. Its important interaction with TOMT facilitates transport into stereocilia. TMC1 Protein, Mouse (Cell-Free, His) is the recombinant mouse-derived TMC1 protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of TMC1 Protein, Mouse (Cell-Free, His) is 757 a.a., with molecular weight of 90.1 kDa.

HY-P70836

	GPNMB/Osteoactivin Protein, Human (HEK293, His) transmembrane Glycoprotein NMB; transmembrane Glycoprotein HGFIN; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as osteoactivin, is a protein thought to have a potential role as a melanin-producing enzyme. Melanogenic enzymes are involved in the production of melanin, the pigment that determines skin, hair and eye color. GPNMB/Osteoactivin Protein, Human (HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (HEK293, His) is 465 a.a., with molecular weight of 80-120 kDa.

HY-P70201

	FLRT2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane protein FLRT2/FLRT2, His; Leucine-Rich Repeat transmembrane protein FLRT2; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 2; FLRT2; KIAA0405	Human	HEK293
	FLRT2 protein is involved in cell-cell adhesion, migration, and axonal guidance through various interactions. It promotes adhesion by binding to ADGRL3 and potentially other sloth proteins. FLRT2 Protein, Human (HEK293, His) is the recombinant human-derived FLRT2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FLRT2 Protein, Human (HEK293, His) is 504 a.a., with molecular weight of 75-85 kDa.

HY-P70924

	FLRT3 Protein, Human (HEK293, His) Leucine-Rich Repeat transmembrane protein FLRT3; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 3; FLRT3; KIAA1469	Human	HEK293
	The FLRT3 protein exhibits multiple roles in cellular processes, affecting cell-cell adhesion, migration, and axonal guidance, with context-dependent attraction or repulsion. FLRT3 is critical for the spatial organization of brain neurons and also contributes to retinal blood vessel development. FLRT3 Protein, Human (HEK293, His) is the recombinant human-derived FLRT3 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of FLRT3 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 60-110 kDa.

HY-P70925

	FLRT1 Protein, Human (504a.a, HEK293, His) Leucine-Rich Repeat transmembrane protein FLRT1; Fibronectin-Like Domain-Containing Leucine-Rich transmembrane protein 1; FLRT1	Human	HEK293
	FLRT1 is a key player in FGF-mediated signaling, activating MAP kinase and enhancing neurite outgrowth through FGFR1-mediated signaling. It helps increase the number and length of neurites. FLRT1 Protein, Human (504a.a, HEK293, His) is the recombinant human-derived FLRT1 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLRT1 Protein, Human (504a.a, HEK293, His) is 504 a.a., with molecular weight of 60-85 kDa.

HY-P76481

	LRRTM4 Protein, Human (HEK293, His) Leucine-rich repeat transmembrane neuronal protein 4	Human	HEK293
	The LRRTM4 protein plays a critical role in the development and maintenance of the vertebrate nervous system, particularly in synaptogenesis and differentiation of excitatory presynaptic elements. LRRTM4 is associated with the AMPA receptor (AMPAR) complex, is located at the periphery of the complex, interacts directly with GluA/GRIA proteins, and helps coordinate the complex network of AMPAR complex assembly and function. LRRTM4 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRTM4 Protein, Human (HEK293, His) is 394 a.a., with molecular weight of ~65 KDa.

HY-P77069

	LRRTM4 Protein, Mouse (HEK293, His) Leucine-rich repeat transmembrane neuronal protein 4	Mouse	HEK293
	LRRTM4 protein is crucial for vertebrate nervous system development and maintenance. It exhibits synaptogenic activity, limited to excitatory presynaptic differentiation. LRRTM4 is associated with the AMPAR complex, regulating AMPAR complex function and synaptic processes. Understanding LRRTM4's interactions within the complex could offer insights into its role in synaptic regulation and neural connectivity. LRRTM4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived LRRTM4 protein, expressed by HEK293 , with C-His labeled tag. The total length of LRRTM4 Protein, Mouse (HEK293, His) is 394 a.a., with molecular weight of ~46.4 KDa.

HY-P77068

	LRRTM3 Protein, Mouse (CHO, His) Leucine-rich repeat transmembrane neuronal protein 3; LRRTM3	Mouse	CHO
	The LRRTM3 protein may contribute to the development and maintenance of the vertebrate nervous system, and in vitro studies highlight its synaptic activity. LRRTM3 specifically affects the differentiation of excitatory presynaptic elements, emphasizing its role in shaping synaptic connections associated with excitatory neurotransmission. LRRTM3 Protein, Mouse (CHO, His) is the recombinant mouse-derived LRRTM3 protein, expressed by CHO , with C-His labeled tag. The total length of LRRTM3 Protein, Mouse (CHO, His) is 389 a.a., with molecular weight of ~46 KDa.

HY-P77247

	TMIGD1 Protein, Human (HEK293, His) transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, His) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-His labeled tag. The total length of TMIGD1 Protein, Human (HEK293, His) is 191 a.a., with molecular weight (glycosylation form) of ~37-55 kDa.

HY-P77248

	TMIGD1 Protein, Human (HEK293, Fc) transmembrane and immunoglobulin domain-containing protein 1; TMIGD	Human	HEK293
	TMIGD1 is a potential regulator that affects multiple cellular processes, including adhesion, migration, proliferation, and morphology. Its protective effect against oxidative damage in renal epithelial cells promotes cell survival. TMIGD1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMIGD1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMIGD1 Protein, Human (HEK293, Fc) is 220 a.a., with molecular weight of ~47.5 KDa.

HY-P76681

	TMX1 Protein, Human (HEK293, Fc) Thioredoxin-related transmembrane protein 1; TMX; TXNDC; TXNDC1	Human	HEK293
	TMX1 Protein is a member of the protein disulfide isomerase (PDI) family and is a transmembrane thiol isomerase. TMX1 Protein can participate in various redox reactions, reversibly oxidizes to disulfide through its active center thiol, and catalyzes the thiol-disulfide exchange reaction. In addition, TMX1 Protein negatively regulates the activation of αibβ3 integrin and platelet aggregation outside the cell. TMX1 Protein, Human (HEK293, Fc) is the recombinant human-derived TMX1 protein, expressed by HEK293 , with C-mFc labeled tag. The total length of TMX1 Protein, Human (HEK293, Fc) is 154 a.a., with molecular weight of 45-50 kDa.

HY-P77116

	GPNMB/Osteoactivin Protein, Mouse (HEK293, His) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Mouse	HEK293
	GPNMB/bone active protein shows promise as a melanogenic enzyme, possibly involved in melanin synthesis. Its regulatory influence on melanin production highlights its critical role in pigment formation. GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is the recombinant mouse-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Mouse (HEK293, His) is 480 a.a., with molecular weight of ~96 kDa.

HY-P702377

	MFN2 Protein, Human (Cell-Free, His) Mitofusin-2; transmembrane GTPase MFN2	Human	E. coli Cell-free
	MFN2, a mitochondrial outer membrane GTPase, regulates mitochondrial dynamics, balancing fusion and fission for dynamic organelle morphology. Its overexpression forms extensive mitochondrial networks, highlighting its organizational role. Beyond shaping structure, MFN2 influences mitochondrial metabolism, impacting obesity and apoptosis. In vascular smooth muscle cells, it regulates proliferation. Crucial in mitochondrial quality control, MFN2 facilitates mitophagy and modulates the unfolded protein response during ER stress, emphasizing its diverse roles in cellular homeostasis and stress responses. MFN2 Protein, Human (Cell-Free, His) is the recombinant human-derived MFN2 protein, expressed by E. coli Cell-free, with N-10*His labeled tag. The total length of MFN2 Protein, Human (Cell-Free, His) is 757 a.a., with molecular weight of 87.9 kDa.

HY-P77251

	TMUB2 Protein, Human (HEK293, His) transmembrane and ubiquitin-like domain-containing protein 2; TMUB2	Human	HEK293
	TMUB2 Protein is a poorly characterized TMUB1 paralog. TMUB2 is a part of various ERAD complexes. In addition, it is a component of the membrane that has transmembrane function. TMUB2 is related to TP53 protein expression. TMUB2 expression increases with age in skin, adipose tissue, blood, and brain and is associated with cancer initiation and progression. TMUB2 Protein, Human (HEK293, His) is the recombinant human-derived TMUB2 protein, expressed by HEK293 , with N-His labeled tag. The total length of TMUB2 Protein, Human (HEK293, His) is 209 a.a., with molecular weight of ~43 kDa.

HY-P70203

	LRRTM2 Protein, Human (HEK293, His) rHuLeucine-rich repeat transmembrane neuronal protein 2/LRRTM2, His; Leucine-Rich Repeat transmembrane Neuronal protein 2; Leucine-Rich Repeat Neuronal 2 protein; LRRTM2; KIAA0416; LRRN2	Human	HEK293
	The LRRTM2 protein is critical for developing and maintaining excitatory synapses, regulating AMPA receptor surface expression, and directing the formation of functional glutamate release sites for synaptic efficacy. LRRTM2 serves as a ligand for presynaptic receptors NRXN1-A and NRXN1-B and participates in transsynaptic signaling. LRRTM2 Protein, Human (HEK293, His) is the recombinant human-derived LRRTM2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of LRRTM2 Protein, Human (HEK293, His) is 389 a.a., with molecular weight of ~74.0 kDa.

HY-P71281

	SECTM1 Protein, Human (HEK293, His) Secreted and transmembrane protein 1; protein K-12; SECTM1; K12	Human	HEK293
	SECTM1 Protein potentially influences thymocyte signaling, indicating a role in thymic regulatory mechanisms. Its interaction with CD7 suggests involvement in cellular processes, potentially influencing thymocyte-associated signaling pathways. SECTM1's significance in thymocyte function and interaction with CD7 hints at a role in modulating immune responses and cellular communication within the thymic microenvironment. SECTM1 Protein, Human (HEK293, His) is the recombinant human-derived SECTM1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SECTM1 Protein, Human (HEK293, His) is 117 a.a., with molecular weight of 18-22 kDa.

HY-P76934

	FLRT2 Protein, Mouse (HEK293, His) Leucine-rich repeat transmembrane protein FLRT2; Flrt2; Kiaa0405	Mouse	HEK293
	The FLRT2 protein plays a key role in cell-cell adhesion, migration, and axonal guidance. Its interaction with ADGRL3 promotes cell-cell adhesion and promotes cortical neuronal migration through interaction with UNC5D. FLRT2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FLRT2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FLRT2 Protein, Mouse (HEK293, His) is 504 a.a., with molecular weight of 60-80 kDa.

HY-P76531

	OSTM1 Protein, Human (HEK293, His) Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; GL	Human	HEK293
	The OSTM1 protein is indispensable for the maturation and function of osteoclasts and melanocytes. It forms a heteromer with CLCN7, with CLCN7 as the α subunit and OSTM1 as the β subunit. OSTM1 Protein, Human (HEK293, His) is the recombinant human-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of OSTM1 Protein, Human (HEK293, His) is 253 a.a., with molecular weight of 40-50 kDa.

HY-P77117

	OSTM1 Protein, Mouse (HEK293, His) Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit; GL	Mouse	HEK293
	OSTM1 Protein is crucial for osteoclast and melanocyte maturation and function, forming heteromers with alpha subunits (CLCN7) to create chloride channel 7. OSTM1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived OSTM1 protein, expressed by HEK293 , with C-His labeled tag. The total length of OSTM1 Protein, Mouse (HEK293, His) is 254 a.a., with molecular weight of ~29.7 KDa.

HY-P75950

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as Osteoactivin, is suggested to potentially function as a melanogenic enzyme. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-His labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, His) is 453 a.a., with molecular weight of 85-90 kDa.

HY-P75951

	GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) transmembrane Glycoprotein NMB; GPNMB; HGFIN; NMB	Human	HEK293
	GPNMB, also known as Osteoactivin, is suggested to potentially function as a melanogenic enzyme. GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is the recombinant human-derived GPNMB/Osteoactivin protein, expressed by HEK293 , with C-hFc labeled tag. The total length of GPNMB/Osteoactivin Protein, Human (Isoform 2, HEK293, Fc) is 453 a.a., with molecular weight of ~107.5 kDa.

HY-P73390

	ROR1 Protein, Human (sf9, His) Inactive tyrosine-protein kinase transmembrane receptor ROR1; ROR1; NTRKR1	Human	Sf9 insect cells
	ROR1 protein's minimal kinase activity in vitro suggests an improbable role as a tyrosine kinase in vivo. It serves as a receptor for WNT5A, activating NFkB signaling and potentially inhibiting WNT3A signaling. Notably, ROR1 plays a vital role in the inner ear, facilitating innervation of auditory hair cells by spiral ganglion neurons. ROR1 Protein, Human (sf9, His) is the recombinant human-derived ROR1 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of ROR1 Protein, Human (sf9, His) is 331 a.a., with molecular weight of 55-70 kDa.

HY-P71443

	VSTM5 Protein, Human (His) Chromosome 11 open reading frame 90; CK090 HUMAN; Uncharacterized protein C11orf90; V set and transmembrane domain containing 5; V-set and transmembrane domain-containing protein 5	Human	E. coli
	The VSTM5 protein acts as a cell adhesion-like membrane protein in the central nervous system (CNS) and exerts a critical influence on the positioning and complexity of central neurons by regulating their membrane morphology and dynamics. It is actively involved in the formation of neuronal dendrites and protrusions, including dendritic filopodia, contributing to the complex structure of neural networks. VSTM5 Protein, Human (His) is the recombinant human-derived VSTM5 protein, expressed by E. coli , with N-His labeled tag. The total length of VSTM5 Protein, Human (His) is 119 a.a., with molecular weight of ~19.3 kDa.

HY-P77430

	KCT2 Protein, Human (HEK293, His) Keratinocyte-associated transmembrane protein 2; KCT2; C5orf15; HTGN29	Human	HEK293
	KCT2 protein, widely expressed across diverse tissues and cell types, indicates potential involvement in various physiological processes, highlighting its ubiquity within the biological landscape. KCT2 Protein, Human (HEK293, His) is the recombinant human-derived KCT2 protein, expressed by HEK293 , with C-His labeled tag. The total length of KCT2 Protein, Human (HEK293, His) is 147 a.a., with molecular weight of 33-47 kDa.

Cat. No.	Product Name	Chemical Structure

HY-15206S1

Glyburide-d3

Glyburide-d₃ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

HY-15206S

Glyburide-d11

Glyburide-d₁₁ is the deuterium labeled Glibenclamide. Glibenclamide (Glyburide) is an orally active ATP-sensitive K+ channel (KATP) inhibitor and can be used for the research of diabetes and obesity[1]. Glibenclamide inhibits P-glycoprotein. Glibenclamide directly binds and blocks the SUR1 subunits of KATP and inhibits the cystic fibrosis transmembrane conductance regulator protein (CFTR)[3]. Glibenclamide interferes with mitochondrial bioenergetics by inducing changes on membrane ion permeability[4]. Glibenclamide can induce autophagy[5].

Cat. No.	Compare	Product Name	Application	Reactivity

HY-P82470

Transmembrane Protein 192 Antibody (YA2215)

transmembrane protein 192
WB Human
HY-P82464

Transmembrane Protein 161B Antibody (YA2209)

transmembrane protein 161B
WB, IP Human
HY-P82480

Transmembrane Protein 85 Antibody (YA2225)

PIG17; TMEM85
WB, IP Human, Mouse, Rat, Hamster
HY-P82475

Transmembrane Protein 30B Antibody (YA2220)

CDC50B
WB Human
HY-P82483

Transmembrane Protein 9B Antibody (YA2228)

C11orf15
WB Human, Mouse, Rat
HY-P82478

Transmembrane Protein 43 Antibody (YA2223)

LUMA; ARVC5; ARVD5; EDMD7
WB, IHC-P Human, Rat

HY-P80940

	STING Antibody ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta; transmembrane protein 173	WB	Human, Mouse
	STING Antibody is a non-conjugated and Rabbit origined polyclonal antibody about 42 kDa, targeting to STING. It can be used for WB assays with N-6*His-tag, in the background of Human, Mouse.

HY-P81419

Claudin 5 Antibody (YA1164)

CLDN5; AWAL; TMVCF; Claudin-5; transmembrane protein deleted in VCFS; TMDVCF
IHC-P Human
HY-P82776

CLPTM1 Antibody (YA2521)

Cleft lip and palate transmembrane protein 1
WB, IP Human
HY-P83115

Fragilis Antibody (YA2860)

IFITM3; Interferon-induced transmembrane protein 3; Dispanin subfamily A member 2b; DSPA2b; Interferon-inducible protein 1-8U
WB, IHC-F, IHC-P, ICC/IF Human
HY-P81399

CD97 Antibody (YA1144)

ADGRE5; Adhesion G protein-coupled receptor E5; CD97 antigen; Leukocyte antigen CD97; Seven span transmembrane protein; TM7LN1
IHC-P Human
HY-P81390

ROR2 Antibody (YA1135)

NTRKR; ROR2; Tyrosine-protein kinase transmembrane receptor ROR2; Neurotrophic tyrosine kinase, receptor-related 2
IHC-P Human
HY-P83147

Ephrin Receptor B4 Antibody (YA2892)

EPHB4; HTK; MYK1; TYRO11; Ephrin type-B receptor 4; Hepatoma transmembrane kinase; Tyrosine-protein kinase TYRO11
WB, IHC-P Human, Mouse, Rat

HY-P81075

	CTLA4 Antibody CD 152; CD152; CD152 antigen; Celiac disease 3; CELIAC3; CTLA 4; CTLA-4; Cytotoxic T cell associated 4; Cytotoxic T lymphocyte associated 4; Cytotoxic T lymphocyte associated antigen 4; Cytotoxic T lymphocyte associated protein 4; Cytotoxic T lymphocyte associated serine esterase 4; Cytotoxic T lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; Cytotoxic T-lymphocyte-associated protein 4; GSE; IDDM12; CD152 isoform; CTLA4_HUMAN; GRD4; ICOS; Ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4.	WB, ELISA, FC,	Human, Mouse, Rat

HY-P83650

	Frizzled 5 Antibody C2orf31; DKFZP434E2135; Frizzled homolog 5; Frizzled-5; Frizzled5; Fz 5; Fz-5; Fz5; FZD 5; hFz5; FZD5; FZD5_HUMAN; FzE 5; FzE5; HFZ 5; HFZ5; MGC129692; Seven transmembrane receptor frizzled 5; Uncharacterized protein C2orf31; Wnt receptor.	WB, IHC-P, IHC-F, FC, ICC/IF, ELISA	Human, Mouse, Rat

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