2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease
  3. GABA Receptor Endogenous Metabolite
  4. Tetrahydrodeoxycorticosterone-d3

Tetrahydrodeoxycorticosterone-d3  (Synonyms: Tetrahydro-11-deoxycorticosterone-d3)

Cat. No.: HY-113346S
Handling Instructions

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Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2][3].

For research use only. We do not sell to patients.

Tetrahydrodeoxycorticosterone-d<sub>3</sub> Chemical Structure

Tetrahydrodeoxycorticosterone-d3 Chemical Structure

CAS No. : 72205-58-4

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500 μg USD 290 In-stock
1 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Tetrahydrodeoxycorticosterone-d3:

Tetrahydrodeoxycorticosterone-d3 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Tetrahydrodeoxycorticosterone-d3

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Tetrahydrodeoxycorticosterone-d3 is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties[1][2][3].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrahydrodeoxycorticosterone-d3 Related Antibodies
Molecular Weight

337.51

Formula

C21H31D3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@]2([2H])C(C([2H])([2H])O)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (296.29 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9629 mL 14.8144 mL 29.6287 mL
5 mM 0.5926 mL 2.9629 mL 5.9258 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9629 mL 14.8144 mL 29.6288 mL 74.0719 mL
5 mM 0.5926 mL 2.9629 mL 5.9258 mL 14.8144 mL
10 mM 0.2963 mL 1.4814 mL 2.9629 mL 7.4072 mL
15 mM 0.1975 mL 0.9876 mL 1.9753 mL 4.9381 mL
20 mM 0.1481 mL 0.7407 mL 1.4814 mL 3.7036 mL
25 mM 0.1185 mL 0.5926 mL 1.1852 mL 2.9629 mL
30 mM 0.0988 mL 0.4938 mL 0.9876 mL 2.4691 mL
40 mM 0.0741 mL 0.3704 mL 0.7407 mL 1.8518 mL
50 mM 0.0593 mL 0.2963 mL 0.5926 mL 1.4814 mL
60 mM 0.0494 mL 0.2469 mL 0.4938 mL 1.2345 mL
80 mM 0.0370 mL 0.1852 mL 0.3704 mL 0.9259 mL
100 mM 0.0296 mL 0.1481 mL 0.2963 mL 0.7407 mL
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Tetrahydrodeoxycorticosterone-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrahydrodeoxycorticosterone-d372205-58-4Tetrahydro-11-deoxycorticosterone-d3GABA ReceptorEndogenous MetaboliteGamma-aminobutyric acid Receptorγ-Aminobutyric acid ReceptorInhibitorinhibitorinhibit

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