2. Immunology/Inflammation
  3. PD-1/PD-L1
  4. WL12

WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

WL12 Chemical Structure

WL12 Chemical Structure

CAS No. : 1886057-64-2

Size Price Stock Quantity
1 mg USD 350 In-stock
5 mg USD 950 In-stock
10 mg USD 1550 In-stock
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100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

WL12 Related Antibodies

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Description

WL12 is a specifically targeting programmed death ligand 1 (PD-L1) binding peptide. WL12 can be radiolabeled by different radionuclides, generating radiotracers, which can assess the tumor PD-L1 expression[1].

IC50 & Target

PD-L1[1]
Molecular Weight

1882.19

Formula

C91H128N22O20S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Cyclo(Ac-Y-{Ala(Me)}-NPHL-{Hyp}-Trp-Ser-{Trp(Me)}-{Nle(Me)}-{Nle(Me)}-{Orn}-Cys)Gly-NH2 (Thioether bridge: Cys14-Ac-Tyr)
Sequence Shortening

Cyclo(Ac-Y-{Ala(Me)}-NPHL-{Hyp}-WS-{Trp(Me)}-{Nle(Me)}-{Nle(Me)}-{Orn}-C)G-NH2 (Thioether bridge: Cys14-Ac-Tyr)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (26.56 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5313 mL 2.6565 mL 5.3130 mL
5 mM 0.1063 mL 0.5313 mL 1.0626 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.5313 mL 2.6565 mL 5.3130 mL 13.2824 mL
5 mM 0.1063 mL 0.5313 mL 1.0626 mL 2.6565 mL
10 mM 0.0531 mL 0.2656 mL 0.5313 mL 1.3282 mL
15 mM 0.0354 mL 0.1771 mL 0.3542 mL 0.8855 mL
20 mM 0.0266 mL 0.1328 mL 0.2656 mL 0.6641 mL
25 mM 0.0213 mL 0.1063 mL 0.2125 mL 0.5313 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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WL12 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WL121886057-64-2WL 12WL-12PD-1/PD-L1PD-1/Programmed death-ligand 1binding peptidetumorInhibitorinhibitorinhibit

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