Search Result

Results for "

vesicle

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) AMPK (1) Androgen Receptor (1) Antibiotic (3) Apoptosis (1) Autophagy (2) Bacterial (2) Biochemical Assay Reagents (4) Chloride Channel (1) COX (1) Dopamine Transporter (2) Dynamin (1) Endogenous Metabolite (5) Fluorescent Dye (13) Fungal (2) HIV (1) iGluR (2) IKK (1) Liposome (9) mAChR (2) Monoamine Transporter (1) mTOR (1) Na+/K+ ATPase (1) nAChR (2) NF-κB (1) NOD-like Receptor (NLR) (2) Oxidative Phosphorylation (1) PD-1/PD-L1 (1) Phospholipase (2) Proteasome (2) Ras (1) Reactive Oxygen Species (1) Ser/Thr Protease (1)
By Research Areas:	Cancer (7) Endocrinology (1) Infection (4) Inflammation/Immunology (6) Metabolic Disease (8) Neurological Disease (15)

By Targets:

Adrenergic Receptor (1)

AMPK (1)

Androgen Receptor (1)

Antibiotic (3)

Apoptosis (1)

Autophagy (2)

Bacterial (2)

Biochemical Assay Reagents (4)

Chloride Channel (1)

COX (1)

Dopamine Transporter (2)

Dynamin (1)

Endogenous Metabolite (5)

Fluorescent Dye (13)

Fungal (2)

HIV (1)

iGluR (2)

IKK (1)

Liposome (9)

mAChR (2)

Monoamine Transporter (1)

mTOR (1)

Na+/K+ ATPase (1)

nAChR (2)

NF-κB (1)

NOD-like Receptor (NLR) (2)

Oxidative Phosphorylation (1)

PD-1/PD-L1 (1)

Phospholipase (2)

Proteasome (2)

Ras (1)

Reactive Oxygen Species (1)

Ser/Thr Protease (1)

By Research Areas:

Cancer (7)

Endocrinology (1)

Infection (4)

Inflammation/Immunology (6)

Metabolic Disease (8)

Neurological Disease (15)

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-113995

(-)-Vesamicol AH5183	mAChR	Neurological Disease
(-)-Vesamicol (AH5183) is an inhibitor of acetylcholine transport into synaptic vesicles, with the IC₅₀ of 75 nM . (-)-Vesamicol can be used for release and recycling of synaptic vesicles study .

HY-D1435

Oxonol VI	Na+/K+ ATPase	Neurological Disease
Oxonol VI acts as an optical indicator for membrane potentials in lipid vesicles. Oxonol VI is suitable for detecting changes of membrane potential associated with the activity of the (Na ⁺ + K ⁺)-ATPase in reconstituted vesicles .

HY-D1438

RH 414

Fluorescent Dye Others

RH 414 is the styryl pyridinium dye. RH 414 can be used for optical monitoring of synaptic vesicle membrane trafficking .
HY-143204

(Rac)-POPC

Liposome Others

(Rac)-POPC is a model phosphatidylcholine for the preparation of giant vesicles (GVs) .
HY-157999

SDI-118

Others Neurological Disease

SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM .

RH 414	Fluorescent Dye	Others
RH 414 is the styryl pyridinium dye. RH 414 can be used for optical monitoring of synaptic vesicle membrane trafficking .

(Rac)-POPC	Liposome	Others
(Rac)-POPC is a model phosphatidylcholine for the preparation of giant vesicles (GVs) .

SDI-118	Others	Neurological Disease
SDI-118 is an orally active modulator for synaptic vesicle glycoprotein 2A (SV2A) with an IC₅₀ of 13 nM .

HY-139322

PEG-8 laurate	Biochemical Assay Reagents	Others
PEG-8 laurate is a single chain surfactant. PEG-8 laurate reduces the skin barrier, and acts as a penetration enhancer. PEG-8 laurate can be used to synthesize elastic vesicles .

HY-D1517

FM 2-10	Fluorescent Dye	Others
FM 2-10 is a fluorescent dye. FM 2-10 is a less hydrophobic version of FM 1-43 (HY-D1434). FM 2-10 can be used for identifying actively firing neurons and investigating the mechanisms of activity-dependent vesicle cycling .

HY-P3586

HKPao Hunter-killer peptide ao; Prohibitin-targeting peptide 1; prohibitin-TP01; Adipotide	Apoptosis	Cancer
HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles .

HY-145539

12-Dipalmitoyl-sn-glycero-3-PS sodium salt	Liposome	Others
12-Dipalmitoyl-sn-glycero-3-PS sodium salt is an anionic diacyl phospholipid, a lipid component in cell membrane. 12-Dipalmitoyl-sn-glycero-3-PS sodium salt can be use in the preparation of catanionic vesicles and liposome .

HY-111548

Spastazoline 2 Publications Verification	Others	Others
Spastazoline is a selective spastin (a microtubule-severing AAA protein) inhibitor, with an IC₅₀ of 99 nM for Human spastin. Spastazoline can be used for cell division- and intracellular vesicle transport-related research .

HY-D1515

FM1-84 Neurodye GH1-84	Fluorescent Dye	Neurological Disease
FM1-84 (Neurodye GH1-84) is a fluorescent dye. FM1-84 has lipophilic and facilitates association with membranes, resulting in an increase in fluorescence intensity (λ_ex=510 nm, λ_em=625 nm). FM1-84 can be used for synaptic vesicle recycling in neurons research .

HY-102068

Clathrin-IN-1	HIV	Infection
Clathrin-IN-1 is a selective clathrin-mediated endocytosis (CME) inhibitor. Clathrin-IN-1 selectively inhibits amphiphysin association of clathrin terminal domain (TD) with an IC₅₀ value of 12 μM. Clathrin-IN-1 acutely interferes with receptor-mediated endocytosis, entry of HIV, and synaptic vesicle recycling .

HY-N7056

4'-Hydroxychalcone	Oxidative Phosphorylation Proteasome	Inflammation/Immunology Cancer
4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria .

HY-112257

S-23 1 Publications Verification	Androgen Receptor	Metabolic Disease
S-23 is an orally active selective androgen receptor modulator (SARM) with a K_i of 1.7 nM. S-23 induces androgen receptor (AR)-mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats .

HY-110174

NAB2	Others	Neurological Disease
NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a agentgable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking .

HY-161329

NLRP3-IN-32	NOD-like Receptor (NLR) Reactive Oxygen Species NF-κB IKK	Inflammation/Immunology
NLRP3-IN-32 (compound 7a), a 3, 4-dihydronaphthalene-1(2H)-one derivative, is a potential NLRP3 inflammatory vesicles inhibitor. NLRP3-IN-32 can block the assembly and activation of NLRP3 inflammasome by down-regulating the expression of NLPR3 and apoptosis-associated speck-like protein containing a CARD (ASC), and inhibiting the production of reactive oxygen species (ROS) and other inflammatory mediators. NLRP3-IN-32 inhibits the phosphorylation of IκBα and NF-κB/p65 and the nuclear translocation of p65, thereby inhibiting NF-κB signaling .

HY-156237

Beclin1-ATG14L interaction inhibitor 1	Autophagy	Others
Beclin1-ATG14L interaction inhibitor 1 (com 19) is a selective Beclin1-ATG14L interaction inhibitor. This protein interaction mechanism specifically targets complex I of the lipid kinase VPS34 without affecting complex II. Because the integrity of VPS34 complex II depends on the Beclin 1-UVRAG interaction. Beclin1-ATG14L interaction inhibitor 1 can disrupt the formation of VPS34 complex I and inhibit autophagy, but does not affect complex II-related vesicle transport .

HY-W250118

Phosphatidylethanolamine

Liposome Others

Phosphatidylethanolamine is a phospholipid. It is used for preparation of vesicle suspensions, commonly called liposomes, or as monolayers.
HY-D1399

Kdn probe-1

Fluorescent Dye Others

Kdn probe-1 is a fluorescent Kdn probe and reveals the localization of AfS in vesicles at the cell surface.
HY-144007

Chol-PEG

Liposome Others

Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .
HY-148977

18:0,22:6 PS sodium

Endogenous Metabolite Metabolic Disease

18:0,22:6 PS sodium is a lipid component of synaptic vesicles and cholesterol, which can be used for metabolic research .
HY-148978

18:0,18:1 PS sodium

Endogenous Metabolite Metabolic Disease

18:0,18:1 PS sodium is a lipid component of synaptic vesicles and cholesterol, which can be used for metabolic research .
HY-136873

UCB-J

Others Others

UCB-J is a positron emission tomography (PET) radioligand for the synaptic vesicle protein 2A (SV2A) .
HY-143695

16:0 TAP

Liposome Others

16:0 TAP is a lipid product. 16:0 TAP can be used for the preparation of giant unilamellar vesicles to deliver agents .
HY-119665

Asteltoxin

AMPK mTOR Cancer

Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation .

Phosphatidylethanolamine	Liposome	Others
Phosphatidylethanolamine is a phospholipid. It is used for preparation of vesicle suspensions, commonly called liposomes, or as monolayers.

Kdn probe-1	Fluorescent Dye	Others
Kdn probe-1 is a fluorescent Kdn probe and reveals the localization of AfS in vesicles at the cell surface.

Chol-PEG	Liposome	Others
Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .

18:0,22:6 PS sodium	Endogenous Metabolite	Metabolic Disease
18:0,22:6 PS sodium is a lipid component of synaptic vesicles and cholesterol, which can be used for metabolic research .

18:0,18:1 PS sodium	Endogenous Metabolite	Metabolic Disease
18:0,18:1 PS sodium is a lipid component of synaptic vesicles and cholesterol, which can be used for metabolic research .

UCB-J	Others	Others
UCB-J is a positron emission tomography (PET) radioligand for the synaptic vesicle protein 2A (SV2A) .

16:0 TAP	Liposome	Others
16:0 TAP is a lipid product. 16:0 TAP can be used for the preparation of giant unilamellar vesicles to deliver agents .

Asteltoxin	AMPK mTOR	Cancer
Asteltoxin is an inhibitor for extracellular vesicles (EV), which exhibits inhibitory effects towards mitochondrial ATP synthase and mTORC1 activation .

HY-163095

RH1115	Autophagy	Neurological Disease
RH1115 (compound 2c) is a modulator of the autophagy-lysosome. RH1115 induces changes to LAMP1 vesicle properties and alters lysosome positioning .

HY-D0040

Calcein 4 Publications Verification Fluorexon	Fluorescent Dye	Others
Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.

HY-N9362

Emodinanthrone	Antibiotic	Infection
Emodinanthrone, an anthraquinone, is a sprecursor of Emodin (HY-14393) with antibiotic activity. Emodinanthrone inhibits respiration-driven solute transport at micromolar concentrations in membrane vesicles of Escherichia coli .

HY-143202

DPhPC	Liposome	Others
DPhPC is a phospholipid used to synthesize bilayer vesicles. DPhPC bilayers do not permit ions to leak in the absence of a pore/ion channel, which can be used for studies on channel proteins .

HY-128419

Biguanidinium-porphyrin	Others	Others
Biguanidinium-porphyrin is a mitochondria-targeting photosensitizer. Biguanidinium-porphyrin distributes within cell membranes with a large component in vesicles that correlated to some extent with the lysosomes and, upon longer exposures, in mitochondria and the cytosolic membrane .

HY-D1612

BODIPY FL C5-Ceramide	Fluorescent Dye	Others
The Golgi apparatus is composed of flattened vesicles superimposed on each other by unit membranes. The flattened vesicles are round with expanded and perforated edges. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye . BODIPY Fl C5-Ceramide is a Golgi-specific green fluorescent dye, which can visualise individual cells . Ex/Em= 505 nm/512 nm.

HY-D1735

BODIPY TR Ceramide Golgi-Red Tracke	Fluorescent Dye	Others
The Golgi apparatus is composed of flattened vesicles superimposed on each other by unit membranes. The flattened vesicles are round with expanded and perforated edges. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. BODIPY TR Ceramide (Golgi-Red Tracke) is a Golgi-specific fluorescent dye, which can visualise individual cells . Ex/Em=589 nm/616 nm.

HY-156753

NorA-IN-1	Others	Cancer
NorA-IN-1 (Compound 16) is a NorA inhibitor. NorA-IN-1 inhibits NorA efflux pump in everted membrane vesicles. NorA-IN-1 can be used for research of multidrug resistance .

HY-106514

Prifelone R 830; R 830T; S 16820	COX	Inflammation/Immunology
Prifelone (R 830; R 830T; S 16820) is a di-tert-butylphenol with anti-inflammatory and antioxidant activity. Prifelone inhibits guinea pig lung oxygenase and bovine seminal vesicle cyclooxygenase .

HY-131002

DPTIP

Phospholipase Inflammation/Immunology

DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC₅₀ of 30 nM .

DPTIP	Phospholipase	Inflammation/Immunology
DPTIP is a potent brain penetrant neutral sphingomyelinase 2 (N-SMase 2) inhibitor (exosome inhibitor), with an IC₅₀ of 30 nM .

HY-W009823

Phenyl benzoate	Chloride Channel	Others
Phenyl benzoate is a benzoate ester obtained by the formal condensation of phenol with benzoic acid. Phenyl benzoate is a chloride transport blocker, inhibits Cl ^--dependent Glu accumulation into vesicles. Phenyl benzoate can be used as preservative in cosmetic products .

HY-101013

D-SNAP S-Nitroso-N-acetylpenicillamine	Fluorescent Dye	Others
D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.

HY-B0979

Lobeline hydrochloride α-Lobeline hydrochloride; L-Lobeline hydrochloride	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) hydrochloride is a brain-penetrant nicotinic receptor agonist. Lobeline hydrochloride increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline hydrochloride is effective in smoking cessation .

HY-B1423

Lobeline α-Lobeline; L-Lobeline
Lobeline (α-Lobeline) is a brain-penetrant nicotinic receptor agonist. Lobeline increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline is effective in smoking cessation .

HY-128420

Lobeline sulfate α-Lobeline sulfate; L-Lobeline sulfate	nAChR Dopamine Transporter	Neurological Disease
Lobeline (α-Lobeline) sulfate is a brain-penetrant nicotinic receptor agonist. Lobeline sulfate increases dopamine (DA) release by inhibiting DA uptake into synaptic vesicles, and altering presynaptic DA storage. Lobeline sulfate is effective in smoking cessation .

HY-D1516

NerveGreen C3	Fluorescent Dye	Others
NerveGreen C3 is a cationic styrene based fluorescent dye. NerveGreen C3 can be used to track synaptic activity at neuromuscular junctions or synapses .

HY-D1629

Calcium Orange AM	Fluorescent Dye	Others
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles .

HY-W440988

DOPE-mPEG, MW 2000	Liposome	Others
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner .

HY-113273B

Diadenosine pentaphosphate pentaammonium	Endogenous Metabolite	Metabolic Disease
Diadenosine pentaphosphate pentaammonium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .

HY-113273C

Diadenosine pentaphosphate pentalithium	Endogenous Metabolite	Metabolic Disease
Diadenosine pentaphosphate pentalithium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .

HY-113273A

Diadenosine pentaphosphate pentasodium	Endogenous Metabolite	Metabolic Disease
Diadenosine pentaphosphate pentasodium is an endogenous vasoactive purine dinucleotide which has been isolated from thrombocytes. Diadenosine polyphosphates (ApnA, n=2–7) have been identified as constituents of secretory vesicles such as in platelets, chromaffin cells, Torpedo synaptic terminals and brain synaptosomes .

HY-P5878

RG33 Peptide	Biochemical Assay Reagents	Metabolic Disease
RG33 Peptide is a diabetes inhibitor that significantly improves glucose clearance in insulin-resistant mice. RG33 Peptide effectively solubilizes lipid vesicles and promotes cholesterol efflux in cultured macrophages. RG33 Peptide is used in research into type 2 diabetes (T2D) .

HY-E70278

(9Z-Octadecenyl)-CoA triammonium	Biochemical Assay Reagents	Metabolic Disease
(9Z-Octadecenyl)-CoA triammonium is a coenzyme. (9Z-Octadecenyl)-CoA triammonium is a long-chain acyl-CoA esters. Long-chain acyl-CoA esters are involved in regulation of fatty acid synthesis, enzyme systems, vesicle trafficking, ion channels and ion pumps .

HY-150220

1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate	Liposome	Others
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can be used for the synthesis of phospholipid vesicle and improve the encapsulation efficiency of proteins .

HY-13863

Hydroxy-Dynasore 3 Publications Verification Dyngo-4a	Dynamin	Neurological Disease
Hydroxy Dynasore (Dyngo-4a), a structural analog of Dynasore (HY-15304), is an potency improved, low cytotoxicity and non‐specific binding dynamin inhibitor with IC₅₀ values of 0.38 μM and 2.3 μM for brain dynamin I and recombinant rat dynamin II, respectively. Hydroxy Dynasore inhibits dynamin‐dependent endocytosis of transferrin with an IC₅₀ of 5.7 μM in vitro.

Cat. No.	Product Name

HY-L168

Extracellular Vesicles (EVs) Compound Library

406 compounds

Extracellular vesicles (EVs) are small membrane binding structures that are released from cells into the surrounding environment and play a crucial role in mediating and regulating intercellular communication related to physiological and pathological processes. EVs are lipid membrane vesicles composed of proteins, lipids, and nucleic acids. EVs can be divided into several types based on their source, such as extracellular vesicles, microcapsules, and apoptotic vesicles. The size range of exosomes is 30-150nm, which are endocrine in multi vesicular endosomes (MVEs); microvesicles (50-1000nm) are secreted directly through extracellular interactions, thereby releasing plasma membrane vesicles. In contrast, apoptotic bodies are usually larger, ranging in size from 1 to 5 μ m. This is generated during programmed cell death. EV plays a crucial role in transmitting information between cells and influencing the behavior and function of receptor cells.

MCE designs a unique collection of 406 small molecules related to extracellular vesicles (EVs). It is a good tool to be used for research on metabolize, cancer and other diseases.

HY-L072

Exosomes Compound Library

47 compounds

Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells in culture. Exosomes contain nucleic acids, proteins, lipids, amino acids, and metabolites, etc. Their diverse constituents can reflect their cell of origin. Exosomes are associated with immune responses, viral pathogenicity, pregnancy, cardiovascular diseases, central nervous system-related diseases, and cancer progression. Proteins, metabolites, and nucleic acids delivered by exosomes into recipient cells effectively alter their biological response. Such exosome-mediated responses can be disease promoting or restraining.

The biology of exosomes in disease is still emerging, and the number of studies addressing their utility in the diagnosis and treatment of various pathologies has increased substantially. MCE supplies a unique collection of 47 compounds with the activity of inhibiting or stimulating exsomes secretion/biosynthesis. MCE Exosomes Compound Library is a useful tool for exsomes research.

HY-L060

Cytoskeleton Compound Library

1276 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 1276 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-D1435

Oxonol VI	Fluorescent Dyes/Probes
Oxonol VI acts as an optical indicator for membrane potentials in lipid vesicles. Oxonol VI is suitable for detecting changes of membrane potential associated with the activity of the (Na ⁺ + K ⁺)-ATPase in reconstituted vesicles .

HY-D1438

RH 414

Dyes

RH 414 is the styryl pyridinium dye. RH 414 can be used for optical monitoring of synaptic vesicle membrane trafficking .

HY-D1515

FM1-84 Neurodye GH1-84	Fluorescent Dyes/Probes
FM1-84 (Neurodye GH1-84) is a fluorescent dye. FM1-84 has lipophilic and facilitates association with membranes, resulting in an increase in fluorescence intensity (λ_ex=510 nm, λ_em=625 nm). FM1-84 can be used for synaptic vesicle recycling in neurons research .

HY-D0040

Calcein 4 Publications Verification Fluorexon	Fluorescent Dyes/Probes
Calcein is a fluorescent dye and self-quenching probe, used as an indicator of lipid vesicle leakage, and also as a complexometric indicator for titration of calcium ions with EDTA, and for fluorometric determination of calcium.

HY-D1517

FM 2-10	Fluorescent Dyes/Probes
FM 2-10 is a fluorescent dye. FM 2-10 is a less hydrophobic version of FM 1-43 (HY-D1434). FM 2-10 can be used for identifying actively firing neurons and investigating the mechanisms of activity-dependent vesicle cycling .

HY-D1612

BODIPY FL C5-Ceramide

Fluorescent Dyes/Probes

The Golgi apparatus is composed of flattened vesicles superimposed on each other by unit membranes. The flattened vesicles are round with expanded and perforated edges. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye . BODIPY Fl C5-Ceramide is a Golgi-specific green fluorescent dye, which can visualise individual cells . Ex/Em= 505 nm/512 nm.

HY-D1735

BODIPY TR Ceramide

Golgi-Red Tracke

Fluorescent Dyes/Probes

The Golgi apparatus is composed of flattened vesicles superimposed on each other by unit membranes. The flattened vesicles are round with expanded and perforated edges. The Golgi fluorescent probe is a BODIPY-labeled ceramide derivative, the synthesis of which occurs in the endoplasmic reticulum and can then be transported to the Golgi via ceramide transport protein (CERT) or vesicular translocation, allowing specific labeling of the dye. BODIPY TR Ceramide (Golgi-Red Tracke) is a Golgi-specific fluorescent dye, which can visualise individual cells . Ex/Em=589 nm/616 nm.

HY-101013

D-SNAP S-Nitroso-N-acetylpenicillamine	Fluorescent Dyes/Probes
D-SNAP (S-Nitroso-N-acetylpenicillamine) can Generate nitric oxide and form superoxides spontaneously under physiological conditions and is often used to probe the cell stress response and stimulate calcium-independent synaptic vesicle release.

HY-D1516

NerveGreen C3	Fluorescent Dyes/Probes
NerveGreen C3 is a cationic styrene based fluorescent dye. NerveGreen C3 can be used to track synaptic activity at neuromuscular junctions or synapses .

HY-D1629

Calcium Orange AM	Fluorescent Dyes/Probes
Calcium Orange AM is an intracellular calcium reporter. Specific fluorescence can be detected when free calcium binds to Calcium Orange AM (Ex/Em=549/576 nm). Calcium Orange AM does not enter the vacuoles and does not compartmentalize into acidic vesicles .

HY-D1560

FG 488 DHPE	Fluorescent Dyes/Probes
FG 488 DHPE is a lipid-coupled fluorochrome, has be used as a fluorophore Oregon Green 488. FG 488 DHPE monitors acidification of lipid vesicles with λex/λem=508/534 nm.FG 488 DHPE is also used for Hv1-induced proton translocation quantificatio with λex/λem=508/534 nm as well .

HY-103466

FM4-64 5 Publications Verification	Fluorescent Dyes/Probes
FM4-64 is a very lipophilic, water-soluble styrene dyes, can specifically bind to cell membranes and inner membrane organelles to produce fluorescence. FM4-64 is widely used in endocytic and exospic membrane structure markers.

Cat. No.	Product Name	Type

HY-145539

12-Dipalmitoyl-sn-glycero-3-PS sodium salt	Drug Delivery
12-Dipalmitoyl-sn-glycero-3-PS sodium salt is an anionic diacyl phospholipid, a lipid component in cell membrane. 12-Dipalmitoyl-sn-glycero-3-PS sodium salt can be use in the preparation of catanionic vesicles and liposome .

HY-W250118

Phosphatidylethanolamine

Drug Delivery

Phosphatidylethanolamine is a phospholipid. It is used for preparation of vesicle suspensions, commonly called liposomes, or as monolayers.
HY-143204

(Rac)-POPC

Drug Delivery

(Rac)-POPC is a model phosphatidylcholine for the preparation of giant vesicles (GVs) .
HY-144007

Chol-PEG

Drug Delivery

Chol-PEG is a nonionic surfactant vesicles and can be used for a blood-persistent drug delivery system .
HY-143695

16:0 TAP

Drug Delivery

16:0 TAP is a lipid product. 16:0 TAP can be used for the preparation of giant unilamellar vesicles to deliver agents .

HY-143202

DPhPC	Drug Delivery
DPhPC is a phospholipid used to synthesize bilayer vesicles. DPhPC bilayers do not permit ions to leak in the absence of a pore/ion channel, which can be used for studies on channel proteins .

HY-W440988

DOPE-mPEG, MW 2000	Drug Delivery
DOPE-mPEG, MW 2000 is a phospholipid polydisperse PEG (or DOPE liposome), can be used for preparation of targeted delivery of liposomal drug and giant unilamellar vesicles (GUVs). DOPE-mPEG, MW 2000 significantly reduces the pH-sensitivity of the liposome in a concentration dependent manner .

HY-150220

1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate	Drug Delivery
1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate is a lipid. 1,5-Dihexadecyl N-(3-carboxy-1-oxopropyl)-L-glutamate can be used for the synthesis of phospholipid vesicle and improve the encapsulation efficiency of proteins .

HY-125619

1,2-Dioctanoyl-sn-glycero-3-phosphocholine

Drug Delivery

1,2-dioctanoyl-sn-glycero-3-phosphocholine, is a phospholipid commonly used as a component of liposome formulations and drug delivery systems. 1,2-dioctanoyl-sn-glycero-3-phosphocholine has unique chemical properties that allow it to form stable bilayers and vesicles, allowing drug encapsulation and delivery to specific targets in the body. It acts as a stabilizer and emulsifier, which can improve the solubility and bioavailability of drugs.

HY-P2149A

Concanavalin A (agarose)

Native Proteins

Concanavalin A (agarose) consists of Concanavalin A (HY-P2149) coupled to agarose. Concanavalin A is a tetrameric metalloprotein lectin isolated from Canavalia ensiformis (jack bean). Concanavalin A (agarose) is used for the purification of glycoproteins, polysaccharides and glycolipids as it binds molecules containing α-D-mannopyranosyl, α-D-glucopyranosyl and sterically related residues. Concanavalin A (agarose) has also be used in other application areas including purification of enzyme-antibody conjugates, purification of IgM and separation of membrane vesicles .

HY-W127487

N-Octadecanoyl-L-homoserine lactone

Biochemical Assay Reagents

Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.

Cat. No.	Product Name	Target	Research Area

HY-P3586

HKPao Hunter-killer peptide ao; Prohibitin-targeting peptide 1; prohibitin-TP01; Adipotide	Apoptosis	Cancer
HKPao (Hunter-killer peptide ao) is a biologically active peptide. HKPao (Hunter-killer peptide ao) has anti-obesity and anti-tumor pro-apoptotic activity to cause release of cytochrome c from vesicles .

HY-P3778

γ-Bag cell peptide	Peptides	Neurological Disease
γ-bag cell peptide is a peptide. γ-bag cell peptide is located near the N-terminus of the egg laying prohormone, the vesicle is released upon insulin stimulation. γ-bag cell peptide can be used for the research of the central and peripheral nervous systems .

HY-P4098

SynB1	Peptides	Others
SynB1 is a cell penetrating polypeptide, internalized by, or is associated with lipid vesicle (LV). SynB1 can be used to lipid vesicle-mediated delivery to cells .

HY-P3095

α-Latrotoxin

Peptides Neurological Disease

α-Latrotoxin, a potent neurotoxin from black widow spider venom, triggers synaptic vesicle exocytosis from presynaptic nerve terminals .

HY-P4120

MHV EPTM	Peptides	Others
MHV EPTM is a peptide used for in vitro giant unilamellar vesicle (GUV) deformation analysis. MHV-EPTM peptide with the GUV membranes made the GUVs smaller in size and more rugged in appearance .

HY-P5878

RG33 Peptide	Biochemical Assay Reagents	Metabolic Disease
RG33 Peptide is a diabetes inhibitor that significantly improves glucose clearance in insulin-resistant mice. RG33 Peptide effectively solubilizes lipid vesicles and promotes cholesterol efflux in cultured macrophages. RG33 Peptide is used in research into type 2 diabetes (T2D) .

HY-P0269

Magainin 1 Magainin I	Bacterial Fungal Antibiotic	Infection
Magainin 1 (Magainin I) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P0269A

Magainin 1 TFA Magainin I TFA	Bacterial Fungal Antibiotic	Infection
Magainin 1 TFA (Magainin I TFA) is an antimicrobial and amphipathic peptide isolated from the skin of Xenopus laevis. Magainin 1 TFA exhibits antibiotic activity against numerous Gram-negative and Gram-positive bacteria .

HY-P1376A

G-Protein antagonist peptide TFA	mAChR Adrenergic Receptor	Endocrinology
G-Protein antagonist peptide TFA is a truncated substance P-related peptide, competes with receptor for G protein binding. G-Protein antagonist peptide TFA inhibits the activation of G_i or G_o by M2 muscarinic cholinergic receptor (M2 mAChR) or of G_s by beta-adrenergic receptor in the reconstituted phospholipid vesicles, assayed by receptor-promoted GTP hydrolysis .

Species:	Human (11) Rat (1)
Tag:	His (9) Tag Free (2) Strep (2) GST (1) Fc (1)
Source:	HEK293 (4) E. coli Cell-free (1) Sf9 insect cells (1) E. coli (6)

Cat. No.	Compare	Product Name	Species	Source

HY-P76700

	VTI1A Protein, Human (HEK293, His) vesicle transport through interaction with t-SNAREs homolog 1A; Vti1-rp2	Human	HEK293
	VTI1A Protein, a V-SNARE, mediates vesicle transport by interacting with t-SNAREs on target membranes, facilitating lipid bilayer fusion. It plays a role in vesicular transport from late endosomes to the trans-Golgi network. Collaborating with VAMP7, it participates in a non-conventional RAB1-dependent route to the cell surface used by KCNIP1 and KCND2. VTI1A interacts with SNARE complexes containing STX5 or STX6, NAPA, and to a lesser extent, NAPG. It is part of a complex with STX6, STX12, VAMP4, and VTI1A. VTI1A Protein, Human (HEK293, His) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-His labeled tag. The total length of VTI1A Protein, Human (HEK293, His) is 187 a.a., with molecular weight of ~29 & 25 & 20 kDa, respectively.

HY-P701843

	SNAP23 Protein, Human SNAP23; Synaptosomal-associated protein 23; SNAP-23; vesicle-membrane fusion protein SNAP-23	Human	E. coli
	SNAP23 Protein is an essential part of the receptor for membrane fusion machinery, regulating vesicle docking and fusion. It forms homotetramers and heterotetramers with STX4 and VAMP3. It interacts with SNAPIN, SYN4, STX1A, and STX12, as well as multiple syntaxins and synaptobrevins/VAMPs. Additionally, it interacts with ZDHHC13 and ZDHHC17. SNAP23 Protein, Human is the recombinant human-derived SNAP23 protein, expressed by E. coli , with tag free. The total length of SNAP23 Protein, Human is 211 a.a., .

HY-P76121

	VAMP3 Protein, Human (His) vesicle-associated membrane protein 3; VAMP-3; Cellubrevin; CEB; Synaptobrevin-3; VAMP3; SYB3	Human	E. coli
	VAMP3 protein is an important SNARE protein that promotes vesicle transport from late endosomes to the trans-Golgi network. Its interaction with BVES, mediated by its C-terminal cytoplasmic tail, is crucial in this process. VAMP3 Protein, Human (His) is the recombinant human-derived VAMP3 protein, expressed by E. coli , with N-His labeled tag. The total length of VAMP3 Protein, Human (His) is 77 a.a., with molecular weight of ~11 kDa.

HY-P76701

	VTI1A Protein, Human (HEK293, Fc) vesicle transport through interaction with t-SNAREs homolog 1A; Vti1-rp2	Human	HEK293
	VTI1A Protein, a V-SNARE, mediates vesicle transport by interacting with t-SNAREs on target membranes, facilitating lipid bilayer fusion. It plays a role in vesicular transport from late endosomes to the trans-Golgi network. Collaborating with VAMP7, it participates in a non-conventional RAB1-dependent route to the cell surface used by KCNIP1 and KCND2. VTI1A interacts with SNARE complexes containing STX5 or STX6, NAPA, and to a lesser extent, NAPG. It is part of a complex with STX6, STX12, VAMP4, and VTI1A. VTI1A Protein, Human (HEK293, Fc) is the recombinant human-derived VTI1A protein, expressed by HEK293 , with N-mFc labeled tag. The total length of VTI1A Protein, Human (HEK293, Fc) is 187 a.a., with molecular weight of ~48.5 kDa.

HY-P701842

	SNAP23 Protein, Human (His, Strep) SNAP23; Synaptosomal-associated protein 23; SNAP-23; vesicle-membrane fusion protein SNAP-23	Human	E. coli
	SNAP23 Protein is an essential part of the receptor for membrane fusion machinery, regulating vesicle docking and fusion. It forms homotetramers and heterotetramers with STX4 and VAMP3. It interacts with SNAPIN, SYN4, STX1A, and STX12, as well as multiple syntaxins and synaptobrevins/VAMPs. Additionally, it interacts with ZDHHC13 and ZDHHC17. SNAP23 Protein, Human (His, Strep) is the recombinant human-derived SNAP23 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of SNAP23 Protein, Human (His, Strep) is 211 a.a., .

HY-P71044

	VAPB Protein, Human (His) vesicle-associated membrane protein-associated protein B/C; VAMP-B/VAMP-C; VAMP-associated protein B/C; VAP-B/VAP-C	Human	E. coli
	VAPB protein interacts with STARD3 through a phosphorylation-dependent mechanism to form a contact site between the endoplasmic reticulum (ER) and late endosomes. VAPB Protein, Human (His) is the recombinant human-derived VAPB protein, expressed by E. coli , with C-6*His labeled tag. The total length of VAPB Protein, Human (His) is 131 a.a., with molecular weight of ~17.0 kDa.

HY-P702054

	Vps29 Protein, Human VPS29; Vacuolar protein sorting-associated protein 29; hVPS29; PEP11 homolog; vesicle protein sorting 29	Human	E. coli
	The Vps29 protein is an important component of the reverse transcriptase cargo-selective complex (CSC), which prevents mispairing of transmembrane cargo proteins leading to lysosomal degradation. It coordinates retrograde transport from endosomes to the trans-Golgi network through distinct pathways involving the SNX-BAR, SNX3, and SNX27 retrosome complexes. Vps29 Protein, Human is the recombinant human-derived Vps29 protein, expressed by E. coli , with tag free. The total length of Vps29 Protein, Human is 182 a.a., .

HY-P702055

	Vps29 Protein, Human (His, Strep) VPS29; Vacuolar protein sorting-associated protein 29; hVPS29; PEP11 homolog; vesicle protein sorting 29	Human	E. coli
	The Vps29 protein is an important component of the reverse transcriptase cargo-selective complex (CSC), which prevents mispairing of transmembrane cargo proteins leading to lysosomal degradation. It coordinates retrograde transport from endosomes to the trans-Golgi network through distinct pathways involving the SNX-BAR, SNX3, and SNX27 retrosome complexes. Vps29 Protein, Human (His, Strep) is the recombinant human-derived Vps29 protein, expressed by E. coli , with N-Strep, N-6*His labeled tag. The total length of Vps29 Protein, Human (His, Strep) is 182 a.a., .

HY-P700879

	PLVAP Protein, Human (HEK293, His) Plasmalemma vesicle-associated protein; FELS; PV1	Human	HEK293
	The PLVAP protein is an endothelial cell-specific membrane protein that plays a key role in the complex structure of endothelial fenestrae by participating in the formation of septa that bridge these fenestrae. Furthermore, it plays a crucial role in the development of stomata within caveolae and transendothelial channels. PLVAP Protein, Human (HEK293, His) is the recombinant human-derived PLVAP protein, expressed by HEK293 , with N-His labeled tag. The total length of PLVAP Protein, Human (HEK293, His) is 394 a.a., with molecular weight of 50-70 kDa.

HY-P702462

	SYP/Synaptophysin Protein, Rat (Cell-Free, His) Synaptophysin; Major synaptic vesicle protein p38	Rat	E. coli Cell-free
	The SYP/synaptophysin protein may have a dual role: organizing membrane components and aiding in vesicle targeting. Its role in the regulation of synaptic plasticity emphasizes its importance in shaping synaptic activity. SYP/Synaptophysin Protein, Rat (Cell-Free, His) is the recombinant rat-derived SYP/Synaptophysin protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of SYP/Synaptophysin Protein, Rat (Cell-Free, His) is 307 a.a., with molecular weight of 34.8 kDa.

HY-P71139

	SP-10/ACRV1 Protein, Human (HEK293, C-His) Acrosomal Protein SP-10; Acrosomal vesicle Protein 1; ACRV1	Human	HEK293
	SP-10/ACRV1 Protein is a testis-specific acrosomal matrix protein, which is evolutionarily conserved among mammals. The gene coding for the SP-10 protein, Acrv1, served as an outstanding model to understand the regulation of male germ-cell-specific gene transcription. The human and mouse SP-10 proteins share homology in the carboxyl terminal region, but contain distinct amino termini. SP-10 probably has an important role in human sperm function, is a promising contraceptive vaccine immunogen for humans, and can serve as a marker protein. SP-10/ACRV1 Protein, Human (HEK293, C-His) is the recombinant human-derived SP-10/ACRV1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SP-10/ACRV1 Protein, Human (HEK293, C-His) is 244 a.a., with molecular weight of ~35.0 kDa.

HY-P701778

	SCYL2 Protein, Human (Sf9, His, GST) SCYL2; SCY1-like protein 2; Coated vesicle-associated kinase of 104 kDa	Human	Sf9 insect cells
	The SCYL2 protein is a component of the AP2-containing clathrin coat and may regulate clathrin-dependent trafficking at the plasma membrane, TGN, and endosomal systems. SCYL2 Protein, Human (Sf9, His, GST) is the recombinant human-derived SCYL2 protein, expressed by Sf9 insect cells , with N-8*His, N-GST labeled tag. The total length of SCYL2 Protein, Human (Sf9, His, GST) is 928 a.a., .

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