[Tyr0] Corticotropin Releasing Factor, ovine

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[Tyr0] Corticotropin Releasing Factor, ovine is a corticotropin releasing factor/hormone isolated from ovine. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin.

For research use only. We do not sell to patients.

[Tyr0] Corticotropin Releasing Factor, ovine Chemical Structure

CAS No. : 83930-34-1

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Description

In Vitro

[Tyr0] Corticotropin Releasing Factor, ovine has a strong binding effect with plasma protein^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[Tyr0] Corticotropin Releasing Factor, ovine (328 μCi/μg; 198 pg/min or 225 pg/min; continuous infusions intravenous; single dose lasting 5-7 hr) shows a long plasma half-life and low metabolic clearance rate in male cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Young adult male cynomolgus monkeys (4.0-6.9 kg)^[1]
Dosage:	10 mL/h for 198 pg/min or 225 pg/min
Administration:	Continuous infusions intravenous; collected every 60 min during 5-7 hr
Result:	Showed a longer plasma half-life than for all other known hypothalamic peptides and its metabolic clearance rate was relatively low and considerably less all other known hypothalamic peptides or adreno-cortico-tropic-hormone (ACTH).

Molecular Weight

4833.48

Formula

C₂₁₄H₃₄₈N₆₀O₆₅S

CAS No.

83930-34-1

Sequence Shortening

Tyr-Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References

[1]. Schulte HM, et al. Metabolic clearance rate and plasma half-life of radioiodinated corticotropin releasing factor in a primate. J Clin Endocrinol Metab. 1982 Nov;55(5):1023-5. [Content Brief]

[2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7. [Content Brief]

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Tyr0] Corticotropin Releasing Factor, ovine83930-34-1Othershypothalamic hormoneadrenocorticotrophic hormoneACTHCRFCRHInhibitorinhibitorinhibit

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[Tyr0] Corticotropin Releasing Factor, ovine