2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SIRT2-IN-8

SIRT2-IN-8 is a potent SIRT2 inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research.

For research use only. We do not sell to patients.

SIRT2-IN-8 Chemical Structure

SIRT2-IN-8 Chemical Structure

CAS No. : 115687-05-3

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1 mg USD 85 In-stock
5 mg USD 190 In-stock
10 mg USD 300 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

SIRT2-IN-8 is a potent SIRT2 inhibitor. SIRT2-IN-8 can be used for Huntington’s and Parkinson’s diseases research[1].

IC50 & Target

SIRT2

 

Molecular Weight

396.83

Formula

C20H17ClN4O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=C(Cl)C=C1)N(CC2)CCN2C(C=C3)=C(C=CC=N4)C4=C3[N+]([O-])=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (126.00 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5200 mL 12.5999 mL 25.1997 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.32%

COA (250 KB) HNMR (272 KB) LCMS (91 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5200 mL 12.5999 mL 25.1997 mL 62.9993 mL
5 mM 0.5040 mL 2.5200 mL 5.0399 mL 12.5999 mL
10 mM 0.2520 mL 1.2600 mL 2.5200 mL 6.2999 mL
15 mM 0.1680 mL 0.8400 mL 1.6800 mL 4.2000 mL
20 mM 0.1260 mL 0.6300 mL 1.2600 mL 3.1500 mL
25 mM 0.1008 mL 0.5040 mL 1.0080 mL 2.5200 mL
30 mM 0.0840 mL 0.4200 mL 0.8400 mL 2.1000 mL
40 mM 0.0630 mL 0.3150 mL 0.6300 mL 1.5750 mL
50 mM 0.0504 mL 0.2520 mL 0.5040 mL 1.2600 mL
60 mM 0.0420 mL 0.2100 mL 0.4200 mL 1.0500 mL
80 mM 0.0315 mL 0.1575 mL 0.3150 mL 0.7875 mL
100 mM 0.0252 mL 0.1260 mL 0.2520 mL 0.6300 mL
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SIRT2-IN-8 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIRT2-IN-8115687-05-3SirtuinParkinson’s diseasesHuntington’s diseasesInhibitorinhibitorinhibit

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