1. GPCR/G Protein Neuronal Signaling
  2. Opioid Receptor
  3. Trimebutine

Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects.

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Trimebutine Chemical Structure

Trimebutine Chemical Structure

CAS No. : 39133-31-8

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Description

Trimebutine is a drug with antimuscarinic and weak mu opioid agonist effects. Target: Opioid Receptor Trimebutine is an agonist of peripheral mu, kappa and delta opiate receptors, used as spasmolytic agent for treatment of both acute and chronic abdominal pain [1]. The major product from drug metabolism of trimebutine in human beings is nor-trimebutine, which comes from removal of one of the methyl groups attached to nitrogen. Trimebutine exerts its effects in part due to causing a premature activation of phase III of the migrating motor complex in the digestive tract [2, 3].

Clinical Trial
Molecular Weight

387.47

Formula

C22H29NO5

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCC(C1=CC=CC=C1)(N(C)C)CC)C2=CC(OC)=C(OC)C(OC)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (258.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5808 mL 12.9042 mL 25.8084 mL
5 mM 0.5162 mL 2.5808 mL 5.1617 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5808 mL 12.9042 mL 25.8084 mL 64.5211 mL
5 mM 0.5162 mL 2.5808 mL 5.1617 mL 12.9042 mL
10 mM 0.2581 mL 1.2904 mL 2.5808 mL 6.4521 mL
15 mM 0.1721 mL 0.8603 mL 1.7206 mL 4.3014 mL
20 mM 0.1290 mL 0.6452 mL 1.2904 mL 3.2261 mL
25 mM 0.1032 mL 0.5162 mL 1.0323 mL 2.5808 mL
30 mM 0.0860 mL 0.4301 mL 0.8603 mL 2.1507 mL
40 mM 0.0645 mL 0.3226 mL 0.6452 mL 1.6130 mL
50 mM 0.0516 mL 0.2581 mL 0.5162 mL 1.2904 mL
60 mM 0.0430 mL 0.2151 mL 0.4301 mL 1.0754 mL
80 mM 0.0323 mL 0.1613 mL 0.3226 mL 0.8065 mL
100 mM 0.0258 mL 0.1290 mL 0.2581 mL 0.6452 mL
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Trimebutine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Trimebutine
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