2. Cell Cycle/DNA Damage
  3. DNA Stain
  4. SiR-Hoechst

SiR-Hoechst is a far-red fluorescent DNA probe being used widely for time-lapse imaging of living cells. SiR-Hoechst is minimally toxic at concentrations as high as 10-25 µM. SiR-Hoechst induces DNA damage responses and G2 arrest at concentrations well below 1 µM.

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SiR-Hoechst Chemical Structure

SiR-Hoechst Chemical Structure

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SiR-Hoechst Related Antibodies

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Description

SiR-Hoechst is a far-red fluorescent DNA probe being used widely for time-lapse imaging of living cells. SiR-Hoechst is minimally toxic at concentrations as high as 10-25 µM. SiR-Hoechst induces DNA damage responses and G2 arrest at concentrations well below 1 µM[1][2].

In Vitro

SiR-Hoechst has some clear advantages: it is selective for DNA; its fluorescence is enhanced upon DNA binding; it is excited by far-red light, avoiding damage caused by the UV light required for traditional Hoechst dyes; and it is compatible with live-cell super-resolution microscopy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SiR-Hoechst Related Antibodies
Molecular Weight

950.21

Formula

C56H59N9O4Si
SMILES

CN(CC1)CCN1C2=CC=C(N3)C(N=C3C4=CC=C(N5)C(N=C5C(C=C6)=CC=C6OCCCCNC(C(C=C7)=CC(C(C8=C([Si]9(C)C)C=C(C=C8)N(C)C)=C(C=C/%10)C9=CC%10=[N+](C)/C)=C7C([O-])=O)=O)=C4)=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SiR-Hoechst Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SiR-HoechstDNA StainInhibitorinhibitorinhibit

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