2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. XSJ-10

XSJ-10 is a HDAC inhibitor containing a RAS/RAF protein interfering unit, with IC50s of 0.05 and 0.04 μM in PANC-1 cells and HT-29 cells. XSJ-10 can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3.

For research use only. We do not sell to patients.

XSJ-10 Chemical Structure

XSJ-10 Chemical Structure

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Description

XSJ-10 is a HDAC inhibitor containing a RAS/RAF protein interfering unit, with IC50s of 0.05 and 0.04 μM in PANC-1 cells and HT-29 cells. XSJ-10 can effectively induce the apoptosis of cancer cells and suppress the tumor by strongly inhibiting the RAS-RAF-MEK-ERK signaling pathway and the acetylation level of HDAC3[1].

IC50 & Target

HDAC1

11.37 nM (IC50)

HDAC2

9.97 nM (IC50)

HDAC3

8.97 nM (IC50)

HDAC8

88.64 nM (IC50)

HDAC4

75.05 nM (IC50)

HDAC5

75.14 nM (IC50)

HDAC7

121.28 nM (IC50)

HDAC9

83.67 nM (IC50)

HDAC6

67.04 nM (IC50)

HDAC10

77.55 nM (IC50)

HDAC11

72.54 nM (IC50)

Molecular Weight

466.50

Formula

C21H26N2O8S
SMILES

COC1=CC(OC)=C(C(OC)=C1)/C=C/S(CC2=CC=C(C(NCC(NO)=O)=C2)OC)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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XSJ-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

XSJ-10XSJ10XSJ 10HDACHistone deacetylasesRASRAFcancerHDAC3PANC-1HT-29MEKERKInhibitorinhibitorinhibit

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XSJ-10
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HY-157740
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