Sulopenem sodium  (Synonyms: CP-70429 sodium)

Sulopenem (sodium)(CP-70429 (sodium)) is an orally active, parenteral penem antibiotic with broad-spectrum activities against Gram-positive and Gram-negative bacteria. Sulopenem has the potential for urinary tract infections and intra-abdominal infections treatment. Sulopenem is inactive against Pseudomonas aeruginosa and Xanthomonas maltophilia^[1][2][3].

371.43

C₁₂H₁₄NNaO₅S₃

112294-81-2

O=C(C(N12)=C(S[C@@H](CC3)C[S@@]3=O)S[C@]2([H])[C@@H]([C@H](O)C)C1=O)O[Na]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Karlowsky JA, et al. In Vitro Activity of Sulopenem, an Oral Penem, against Urinary Isolates of Escherichia coli. Antimicrob Agents Chemother. 2018;63(1):e01832-18. Published 2018 Dec 21.  [Content Brief]

  [2]. Minamimura M, et al. In vitro antibacterial activity and beta-lactamase stability of CP-70,429 a new penem antibiotic. Antimicrob Agents Chemother. 1993;37(7):1547-1551.  [Content Brief]

  [3]. Nagashima M, et al. In vitro and in vivo activities of sulopenem compared with those of imipenem and cephalosporins. Jpn J Antibiot. 1996;49(4):303-323.  [Content Brief]