2. Apoptosis
  3. Apoptosis
  4. Tafasitamab

Tafasitamab  (Synonyms: XmAb5574; MOR00208; Tafasitamab-cxix)

Cat. No.: HY-P9981 Purity: 98.53%
COA

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Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19.

For research use only. We do not sell to patients.

Tafasitamab Chemical Structure

Tafasitamab Chemical Structure

CAS No. : 1422527-84-1

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Based on 1 publication(s) in Google Scholar

Tafasitamab Related Antibodies

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Description

Tafasitamab (XmAb5574) is an Fc-modified, humanized monoclonal antibody that binds to the human B-cell surface antigenCD19[1][2].

In Vitro

Tafasitamab (XmAb5574) induces cytotoxicity against Mino and Jeko (MCL) cell lines? in an E/T ratio-dependent manner. Tafasitamab (XmAb5574) increases ADCP and antiproliferative? activity. Tafasitamab (XmAb5574) enhances antiproliferative apoptotic activity due to caspase-induced apoptosis[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tafasitamab Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: NHL cell lines and primary CLL and MCL cells by γδ T cells
Concentration:
Incubation Time: 2 h
Result: Induced killing of NHL cell lines and primary CLL and MCL cells by γδ T cells.

Cell Proliferation Assay[2]

Cell Line: SU-DHL-6 cells
Concentration:
Incubation Time: 72 h
Result: Showed potent antiproliferative effects on tumor cell.

Apoptosis Analysis[2]

Cell Line: SU-DHL-6 cells
Concentration: 0-4 ng/mL
Incubation Time: 48 h
Result: Showed potent antiproliferative effects due to caspase-induced apoptosis
In Vivo

Tafasitamab (SC, once on Day 1, 2.5 μg/kg) inhibits lymphoma growth in disseminated BL mouse xenograft tumor models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Disseminated Raji model[1].
Dosage: 2.5 μg/kg
Administration: Tafasitamab (SC, once on Day 1, 2.5 μg/kg)
Result: Showed antitumor activity in disseminated Raji model.
Animal Model: Disseminated Ramos model[1].
Dosage: 10 mg/kg
Administration: Tafasitamab (IV, on Days 3, 6, 10, 13, 17, and 20 at a dose of 10 mg/kg)
Result: Showed antitumor activity in disseminated Ramos model.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Tafasitamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.53%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Tafasitamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tafasitamab1422527-84-1XmAb5574 MOR00208 Tafasitamab-cxixXmAb 5574XmAb-5574MOR00208MOR 00208MOR-00208ApoptosisCD19 antibodyb-cellimmunotherapyInhibitorinhibitorinhibit

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