2. Anti-infection
  3. Parasite
  4. SJ000025081

SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii.

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SJ000025081 Chemical Structure

SJ000025081 Chemical Structure

CAS No. : 421571-66-6

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Description

SJ000025081 is a dihydropyridine and acts as a potent antimalarial agent. SJ000025081 results in an obvious suppression of the parasitemia in a murine malaria model infected with P. yoelii[1].

In Vivo

SJ000025081 (intraperitoneal injection; 25 mg/kg; single dose; suspension in 1% methylcellulose) exhibits a good PK profile, the Cmax, Cmax/Dose, Tmax and AUC values are 0.224 µg/ml, 0.0113 µg/ml per mg/ml, 1.0 h and 0.224 µg.h/ml, respectively[1].
SJ000025081 (intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days) exhibits an antimalarial activity in a dose-dependent manner and displays efficacy in a murine malaria model infected with P. yoelii. SJ000025081 can result in a 90% suppression of the parasitemia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6 weeks old CD-1 mice[1]
Dosage: 5 mg/kg; 10 mg/kg; 25 mg/kg; 50 mg/kg; 100 mg/kg
Administration: Intraperitoneal injection; 5-100 mg/kg; twice-daily; 3 days
Result: Was active in a malaria murine model infected with P. yoelii.
Molecular Weight

479.54

Formula

C28H30FNO5
CAS No.
SMILES

O=C(C1=C(C)NC2=C(C(CC(C3=CC=C(OC)C(OC)=C3)C2)=O)C1C4=CC=CC=C4F)OCCC
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SJ000025081 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SJ000025081421571-66-6SJ 000025081SJ-000025081ParasiteantimalarialparasitemiamalariaP. yoeliidihydropyridinePlasmodium falciparumInhibitorinhibitorinhibit

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