SHP099 hydrochloride

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SHP099 hydrochloride is an allosteric SHP2 inhibitor, with IC₅₀s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2^D61Y, SHP2E69K, SHP2^A72V, SHP2^E76K. SHP099 hydrochloride inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC₅₀: 0.32 and 1.73 μM). SHP099 hydrochloride inhibits RAS-ERK signaling and inhibit tumor growth.

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SHP099 hydrochloride Chemical Structure

CAS No. : 1801747-11-4

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Other In-stock Forms of SHP099 hydrochloride:

SHP099 SHP099 monohydrochloride

Other Forms of SHP099 hydrochloride:

SHP099 In-stock
SHP099 monohydrochloride In-stock

53 Publications Citing Use of MCE SHP099 hydrochloride

: SHP099 hydrochloride purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2018 Oct;8(10):1237-1249. [Abstract]; Immunoblots of whole cell lysates or GST-RBD-precipitated (RAS-GTP, KRASGTP and NRAS-GTP) lysates from PDAC cells treated with DMSO, SHP099 10 μM, AZD6244 1 μM, or both drugs for the times indicated.

: SHP099 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2019 Apr 1;10(1):1473. [Abstract]; SHP099 inhibits IRS1-AP2 interaction in primary hepatocytes.

: SHP099 hydrochloride purchased from MedChemExpress. Usage Cited in: Hepatology. 2018 Jul;68(1):333-348. [Abstract]; Primary human HSCs are treated with SHP099 for 1 hour. PDGF-BB is added and cells are cultured for 12 additional hours. Whole cell lysates and EVs are examined by WB (n=6).

: SHP099 hydrochloride purchased from MedChemExpress. Usage Cited in: Open Biol. 2017 May;7(5). pii: 170066. [Abstract]; Comparing the effects of SHP2 degradation and allosteric inhibition on Ras/MAPK signalling. (a) Human U2OS, A549, K-562 and MDA-MB-468 cells are treated with DMSO control or 1, 5 and 10 µM SHP099 for 2 h prior to lysis. Extracts (10 µg protein) are resolved by SDS-PAGE and transferred to nitrocellulose membranes, which are subjected to western blotting with the indicated antibodies. (b) Uninfected U2OS cells (WT) or cells infected with retroviruses encoding VHL, aCS3 and VHL-aCS3 are treated wit

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Description	SHP099 hydrochloride is an allosteric SHP2 inhibitor, with IC₅₀s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2^D61Y, SHP2E69K, SHP2^A72V, SHP2^E76K. SHP099 hydrochloride inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC₅₀: 0.32 and 1.73 μM). SHP099 hydrochloride inhibits RAS-ERK signaling and inhibit tumor growth^[1]^[2].
IC₅₀ & Target	0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2^D61Y, SHP2E69K, SHP2^A72V, SHP2^E76K^[1]
Formula	C₁₆H₁₉Cl₂N₅.xClH
CAS No.	1801747-11-4
SMILES	ClC1=CC=CC(C2=NC=C(N3CCC(C)(CC3)N)N=C2N)=C1Cl.Cl.[x]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (271 KB) Handling Instructions (2659 KB)
References	[1]. Sun X, et al. Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099. Leukemia. 2018 May;32(5):1246-1249. [Content Brief] [2]. Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52. [Content Brief]