Z-AEVD-FMK

Cat. No.: HY-125305 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs).

For research use only. We do not sell to patients.

Z-AEVD-FMK Chemical Structure

CAS No. : 1135688-47-9

Size	Price	Stock	Quantity
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1750	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 2800	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 4450	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Description

Z-AEVD-FMK is a cleavable ADC linker for the synthesis of antibody active molecule conjugates (ADCs).

Molecular Weight

610.63

Formula

C₂₈H₃₉FN₄O₁₀

CAS No.

1135688-47-9

Appearance

Solid

Color

White to light yellow

SMILES

O=C(OC)C[C@@H](C(CF)=O)NC([C@H](C(C)C)NC([C@H](CCC(OC)=O)NC([C@H](C)NC(OCC1=CC=CC=C1)=O)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (204.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6377 mL	8.1883 mL	16.3765 mL
5 mM	0.3275 mL	1.6377 mL	3.2753 mL
10 mM	0.1638 mL	0.8188 mL	1.6377 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (241 KB) SDS (252 KB)

COA (247 KB) HNMR (271 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6377 mL	8.1883 mL	16.3765 mL	40.9413 mL
	5 mM	0.3275 mL	1.6377 mL	3.2753 mL	8.1883 mL
	10 mM	0.1638 mL	0.8188 mL	1.6377 mL	4.0941 mL
	15 mM	0.1092 mL	0.5459 mL	1.0918 mL	2.7294 mL
	20 mM	0.0819 mL	0.4094 mL	0.8188 mL	2.0471 mL
	25 mM	0.0655 mL	0.3275 mL	0.6551 mL	1.6377 mL
	30 mM	0.0546 mL	0.2729 mL	0.5459 mL	1.3647 mL
	40 mM	0.0409 mL	0.2047 mL	0.4094 mL	1.0235 mL
	50 mM	0.0328 mL	0.1638 mL	0.3275 mL	0.8188 mL
	60 mM	0.0273 mL	0.1365 mL	0.2729 mL	0.6824 mL
	80 mM	0.0205 mL	0.1024 mL	0.2047 mL	0.5118 mL
	100 mM	0.0164 mL	0.0819 mL	0.1638 mL	0.4094 mL

Z-AEVD-FMK Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-AEVD-FMK1135688-47-9ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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